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Entry version 146 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Type-1 angiotensin II receptor-associated protein

Gene

AGTRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q6RW13

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6802952, Signaling by BRAF and RAF fusions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGTRAP
Synonyms:ATRAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177674.15

Human Gene Nomenclature Database

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HGNCi
HGNC:13539, AGTRAP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608729, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6RW13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 55CytoplasmicSequence analysisAdd BLAST11
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 86ExtracellularSequence analysis10
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 159CytoplasmicSequence analysisAdd BLAST52

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57085

Open Targets

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OpenTargetsi
ENSG00000177674

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38363

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6RW13, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGTRAP

Domain mapping of disease mutations (DMDM)

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DMDMi
71152303

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647351 – 159Type-1 angiotensin II receptor-associated proteinAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6RW13

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6RW13

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6RW13

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6RW13

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6RW13

PeptideAtlas

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PeptideAtlasi
Q6RW13

PRoteomics IDEntifications database

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PRIDEi
Q6RW13

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67329 [Q6RW13-1]
67330 [Q6RW13-2]
67331 [Q6RW13-3]
67332 [Q6RW13-4]
67333 [Q6RW13-5]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q6RW13-1 [Q6RW13-1]
Q6RW13-2 [Q6RW13-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6RW13

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6RW13

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q6RW13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177674, Expressed in blood and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6RW13, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6RW13, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177674, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RACK1, and with the C-terminal region of AGTR1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6RW13
With#Exp.IntAct
ACSF2 [Q96CM8]4EBI-741181,EBI-2876502
ALDH18A1 [P54886]3EBI-741181,EBI-1210304
AP3M1 [Q9Y2T2]3EBI-741181,EBI-2371151
ARAF [Q96II5]3EBI-741181,EBI-9383168
ARFIP2 [P53365]4EBI-741181,EBI-638194
BPIFA2 [Q96DR5]3EBI-741181,EBI-10284754
C12orf10 [Q86UA3]3EBI-741181,EBI-10258793
CAPNS1 [P04632]3EBI-741181,EBI-711828
CD160 [O95971]3EBI-741181,EBI-4314390
COQ8A [Q8NI60]4EBI-741181,EBI-745535
CRCT1 [Q9UGL9]3EBI-741181,EBI-713677
DDA1 [Q9BW61]3EBI-741181,EBI-2510241
DDX55 [Q8NHQ9]3EBI-741181,EBI-5459844
ECPAS [Q5VYK3]3EBI-741181,EBI-521451
FAM114A1 [Q8IWE2]3EBI-741181,EBI-2686288
FAM160A2 [Q8N612]3EBI-741181,EBI-742137
FARS2 [O95363]3EBI-741181,EBI-2513774
FASTKD3 [Q14CZ7]3EBI-741181,EBI-10234819
FATE1 [Q969F0]3EBI-741181,EBI-743099
GABARAPL2 [P60520]3EBI-741181,EBI-720116
GAD1 [Q8IVA8]3EBI-741181,EBI-10209663
GAD1 [Q99259]3EBI-741181,EBI-743184
GAD2 [Q05329]3EBI-741181,EBI-9304251
GDNF [P39905]3EBI-741181,EBI-10207709
GTF3C1 [Q12789]3EBI-741181,EBI-357956
H4C7 [Q99525]3EBI-741181,EBI-10294329
HARS2 [P49590]3EBI-741181,EBI-3909030
HMGB1 [P09429]3EBI-741181,EBI-389432
HSCB [Q8IWL3]4EBI-741181,EBI-1805738
HSPA4 [P34932]3EBI-741181,EBI-356933
ISCU [Q9H1K1]3EBI-741181,EBI-1047335
LMO2 [P25791]3EBI-741181,EBI-739696
LNX1 [Q8TBB1]3EBI-741181,EBI-739832
MCEE [Q96PE7]4EBI-741181,EBI-10292326
MIEF1 [Q9NQG6]3EBI-741181,EBI-740987
MIEF2 [Q96C03]3EBI-741181,EBI-750153
MRM1 [Q6IN84]3EBI-741181,EBI-5454865
MTERF3 [Q96E29]3EBI-741181,EBI-7825321
MUTYH - isoform Alpha-3 [Q9UIF7-3]3EBI-741181,EBI-10321956
NDRG4 [Q9ULP0]3EBI-741181,EBI-10323810
NFU1 [Q9UMS0]3EBI-741181,EBI-725252
NFYB [P25208]3EBI-741181,EBI-389728
NKG7 [Q16617]3EBI-741181,EBI-3919611
PBX3 [Q5JS98]3EBI-741181,EBI-10244393
PBX3 [Q96AL5]3EBI-741181,EBI-741171
PCTP [Q9UKL6]3EBI-741181,EBI-4402391
PDHX [O00330]5EBI-741181,EBI-751566
PIMREG [Q9BSJ6]3EBI-741181,EBI-2568609
PITPNC1 [Q9UKF7]6EBI-741181,EBI-749241
PTPN9 [P43378]5EBI-741181,EBI-742898
PTPN9 [Q6IQ43]3EBI-741181,EBI-10250413
RMDN2 [Q96LZ7]3EBI-741181,EBI-2806908
SENP2 [Q9HC62]3EBI-741181,EBI-714881
SNX1 [Q13596]3EBI-741181,EBI-2822329
SPG21 [Q9NZD8]5EBI-741181,EBI-742688
SSX3 [Q99909]3EBI-741181,EBI-10295431
SSX5 [O60225]5EBI-741181,EBI-10186198
STAG3L1 [Q7L1H2]3EBI-741181,EBI-10255998
SUCLA2 [E5KS60]3EBI-741181,EBI-10176959
SYT16 [Q17RD7]5EBI-741181,EBI-10238936
TBRG4 [Q969Z0]3EBI-741181,EBI-702328
TCEANC2 [Q96MN5]3EBI-741181,EBI-5462748
TFAM [Q00059]3EBI-741181,EBI-1049924
TPD52L3 [Q96J77]3EBI-741181,EBI-932162
TUBA1B [P68363]3EBI-741181,EBI-487083
TXN2 [Q99757]3EBI-741181,EBI-2932492
ZFYVE21 [Q9BQ24]3EBI-741181,EBI-2849569
AGTRAP - isoform 2 [Q6RW13-2]
With#Exp.IntAct
itself3EBI-11522760,EBI-11522760
ANKS6 [Q68DC2]3EBI-11522760,EBI-7054139
AP3M1 [Q9Y2T2]3EBI-11522760,EBI-2371151
APOA4 [P06727]3EBI-11522760,EBI-1222447
AQP6 [Q13520]3EBI-11522760,EBI-13059134
ARFIP2 [P53365]3EBI-11522760,EBI-638194
ATP5F1E [P56381]3EBI-11522760,EBI-3904845
BCL2L13 [Q9BXK5]3EBI-11522760,EBI-747430
BPIFA2 [Q96DR5]3EBI-11522760,EBI-10284754
C12orf10 [Q9HB07]3EBI-11522760,EBI-709754
CCDC70 [Q6NSX1]3EBI-11522760,EBI-6873045
CD79A [P11912]3EBI-11522760,EBI-7797864
CELA3A [P09093]3EBI-11522760,EBI-8646391
COQ8A [Q8NI60]6EBI-11522760,EBI-745535
CPLX4 [Q7Z7G2]3EBI-11522760,EBI-18013275
CYB5R3 [P00387]3EBI-11522760,EBI-1046040
CYBC1 [Q9BQA9]3EBI-11522760,EBI-2680384
DIABLO [Q9NR28]6EBI-11522760,EBI-517508
DNAJC1 [Q96KC8]3EBI-11522760,EBI-296550
ECPAS [Q5VYK3]3EBI-11522760,EBI-521451
ERGIC3 [Q9Y282]3EBI-11522760,EBI-781551
ETFRF1 [Q6IPR1]3EBI-11522760,EBI-12292149
FAM209A [Q5JX71]3EBI-11522760,EBI-18304435
FARS2 [O95363]3EBI-11522760,EBI-2513774
FATE1 [Q969F0]3EBI-11522760,EBI-743099
FFAR2 [O15552]3EBI-11522760,EBI-2833872
FGA [A0A0S2Z3E9]3EBI-11522760,EBI-16439102
FNDC9 [Q8TBE3]3EBI-11522760,EBI-12142257
GAD1 [A0A0S2Z4D9]3EBI-11522760,EBI-16430771
GAD1 [Q99259]6EBI-11522760,EBI-743184
GAD2 [Q05329]3EBI-11522760,EBI-9304251
GPR152 [Q8TDT2]3EBI-11522760,EBI-13345167
GPX8 [Q8TED1]3EBI-11522760,EBI-11721746
GTF2H1 [P32780]3EBI-11522760,EBI-715539
HIBADH [P31937]3EBI-11522760,EBI-11427100
HSBP1L1 [C9JCN9]3EBI-11522760,EBI-2685549
HSD17B13 [Q7Z5P4]3EBI-11522760,EBI-18053395
HSFX2 [Q9UBD0]3EBI-11522760,EBI-947253
IL7R [P16871]3EBI-11522760,EBI-80490
KCNK5 [O95279]3EBI-11522760,EBI-3934936
KIR2DL3 [P43628]3EBI-11522760,EBI-8632435
KIR3DL3 [Q8N743]3EBI-11522760,EBI-17272405
LNX1 [Q8TBB1]3EBI-11522760,EBI-739832
LRRC4C [Q9HCJ2]3EBI-11522760,EBI-3925442
LRRC59 [Q96AG4]3EBI-11522760,EBI-358888
MCEE [Q96PE7]6EBI-11522760,EBI-10292326
MGST3 [O14880]3EBI-11522760,EBI-724754
MIEF1 [Q9NQG6]3EBI-11522760,EBI-740987
MIEF2 - isoform 3 [Q96C03-3]3EBI-11522760,EBI-11988931
MMD [Q15546]3EBI-11522760,EBI-17873222
MRM1 [Q6IN84]3EBI-11522760,EBI-5454865
MRPL11 [Q9Y3B7]3EBI-11522760,EBI-5453723
MRRF [Q96E11]3EBI-11522760,EBI-2855755
MTERF3 [Q96E29]3EBI-11522760,EBI-7825321
NDRG4 - isoform 2 [Q9ULP0-2]6EBI-11522760,EBI-11978907
NDUFAF3 [Q9BU61]3EBI-11522760,EBI-2114801
NKG7 [Q16617]3EBI-11522760,EBI-3919611
PBX3 [Q96AL5]3EBI-11522760,EBI-741171
PCYT1A [P49585]3EBI-11522760,EBI-2563309
PIMREG [Q9BSJ6]3EBI-11522760,EBI-2568609
PITPNC1 - isoform 2 [Q9UKF7-2]3EBI-11522760,EBI-14223623
PNPO [Q9NVS9]6EBI-11522760,EBI-11030787
POLDIP2 [Q9Y2S7]3EBI-11522760,EBI-713000
PPIF [P30405]3EBI-11522760,EBI-5544229
PRPF18 [Q99633]3EBI-11522760,EBI-2798416
PTPN9 [P43378]3EBI-11522760,EBI-742898
RAB30 [Q15771]3EBI-11522760,EBI-3924277
RBFA [Q8N0V3]3EBI-11522760,EBI-3232108
RETREG3 [Q86VR2]3EBI-11522760,EBI-10192441
RMDN2 [Q96LZ7]3EBI-11522760,EBI-2806908
S100B [A8MRB1]3EBI-11522760,EBI-16432654
SCAND1 [P57086]3EBI-11522760,EBI-745846
SENP2 [Q9HC62]3EBI-11522760,EBI-714881
SH3GLB1 [Q9Y371]3EBI-11522760,EBI-2623095
SLC18A1 - isoform 3 [P54219-3]3EBI-11522760,EBI-17595455
SLC7A14 [Q8TBB6]3EBI-11522760,EBI-5235586
SMG9 [Q9H0W8]3EBI-11522760,EBI-2872322
SPG21 [Q9NZD8]3EBI-11522760,EBI-742688
SSX5 - isoform 2 [O60225-2]3EBI-11522760,EBI-12033476
STAR [P49675]3EBI-11522760,EBI-722932
STARD4 [Q96DR4]3EBI-11522760,EBI-17217258
STMN4 - isoform 2 [Q9H169-2]3EBI-11522760,EBI-20117546
STX1A [Q16623]3EBI-11522760,EBI-712466
SUCLA2 [Q9P2R7]6EBI-11522760,EBI-2269898
SYT16 [Q17RD7]3EBI-11522760,EBI-10238936
TBRG4 [Q969Z0]3EBI-11522760,EBI-702328
TCEA2 [Q15560]3EBI-11522760,EBI-710310
TFAM [Q00059]3EBI-11522760,EBI-1049924
THAP4 [Q8WY91]3EBI-11522760,EBI-726691
TMEM139 [Q8IV31]3EBI-11522760,EBI-7238458
TMPPE [Q6ZT21]3EBI-11522760,EBI-11724433
TTPA [P49638]3EBI-11522760,EBI-10210710
TXN2 [Q99757]3EBI-11522760,EBI-2932492
UBE2I [Q7KZS0]3EBI-11522760,EBI-10180829
YARS2 [Q9Y2Z4]3EBI-11522760,EBI-1049286

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121356, 103 interactors

Protein interaction database and analysis system

More...
IntActi
Q6RW13, 145 interactors

Molecular INTeraction database

More...
MINTi
Q6RW13

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319713

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6RW13, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni110 – 122Interaction with AGTR1Add BLAST13

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S36M, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017402

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_148105_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6RW13

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFYNFLF

Database of Orthologous Groups

More...
OrthoDBi
1325275at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6RW13

TreeFam database of animal gene trees

More...
TreeFami
TF324477

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009436, AGTRAP

The PANTHER Classification System

More...
PANTHERi
PTHR16521, PTHR16521, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06396, AGTRAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00805, AGTRAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6RW13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS
60 70 80 90 100
IDAISMFLGG LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP
110 120 130 140 150
LSCCFVYHMY RERGGELLVH TGFLGSSQDR SAYQTIDSAE APADPFAVPE

GRSQDARGY
Length:159
Mass (Da):17,419
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E1D5C7E79AE6BC5
GO
Isoform 2 (identifier: Q6RW13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-121: Missing.

Show »
Length:152
Mass (Da):16,669
Checksum:i637C01214175C3C9
GO
Isoform 3 (identifier: Q6RW13-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RLPHVPGARG

Show »
Length:147
Mass (Da):16,048
Checksum:i27B4716DE9C64CEC
GO
Isoform 5 (identifier: Q6RW13-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RGFPWVFSGP

Show »
Length:155
Mass (Da):16,966
Checksum:iC78BE559AC52A0A0
GO
Isoform 4 (identifier: Q6RW13-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-159: VILLGHWLLT...EGRSQDARGY → GLHCILRLLC...RGFPWVFSGP

Show »
Length:111
Mass (Da):11,948
Checksum:i5ECC78C7CD1D332B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBK6D6RBK6_HUMAN
Type-1 angiotensin II receptor-asso...
AGTRAP
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB40D6RB40_HUMAN
Type-1 angiotensin II receptor-asso...
AGTRAP
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R9H3X6R9H3_HUMAN
Type-1 angiotensin II receptor-asso...
AGTRAP
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158G → R in AAF89547 (Ref. 2) Curated1
Sequence conflicti159Y → S in AAL26806 (PubMed:11733189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023075143A → V1 PublicationCorresponds to variant dbSNP:rs17875960Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03929110 – 159VILLG…DARGY → GLHCILRLLCLGQLHHPGLG RVGCGSAGLHRRHKHVSGWL AGHHLPGHRAHQHLLPAGQP HGHGPLWRGHGHPQLAAQAA LLLLRLPHVPGARGFPWVFS GP in isoform 4. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_03929021 – 159WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARG in isoform 3. CuratedAdd BLAST139
Alternative sequenceiVSP_04040621 – 159WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARGFPWVFSGP in isoform 5. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_014839115 – 121Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF312374 mRNA Translation: AAL26806.1
AF165187 mRNA Translation: AAF89547.1
CA866314 mRNA No translation available.
AY488088 Genomic DNA Translation: AAR25556.1
AL953897 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71702.1
BC017328 mRNA Translation: AAH17328.1
BE782705 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS136.1 [Q6RW13-1]
CCDS30585.1 [Q6RW13-2]
CCDS30586.1 [Q6RW13-4]
CCDS41248.1 [Q6RW13-3]
CCDS44056.1 [Q6RW13-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001035284.1, NM_001040194.1 [Q6RW13-2]
NP_001035285.1, NM_001040195.1 [Q6RW13-4]
NP_001035286.1, NM_001040196.1 [Q6RW13-5]
NP_001035287.1, NM_001040197.1 [Q6RW13-3]
NP_065083.3, NM_020350.4 [Q6RW13-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314340; ENSP00000319713; ENSG00000177674 [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674 [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674 [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674 [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674 [Q6RW13-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57085

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57085

UCSC genome browser

More...
UCSCi
uc001ast.4, human [Q6RW13-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312374 mRNA Translation: AAL26806.1
AF165187 mRNA Translation: AAF89547.1
CA866314 mRNA No translation available.
AY488088 Genomic DNA Translation: AAR25556.1
AL953897 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71702.1
BC017328 mRNA Translation: AAH17328.1
BE782705 mRNA No translation available.
CCDSiCCDS136.1 [Q6RW13-1]
CCDS30585.1 [Q6RW13-2]
CCDS30586.1 [Q6RW13-4]
CCDS41248.1 [Q6RW13-3]
CCDS44056.1 [Q6RW13-5]
RefSeqiNP_001035284.1, NM_001040194.1 [Q6RW13-2]
NP_001035285.1, NM_001040195.1 [Q6RW13-4]
NP_001035286.1, NM_001040196.1 [Q6RW13-5]
NP_001035287.1, NM_001040197.1 [Q6RW13-3]
NP_065083.3, NM_020350.4 [Q6RW13-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121356, 103 interactors
IntActiQ6RW13, 145 interactors
MINTiQ6RW13
STRINGi9606.ENSP00000319713

PTM databases

iPTMnetiQ6RW13
PhosphoSitePlusiQ6RW13
SwissPalmiQ6RW13

Polymorphism and mutation databases

BioMutaiAGTRAP
DMDMi71152303

Proteomic databases

EPDiQ6RW13
jPOSTiQ6RW13
MassIVEiQ6RW13
MaxQBiQ6RW13
PaxDbiQ6RW13
PeptideAtlasiQ6RW13
PRIDEiQ6RW13
ProteomicsDBi67329 [Q6RW13-1]
67330 [Q6RW13-2]
67331 [Q6RW13-3]
67332 [Q6RW13-4]
67333 [Q6RW13-5]
TopDownProteomicsiQ6RW13-1 [Q6RW13-1]
Q6RW13-2 [Q6RW13-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28197, 218 antibodies

The DNASU plasmid repository

More...
DNASUi
57085

Genome annotation databases

EnsembliENST00000314340; ENSP00000319713; ENSG00000177674 [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674 [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674 [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674 [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674 [Q6RW13-5]
GeneIDi57085
KEGGihsa:57085
UCSCiuc001ast.4, human [Q6RW13-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57085
DisGeNETi57085
EuPathDBiHostDB:ENSG00000177674.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AGTRAP
HGNCiHGNC:13539, AGTRAP
HPAiENSG00000177674, Tissue enhanced (blood)
MIMi608729, gene
neXtProtiNX_Q6RW13
OpenTargetsiENSG00000177674
PharmGKBiPA38363

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S36M, Eukaryota
GeneTreeiENSGT00390000017402
HOGENOMiCLU_148105_0_0_1
InParanoidiQ6RW13
OMAiEFYNFLF
OrthoDBi1325275at2759
PhylomeDBiQ6RW13
TreeFamiTF324477

Enzyme and pathway databases

PathwayCommonsiQ6RW13
ReactomeiR-HSA-6802952, Signaling by BRAF and RAF fusions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57085, 3 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AGTRAP, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AGTRAP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57085
PharosiQ6RW13, Tbio

Protein Ontology

More...
PROi
PR:Q6RW13
RNActiQ6RW13, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177674, Expressed in blood and 207 other tissues
ExpressionAtlasiQ6RW13, baseline and differential
GenevisibleiQ6RW13, HS

Family and domain databases

InterProiView protein in InterPro
IPR009436, AGTRAP
PANTHERiPTHR16521, PTHR16521, 1 hit
PfamiView protein in Pfam
PF06396, AGTRAP, 1 hit
SMARTiView protein in SMART
SM00805, AGTRAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RW13
Secondary accession number(s): A8MVQ5
, Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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