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Entry version 143 (16 Oct 2019)
Sequence version 3 (05 Feb 2008)
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Protein

POTE ankyrin domain family member E

Gene

POTEE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6S8J3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POTE ankyrin domain family member E
Alternative name(s):
ANKRD26-like family C member 1A
Prostate, ovary, testis-expressed protein on chromosome 2
Short name:
POTE-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POTEE
Synonyms:A26C1A, POTE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33895 POTEE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608914 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6S8J3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724783

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6S8J3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POTEE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166898073

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669141 – 1075POTE ankyrin domain family member EAdd BLAST1075

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6S8J3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6S8J3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6S8J3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6S8J3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6S8J3

PeptideAtlas

More...
PeptideAtlasi
Q6S8J3

PRoteomics IDEntifications database

More...
PRIDEi
Q6S8J3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67347 [Q6S8J3-1]
67348 [Q6S8J3-2]
67349 [Q6S8J3-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6S8J3-1 [Q6S8J3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6S8J3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6S8J3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6S8J3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188219 Expressed in 11 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6S8J3 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041264
HPA041271
HPA042822
HPA043260

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
138656, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q6S8J3, 28 interactors

Molecular INTeraction database

More...
MINTi
Q6S8J3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000439189

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6S8J3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati172 – 201ANK 1Add BLAST30
Repeati205 – 234ANK 2Add BLAST30
Repeati238 – 267ANK 3Add BLAST30
Repeati271 – 300ANK 4Add BLAST30
Repeati304 – 333ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni702 – 1075Actin-likeAdd BLAST374

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili399 – 435Sequence analysisAdd BLAST37
Coiled coili642 – 698Sequence analysisAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115614

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6S8J3

KEGG Orthology (KO)

More...
KOi
K17299

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPICELL

Database of Orthologous Groups

More...
OrthoDBi
649708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6S8J3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00022 Actin, 1 hit
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00190 ACTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00268 ACTIN, 1 hit
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6S8J3-1) [UniParc]FASTAAdd to basket
Also known as: POTE2A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSKVGAW GDYDDSAFME PRYHVRGEDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDVNKKD KQKRTALHLA SANGNSEVVK LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICQLLSDY KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK
410 420 430 440 450
MSQELEINKD GDREVEEEMK KHESNNVGLL ENLTNGVTAG NGDNGLIPQR
460 470 480 490 500
KSRTPENQQF PDNESEEYHR ICELLSDYKE KQMPKYSSEN SNPEQDLKLT
510 520 530 540 550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHGSTHV
560 570 580 590 600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
610 620 630 640 650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST
660 670 680 690 700
LREEIAMLRL ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT
710 720 730 740 750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK
760 770 780 790 800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
810 820 830 840 850
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP SLYTSGRTTG
860 870 880 890 900
IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF
910 920 930 940 950
TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
960 970 980 990 1000
GNERFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS
1010 1020 1030 1040 1050
GGTTMYPGMA HRMQKEIAAL APSMMKIRII APPKRKYSVW VGGSILASLS
1060 1070
TFQQMWISKQ EYDESGPSIV HRKCF
Length:1,075
Mass (Da):121,363
Last modified:February 5, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i581F842CDDC13EFC
GO
Isoform 2 (identifier: Q6S8J3-2) [UniParc]FASTAAdd to basket
Also known as: POTE2B

The sequence of this isoform differs from the canonical sequence as follows:
     212-212: K → KVCSSQLYQHE
     377-384: QELKLTSE → NVSRTRNK
     385-1075: Missing.

Show »
Length:394
Mass (Da):44,113
Checksum:i58C1E27852BD4DA4
GO
Isoform 3 (identifier: Q6S8J3-3) [UniParc]FASTAAdd to basket
Also known as: POTE2C, POTE2D

The sequence of this isoform differs from the canonical sequence as follows:
     376-376: E → G
     377-1075: Missing.

Show »
Length:376
Mass (Da):41,909
Checksum:i7804E08803E5A577
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X067A0A087X067_HUMAN
POTE ankyrin domain family member E
POTEE
508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346V → G in AAS58867 (PubMed:15276201).Curated1
Sequence conflicti378E → D in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti546G → R in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti563G → A in AAS58865 (PubMed:15276201).Curated1
Sequence conflicti578P → L in AAS58865 (PubMed:15276201).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011969212K → KVCSSQLYQHE in isoform 2. 1 Publication1
Alternative sequenceiVSP_011970376E → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_011971377 – 1075Missing in isoform 3. 1 PublicationAdd BLAST699
Alternative sequenceiVSP_011972377 – 384QELKLTSE → NVSRTRNK in isoform 2. 1 Publication8
Alternative sequenceiVSP_011973385 – 1075Missing in isoform 2. 1 PublicationAdd BLAST691

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC131180 Genomic DNA No translation available.
AY462868 mRNA Translation: AAS58862.1
AY462871 mRNA Translation: AAS58865.1
AY462872 mRNA Translation: AAS58866.1
AY462873 mRNA Translation: AAS58867.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46414.1 [Q6S8J3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001077007.1, NM_001083538.1 [Q6S8J3-1]
XP_016859650.1, XM_017004161.1 [Q6S8J3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
445582

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:445582

UCSC genome browser

More...
UCSCi
uc002tsn.3 human [Q6S8J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131180 Genomic DNA No translation available.
AY462868 mRNA Translation: AAS58862.1
AY462871 mRNA Translation: AAS58865.1
AY462872 mRNA Translation: AAS58866.1
AY462873 mRNA Translation: AAS58867.1
CCDSiCCDS46414.1 [Q6S8J3-1]
RefSeqiNP_001077007.1, NM_001083538.1 [Q6S8J3-1]
XP_016859650.1, XM_017004161.1 [Q6S8J3-1]

3D structure databases

SMRiQ6S8J3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi138656, 36 interactors
IntActiQ6S8J3, 28 interactors
MINTiQ6S8J3
STRINGi9606.ENSP00000439189

PTM databases

iPTMnetiQ6S8J3
PhosphoSitePlusiQ6S8J3
SwissPalmiQ6S8J3

Polymorphism and mutation databases

BioMutaiPOTEE
DMDMi166898073

Proteomic databases

EPDiQ6S8J3
jPOSTiQ6S8J3
MassIVEiQ6S8J3
MaxQBiQ6S8J3
PaxDbiQ6S8J3
PeptideAtlasiQ6S8J3
PRIDEiQ6S8J3
ProteomicsDBi67347 [Q6S8J3-1]
67348 [Q6S8J3-2]
67349 [Q6S8J3-3]
TopDownProteomicsiQ6S8J3-1 [Q6S8J3-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
445582

Genome annotation databases

EnsembliENST00000356920; ENSP00000439189; ENSG00000188219 [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219 [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219 [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219 [Q6S8J3-3]
GeneIDi445582
KEGGihsa:445582
UCSCiuc002tsn.3 human [Q6S8J3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
445582

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POTEE
HGNCiHGNC:33895 POTEE
HPAiHPA041264
HPA041271
HPA042822
HPA043260
MIMi608914 gene
neXtProtiNX_Q6S8J3
OpenTargetsiENSG00000188219
PharmGKBiPA164724783

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA
GeneTreeiENSGT00940000163068
HOGENOMiHOG000115614
InParanoidiQ6S8J3
KOiK17299
OMAiNPICELL
OrthoDBi649708at2759
PhylomeDBiQ6S8J3

Enzyme and pathway databases

SignaLinkiQ6S8J3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POTEE human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
445582
PharosiQ6S8J3

Protein Ontology

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PROi
PR:Q6S8J3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188219 Expressed in 11 organ(s), highest expression level in testis
ExpressionAtlasiQ6S8J3 baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOTEE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6S8J3
Secondary accession number(s): Q6S8J4, Q6S8J5, Q6S8J8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: February 5, 2008
Last modified: October 16, 2019
This is version 143 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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