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Protein

Chloride channel protein

Gene

Clcn7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transportUniRule annotationSAAS annotation, Transport
LigandChlorideUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel proteinUniRule annotation
Gene namesi
Name:Clcn7Imported
ORF Names:mCG_140476Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1347048 Clcn7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei125 – 146HelicalUniRule annotationAdd BLAST22
Transmembranei174 – 195HelicalUniRule annotationAdd BLAST22
Transmembranei225 – 243HelicalUniRule annotationAdd BLAST19
Transmembranei286 – 309HelicalUniRule annotationAdd BLAST24
Transmembranei321 – 343HelicalUniRule annotationAdd BLAST23
Transmembranei373 – 397HelicalUniRule annotationAdd BLAST25
Transmembranei409 – 431HelicalUniRule annotationAdd BLAST23
Transmembranei486 – 504HelicalUniRule annotationAdd BLAST19
Transmembranei516 – 539HelicalUniRule annotationAdd BLAST24
Transmembranei545 – 567HelicalUniRule annotationAdd BLAST23
Transmembranei579 – 600HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000036636 Expressed in 276 organ(s), highest expression level in cardiac ventricle

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini629 – 693CBSInterPro annotationAdd BLAST65
Domaini739 – 797CBSInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the chloride channel (TC 2.A.49) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0474 Eukaryota
COG0038 LUCA
HOVERGENiHBG050985
KOiK05016
OrthoDBiEOG091G02SB

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644 CBS_dom
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
IPR002249 Cl_channel-7
PfamiView protein in Pfam
PF00571 CBS, 2 hits
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
PR01118 CLCHANNEL7
SMARTiView protein in SMART
SM00116 CBS, 2 hits
SUPFAMiSSF81340 SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Complete.

Q6RUT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANVSKKVSW SGRDRDDEEG APLLRRTGQP DEETPLLNGA GPGARQSHSA
60 70 80 90 100
LFRIGQMNNV ELDDELLDPE VDPPHTFPKE IPHNEKLLSL KYESLDYDNS
110 120 130 140 150
ENQLFLEEER RINHTAFRTV EIKRWVICAL IGILTGLVAC FIDIVVENLA
160 170 180 190 200
GLKYRVIKDN IDKFTEKGGL SFSLLLWATL NSAFVLVGSV IVAFIEPVAA
210 220 230 240 250
GSGIPQIKCF LNGVKIPHVV RLKTLVIKVS GVILSVVGGL AVGKEGPMIH
260 270 280 290 300
SGSVIAAGIS QGRSTSLKRD FKIFEYFRRD TEKRDFVSAG AAAGVSAAFG
310 320 330 340 350
APVGGVLFSL EEGASFWNQF LTWRIFFASM ISTFTLNFVL SIYHGNMWDL
360 370 380 390 400
SSPGLINFGR FDSEKMAYTI HEIPVFIAMG VVGGILGAVF NALNYWLTMF
410 420 430 440 450
RIRYIHRPCL QVIEAMLVAA VTATVAFVLI YSSRDCQPLQ GSSMSYPLQL
460 470 480 490 500
FCADGEYNSM AAAFFNTPEK SVVSLFHDPP GSYNPMTLGL FTLVYFFLAC
510 520 530 540 550
WTYGLTVSAG VFIPSLLIGA AWGRLFGISL SYLTGAAIWA DPGKYALMGA
560 570 580 590 600
AAQLGGIVRM TLSLTVIMME ATSNVTYGFP IMLVLMTAKI VGDVFIEGLY
610 620 630 640 650
DMHIQLQSVP FLHWEAPVTS HSLTAREVMS TPVTCLRRRE KVGIIVDVLS
660 670 680 690 700
DTASNHNGFP VVEDVGDTQP ARLQGLILRS QLIVLLKHKV FVERSNMGLV
710 720 730 740 750
QRRLRLKDFR DAYPRFPPIQ SIHVSQDERE CTMDLSEFMN PSPYTVPQEA
760 770 780 790 800
SLPRVFKLFR ALGLRHLVVV DNHNQVVGLV TRKDLARYRL GKGGLEELSL

AQT
Length:803
Mass (Da):88,713
Last modified:May 10, 2005 - v1
Checksum:iA7D6DA5791DAA48C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491413 Genomic DNA Translation: AAS21646.1
AK030444 mRNA Translation: BAC26967.1
CH466606 Genomic DNA Translation: EDL22403.1
RefSeqiNP_036060.1, NM_011930.4
UniGeneiMm.270587

Genome annotation databases

GeneIDi26373
KEGGimmu:26373

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491413 Genomic DNA Translation: AAS21646.1
AK030444 mRNA Translation: BAC26967.1
CH466606 Genomic DNA Translation: EDL22403.1
RefSeqiNP_036060.1, NM_011930.4
UniGeneiMm.270587

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26373
KEGGimmu:26373

Organism-specific databases

CTDi1186
MGIiMGI:1347048 Clcn7

Phylogenomic databases

eggNOGiKOG0474 Eukaryota
COG0038 LUCA
HOVERGENiHBG050985
KOiK05016
OrthoDBiEOG091G02SB

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036636 Expressed in 276 organ(s), highest expression level in cardiac ventricle

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644 CBS_dom
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
IPR002249 Cl_channel-7
PfamiView protein in Pfam
PF00571 CBS, 2 hits
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
PR01118 CLCHANNEL7
SMARTiView protein in SMART
SM00116 CBS, 2 hits
SUPFAMiSSF81340 SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ6RUT9_MOUSE
AccessioniPrimary (citable) accession number: Q6RUT9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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