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Protein
Submitted name:

Acetylcholine receptor beta subunit

Gene
N/A
Organism
Torpedo marmorata (Marbled electric ray)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine receptor beta subunitImported
OrganismiTorpedo marmorata (Marbled electric ray)Imported
Taxonomic identifieri7788 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaTorpediniformesTorpedinidaeTorpedo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei242 – 266HelicalSequence analysisAdd BLAST25
Transmembranei273 – 291HelicalSequence analysisAdd BLAST19
Transmembranei303 – 328HelicalSequence analysisAdd BLAST26
Transmembranei462 – 480HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500427953125 – 493Sequence analysisAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi152 ↔ 166Combined sources
Disulfide bondi152InterchainCombined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-2635 Acetylcholine receptor, alpha1-beta1-gamma-delta

Structurei

3D structure databases

ProteinModelPortaliQ6S3I0
SMRiQ6S3I0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6S3I0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 241Neur_chan_LBDInterPro annotationAdd BLAST213
Domaini248 – 479Neur_chan_membInterPro annotationAdd BLAST232

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG003756

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q6S3I0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDVRRMALG LVVMMALALS GVGASVMEDT LLSVLFENYN PKVRPSQTVG
60 70 80 90 100
DKVTVRVGLT LTSLLILNEK NEEMTTSVFL NLAWTDYRLQ WDPAAYEGIK
110 120 130 140 150
DLSIPSDDVW QPDIVLMNNN DGSFEITLHV NVLVQHTGAV SWHPSAIYRS
160 170 180 190 200
SCTIKVMYFP FDWQNCTMVF KSYTYDTSEV ILQHALDAKG EREVKEIMIN
210 220 230 240 250
QDAFTENGQW SIEHKPSRKN WRSDDPSYED VTFYLIIQRK PLFYIVYTIV
260 270 280 290 300
PCILISILAI LVFYLPPDAG EKMSLSISAL LALTVFLLLL ADKVPETSLS
310 320 330 340 350
VPIIISYLMF IMILVAFSVI LSVVVLNLHH RSPNTHTMPN WIRQIFIETL
360 370 380 390 400
PPFLWIQRPV TTPSPDSKPT IISRANDEYF IRKPAGDFVC PVDNARVAVQ
410 420 430 440 450
PERLFSEMKW HLNGLTQPVT LPQDLKEAVE AIKYIAEQLE SASEFDDLKK
460 470 480 490
DWQYVAMVAD RLFLYIFITM CSIGTFSIFL DASHNVPPDN PFA
Length:493
Mass (Da):56,076
Last modified:July 5, 2004 - v1
Checksum:iBC64EE404C6418A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472103 mRNA Translation: AAR29361.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472103 mRNA Translation: AAR29361.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BG9electron microscopy4.00B25-493[»]
4AQ5electron microscopy6.20B1-493[»]
4AQ9electron microscopy6.20B1-493[»]
4BOGelectron microscopy50.000/B/G/L/Q/V1-493[»]
4BOIelectron microscopy41.00B1-493[»]
4BONelectron microscopy40.00B1-493[»]
4BOOelectron microscopy42.00B1-493[»]
4BORelectron microscopy42.00B1-493[»]
4BOTelectron microscopy42.00B1-493[»]
ProteinModelPortaliQ6S3I0
SMRiQ6S3I0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2635 Acetylcholine receptor, alpha1-beta1-gamma-delta

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003756

Miscellaneous databases

EvolutionaryTraceiQ6S3I0

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6S3I0_TORMA
AccessioniPrimary (citable) accession number: Q6S3I0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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