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UniProtKB - Q6S8J3 (POTEE_HUMAN)

Entry version 153 (29 Sep 2021)
Sequence version 3 (05 Feb 2008)
Previous versions | rss
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Protein

POTE ankyrin domain family member E

Gene

POTEE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6S8J3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9035034, RHOF GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6S8J3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POTE ankyrin domain family member E
Alternative name(s):
ANKRD26-like family C member 1A
Prostate, ovary, testis-expressed protein on chromosome 2
Short name:
POTE-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POTEE
Synonyms:A26C1A, POTE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33895, POTEE

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608914, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6S8J3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188219

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		445582

Open Targets

More...OpenTargetsi		ENSG00000188219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164724783

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6S8J3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POTEE

Domain mapping of disease mutations (DMDM)

More...DMDMi		166898073

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669141 – 1075POTE ankyrin domain family member EAdd BLAST1075

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6S8J3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6S8J3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6S8J3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6S8J3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6S8J3

PeptideAtlas

More...PeptideAtlasi		Q6S8J3

PRoteomics IDEntifications database

More...PRIDEi		Q6S8J3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67347 [Q6S8J3-1]
67348 [Q6S8J3-2]
67349 [Q6S8J3-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q6S8J3-1 [Q6S8J3-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6S8J3, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6S8J3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6S8J3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6S8J3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6S8J3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188219, Expressed in testis and 16 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6S8J3, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188219, Group enriched (blood, prostate, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		138656, 68 interactors

Protein interaction database and analysis system

More...IntActi		Q6S8J3, 32 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000439189

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6S8J3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6S8J3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati172 – 201ANK 1Add BLAST30
Repeati205 – 234ANK 2Add BLAST30
Repeati238 – 267ANK 3Add BLAST30
Repeati271 – 300ANK 4Add BLAST30
Repeati304 – 333ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni369 – 530DisorderedSequence analysisAdd BLAST162
Regioni544 – 599DisorderedSequence analysisAdd BLAST56
Regioni702 – 1075Actin-likeAdd BLAST374

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili399 – 435Sequence analysisAdd BLAST37
Coiled coili642 – 698Sequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi378 – 393Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi403 – 425Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi427 – 459Polar residuesSequence analysisAdd BLAST33
Compositional biasi460 – 484Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi496 – 530Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi583 – 599Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0676, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010163_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6S8J3

Identification of Orthologs from Complete Genome Data

More...OMAi		NPICELL

Database of Orthologous Groups

More...OrthoDBi		649708at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6S8J3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR004001, Actin_CS
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043129, ATPase_NBD
IPR039497, CC144C-like_CC_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00022, Actin, 1 hit
PF12796, Ank_2, 2 hits
PF14915, CCDC144C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00190, ACTIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00268, ACTIN, 1 hit
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00432, ACTINS_2, 1 hit
PS01132, ACTINS_ACT_LIKE, 1 hit
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6S8J3-1) [UniParc]FASTAAdd to basket
Also known as: POTE2A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD 
        60         70         80         90        100
DSAMKTLRSK MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK 
       110        120        130        140        150
WCCHCFPCCR GSGKSKVGAW GDYDDSAFME PRYHVRGEDL DKLHRAAWWG 
       160        170        180        190        200
KVPRKDLIVM LRDTDVNKKD KQKRTALHLA SANGNSEVVK LLLDRRCQLN 
       210        220        230        240        250
VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE 
       260        270        280        290        300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA 
       310        320        330        340        350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH 
       360        370        380        390        400
HVICQLLSDY KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK 
       410        420        430        440        450
MSQELEINKD GDREVEEEMK KHESNNVGLL ENLTNGVTAG NGDNGLIPQR 
       460        470        480        490        500
KSRTPENQQF PDNESEEYHR ICELLSDYKE KQMPKYSSEN SNPEQDLKLT 
       510        520        530        540        550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHGSTHV 
       560        570        580        590        600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ 
       610        620        630        640        650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST 
       660        670        680        690        700
LREEIAMLRL ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT 
       710        720        730        740        750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK 
       760        770        780        790        800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE 
       810        820        830        840        850
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP SLYTSGRTTG 
       860        870        880        890        900
IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF 
       910        920        930        940        950
TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI 
       960        970        980        990       1000
GNERFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS 
      1010       1020       1030       1040       1050
GGTTMYPGMA HRMQKEIAAL APSMMKIRII APPKRKYSVW VGGSILASLS 
      1060       1070 
TFQQMWISKQ EYDESGPSIV HRKCF
Length:1,075
Mass (Da):121,363
Last modified:February 5, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i581F842CDDC13EFC
GO
Isoform 2 (identifier: Q6S8J3-2) [UniParc]FASTAAdd to basket
Also known as: POTE2B

The sequence of this isoform differs from the canonical sequence as follows:
     212-212: K → KVCSSQLYQHE
     377-384: QELKLTSE → NVSRTRNK
     385-1075: Missing.

Show »
Length:394
Mass (Da):44,113
Checksum:i58C1E27852BD4DA4
GO
Isoform 3 (identifier: Q6S8J3-3) [UniParc]FASTAAdd to basket
Also known as: POTE2C, POTE2D

The sequence of this isoform differs from the canonical sequence as follows:
     376-376: E → G
     377-1075: Missing.

Show »
Length:376
Mass (Da):41,909
Checksum:i7804E08803E5A577
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X067A0A087X067_HUMAN
POTE ankyrin domain family member E
POTEE
508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346V → G in AAS58867 (PubMed:15276201).Curated1
Sequence conflicti378E → D in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti546G → R in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti563G → A in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti578P → L in AAS58865 (PubMed:15276201).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011969212K → KVCSSQLYQHE in isoform 2. 1 Publication1
Alternative sequenceiVSP_011970376E → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_011971377 – 1075Missing in isoform 3. 1 PublicationAdd BLAST699
Alternative sequenceiVSP_011972377 – 384QELKLTSE → NVSRTRNK in isoform 2. 1 Publication8
Alternative sequenceiVSP_011973385 – 1075Missing in isoform 2. 1 PublicationAdd BLAST691

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC131180 Genomic DNA No translation available.
AY462868 mRNA Translation: AAS58862.1
AY462871 mRNA Translation: AAS58865.1
AY462872 mRNA Translation: AAS58866.1
AY462873 mRNA Translation: AAS58867.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46414.1 [Q6S8J3-1]

NCBI Reference Sequences

More...RefSeqi		NP_001077007.1, NM_001083538.1 [Q6S8J3-1]
XP_016859650.1, XM_017004161.1 [Q6S8J3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3]
ENST00000683005; ENSP00000507284; ENSG00000188219 [Q6S8J3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		445582

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:445582

UCSC genome browser

More...UCSCi		uc002tsn.3, human [Q6S8J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131180 Genomic DNA No translation available.
AY462868 mRNA Translation: AAS58862.1
AY462871 mRNA Translation: AAS58865.1
AY462872 mRNA Translation: AAS58866.1
AY462873 mRNA Translation: AAS58867.1
CCDSiCCDS46414.1 [Q6S8J3-1]
RefSeqiNP_001077007.1, NM_001083538.1 [Q6S8J3-1]
XP_016859650.1, XM_017004161.1 [Q6S8J3-1]

3D structure databases

SMRiQ6S8J3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi138656, 68 interactors
IntActiQ6S8J3, 32 interactors
STRINGi9606.ENSP00000439189

PTM databases

GlyGeniQ6S8J3, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ6S8J3
MetOSiteiQ6S8J3
PhosphoSitePlusiQ6S8J3
SwissPalmiQ6S8J3

Genetic variation databases

BioMutaiPOTEE
DMDMi166898073

Proteomic databases

EPDiQ6S8J3
jPOSTiQ6S8J3
MassIVEiQ6S8J3
MaxQBiQ6S8J3
PaxDbiQ6S8J3
PeptideAtlasiQ6S8J3
PRIDEiQ6S8J3
ProteomicsDBi67347 [Q6S8J3-1]
67348 [Q6S8J3-2]
67349 [Q6S8J3-3]
TopDownProteomicsiQ6S8J3-1 [Q6S8J3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		56140, 73 antibodies

The DNASU plasmid repository

More...DNASUi		445582

Genome annotation databases

EnsembliENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3]
ENST00000683005; ENSP00000507284; ENSG00000188219 [Q6S8J3-1]
GeneIDi445582
KEGGihsa:445582
UCSCiuc002tsn.3, human [Q6S8J3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		445582
DisGeNETi445582

GeneCards: human genes, protein and diseases

More...GeneCardsi		POTEE
HGNCiHGNC:33895, POTEE
HPAiENSG00000188219, Group enriched (blood, prostate, testis)
MIMi608914, gene
neXtProtiNX_Q6S8J3
OpenTargetsiENSG00000188219
PharmGKBiPA164724783
VEuPathDBiHostDB:ENSG00000188219

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0676, Eukaryota
GeneTreeiENSGT00940000163068
HOGENOMiCLU_010163_0_0_1
InParanoidiQ6S8J3
OMAiNPICELL
OrthoDBi649708at2759
PhylomeDBiQ6S8J3

Enzyme and pathway databases

PathwayCommonsiQ6S8J3
ReactomeiR-HSA-9035034, RHOF GTPase cycle
SignaLinkiQ6S8J3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		445582, 46 hits in 927 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POTEE, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		445582
PharosiQ6S8J3, Tbio

Protein Ontology

More...PROi		PR:Q6S8J3
RNActiQ6S8J3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188219, Expressed in testis and 16 other tissues
ExpressionAtlasiQ6S8J3, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR004001, Actin_CS
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043129, ATPase_NBD
IPR039497, CC144C-like_CC_dom
PfamiView protein in Pfam
PF00022, Actin, 1 hit
PF12796, Ank_2, 2 hits
PF14915, CCDC144C, 1 hit
PRINTSiPR00190, ACTIN
SMARTiView protein in SMART
SM00268, ACTIN, 1 hit
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS00432, ACTINS_2, 1 hit
PS01132, ACTINS_ACT_LIKE, 1 hit
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOTEE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6S8J3
Secondary accession number(s): Q6S8J4, Q6S8J5, Q6S8J8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: February 5, 2008
Last modified: September 29, 2021
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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