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Entry version 87 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Uncharacterized protein C19orf48

Gene

C19orf48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C19orf48
Alternative name(s):
Multidrug resistance-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29667 C19orf48

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6RUI8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84798

Open Targets

More...
OpenTargetsi
ENSG00000167747

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149544

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C19orf48

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002710501 – 117Uncharacterized protein C19orf48Add BLAST117

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6RUI8

PeptideAtlas

More...
PeptideAtlasi
Q6RUI8

PRoteomics IDEntifications database

More...
PRIDEi
Q6RUI8

ProteomicsDB human proteome resource

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ProteomicsDBi
67326

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6RUI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6RUI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167747 Expressed in 91 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6RUI8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6RUI8 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA042000

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
9606.ENSP00000471463

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410JJ5S Eukaryota
ENOG4111B5M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111995

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6RUI8

Identification of Orthologs from Complete Genome Data

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OMAi
WISGLPR

Database of Orthologous Groups

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OrthoDBi
1448805at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6RUI8

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040906 DUF5535

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17687 DUF5535, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6RUI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVLEAVLEI QAITGSRLLS MVPGPARPPG SCWDPTQCTR TWLLSHTPRR
60 70 80 90 100
RWISGLPRAS CRLGEEPPPL PYCDQAYGEE LSIRHRETWA WLSRTDTAWP
110
GAPGVKQARI LGELLLV
Length:117
Mass (Da):13,085
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77A87C1DC40665DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0298527V → I. Corresponds to variant dbSNP:rs7251816Ensembl.1
Natural variantiVAR_02985384R → C. Corresponds to variant dbSNP:rs4802741Ensembl.1
Natural variantiVAR_029854104G → E. Corresponds to variant dbSNP:rs4801853Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY491972 mRNA Translation: AAR36899.1
BC037227 mRNA Translation: AAH37227.1
BC051842 mRNA Translation: AAH51842.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12803.1

NCBI Reference Sequences

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RefSeqi
NP_001277078.1, NM_001290149.1
NP_001277079.1, NM_001290150.1
NP_001277080.1, NM_001290151.1
NP_001277081.1, NM_001290152.1
NP_001277082.1, NM_001290153.1
NP_001277083.1, NM_001290154.1
NP_001277084.1, NM_001290155.1
NP_116101.1, NM_032712.2
NP_954857.1, NM_199249.2
NP_954858.1, NM_199250.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345523; ENSP00000301419; ENSG00000167747
ENST00000391812; ENSP00000375688; ENSG00000167747

Database of genes from NCBI RefSeq genomes

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GeneIDi
84798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84798

UCSC genome browser

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UCSCi
uc002pte.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491972 mRNA Translation: AAR36899.1
BC037227 mRNA Translation: AAH37227.1
BC051842 mRNA Translation: AAH51842.1
CCDSiCCDS12803.1
RefSeqiNP_001277078.1, NM_001290149.1
NP_001277079.1, NM_001290150.1
NP_001277080.1, NM_001290151.1
NP_001277081.1, NM_001290152.1
NP_001277082.1, NM_001290153.1
NP_001277083.1, NM_001290154.1
NP_001277084.1, NM_001290155.1
NP_116101.1, NM_032712.2
NP_954857.1, NM_199249.2
NP_954858.1, NM_199250.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000471463

PTM databases

iPTMnetiQ6RUI8
PhosphoSitePlusiQ6RUI8

Polymorphism and mutation databases

BioMutaiC19orf48

Proteomic databases

PaxDbiQ6RUI8
PeptideAtlasiQ6RUI8
PRIDEiQ6RUI8
ProteomicsDBi67326

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345523; ENSP00000301419; ENSG00000167747
ENST00000391812; ENSP00000375688; ENSG00000167747
GeneIDi84798
KEGGihsa:84798
UCSCiuc002pte.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84798
DisGeNETi84798

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C19orf48
HGNCiHGNC:29667 C19orf48
HPAiHPA042000
neXtProtiNX_Q6RUI8
OpenTargetsiENSG00000167747
PharmGKBiPA145149544

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JJ5S Eukaryota
ENOG4111B5M LUCA
GeneTreeiENSGT00940000167641
HOGENOMiHOG000111995
InParanoidiQ6RUI8
OMAiWISGLPR
OrthoDBi1448805at2759
PhylomeDBiQ6RUI8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C19orf48 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84798

Protein Ontology

More...
PROi
PR:Q6RUI8

Gene expression databases

BgeeiENSG00000167747 Expressed in 91 organ(s), highest expression level in prostate gland
ExpressionAtlasiQ6RUI8 baseline and differential
GenevisibleiQ6RUI8 HS

Family and domain databases

InterProiView protein in InterPro
IPR040906 DUF5535
PfamiView protein in Pfam
PF17687 DUF5535, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCS048_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RUI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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