UniProtKB - Q6S9V7 (CISY_KATPE)
Protein
Citrate synthase, mitochondrial
Gene
cs
Organism
Katsuwonus pelamis (Skipjack tuna) (Bonito)
Status
Functioni
Miscellaneous
Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Catalytic activityi
- EC:2.3.3.1PROSITE-ProRule annotation
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Citrate synthase, mitochondrial (cs)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 304 | PROSITE-ProRule annotation | 1 | |
Active sitei | 350 | PROSITE-ProRule annotation | 1 | |
Active sitei | 405 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- citrate (Si)-synthase activity Source: UniProtKB
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB
- citrate metabolic process Source: InterPro
- tricarboxylic acid cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Tricarboxylic acid cycle |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Names & Taxonomyi
Protein namesi | Recommended name: Citrate synthase, mitochondrial (EC:2.3.3.1)Alternative name(s): Citrate (Si)-synthase |
Gene namesi | Name:cs |
Organismi | Katsuwonus pelamis (Skipjack tuna) (Bonito) |
Taxonomic identifieri | 8226 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Pelagiaria › Scombriformes › Scombridae › Katsuwonus |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 30 | MitochondrionBy similarityAdd BLAST | 30 | |
ChainiPRO_0000253903 | 31 – 469 | Citrate synthase, mitochondrialAdd BLAST | 439 |
Interactioni
Subunit structurei
Homodimer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the citrate synthase family.Curated
Keywords - Domaini
Transit peptideFamily and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR010109, Citrate_synthase_euk IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
TIGRFAMsi | TIGR01793, cit_synth_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6S9V7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFLSVSRLA PKLLNSKNAT YFLVAARNAS ASTTNLKDVL SDLIPKEQSR
60 70 80 90 100
IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP EEGIRFRGYS
110 120 130 140 150
IPECQKLLPK APGGEEPLPE GLFWLLVTGQ VPTEEQVKWV SKEWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ FSAAITALNS ESSFARAYSE GVHKTKYWEF
210 220 230 240 250
VYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSNLDWS HNFTNMLGYS
260 270 280 290 300
EAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFSAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTALQK EMGGEVSDER MRDYIWNTLK SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY TCQREFALKH LPNDPMFKLV AQLYKIVPNV LLEQGKAKNP
410 420 430 440 450
WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLAQLV WSRALGFPLE
460
RPKSMSTDGL MTLVGAKSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY461850 mRNA Translation: AAR98860.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY461850 mRNA Translation: AAR98860.1 |
3D structure databases
SMRi | Q6S9V7 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR010109, Citrate_synthase_euk IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
TIGRFAMsi | TIGR01793, cit_synth_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CISY_KATPE | |
Accessioni | Q6S9V7Primary (citable) accession number: Q6S9V7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 7, 2020 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families