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UniProtKB - Q6RWA9 (AT1A_TAESO)
Protein
Sodium/potassium-transporting ATPase subunit alpha
Gene
N/A
Organism
Taenia solium (Pork tapeworm)
Status
Functioni
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity).
By similarityCatalytic activityi
- EC:7.2.2.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 368 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 708 | MagnesiumBy similarity | 1 | |
Metal bindingi | 712 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- P-type sodium:potassium-exchanging transporter activity Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alpha (EC:7.2.2.13)Short name: Na(+)/K(+) ATPase alpha subunit Alternative name(s): Sodium pump subunit alpha TNaK1-alpha |
Organismi | Taenia solium (Pork tapeworm) |
Taxonomic identifieri | 6204 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Cestoda › Eucestoda › Cyclophyllidea › Taeniidae › Taenia |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 281 – 300 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 313 – 330 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 764 – 783 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 794 – 814 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 834 – 856 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 909 – 928 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 942 – 960 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 976 – 996 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291569 | 1 – 1014 | Sodium/potassium-transporting ATPase subunit alphaAdd BLAST | 1014 |
Keywords - PTMi
PhosphoproteinExpressioni
Tissue specificityi
Preferentially localized in muscle cells and protonephridial ducts, and in small quantities in the tegument of cysticerci.1 Publication
Interactioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
CuratedFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 48 – 73 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6RWA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKSRGDKYR DATDGKKDAK KDLNELKQEL AMDEHQISLD ELYARLGTNP
60 70 80 90 100
DTGLTSEQAK TRLDRDGPNA LTPPKTTPEW VKFCKNMFGG FSLLLWIGAV
110 120 130 140 150
LCFIAHGIPC WCAGEPYLYD NLYLGIVLAA VVVITGCFSY YQESKSSKIM
160 170 180 190 200
ESFAKLVPQY AVVIRGGQRI DAPAEALVVG DIIDVKFGDR VPADIRVIKA
210 220 230 240 250
SSFKVDNSAL TGESEPQTRT AEYTNENPLE TKNLAFFSTN AVEGTCRGVV
260 270 280 290 300
VATGDRTVMG RIANLASGLE MGATPIAREI AHFIHIITGV AVFLGVTFFI
310 320 330 340 350
IAFILGYYWL DAVIFLIGII VANVPEGLLA TVTVCLTLTA KRMASKNCLV
360 370 380 390 400
KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNKIF EADTSDDQST
410 420 430 440 450
ANYSRASSTW MALSRIAMLC NRAEFKPGEE TNPVLKRECN GDASESALLK
460 470 480 490 500
CVGLSIGGVT GYRTDKPKVA EIPFNSTNKY QVSVHQTDDG DERYLVVMKG
510 520 530 540 550
APERILDRCS TVLMEGQELH MDDQWRESFN NAYLELGGIG ERVLGFCDLR
560 570 580 590 600
LPADKFPRGF KFDIDEPNFP IEGMPFVGLM SMIDPPRAAV PDAVSKCRSA
610 620 630 640 650
GIKVVMVTGD HPITAKAIAK GVGIISDGNK TVEDIAAERG VPVSQVNPRE
660 670 680 690 700
ASACVVHGSD LRDMTPAQID EILENHSEIV FARTSPQQKL IIVEGIQRMG
710 720 730 740 750
AIVAVTGDGV NDSPALKKAD IGVAMGITGS DVSKQAADMI LLDDNFASIV
760 770 780 790 800
TGVEEGRIIF DNLKKSIAYT LTSNIPEITP FLIFILADVP LPLGTITILC
810 820 830 840 850
IDLGTDMVPA ISLAYEEAED IMKRMPRDPF RDKLVNERLI SMAYGQIGMI
860 870 880 890 900
QASGGFFVYF VIMAENGFWP SRLLGLRKQW DSPAINDVAD SYGQEWTYTQ
910 920 930 940 950
RKRLEYTCHT AFFASIVIVQ WTDLLICKTR KNSIYQQGMW NHHLTFGLFF
960 970 980 990 1000
ETTLAIFLSY CPGLEHGLRM MPLRWTWWLP VLPFSVSIFI FDEVRKKFLR
1010
TLPPGNWVER ETNY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY487828 mRNA Translation: AAS59168.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY487828 mRNA Translation: AAS59168.1 |
3D structure databases
AlphaFoldDBi | Q6RWA9 |
SMRi | Q6RWA9 |
ModBasei | Search... |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1A_TAESO | |
Accessioni | Q6RWA9Primary (citable) accession number: Q6RWA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |