UniProtKB - Q6RY98 (SRTXL_ATRMM)
Protein
Long-sarafotoxin
Gene
N/A
Organism
Atractaspis microlepidota microlepidota
Status
Functioni
Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. The major effects of sarafotoxin-m are a progressive decrease in heart rate (bradycardia) that turns into an arrhythmic phase that is followed by an A-V block.1 Publication
Sarafotoxin-m: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays low agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the micromolar range) (PubMed:21889567).By similarity2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 2 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 50 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 98 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 146 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 194 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 242 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 290 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 338 | Endothelin-receptor binding siteBy similarity | 1 |
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of vasoconstriction Source: InterPro
- vasoconstriction Source: UniProtKB-KW
Keywordsi
Molecular function | Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor |
Names & Taxonomyi
Protein namesi | Recommended name: Long-sarafotoxinShort name: L-SRTX Cleaved into the following 6 chains: |
Organismi | Atractaspis microlepidota microlepidota |
Taxonomic identifieri | 172021 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Lamprophiidae › Atractaspidinae › Atractaspis › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
Sarafotoxin-m: LD50 is 27-37 µg/kg by intravenous injection into mice.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 51 – 53 | Missing : Drastic 4-orders or magnitude increase in affinity for ET-B receptors. 1 Publication | 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000315373 | ‹1 – 5 | Sarafotoxin-m5 | ›5 | |
PropeptideiPRO_0000315374 | 6 – 29 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092481 | 30 – 53 | Sarafotoxin-mAdd BLAST | 24 | |
PropeptideiPRO_0000315375 | 54 – 77 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092482 | 78 – 101 | Sarafotoxin-m1Add BLAST | 24 | |
PropeptideiPRO_0000315376 | 102 – 125 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092483 | 126 – 149 | Sarafotoxin-m3Add BLAST | 24 | |
PropeptideiPRO_0000315377 | 150 – 173 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092484 | 174 – 197 | Sarafotoxin-m2Add BLAST | 24 | |
PropeptideiPRO_0000315378 | 198 – 221 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092485 | 222 – 245 | Sarafotoxin-m2Add BLAST | 24 | |
PropeptideiPRO_0000315379 | 246 – 269 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092486 | 270 – 293 | Sarafotoxin-mAdd BLAST | 24 | |
PropeptideiPRO_0000315380 | 294 – 317 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_5000092487 | 318 – 341 | Sarafotoxin-m4Add BLAST | 24 | |
PropeptideiPRO_0000315381 | 342 – 351 | 10 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 44 | 1 Publication | ||
Disulfide bondi | 32 ↔ 40 | 1 Publication | ||
Disulfide bondi | 78 ↔ 92 | By similarity | ||
Disulfide bondi | 80 ↔ 88 | By similarity | ||
Disulfide bondi | 126 ↔ 140 | By similarity | ||
Disulfide bondi | 128 ↔ 136 | By similarity | ||
Disulfide bondi | 174 ↔ 188 | By similarity | ||
Disulfide bondi | 176 ↔ 184 | By similarity | ||
Disulfide bondi | 222 ↔ 236 | By similarity | ||
Disulfide bondi | 224 ↔ 232 | By similarity | ||
Disulfide bondi | 270 ↔ 284 | By similarity | ||
Disulfide bondi | 272 ↔ 280 | By similarity | ||
Disulfide bondi | 318 ↔ 332 | By similarity | ||
Disulfide bondi | 320 ↔ 328 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LDF | NMR | - | A | 270-293 | [»] | |
SMRi | Q6RY98 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6RY98 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 53 | 1Add BLAST | 48 | |
Repeati | 54 – 101 | 2Add BLAST | 48 | |
Repeati | 102 – 149 | 3Add BLAST | 48 | |
Repeati | 150 – 197 | 4Add BLAST | 48 | |
Repeati | 198 – 245 | 5Add BLAST | 48 | |
Repeati | 246 – 293 | 6Add BLAST | 48 | |
Repeati | 294 – 341 | 7Add BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 6 – 341 | 7 X 48 AA tandem repeatsAdd BLAST | 336 |
Sequence similaritiesi
Belongs to the endothelin/sarafotoxin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
HOVERGENi | HBG017852 |
Family and domain databases
InterProi | View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin |
Pfami | View protein in Pfam PF00322 Endothelin, 7 hits |
PRINTSi | PR00365 ENDOTHELIN |
SMARTi | View protein in SMART SM00272 END, 7 hits |
PROSITEi | View protein in PROSITE PS00270 ENDOTHELIN, 7 hits |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6RY98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IWDEPVVVSA RDTEEAARVP SPQKRSQPLC SCNDINDKEC MYFCHQDVIW
60 70 80 90 100
DEPVVVSVRD TEEAARVPSP QKRPQPRCSC NDMNDKECMY FCHQDVIWDE
110 120 130 140 150
PVVVSVRDTE EAARVPSPQK RSQPRCSCND MNDKECVYFC HLDIIWDEPV
160 170 180 190 200
VVSVRDTEEA TRVPSPQKRS QPLCSCNDIN DKECMYFCHQ DIIWDEPVVV
210 220 230 240 250
SVRDTEEAAR VPSPQKRSQP LCSCNDINDK ECMYFCHQDI IWDEPVVVSV
260 270 280 290 300
RDTEEAARVP SPQKRSQPLC SCNDINDKEC MYFCHQDVIW DEPVVVSVQD
310 320 330 340 350
TEEAARVPSP QKRSQPLCSC NNMSDKECLN FCNLDIIWEN VDTSADPEFL
G
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY485934 mRNA Translation: AAR84382.1 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY485934 mRNA Translation: AAR84382.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LDF | NMR | - | A | 270-293 | [»] | |
SMRi | Q6RY98 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Phylogenomic databases
HOVERGENi | HBG017852 |
Miscellaneous databases
EvolutionaryTracei | Q6RY98 |
Family and domain databases
InterProi | View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin |
Pfami | View protein in Pfam PF00322 Endothelin, 7 hits |
PRINTSi | PR00365 ENDOTHELIN |
SMARTi | View protein in SMART SM00272 END, 7 hits |
PROSITEi | View protein in PROSITE PS00270 ENDOTHELIN, 7 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | SRTXL_ATRMM | |
Accessioni | Q6RY98Primary (citable) accession number: Q6RY98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 20, 2017 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references