UniProtKB - Q6S8J3 (POTEE_HUMAN)
Protein
POTE ankyrin domain family member E
Gene
POTEE
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- retina homeostasis Source: UniProtKB
- substantia nigra development Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6S8J3 |
SignaLinki | Q6S8J3 |
Names & Taxonomyi
Protein namesi | Recommended name: POTE ankyrin domain family member EAlternative name(s): ANKRD26-like family C member 1A Prostate, ovary, testis-expressed protein on chromosome 2 Short name: POTE-2 |
Gene namesi | Name:POTEE Synonyms:A26C1A, POTE2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33895, POTEE |
MIMi | 608914, gene |
neXtProti | NX_Q6S8J3 |
VEuPathDBi | HostDB:ENSG00000188219.14 |
Subcellular locationi
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 445582 |
OpenTargetsi | ENSG00000188219 |
PharmGKBi | PA164724783 |
Miscellaneous databases
Pharosi | Q6S8J3, Tbio |
Genetic variation databases
BioMutai | POTEE |
DMDMi | 166898073 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066914 | 1 – 1075 | POTE ankyrin domain family member EAdd BLAST | 1075 |
Proteomic databases
EPDi | Q6S8J3 |
jPOSTi | Q6S8J3 |
MassIVEi | Q6S8J3 |
MaxQBi | Q6S8J3 |
PaxDbi | Q6S8J3 |
PeptideAtlasi | Q6S8J3 |
PRIDEi | Q6S8J3 |
ProteomicsDBi | 67347 [Q6S8J3-1] 67348 [Q6S8J3-2] 67349 [Q6S8J3-3] |
TopDownProteomicsi | Q6S8J3-1 [Q6S8J3-1] |
PTM databases
iPTMneti | Q6S8J3 |
MetOSitei | Q6S8J3 |
PhosphoSitePlusi | Q6S8J3 |
SwissPalmi | Q6S8J3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188219, Expressed in testis and 16 other tissues |
ExpressionAtlasi | Q6S8J3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000188219, Group enriched (blood, prostate, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 138656, 68 interactors |
IntActi | Q6S8J3, 31 interactors |
MINTi | Q6S8J3 |
STRINGi | 9606.ENSP00000439189 |
Miscellaneous databases
RNActi | Q6S8J3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 172 – 201 | ANK 1Add BLAST | 30 | |
Repeati | 205 – 234 | ANK 2Add BLAST | 30 | |
Repeati | 238 – 267 | ANK 3Add BLAST | 30 | |
Repeati | 271 – 300 | ANK 4Add BLAST | 30 | |
Repeati | 304 – 333 | ANK 5Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 702 – 1075 | Actin-likeAdd BLAST | 374 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 399 – 435 | Sequence analysisAdd BLAST | 37 | |
Coiled coili | 642 – 698 | Sequence analysisAdd BLAST | 57 |
Sequence similaritiesi
In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000163068 |
HOGENOMi | CLU_010163_0_0_1 |
InParanoidi | Q6S8J3 |
OMAi | NPICELL |
OrthoDBi | 649708at2759 |
PhylomeDBi | Q6S8J3 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR043129, ATPase_NBD IPR039497, CC144C-like_CC_dom |
Pfami | View protein in Pfam PF00022, Actin, 1 hit PF12796, Ank_2, 2 hits PF14915, CCDC144C, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6S8J3-1) [UniParc]FASTAAdd to basket
Also known as: POTE2A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSKVGAW GDYDDSAFME PRYHVRGEDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDVNKKD KQKRTALHLA SANGNSEVVK LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICQLLSDY KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK
410 420 430 440 450
MSQELEINKD GDREVEEEMK KHESNNVGLL ENLTNGVTAG NGDNGLIPQR
460 470 480 490 500
KSRTPENQQF PDNESEEYHR ICELLSDYKE KQMPKYSSEN SNPEQDLKLT
510 520 530 540 550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHGSTHV
560 570 580 590 600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
610 620 630 640 650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST
660 670 680 690 700
LREEIAMLRL ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT
710 720 730 740 750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK
760 770 780 790 800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
810 820 830 840 850
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP SLYTSGRTTG
860 870 880 890 900
IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF
910 920 930 940 950
TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
960 970 980 990 1000
GNERFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS
1010 1020 1030 1040 1050
GGTTMYPGMA HRMQKEIAAL APSMMKIRII APPKRKYSVW VGGSILASLS
1060 1070
TFQQMWISKQ EYDESGPSIV HRKCF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X067 | A0A087X067_HUMAN | POTE ankyrin domain family member E | POTEE | 508 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 346 | V → G in AAS58867 (PubMed:15276201).Curated | 1 | |
Sequence conflicti | 378 | E → D in AAS58865 (PubMed:15276201).Curated | 1 | |
Sequence conflicti | 546 | G → R in AAS58865 (PubMed:15276201).Curated | 1 | |
Sequence conflicti | 563 | G → A in AAS58865 (PubMed:15276201).Curated | 1 | |
Sequence conflicti | 578 | P → L in AAS58865 (PubMed:15276201).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011969 | 212 | K → KVCSSQLYQHE in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_011970 | 376 | E → G in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_011971 | 377 – 1075 | Missing in isoform 3. 1 PublicationAdd BLAST | 699 | |
Alternative sequenceiVSP_011972 | 377 – 384 | QELKLTSE → NVSRTRNK in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_011973 | 385 – 1075 | Missing in isoform 2. 1 PublicationAdd BLAST | 691 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC131180 Genomic DNA No translation available. AY462868 mRNA Translation: AAS58862.1 AY462871 mRNA Translation: AAS58865.1 AY462872 mRNA Translation: AAS58866.1 AY462873 mRNA Translation: AAS58867.1 |
CCDSi | CCDS46414.1 [Q6S8J3-1] |
RefSeqi | NP_001077007.1, NM_001083538.1 [Q6S8J3-1] XP_016859650.1, XM_017004161.1 [Q6S8J3-1] |
Genome annotation databases
Ensembli | ENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1] ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2] ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3] ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3] |
GeneIDi | 445582 |
KEGGi | hsa:445582 |
UCSCi | uc002tsn.3, human [Q6S8J3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC131180 Genomic DNA No translation available. AY462868 mRNA Translation: AAS58862.1 AY462871 mRNA Translation: AAS58865.1 AY462872 mRNA Translation: AAS58866.1 AY462873 mRNA Translation: AAS58867.1 |
CCDSi | CCDS46414.1 [Q6S8J3-1] |
RefSeqi | NP_001077007.1, NM_001083538.1 [Q6S8J3-1] XP_016859650.1, XM_017004161.1 [Q6S8J3-1] |
3D structure databases
SMRi | Q6S8J3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 138656, 68 interactors |
IntActi | Q6S8J3, 31 interactors |
MINTi | Q6S8J3 |
STRINGi | 9606.ENSP00000439189 |
PTM databases
iPTMneti | Q6S8J3 |
MetOSitei | Q6S8J3 |
PhosphoSitePlusi | Q6S8J3 |
SwissPalmi | Q6S8J3 |
Genetic variation databases
BioMutai | POTEE |
DMDMi | 166898073 |
Proteomic databases
EPDi | Q6S8J3 |
jPOSTi | Q6S8J3 |
MassIVEi | Q6S8J3 |
MaxQBi | Q6S8J3 |
PaxDbi | Q6S8J3 |
PeptideAtlasi | Q6S8J3 |
PRIDEi | Q6S8J3 |
ProteomicsDBi | 67347 [Q6S8J3-1] 67348 [Q6S8J3-2] 67349 [Q6S8J3-3] |
TopDownProteomicsi | Q6S8J3-1 [Q6S8J3-1] |
Protocols and materials databases
Antibodypediai | 56140, 66 antibodies |
DNASUi | 445582 |
Genome annotation databases
Ensembli | ENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1] ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2] ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3] ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3] |
GeneIDi | 445582 |
KEGGi | hsa:445582 |
UCSCi | uc002tsn.3, human [Q6S8J3-1] |
Organism-specific databases
CTDi | 445582 |
DisGeNETi | 445582 |
GeneCardsi | POTEE |
HGNCi | HGNC:33895, POTEE |
HPAi | ENSG00000188219, Group enriched (blood, prostate, testis) |
MIMi | 608914, gene |
neXtProti | NX_Q6S8J3 |
OpenTargetsi | ENSG00000188219 |
PharmGKBi | PA164724783 |
VEuPathDBi | HostDB:ENSG00000188219.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000163068 |
HOGENOMi | CLU_010163_0_0_1 |
InParanoidi | Q6S8J3 |
OMAi | NPICELL |
OrthoDBi | 649708at2759 |
PhylomeDBi | Q6S8J3 |
Enzyme and pathway databases
PathwayCommonsi | Q6S8J3 |
SignaLinki | Q6S8J3 |
Miscellaneous databases
BioGRID-ORCSi | 445582, 45 hits in 905 CRISPR screens |
ChiTaRSi | POTEE, human |
GenomeRNAii | 445582 |
Pharosi | Q6S8J3, Tbio |
PROi | PR:Q6S8J3 |
RNActi | Q6S8J3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188219, Expressed in testis and 16 other tissues |
ExpressionAtlasi | Q6S8J3, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR043129, ATPase_NBD IPR039497, CC144C-like_CC_dom |
Pfami | View protein in Pfam PF00022, Actin, 1 hit PF12796, Ank_2, 2 hits PF14915, CCDC144C, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POTEE_HUMAN | |
Accessioni | Q6S8J3Primary (citable) accession number: Q6S8J3 Secondary accession number(s): Q6S8J4, Q6S8J5, Q6S8J8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | February 5, 2008 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families