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Protein

POTE ankyrin domain family member E

Gene

POTEE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ6S8J3

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member E
Alternative name(s):
ANKRD26-like family C member 1A
Prostate, ovary, testis-expressed protein on chromosome 2
Short name:
POTE-2
Gene namesi
Name:POTEE
Synonyms:A26C1A, POTE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000188219.14
HGNCiHGNC:33895 POTEE
MIMi608914 gene
neXtProtiNX_Q6S8J3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188219
PharmGKBiPA164724783

Polymorphism and mutation databases

BioMutaiPOTEE
DMDMi166898073

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669141 – 1075POTE ankyrin domain family member EAdd BLAST1075

Proteomic databases

EPDiQ6S8J3
MaxQBiQ6S8J3
PaxDbiQ6S8J3
PeptideAtlasiQ6S8J3
PRIDEiQ6S8J3
ProteomicsDBi67347
67348 [Q6S8J3-2]
67349 [Q6S8J3-3]
TopDownProteomicsiQ6S8J3-1 [Q6S8J3-1]

PTM databases

iPTMnetiQ6S8J3
PhosphoSitePlusiQ6S8J3
SwissPalmiQ6S8J3

Expressioni

Gene expression databases

BgeeiENSG00000188219 Expressed in 11 organ(s), highest expression level in testis
CleanExiHS_POTEE
ExpressionAtlasiQ6S8J3 baseline and differential

Organism-specific databases

HPAiHPA041264
HPA041271
HPA042822
HPA043260

Interactioni

Protein-protein interaction databases

BioGridi138656, 30 interactors
IntActiQ6S8J3, 6 interactors
STRINGi9606.ENSP00000439189

Structurei

3D structure databases

ProteinModelPortaliQ6S8J3
SMRiQ6S8J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati172 – 201ANK 1Add BLAST30
Repeati205 – 234ANK 2Add BLAST30
Repeati238 – 267ANK 3Add BLAST30
Repeati271 – 300ANK 4Add BLAST30
Repeati304 – 333ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni702 – 1075Actin-likeAdd BLAST374

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili399 – 435Sequence analysisAdd BLAST37
Coiled coili642 – 698Sequence analysisAdd BLAST57

Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA
GeneTreeiENSGT00560000076605
HOGENOMiHOG000115614
InParanoidiQ6S8J3
KOiK17299
OrthoDBiEOG091G077A
PhylomeDBiQ6S8J3

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6S8J3-1) [UniParc]FASTAAdd to basket
Also known as: POTE2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSKVGAW GDYDDSAFME PRYHVRGEDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDVNKKD KQKRTALHLA SANGNSEVVK LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICQLLSDY KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK
410 420 430 440 450
MSQELEINKD GDREVEEEMK KHESNNVGLL ENLTNGVTAG NGDNGLIPQR
460 470 480 490 500
KSRTPENQQF PDNESEEYHR ICELLSDYKE KQMPKYSSEN SNPEQDLKLT
510 520 530 540 550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHGSTHV
560 570 580 590 600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
610 620 630 640 650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST
660 670 680 690 700
LREEIAMLRL ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT
710 720 730 740 750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK
760 770 780 790 800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
810 820 830 840 850
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP SLYTSGRTTG
860 870 880 890 900
IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF
910 920 930 940 950
TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
960 970 980 990 1000
GNERFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS
1010 1020 1030 1040 1050
GGTTMYPGMA HRMQKEIAAL APSMMKIRII APPKRKYSVW VGGSILASLS
1060 1070
TFQQMWISKQ EYDESGPSIV HRKCF
Length:1,075
Mass (Da):121,363
Last modified:February 5, 2008 - v3
Checksum:i581F842CDDC13EFC
GO
Isoform 2 (identifier: Q6S8J3-2) [UniParc]FASTAAdd to basket
Also known as: POTE2B

The sequence of this isoform differs from the canonical sequence as follows:
     212-212: K → KVCSSQLYQHE
     377-384: QELKLTSE → NVSRTRNK
     385-1075: Missing.

Show »
Length:394
Mass (Da):44,113
Checksum:i58C1E27852BD4DA4
GO
Isoform 3 (identifier: Q6S8J3-3) [UniParc]FASTAAdd to basket
Also known as: POTE2C, POTE2D

The sequence of this isoform differs from the canonical sequence as follows:
     376-376: E → G
     377-1075: Missing.

Show »
Length:376
Mass (Da):41,909
Checksum:i7804E08803E5A577
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X067A0A087X067_HUMAN
POTE ankyrin domain family member E
POTEE
508Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346V → G in AAS58867 (PubMed:15276201).Curated1
Sequence conflicti378E → D in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti546G → R in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti563G → A in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti578P → L in AAS58865 (PubMed:15276201).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011969212K → KVCSSQLYQHE in isoform 2. 1 Publication1
Alternative sequenceiVSP_011970376E → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_011971377 – 1075Missing in isoform 3. 1 PublicationAdd BLAST699
Alternative sequenceiVSP_011972377 – 384QELKLTSE → NVSRTRNK in isoform 2. 1 Publication8
Alternative sequenceiVSP_011973385 – 1075Missing in isoform 2. 1 PublicationAdd BLAST691

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131180 Genomic DNA No translation available.
AY462868 mRNA Translation: AAS58862.1
AY462871 mRNA Translation: AAS58865.1
AY462872 mRNA Translation: AAS58866.1
AY462873 mRNA Translation: AAS58867.1
CCDSiCCDS46414.1 [Q6S8J3-1]
RefSeqiNP_001077007.1, NM_001083538.1 [Q6S8J3-1]
XP_016859650.1, XM_017004161.1 [Q6S8J3-1]
UniGeneiHs.686146

Genome annotation databases

EnsembliENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3]
GeneIDi445582
KEGGihsa:445582
UCSCiuc002tsn.3 human [Q6S8J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131180 Genomic DNA No translation available.
AY462868 mRNA Translation: AAS58862.1
AY462871 mRNA Translation: AAS58865.1
AY462872 mRNA Translation: AAS58866.1
AY462873 mRNA Translation: AAS58867.1
CCDSiCCDS46414.1 [Q6S8J3-1]
RefSeqiNP_001077007.1, NM_001083538.1 [Q6S8J3-1]
XP_016859650.1, XM_017004161.1 [Q6S8J3-1]
UniGeneiHs.686146

3D structure databases

ProteinModelPortaliQ6S8J3
SMRiQ6S8J3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138656, 30 interactors
IntActiQ6S8J3, 6 interactors
STRINGi9606.ENSP00000439189

PTM databases

iPTMnetiQ6S8J3
PhosphoSitePlusiQ6S8J3
SwissPalmiQ6S8J3

Polymorphism and mutation databases

BioMutaiPOTEE
DMDMi166898073

Proteomic databases

EPDiQ6S8J3
MaxQBiQ6S8J3
PaxDbiQ6S8J3
PeptideAtlasiQ6S8J3
PRIDEiQ6S8J3
ProteomicsDBi67347
67348 [Q6S8J3-2]
67349 [Q6S8J3-3]
TopDownProteomicsiQ6S8J3-1 [Q6S8J3-1]

Protocols and materials databases

DNASUi445582
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3]
GeneIDi445582
KEGGihsa:445582
UCSCiuc002tsn.3 human [Q6S8J3-1]

Organism-specific databases

CTDi445582
EuPathDBiHostDB:ENSG00000188219.14
GeneCardsiPOTEE
H-InvDBiHIX0024222
HIX0029907
HGNCiHGNC:33895 POTEE
HPAiHPA041264
HPA041271
HPA042822
HPA043260
MIMi608914 gene
neXtProtiNX_Q6S8J3
OpenTargetsiENSG00000188219
PharmGKBiPA164724783
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA
GeneTreeiENSGT00560000076605
HOGENOMiHOG000115614
InParanoidiQ6S8J3
KOiK17299
OrthoDBiEOG091G077A
PhylomeDBiQ6S8J3

Enzyme and pathway databases

SignaLinkiQ6S8J3

Miscellaneous databases

ChiTaRSiPOTEE human
GenomeRNAii445582
PROiPR:Q6S8J3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188219 Expressed in 11 organ(s), highest expression level in testis
CleanExiHS_POTEE
ExpressionAtlasiQ6S8J3 baseline and differential

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPOTEE_HUMAN
AccessioniPrimary (citable) accession number: Q6S8J3
Secondary accession number(s): Q6S8J4, Q6S8J5, Q6S8J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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