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Protein

Acidic mammalian chitinase

Gene

Chia

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity).By similarity

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140Proton donorPROSITE-ProRule annotation1
Binding sitei141ChitooligosaccharideBy similarity1
Binding sitei360ChitooligosaccharideBy similarity1

GO - Molecular functioni

  • chitinase activity Source: RGD
  • chitin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processApoptosis, Carbohydrate metabolism, Chitin degradation, Immunity, Inflammatory response, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14
GH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic mammalian chitinase (EC:3.2.1.14)
Short name:
AMCase
Gene namesi
Name:Chia
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303058 Chia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001194622 – 473Acidic mammalian chitinaseAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 51PROSITE-ProRule annotation
Disulfide bondi49 ↔ 394PROSITE-ProRule annotation
Disulfide bondi307 ↔ 372PROSITE-ProRule annotation
Disulfide bondi457 ↔ 470PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6RY07
PRIDEiQ6RY07

Interactioni

Subunit structurei

Interacts with EGFR.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044947

Structurei

3D structure databases

ProteinModelPortaliQ6RY07
SMRiQ6RY07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 473Chitin-binding type-2PROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 71Chitooligosaccharide bindingBy similarity2
Regioni97 – 100Chitooligosaccharide bindingBy similarity4
Regioni210 – 213Chitooligosaccharide bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi409 – 425Gly/Ser-richAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiQ6RY07
KOiK01183
PhylomeDBiQ6RY07

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01607 CBM_14, 1 hit
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00494 ChtBD2, 1 hit
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit
SSF57625 SSF57625, 1 hit
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 1 hit
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RY07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLILVTGL VLLLNVQLGS AYNLVCYFTN WAQYRPGLGS FKPDDINPCL
60 70 80 90 100
CTHLIYAFAG MQNNQITTIE WNDVTLYKAF NDLKNRNSKL KTLLAIGGWN
110 120 130 140 150
FGTAPFTTMV STSQNRQTFI TSVIKFLRQY GFDGLDLDWE YPGSRGSPPQ
160 170 180 190 200
DKHLFTVLVK ELREAFEQEA IESNRPRLMV TAAVAAGISN IQAGYEIPEL
210 220 230 240 250
SQYLDFIHVM TYDLHGSWDG YTGENSPLYK LPTETGSNAY LNVDYVMNYW
260 270 280 290 300
KDNGAPAEKL IVGFPEYGHT YILSNPSDTG IGAPTSGNGP AGPYTRQAGF
310 320 330 340 350
WAYYEICTFL RNGATQDWDA PQEVPYAYKG NEWVGYDNIK SFSVKAQWLK
360 370 380 390 400
QNNFGGAMIW AIDLDDFTGS FCDQGKFPLT STLNKALDIP TAGCTAPDLP
410 420 430 440 450
SEPVTTPPGS GSGGGSSGGG SEGSGFCAGK ADGLYPVADD RNAFWHCING
460 470
ITYQQHCQAG LVFDTSCNCC NWP
Length:473
Mass (Da):51,951
Last modified:July 5, 2004 - v1
Checksum:iFBB0DB91A42C1EFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY486074 mRNA Translation: AAR28968.1
RefSeqiNP_997469.1, NM_207586.2
UniGeneiRn.43692

Genome annotation databases

GeneIDi113901
KEGGirno:113901
UCSCiRGD:1303058 rat

Similar proteinsi

Entry informationi

Entry nameiCHIA_RAT
AccessioniPrimary (citable) accession number: Q6RY07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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