UniProtKB - Q6S4N2 (HS71B_PIG)
Heat shock 70 kDa protein 1B
HSPA1B
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 71 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 15 | ATPBy similarity | 4 | |
Nucleotide bindingi | 202 – 204 | ATPBy similarity | 3 | |
Nucleotide bindingi | 268 – 275 | ATPBy similarity | 8 | |
Nucleotide bindingi | 339 – 342 | ATPBy similarity | 4 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- ubiquitin protein ligase binding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- positive regulation of microtubule nucleation Source: UniProtKB
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- protein refolding Source: UniProtKB
- regulation of mitotic spindle assembly Source: UniProtKB
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 1BAlternative name(s): Heat shock 70 kDa protein 2 Short name: HSP70.2 |
Gene namesi | Name:HSPA1B |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- centrosome By similarity
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000078253 | 2 – 641 | Heat shock 70 kDa protein 1BAdd BLAST | 640 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 77 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 108 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 246 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 348 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 469 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 561 | N6,N6,N6-trimethyllysine; by METTL21A; alternateBy similarity | 1 | |
Modified residuei | 561 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 631 | PhosphoserineBy similarity | 1 | |
Modified residuei | 633 | PhosphoserineBy similarity | 1 | |
Modified residuei | 636 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q6S4N2 |
PeptideAtlasi | Q6S4N2 |
PRIDEi | Q6S4N2 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Component of the CatSper complex.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2.
Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed.
Interacts with METTL21A.
Interacts with TRIM5 (via B30.2/SPRY domain).
Interacts with PRKN.
Interacts with FOXP3.
Interacts with NOD2; the interaction enhances NOD2 stability.
Interacts with DNAJC9 (via J domain).
Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes.
Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively.
Interacts with NEDD1 and SMAD3.
Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105.
Interacts with DNAJC8.
By similarityGO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- ubiquitin protein ligase binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000020097 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 386 | Nucleotide-binding domain (NBD)By similarityAdd BLAST | 385 | |
Regioni | 394 – 509 | Substrate-binding domain (SBD)By similarityAdd BLAST | 116 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
InParanoidi | Q6S4N2 |
OrthoDBi | 288077at2759 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAKSVAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA LNPQNTVFDA KRLIGRKFGD PVVQADMKHW PFRVINDGDK
110 120 130 140 150
PKVQVSYKGE TKAFYPEEIS SMVLTKMKEI AEAYLGHPVS NAVITVPAYF
160 170 180 190 200
NDSQRQATKD AGVIAGLNVL RIINEPTAAA IAYGLDRTGK GERNVLIFDL
210 220 230 240 250
GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH FVEEFKRKHK
260 270 280 290 300
KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA
310 320 330 340 350
RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL
360 370 380 390 400
QDFFNGRDLN KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS
410 420 430 440 450
LGLETAGGVM TALIKRNSTI PTKQTQIFTT YSDNQPGVLI QVYEGERAMT
460 470 480 490 500
RDNNLLGRFE LSGIPPAPRG VPQIEVTFDI DANGILNVTA TDKSTGKANK
510 520 530 540 550
ITITNDKGRL SKEEIERMVQ EAEKYKAEDE IQRERVSAKN ALESYAFNMK
560 570 580 590 600
SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE
610 620 630 640
QVCNPIISGL YQGAGGPGAG GFGAQAPKGG SGSGPTIEEV D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY466608 mRNA Translation: AAR30953.1 |
RefSeqi | NP_998931.1, NM_213766.1 |
Genome annotation databases
Ensembli | ENSSSCT00005066003; ENSSSCP00005040864; ENSSSCG00005041223 |
GeneIDi | 396648 |
KEGGi | ssc:396648 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY466608 mRNA Translation: AAR30953.1 |
RefSeqi | NP_998931.1, NM_213766.1 |
3D structure databases
SMRi | Q6S4N2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000020097 |
Proteomic databases
PaxDbi | Q6S4N2 |
PeptideAtlasi | Q6S4N2 |
PRIDEi | Q6S4N2 |
Genome annotation databases
Ensembli | ENSSSCT00005066003; ENSSSCP00005040864; ENSSSCG00005041223 |
GeneIDi | 396648 |
KEGGi | ssc:396648 |
Organism-specific databases
CTDi | 100535101 |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
InParanoidi | Q6S4N2 |
OrthoDBi | 288077at2759 |
Miscellaneous databases
PROi | PR:Q6S4N2 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HS71B_PIG | |
Accessioni | Q6S4N2Primary (citable) accession number: Q6S4N2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families