Rac1

Functionⁱ

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.By similarity5 Publications

Activity regulationⁱ

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	60	GTP; via amide nitrogenBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	13 – 18	GTPBy similarity	6
Nucleotide bindingⁱ	30 – 35	GTPBy similarity	6
Nucleotide bindingⁱ	116 – 118	GTPBy similarity	3
Nucleotide bindingⁱ	159 – 160	GTPBy similarity	2

GO - Molecular functionⁱ

ATPase binding
Source: RGD
Inferred from physical interactionⁱ
- 20671235
GTPase activity
Source: RGD
Inferred from direct assayⁱ
- 12672819
GTP binding
Source: RGD
Inferred from direct assayⁱ
- 12672819
histone deacetylase binding
Source: RGD
Inferred from physical interactionⁱ
- 22679019
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20861382
Rab GTPase binding
Source: RGD
Inferred from physical interactionⁱ
- 16040606
Rho GDP-dissociation inhibitor binding
Source: RGD
Inferred from physical interactionⁱ
- 22564631
thioesterase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: RGD
Inferred from direct assayⁱ
- 10350213
actin filament organization
Source: RGD
Inferred from mutant phenotypeⁱ
- 12413953
bone resorption
Source: RGD
Inferred from direct assayⁱ
- 10350213
cell motility Source: UniProtKB
cell projection assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 11756405
cellular response to mechanical stimulus
Source: RGD
Inferred from direct assayⁱ
- 12105187
chemotaxis
Source: RGD
Inferred from mutant phenotypeⁱ
- 11756405
hepatocyte growth factor receptor signaling pathway Source: Ensembl
lamellipodium assembly Source: Ensembl
localization within membrane Source: Ensembl
mast cell chemotaxis
Source: RGD
Inferred from mutant phenotypeⁱ
- 12413953
negative regulation of interleukin-23 production Source: Ensembl
neuron migration Source: UniProtKB
neuron projection morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of DNA replication
Source: RGD
Inferred from mutant phenotypeⁱ
- 9487126
positive regulation of focal adhesion assembly Source: Ensembl
positive regulation of lamellipodium assembly
Source: RGD
Inferred from mutant phenotypeⁱ
- 12105187
positive regulation of microtubule polymerization Source: Ensembl
positive regulation of neutrophil chemotaxis Source: Ensembl
positive regulation of protein phosphorylation Source: UniProtKB
positive regulation of stress fiber assembly Source: Ensembl
positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
Rac protein signal transduction
Source: SynGO
Inferred from direct assayⁱ
- 15800193
regulation of cell migration Source: UniProtKB
regulation of cell size Source: Ensembl
regulation of nitric oxide biosynthetic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 16055727
regulation of respiratory burst Source: Ensembl
Rho protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ruffle assembly Source: Ensembl
semaphorin-plexin signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20696765
substrate adhesion-dependent cell spreading Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-114604 GPVI-mediated activation cascade R-RNO-1433557 Signaling by SCF-KIT R-RNO-193648 NRAGE signals death through JNK R-RNO-194840 Rho GTPase cycle R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation R-RNO-2424491 DAP12 signaling R-RNO-2871796 FCERI mediated MAPK activation R-RNO-376172 DSCAM interactions R-RNO-389359 CD28 dependent Vav1 pathway R-RNO-3928662 EPHB-mediated forward signaling R-RNO-3928664 Ephrin signaling R-RNO-3928665 EPH-ephrin mediated repulsion of cells R-RNO-399954 Sema3A PAK dependent Axon repulsion R-RNO-4086400 PCP/CE pathway R-RNO-416482 G alpha (12/13) signalling events R-RNO-416550 Sema4D mediated inhibition of cell attachment and migration R-RNO-418885 DCC mediated attractive signaling R-RNO-4420097 VEGFA-VEGFR2 Pathway R-RNO-445144 Signal transduction by L1 R-RNO-5218920 VEGFR2 mediated vascular permeability R-RNO-5625740 RHO GTPases activate PKNs R-RNO-5625900 RHO GTPases activate CIT R-RNO-5625970 RHO GTPases activate KTN1 R-RNO-5626467 RHO GTPases activate IQGAPs R-RNO-5627123 RHO GTPases activate PAKs R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs R-RNO-5663220 RHO GTPases Activate Formins R-RNO-5668599 RHO GTPases Activate NADPH Oxidases R-RNO-5687128 MAPK6/MAPK4 signaling R-RNO-6798695 Neutrophil degranulation R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-RNO-8875555 MET activates RAP1 and RAC1 R-RNO-9032759 NTRK2 activates RAC1 R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-RNO-114604 GPVI-mediated activation cascade
R-RNO-1433557 Signaling by SCF-KIT
R-RNO-193648 NRAGE signals death through JNK
R-RNO-194840 Rho GTPase cycle
R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-2424491 DAP12 signaling
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-376172 DSCAM interactions
R-RNO-389359 CD28 dependent Vav1 pathway
R-RNO-3928662 EPHB-mediated forward signaling
R-RNO-3928664 Ephrin signaling
R-RNO-3928665 EPH-ephrin mediated repulsion of cells
R-RNO-399954 Sema3A PAK dependent Axon repulsion
R-RNO-4086400 PCP/CE pathway
R-RNO-416482 G alpha (12/13) signalling events
R-RNO-416550 Sema4D mediated inhibition of cell attachment and migration
R-RNO-418885 DCC mediated attractive signaling
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-445144 Signal transduction by L1
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-5625740 RHO GTPases activate PKNs
R-RNO-5625900 RHO GTPases activate CIT
R-RNO-5625970 RHO GTPases activate KTN1
R-RNO-5626467 RHO GTPases activate IQGAPs
R-RNO-5627123 RHO GTPases activate PAKs
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-5668599 RHO GTPases Activate NADPH Oxidases
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-6798695 Neutrophil degranulation
R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-RNO-8875555 MET activates RAP1 and RAC1
R-RNO-9032759 NTRK2 activates RAC1
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related C3 botulinum toxin substrate 1 Alternative name(s): p21-Rac1
Gene namesⁱ	Name:Rac1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 12

Organism-specific databases

Rat genome database More...RGDⁱ	619755 Rac1

RGDⁱ

619755 Rac1

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	12	G → V: Constitutively active. Increases PAK1 and LIMK1 phosphorylation and NR3C2 nuclear localization in podocytes. 1 Publication	1
Mutagenesisⁱ	17	T → N: Dominant negatif. Reduces NMDA receptor-mediated synaptic currents. 1 Publication	1
Mutagenesisⁱ	61	Q → L: Constitutively active. Interacts with PPP5C. 2 Publications	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000042040	1 – 189	Ras-related C3 botulinum toxin substrate 1Add BLAST		189
PropeptideⁱPRO_0000042041	190 – 192	Removed in mature formBy similarity		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	147	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	189	Cysteine methyl esterBy similarity	1
Lipidationⁱ	189	S-geranylgeranyl cysteineBy similarity	1

Post-translational modificationⁱ

GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.By similarity

Keywords - PTMⁱ

Isopeptide bond, Lipoprotein, Methylation, Prenylation, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q6RUV5
PRIDEⁱ	Q6RUV5

PTM databases

iPTMnetⁱ	Q6RUV5
PhosphoSitePlusⁱ	Q6RUV5
SwissPalmⁱ	Q6RUV5

Expressionⁱ

Tissue specificityⁱ

Osteoclasts.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000001068 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	Q6RUV5 baseline and differential
Genevisibleⁱ	Q6RUV5 RN

Interactionⁱ

Subunit structureⁱ

Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins PREX1, RASGRF2, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires PAK1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with S100A8 and calprotectin (S100A8/9). Interacts with PACSIN2. Interacts with ITGB1BP1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RAPH1 (via Ras associating and PH domains) (By similarity). Interacts with MTSS1L (via IMD domain); this interaction may be important to potentiate PDGF-induced RAC1 activation. Interacts with PAK2. Interacts (GTP-bound form) with SH3RF1 and SH3RF3. Found in a complex with SH3RF1, MAPK8IP1/JIP1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8/JNK1 (By similarity). Interacts (both active GTP- or inactive GDP-bound forms) with SH3RF2 (PubMed:22128169).By similarity4 Publications

GO - Molecular functionⁱ

ATPase binding
Source: RGD
Inferred from physical interactionⁱ
- 20671235
histone deacetylase binding
Source: RGD
Inferred from physical interactionⁱ
- 22679019
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20861382
Rab GTPase binding
Source: RGD
Inferred from physical interactionⁱ
- 16040606
Rho GDP-dissociation inhibitor binding
Source: RGD
Inferred from physical interactionⁱ
- 22564631
thioesterase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	264467, 6 interactors
CORUMⁱ	Q6RUV5
Database of interacting proteins More...DIPⁱ	DIP-37114N
IntActⁱ	Q6RUV5, 4 interactors
STRINGⁱ	10116.ENSRNOP00000001417

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6RUV5
SMRⁱ	Q6RUV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	32 – 40	Effector regionSequence analysis		9

Domainⁱ

The effector region mediates interaction with DEF6.By similarity

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0393 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118978
HOGENOMⁱ	HOG000233974
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q6RUV5
KEGG Orthology (KO) More...KOⁱ	K04392
PhylomeDBⁱ	Q6RUV5

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR003578 Small_GTPase_Rho
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51420 RHO, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q6RUV5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP 
        60         70         80         90        100
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE 
       110        120        130        140        150
VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG 
       160        170        180        190 
AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL

Length:192

Mass (Da):21,450

Last modified:July 5, 2004 - v1

Checksum:ⁱACEDF83A45E5EA67

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2K0X4	A0A0G2K0X4_RAT	Ras-related C3 botulinum toxin subs... Ras-related C3 botulinum toxin substrate 1	Rac1	217	Annotation score:
A0A0U1RS21	A0A0U1RS21_RAT	Ras-related C3 botulinum toxin subs... Ras-related C3 botulinum toxin substrate 1	Rac1	115	Annotation score:
A0A0U1RS18	A0A0U1RS18_RAT	Ras-related C3 botulinum toxin subs... Ras-related C3 botulinum toxin substrate 1	Rac1	22	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY491395 mRNA Translation: AAR84574.1
NCBI Reference Sequences More...RefSeqⁱ	NP_599193.1, NM_134366.1
UniGeneⁱ	Rn.228585 Rn.29157

Genome annotation databases

Ensemblⁱ	ENSRNOT00000001417; ENSRNOP00000001417; ENSRNOG00000001068
GeneIDⁱ	363875
KEGGⁱ	rno:363875

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6RUV5	Ras-related C3 botulinum toxin substrate 1	)	HUMAN		192	UniRef100_P63000
Ras-related C3 botulinum toxin substrate 1		BOVIN		192
Ras-related C3 botulinum toxin substrate 1		CANLF		192
Ras-related C3 botulinum toxin substrate 1		MOUSE		192
Ras-related C3 botulinum toxin substrate 1		ALLMI		214
+46

Protein	Similar proteins		Species	Score	Length	Source
Q6RUV5	Ras-related C3 botulinum toxin substrate 1	)	HUMAN		192	UniRef90_P63000
Ras-related C3 botulinum toxin substrate 1		BOVIN		192
Ras-related C3 botulinum toxin substrate 1		CANLF		192
Ras-related C3 botulinum toxin substrate 1		MOUSE		192
Ras-related C3 botulinum toxin substrate 1		ALLMI		214
+68

Protein	Similar proteins		Species	Score	Length	Source
Q6RUV5	Ras-related C3 botulinum toxin substrate 1	)	HUMAN		192	UniRef50_P63000
Ras-related C3 botulinum toxin substrate 1		BOVIN		192
Ras-related C3 botulinum toxin substrate 1		CANLF		192
Ras-related C3 botulinum toxin substrate 1		MOUSE		192
Rac-like GTP-binding protein RAC13		GOSHI		196
+125

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY491395 mRNA Translation: AAR84574.1
RefSeqⁱ	NP_599193.1, NM_134366.1
UniGeneⁱ	Rn.228585 Rn.29157

3D structure databases

ProteinModelPortalⁱ	Q6RUV5
SMRⁱ	Q6RUV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	264467, 6 interactors
CORUMⁱ	Q6RUV5
DIPⁱ	DIP-37114N
IntActⁱ	Q6RUV5, 4 interactors
STRINGⁱ	10116.ENSRNOP00000001417

PTM databases

iPTMnetⁱ	Q6RUV5
PhosphoSitePlusⁱ	Q6RUV5
SwissPalmⁱ	Q6RUV5

Proteomic databases

PaxDbⁱ	Q6RUV5
PRIDEⁱ	Q6RUV5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000001417; ENSRNOP00000001417; ENSRNOG00000001068
GeneIDⁱ	363875
KEGGⁱ	rno:363875

Organism-specific databases

CTDⁱ	5879
RGDⁱ	619755 Rac1

Phylogenomic databases

eggNOGⁱ	KOG0393 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00760000118978
HOGENOMⁱ	HOG000233974
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q6RUV5
KOⁱ	K04392
PhylomeDBⁱ	Q6RUV5

Enzyme and pathway databases

Reactomeⁱ	R-RNO-114604 GPVI-mediated activation cascade R-RNO-1433557 Signaling by SCF-KIT R-RNO-193648 NRAGE signals death through JNK R-RNO-194840 Rho GTPase cycle R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation R-RNO-2424491 DAP12 signaling R-RNO-2871796 FCERI mediated MAPK activation R-RNO-376172 DSCAM interactions R-RNO-389359 CD28 dependent Vav1 pathway R-RNO-3928662 EPHB-mediated forward signaling R-RNO-3928664 Ephrin signaling R-RNO-3928665 EPH-ephrin mediated repulsion of cells R-RNO-399954 Sema3A PAK dependent Axon repulsion R-RNO-4086400 PCP/CE pathway R-RNO-416482 G alpha (12/13) signalling events R-RNO-416550 Sema4D mediated inhibition of cell attachment and migration R-RNO-418885 DCC mediated attractive signaling R-RNO-4420097 VEGFA-VEGFR2 Pathway R-RNO-445144 Signal transduction by L1 R-RNO-5218920 VEGFR2 mediated vascular permeability R-RNO-5625740 RHO GTPases activate PKNs R-RNO-5625900 RHO GTPases activate CIT R-RNO-5625970 RHO GTPases activate KTN1 R-RNO-5626467 RHO GTPases activate IQGAPs R-RNO-5627123 RHO GTPases activate PAKs R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs R-RNO-5663220 RHO GTPases Activate Formins R-RNO-5668599 RHO GTPases Activate NADPH Oxidases R-RNO-5687128 MAPK6/MAPK4 signaling R-RNO-6798695 Neutrophil degranulation R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-RNO-8875555 MET activates RAP1 and RAC1 R-RNO-9032759 NTRK2 activates RAC1 R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-RNO-114604 GPVI-mediated activation cascade
R-RNO-1433557 Signaling by SCF-KIT
R-RNO-193648 NRAGE signals death through JNK
R-RNO-194840 Rho GTPase cycle
R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-2424491 DAP12 signaling
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-376172 DSCAM interactions
R-RNO-389359 CD28 dependent Vav1 pathway
R-RNO-3928662 EPHB-mediated forward signaling
R-RNO-3928664 Ephrin signaling
R-RNO-3928665 EPH-ephrin mediated repulsion of cells
R-RNO-399954 Sema3A PAK dependent Axon repulsion
R-RNO-4086400 PCP/CE pathway
R-RNO-416482 G alpha (12/13) signalling events
R-RNO-416550 Sema4D mediated inhibition of cell attachment and migration
R-RNO-418885 DCC mediated attractive signaling
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-445144 Signal transduction by L1
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-5625740 RHO GTPases activate PKNs
R-RNO-5625900 RHO GTPases activate CIT
R-RNO-5625970 RHO GTPases activate KTN1
R-RNO-5626467 RHO GTPases activate IQGAPs
R-RNO-5627123 RHO GTPases activate PAKs
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-5668599 RHO GTPases Activate NADPH Oxidases
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-6798695 Neutrophil degranulation
R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-RNO-8875555 MET activates RAP1 and RAC1
R-RNO-9032759 NTRK2 activates RAC1
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6RUV5

PROⁱ

PR:Q6RUV5

Gene expression databases

Bgeeⁱ	ENSRNOG00000001068 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	Q6RUV5 baseline and differential
Genevisibleⁱ	Q6RUV5 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR003578 Small_GTPase_Rho
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51420 RHO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAC1_RAT
Accessionⁱ	Q6RUV5Primary (citable) accession number: Q6RUV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - Q6RUV5 (RAC1_RAT)

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Ras-related C3 botulinum toxin substrate 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ