UniProtKB - Q6RY98 (SRTXL_ATRMM)

BLAST

>sp|Q6RY98|SRTXL_ATRMM Long-sarafotoxin (Fragment) OS=Atractaspis microlepidota microlepidota OX=172021 PE=1 SV=1
IWDEPVVVSARDTEEAARVPSPQKRSQPLCSCNDINDKECMYFCHQDVIWDEPVVVSVRD
TEEAARVPSPQKRPQPRCSCNDMNDKECMYFCHQDVIWDEPVVVSVRDTEEAARVPSPQK
RSQPRCSCNDMNDKECVYFCHLDIIWDEPVVVSVRDTEEATRVPSPQKRSQPLCSCNDIN
DKECMYFCHQDIIWDEPVVVSVRDTEEAARVPSPQKRSQPLCSCNDINDKECMYFCHQDI
IWDEPVVVSVRDTEEAARVPSPQKRSQPLCSCNDINDKECMYFCHQDVIWDEPVVVSVQD
TEEAARVPSPQKRSQPLCSCNNMSDKECLNFCNLDIIWENVDTSADPEFLG

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History
Entry version 45 (20 Dec 2017)
Sequence version 1 (05 Jul 2004)
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Protein

Long-sarafotoxin

Gene

N/A

Organism

Atractaspis microlepidota microlepidota

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. The major effects of sarafotoxin-m are a progressive decrease in heart rate (bradycardia) that turns into an arrhythmic phase that is followed by an A-V block.1 Publication

Sarafotoxin-m: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays low agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the micromolar range) (PubMed:21889567).By similarity2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	2	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	50	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	98	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	146	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	194	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	242	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	290	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	338	Endothelin-receptor binding siteBy similarity	1

GO - Molecular functionⁱ

toxin activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of vasoconstriction Source: InterPro
vasoconstriction Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

Molecular function

Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Long-sarafotoxin Short name: L-SRTX Cleaved into the following 6 chains: Sarafotoxin-m Short name: SRTX-m Sarafotoxin-m1 Short name: SRTX-m1 Sarafotoxin-m2 Short name: SRTX-m2 Sarafotoxin-m3 Short name: SRTX-m3 Sarafotoxin-m4 Short name: SRTX-m4 Sarafotoxin-m5 Short name: SRTX-m5
Organismⁱ	Atractaspis microlepidota microlepidota
Taxonomic identifierⁱ	172021 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Lamprophiidae › Atractaspidinae › Atractaspis › Atractaspis microlepidota

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Toxic doseⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	51 – 53	Missing : Drastic 4-orders or magnitude increase in affinity for ET-B receptors. 1 Publication		3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
PeptideⁱPRO_0000315373	‹1 – 5	Sarafotoxin-m5	›5
PropeptideⁱPRO_0000315374	6 – 29	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092481	30 – 53	Sarafotoxin-mAdd BLAST	24
PropeptideⁱPRO_0000315375	54 – 77	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092482	78 – 101	Sarafotoxin-m1Add BLAST	24
PropeptideⁱPRO_0000315376	102 – 125	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092483	126 – 149	Sarafotoxin-m3Add BLAST	24
PropeptideⁱPRO_0000315377	150 – 173	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092484	174 – 197	Sarafotoxin-m2Add BLAST	24
PropeptideⁱPRO_0000315378	198 – 221	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092485	222 – 245	Sarafotoxin-m2Add BLAST	24
PropeptideⁱPRO_0000315379	246 – 269	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092486	270 – 293	Sarafotoxin-mAdd BLAST	24
PropeptideⁱPRO_0000315380	294 – 317	1 PublicationAdd BLAST	24
PeptideⁱPRO_5000092487	318 – 341	Sarafotoxin-m4Add BLAST	24
PropeptideⁱPRO_0000315381	342 – 351		10

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	30 ↔ 44	1 Publication
Disulfide bondⁱ	32 ↔ 40	1 Publication
Disulfide bondⁱ	78 ↔ 92	By similarity
Disulfide bondⁱ	80 ↔ 88	By similarity
Disulfide bondⁱ	126 ↔ 140	By similarity
Disulfide bondⁱ	128 ↔ 136	By similarity
Disulfide bondⁱ	174 ↔ 188	By similarity
Disulfide bondⁱ	176 ↔ 184	By similarity
Disulfide bondⁱ	222 ↔ 236	By similarity
Disulfide bondⁱ	224 ↔ 232	By similarity
Disulfide bondⁱ	270 ↔ 284	By similarity
Disulfide bondⁱ	272 ↔ 280	By similarity
Disulfide bondⁱ	318 ↔ 332	By similarity
Disulfide bondⁱ	320 ↔ 328	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	273 – 275	Combined sources		3
Helixⁱ	277 – 286	Combined sources		10

Show more details

3D structure databases

SMRⁱ	Q6RY98
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q6RY98

EvolutionaryTraceⁱ

Q6RY98

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	6 – 53	1Add BLAST	48
Repeatⁱ	54 – 101	2Add BLAST	48
Repeatⁱ	102 – 149	3Add BLAST	48
Repeatⁱ	150 – 197	4Add BLAST	48
Repeatⁱ	198 – 245	5Add BLAST	48
Repeatⁱ	246 – 293	6Add BLAST	48
Repeatⁱ	294 – 341	7Add BLAST	48

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	6 – 341	7 X 48 AA tandem repeatsAdd BLAST		336

Sequence similaritiesⁱ

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

HOVERGENⁱ	HBG017852

HOVERGENⁱ

HBG017852

Family and domain databases

InterProⁱ	View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00322 Endothelin, 7 hits
PRINTSⁱ	PR00365 ENDOTHELIN
SMARTⁱ	View protein in SMART SM00272 END, 7 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 7 hits

Sequenceⁱ

Sequence statusⁱ: Fragment.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6RY98-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
IWDEPVVVSA RDTEEAARVP SPQKRSQPLC SCNDINDKEC MYFCHQDVIW 
        60         70         80         90        100
DEPVVVSVRD TEEAARVPSP QKRPQPRCSC NDMNDKECMY FCHQDVIWDE 
       110        120        130        140        150
PVVVSVRDTE EAARVPSPQK RSQPRCSCND MNDKECVYFC HLDIIWDEPV 
       160        170        180        190        200
VVSVRDTEEA TRVPSPQKRS QPLCSCNDIN DKECMYFCHQ DIIWDEPVVV 
       210        220        230        240        250
SVRDTEEAAR VPSPQKRSQP LCSCNDINDK ECMYFCHQDI IWDEPVVVSV 
       260        270        280        290        300
RDTEEAARVP SPQKRSQPLC SCNDINDKEC MYFCHQDVIW DEPVVVSVQD 
       310        320        330        340        350
TEEAARVPSP QKRSQPLCSC NNMSDKECLN FCNLDIIWEN VDTSADPEFL 

G

Length:351

Mass (Da):40,341

Last modified:July 5, 2004 - v1

Checksum:ⁱF901846C8D6E01CC

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1			1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY485934 mRNA Translation: AAR84382.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AY485934 mRNA Translation: AAR84382.1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY485934 mRNA Translation: AAR84382.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AY485934 mRNA Translation: AAR84382.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LDF	NMR	-	A	270-293	[»]
SMRⁱ	Q6RY98
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG017852

HOVERGENⁱ

HBG017852

Miscellaneous databases

EvolutionaryTraceⁱ	Q6RY98

EvolutionaryTraceⁱ

Q6RY98

Family and domain databases

InterProⁱ	View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin
Pfamⁱ	View protein in Pfam PF00322 Endothelin, 7 hits
PRINTSⁱ	PR00365 ENDOTHELIN
SMARTⁱ	View protein in SMART SM00272 END, 7 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRTXL_ATRMM
Accessionⁱ	Q6RY98Primary (citable) accession number: Q6RY98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	July 5, 2004
	Last modified:	December 20, 2017
	This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Annotation program	Animal Toxin Annotation Program

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - Q6RY98 (SRTXL_ATRMM)

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Long-sarafotoxin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ