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Entry version 74 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Protein UL141

Gene

UL141

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus downregulates their cell surface expression.2 Publications

Caution

The UL/b' region coding for this gene is deleted in some HHV-5 laboratory strains, like strains AD169 or Towne.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Modulation of host NK-cell activity by virus, Viral immunoevasion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein UL141
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UL141
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri295027 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000938 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000169440 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini37 – 278ExtracellularSequence analysisAdd BLAST242
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 338CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Add BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025380237 – 338Protein UL141Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi117N-linked (GlcNAc...) asparagine; by hostSequence analysis1 Publication1
Glycosylationi132N-linked (GlcNAc...) asparagine; by hostSequence analysis1 Publication1
Glycosylationi147N-linked (GlcNAc...) asparagine; by hostSequence analysis1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6RJQ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6RJQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Early-late protein.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with human PVR.

Interacts with human TNFRSF10A and TNFRSF10B.

Forms a homodimer that engages two TNFRSF10B monomers.

3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6RJQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K21049

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.3790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR031918 UL141
IPR038504 UL141-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16758 UL141, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RJQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCRRESLRTL PWLFWVLLSC PRLLEYSSSS FPFATADIAE KMWAENYETT
60 70 80 90 100
SPAPVLVAEG EQVTIPCTVM THSWPMVSIR ARFCRSHDGS DELILDAVKG
110 120 130 140 150
HRLMNGLQYR LPYATWNFSQ LHLGQIFSLT FNVSTDTAGM YECVLRNYSH
160 170 180 190 200
GLIMQRFVIL TQLETLSRPD EPCCTPALGR YSLGDQIWSP TPWRLRNHDC
210 220 230 240 250
GMYRGFQRNY FYIGRADAED CWKPACPDEE PDRCWTVIQR YRLPGDCYRS
260 270 280 290 300
QPHPPKFLPV TPAPPADIDT GMSPWATRGI AAFLGFWSIF TVCFLCYLCY
310 320 330
LQCCGRWCPT PGRGRRGGEG YRRLPTYDSY PGVKKMKR
Length:338
Mass (Da):38,918
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3E1152EB676F6CE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti8R → Q in strain: Isolate 1M. 1
Natural varianti16V → T in strain: Isolate 45J. 1
Natural varianti24L → F in strain: Isolate 1M, Isolate 10J, Isolate 2J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 14, Isolate 32C, Isolate 39J, Isolate 63J, Isolate 25J and Isolate 9J. 1
Natural varianti25E → K in strain: Isolate 10J, Isolate 2J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 14, Isolate 32C, Isolate 39J and Isolate 63J. 1
Natural varianti26Y → H in strain: Isolate 8J, Isolate 16m and Isolate 63J. 1
Natural varianti28S → F in strain: Isolate 84. 1
Natural varianti30S → L in strain: Isolate 8J and Isolate 16m. 1
Natural varianti35T → I in strain: Isolate 45J. 1
Natural varianti135T → M in strain: Isolate 2J, Isolate 10J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 45J and Isolate 14. 1
Natural varianti139G → S in strain: Isolate 10J. 1
Natural varianti202M → T in strain: Isolate 2J, Isolate 10J, Isolate 25J, Isolate 39J, Isolate 45J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33 and Isolate 14. 1
Natural varianti218A → V in strain: Isolate 2J, Isolate 10J, Isolate 25J, Isolate 29C, Isolate 27C, Isolate 39J, Isolate 18M, Isolate 33J and Isolate 14. 1
Natural varianti306R → H. 1
Natural varianti323R → C in strain: Isolate 13J and Isolate 51C. 1
Natural varianti334K → R in strain: Isolate 2J, Isolate 10J, Isolate 45J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J and Isolate 14. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX512197 Genomic DNA Translation: AAR31489.1
AY446894 Genomic DNA Translation: AAR31679.1
AY600463 Genomic DNA Translation: AAT68302.1
AY496555 Genomic DNA Translation: AAR92108.1
AY496547 Genomic DNA Translation: AAR92100.1
AY600467 Genomic DNA Translation: AAT68306.1
AY496549 Genomic DNA Translation: AAR92102.1
AY496550 Genomic DNA Translation: AAR92103.1
AY941105 Genomic DNA Translation: AAX57274.1
AY496551 Genomic DNA Translation: AAR92104.1
AY600465 Genomic DNA Translation: AAT68304.1
AY600466 Genomic DNA Translation: AAT68305.1
AY600464 Genomic DNA Translation: AAT68303.1
AY600462 Genomic DNA Translation: AAT68301.1
AY496552 Genomic DNA Translation: AAR92105.1
AY496548 Genomic DNA Translation: AAR92101.1
AY600468 Genomic DNA Translation: AAT68307.1
AY600461 Genomic DNA Translation: AAT68300.1
AY600459 Genomic DNA Translation: AAT68298.1
AY941104 Genomic DNA Translation: AAX57273.1
AY496554 Genomic DNA Translation: AAR92107.1
AY600460 Genomic DNA Translation: AAT68299.1
AY496553 Genomic DNA Translation: AAR92106.1

NCBI Reference Sequences

More...
RefSeqi
YP_081575.1, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3077418

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077418

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX512197 Genomic DNA Translation: AAR31489.1
AY446894 Genomic DNA Translation: AAR31679.1
AY600463 Genomic DNA Translation: AAT68302.1
AY496555 Genomic DNA Translation: AAR92108.1
AY496547 Genomic DNA Translation: AAR92100.1
AY600467 Genomic DNA Translation: AAT68306.1
AY496549 Genomic DNA Translation: AAR92102.1
AY496550 Genomic DNA Translation: AAR92103.1
AY941105 Genomic DNA Translation: AAX57274.1
AY496551 Genomic DNA Translation: AAR92104.1
AY600465 Genomic DNA Translation: AAT68304.1
AY600466 Genomic DNA Translation: AAT68305.1
AY600464 Genomic DNA Translation: AAT68303.1
AY600462 Genomic DNA Translation: AAT68301.1
AY496552 Genomic DNA Translation: AAR92105.1
AY496548 Genomic DNA Translation: AAR92101.1
AY600468 Genomic DNA Translation: AAT68307.1
AY600461 Genomic DNA Translation: AAT68300.1
AY600459 Genomic DNA Translation: AAT68298.1
AY941104 Genomic DNA Translation: AAX57273.1
AY496554 Genomic DNA Translation: AAR92107.1
AY600460 Genomic DNA Translation: AAT68299.1
AY496553 Genomic DNA Translation: AAR92106.1
RefSeqiYP_081575.1, NC_006273.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I9XX-ray2.10A/B32-246[»]
4JM0X-ray3.25A/B30-279[»]
SMRiQ6RJQ3
ModBaseiSearch...

PTM databases

iPTMnetiQ6RJQ3

Proteomic databases

PRIDEiQ6RJQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077418
KEGGivg:3077418

Phylogenomic databases

KOiK21049

Family and domain databases

Gene3Di2.60.40.3790, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR031918 UL141
IPR038504 UL141-like_sf
PfamiView protein in Pfam
PF16758 UL141, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUL141_HCMVM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RJQ3
Secondary accession number(s): Q56JA4
, Q6E2A5, Q6E2A6, Q6E2A7, Q6E2B3, Q6E2B4, Q6RJP5, Q6RJP6, Q6RJP7, Q6RJP9, Q6RJQ0, Q6RJQ1, Q6SWK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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