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Protein

Type-1 angiotensin II receptor-associated protein

Gene

AGTRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:AGTRAP
Synonyms:ATRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177674.15
HGNCiHGNC:13539 AGTRAP
MIMi608729 gene
neXtProtiNX_Q6RW13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 55CytoplasmicSequence analysisAdd BLAST11
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 86ExtracellularSequence analysis10
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 159CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57085
OpenTargetsiENSG00000177674
PharmGKBiPA38363

Polymorphism and mutation databases

BioMutaiAGTRAP
DMDMi71152303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647351 – 159Type-1 angiotensin II receptor-associated proteinAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6RW13
MaxQBiQ6RW13
PaxDbiQ6RW13
PeptideAtlasiQ6RW13
PRIDEiQ6RW13
ProteomicsDBi67329
67330 [Q6RW13-2]
67331 [Q6RW13-3]
67332 [Q6RW13-4]
67333 [Q6RW13-5]
TopDownProteomicsiQ6RW13-1 [Q6RW13-1]
Q6RW13-2 [Q6RW13-2]

PTM databases

iPTMnetiQ6RW13
PhosphoSitePlusiQ6RW13
SwissPalmiQ6RW13

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000177674 Expressed in 192 organ(s), highest expression level in blood
CleanExiHS_AGTRAP
ExpressionAtlasiQ6RW13 baseline and differential
GenevisibleiQ6RW13 HS

Organism-specific databases

HPAiHPA044120

Interactioni

Subunit structurei

Interacts with RACK1, and with the C-terminal region of AGTR1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACSF2Q96CM83EBI-741181,EBI-2876502
ALDH18A1P548863EBI-741181,EBI-1210304
AP3M1Q9Y2T23EBI-741181,EBI-2371151
ARAFQ96II53EBI-741181,EBI-9383168
ARFIP2P533654EBI-741181,EBI-638194
BPIFA2Q96DR53EBI-741181,EBI-10284754
C12orf10Q86UA33EBI-741181,EBI-10258793
CAPNS1P046323EBI-741181,EBI-711828
CD160O959713EBI-741181,EBI-4314390
COQ8AQ8NI605EBI-11522760,EBI-745535
CRCT1Q9UGL93EBI-741181,EBI-713677
DDA1Q9BW613EBI-741181,EBI-2510241
DDX55Q8NHQ93EBI-741181,EBI-5459844
DIABLOQ9NR285EBI-11522760,EBI-517508
ECPASQ5VYK33EBI-741181,EBI-521451
FAM114A1Q8IWE23EBI-741181,EBI-2686288
FAM160A2Q8N6123EBI-741181,EBI-742137
FARS2O953633EBI-741181,EBI-2513774
FASTKD3Q14CZ73EBI-741181,EBI-10234819
FATE1Q969F03EBI-741181,EBI-743099
FGAA0A0S2Z3E93EBI-11522760,EBI-16439102
GABARAPL2P605203EBI-741181,EBI-720116
GAD1A0A0S2Z4D93EBI-11522760,EBI-16430771
GAD1Q8IVA83EBI-741181,EBI-10209663
GAD1Q992595EBI-11522760,EBI-743184
GAD2Q053293EBI-741181,EBI-9304251
GDNFP399053EBI-741181,EBI-10207709
GTF3C1Q127893EBI-741181,EBI-357956
HARS2P495903EBI-741181,EBI-3909030
HIST1H4GQ995253EBI-741181,EBI-10294329
HMGB1P094293EBI-741181,EBI-389432
HSCBQ8IWL33EBI-741181,EBI-1805738
HSPA4P349323EBI-741181,EBI-356933
ISCUQ9H1K13EBI-741181,EBI-1047335
LMO2P257913EBI-741181,EBI-739696
LNX1Q8TBB13EBI-741181,EBI-739832
MCEEQ96PE75EBI-11522760,EBI-10292326
MIEF1Q9NQG63EBI-741181,EBI-740987
MIEF2Q96C033EBI-741181,EBI-750153
MRM1Q6IN843EBI-741181,EBI-5454865
MTERF3Q96E293EBI-741181,EBI-7825321
MUTYHQ9UIF7-33EBI-741181,EBI-10321956
NDRG4Q9ULP03EBI-741181,EBI-10323810
NDRG4Q9ULP0-25EBI-11522760,EBI-11978907
NFU1Q9UMS03EBI-741181,EBI-725252
NFYBP252083EBI-741181,EBI-389728
NKG7Q166173EBI-741181,EBI-3919611
PBX3Q5JS983EBI-741181,EBI-10244393
PBX3Q96AL53EBI-741181,EBI-741171
PCTPQ9UKL63EBI-741181,EBI-4402391
PDHXO003304EBI-741181,EBI-751566
PIMREGQ9BSJ63EBI-741181,EBI-2568609
PITPNC1Q9UKF76EBI-741181,EBI-749241
PNPOQ9NVS95EBI-11522760,EBI-11030787
PTPN9P433784EBI-741181,EBI-742898
PTPN9Q6IQ433EBI-741181,EBI-10250413
RMDN2Q96LZ73EBI-741181,EBI-2806908
S100BA8MRB13EBI-11522760,EBI-16432654
SENP2Q9HC623EBI-741181,EBI-714881
SNX1Q135963EBI-741181,EBI-2822329
SPG21Q9NZD84EBI-741181,EBI-742688
SSX3Q999093EBI-741181,EBI-10295431
SSX5O602253EBI-741181,EBI-10186198
STAG3L1Q7L1H23EBI-741181,EBI-10255998
SUCLA2E5KS603EBI-741181,EBI-10176959
SUCLA2Q9P2R75EBI-11522760,EBI-2269898
SYT16Q17RD73EBI-741181,EBI-10238936
TBRG4Q969Z03EBI-741181,EBI-702328
TCEANC2Q96MN53EBI-741181,EBI-5462748
TFAMQ000593EBI-741181,EBI-1049924
TPD52L3Q96J773EBI-741181,EBI-932162
TUBA1BP683633EBI-741181,EBI-487083
TXN2Q997573EBI-741181,EBI-2932492
ZFYVE21Q9BQ243EBI-741181,EBI-2849569

Protein-protein interaction databases

BioGridi121356, 96 interactors
IntActiQ6RW13, 138 interactors
MINTiQ6RW13
STRINGi9606.ENSP00000319713

Structurei

3D structure databases

ProteinModelPortaliQ6RW13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 122Interaction with AGTR1Add BLAST13

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYP8 Eukaryota
ENOG4111P37 LUCA
GeneTreeiENSGT00390000017402
HOGENOMiHOG000034218
HOVERGENiHBG080881
InParanoidiQ6RW13
OMAiYHMYRER
OrthoDBiEOG091G0TSZ
PhylomeDBiQ6RW13
TreeFamiTF324477

Family and domain databases

InterProiView protein in InterPro
IPR009436 AGTRAP
PANTHERiPTHR16521 PTHR16521, 1 hit
PfamiView protein in Pfam
PF06396 AGTRAP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD357679 PD357679, 1 hit
SMARTiView protein in SMART
SM00805 AGTRAP, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q6RW13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS
60 70 80 90 100
IDAISMFLGG LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP
110 120 130 140 150
LSCCFVYHMY RERGGELLVH TGFLGSSQDR SAYQTIDSAE APADPFAVPE

GRSQDARGY
Length:159
Mass (Da):17,419
Last modified:July 5, 2004 - v1
Checksum:i7E1D5C7E79AE6BC5
GO
Isoform 2 (identifier: Q6RW13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-121: Missing.

Show »
Length:152
Mass (Da):16,669
Checksum:i637C01214175C3C9
GO
Isoform 3 (identifier: Q6RW13-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RLPHVPGARG

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,048
Checksum:i27B4716DE9C64CEC
GO
Isoform 5 (identifier: Q6RW13-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RGFPWVFSGP

Show »
Length:155
Mass (Da):16,966
Checksum:iC78BE559AC52A0A0
GO
Isoform 4 (identifier: Q6RW13-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-159: VILLGHWLLT...EGRSQDARGY → GLHCILRLLC...RGFPWVFSGP

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):11,948
Checksum:i5ECC78C7CD1D332B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBK6D6RBK6_HUMAN
Type-1 angiotensin II receptor-asso...
AGTRAP
155Annotation score:
D6RB40D6RB40_HUMAN
Type-1 angiotensin II receptor-asso...
AGTRAP
63Annotation score:
X6R9H3X6R9H3_HUMAN
Type-1 angiotensin II receptor-asso...
AGTRAP
159Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158G → R in AAF89547 (Ref. 2) Curated1
Sequence conflicti159Y → S in AAL26806 (PubMed:11733189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023075143A → V1 PublicationCorresponds to variant dbSNP:rs17875960Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03929110 – 159VILLG…DARGY → GLHCILRLLCLGQLHHPGLG RVGCGSAGLHRRHKHVSGWL AGHHLPGHRAHQHLLPAGQP HGHGPLWRGHGHPQLAAQAA LLLLRLPHVPGARGFPWVFS GP in isoform 4. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_03929021 – 159WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARG in isoform 3. CuratedAdd BLAST139
Alternative sequenceiVSP_04040621 – 159WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARGFPWVFSGP in isoform 5. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_014839115 – 121Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312374 mRNA Translation: AAL26806.1
AF165187 mRNA Translation: AAF89547.1
CA866314 mRNA No translation available.
AY488088 Genomic DNA Translation: AAR25556.1
AL953897 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71702.1
BC017328 mRNA Translation: AAH17328.1
BE782705 mRNA No translation available.
CCDSiCCDS136.1 [Q6RW13-1]
CCDS30585.1 [Q6RW13-2]
CCDS30586.1 [Q6RW13-4]
CCDS41248.1 [Q6RW13-3]
CCDS44056.1 [Q6RW13-5]
RefSeqiNP_001035284.1, NM_001040194.1 [Q6RW13-2]
NP_001035285.1, NM_001040195.1 [Q6RW13-4]
NP_001035286.1, NM_001040196.1 [Q6RW13-5]
NP_001035287.1, NM_001040197.1 [Q6RW13-3]
NP_065083.3, NM_020350.4 [Q6RW13-1]
UniGeneiHs.464438

Genome annotation databases

EnsembliENST00000314340; ENSP00000319713; ENSG00000177674 [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674 [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674 [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674 [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674 [Q6RW13-5]
GeneIDi57085
KEGGihsa:57085
UCSCiuc001ast.4 human [Q6RW13-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312374 mRNA Translation: AAL26806.1
AF165187 mRNA Translation: AAF89547.1
CA866314 mRNA No translation available.
AY488088 Genomic DNA Translation: AAR25556.1
AL953897 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71702.1
BC017328 mRNA Translation: AAH17328.1
BE782705 mRNA No translation available.
CCDSiCCDS136.1 [Q6RW13-1]
CCDS30585.1 [Q6RW13-2]
CCDS30586.1 [Q6RW13-4]
CCDS41248.1 [Q6RW13-3]
CCDS44056.1 [Q6RW13-5]
RefSeqiNP_001035284.1, NM_001040194.1 [Q6RW13-2]
NP_001035285.1, NM_001040195.1 [Q6RW13-4]
NP_001035286.1, NM_001040196.1 [Q6RW13-5]
NP_001035287.1, NM_001040197.1 [Q6RW13-3]
NP_065083.3, NM_020350.4 [Q6RW13-1]
UniGeneiHs.464438

3D structure databases

ProteinModelPortaliQ6RW13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121356, 96 interactors
IntActiQ6RW13, 138 interactors
MINTiQ6RW13
STRINGi9606.ENSP00000319713

PTM databases

iPTMnetiQ6RW13
PhosphoSitePlusiQ6RW13
SwissPalmiQ6RW13

Polymorphism and mutation databases

BioMutaiAGTRAP
DMDMi71152303

Proteomic databases

EPDiQ6RW13
MaxQBiQ6RW13
PaxDbiQ6RW13
PeptideAtlasiQ6RW13
PRIDEiQ6RW13
ProteomicsDBi67329
67330 [Q6RW13-2]
67331 [Q6RW13-3]
67332 [Q6RW13-4]
67333 [Q6RW13-5]
TopDownProteomicsiQ6RW13-1 [Q6RW13-1]
Q6RW13-2 [Q6RW13-2]

Protocols and materials databases

DNASUi57085
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314340; ENSP00000319713; ENSG00000177674 [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674 [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674 [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674 [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674 [Q6RW13-5]
GeneIDi57085
KEGGihsa:57085
UCSCiuc001ast.4 human [Q6RW13-1]

Organism-specific databases

CTDi57085
DisGeNETi57085
EuPathDBiHostDB:ENSG00000177674.15
GeneCardsiAGTRAP
HGNCiHGNC:13539 AGTRAP
HPAiHPA044120
MIMi608729 gene
neXtProtiNX_Q6RW13
OpenTargetsiENSG00000177674
PharmGKBiPA38363
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYP8 Eukaryota
ENOG4111P37 LUCA
GeneTreeiENSGT00390000017402
HOGENOMiHOG000034218
HOVERGENiHBG080881
InParanoidiQ6RW13
OMAiYHMYRER
OrthoDBiEOG091G0TSZ
PhylomeDBiQ6RW13
TreeFamiTF324477

Enzyme and pathway databases

ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRSiAGTRAP human
GeneWikiiAGTRAP
GenomeRNAii57085
PROiPR:Q6RW13
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177674 Expressed in 192 organ(s), highest expression level in blood
CleanExiHS_AGTRAP
ExpressionAtlasiQ6RW13 baseline and differential
GenevisibleiQ6RW13 HS

Family and domain databases

InterProiView protein in InterPro
IPR009436 AGTRAP
PANTHERiPTHR16521 PTHR16521, 1 hit
PfamiView protein in Pfam
PF06396 AGTRAP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD357679 PD357679, 1 hit
SMARTiView protein in SMART
SM00805 AGTRAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATRAP_HUMAN
AccessioniPrimary (citable) accession number: Q6RW13
Secondary accession number(s): A8MVQ5
, Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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