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Entry version 111 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Electrogenic sodium bicarbonate cotransporter 4

Gene

Slc4a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na+:HCO3- stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na+:HCO3- cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-425381, Bicarbonate transporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electrogenic sodium bicarbonate cotransporter 4
Alternative name(s):
Solute carrier family 4 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc4a5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1303009, Slc4a5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 513CytoplasmicSequence analysisAdd BLAST513
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei514 – 536HelicalSequence analysisAdd BLAST23
Topological domaini537 – 547ExtracellularSequence analysisAdd BLAST11
Transmembranei548 – 579HelicalSequence analysisAdd BLAST32
Topological domaini580 – 598CytoplasmicSequence analysisAdd BLAST19
Transmembranei599 – 620HelicalSequence analysisAdd BLAST22
Topological domaini621 – 734ExtracellularSequence analysisAdd BLAST114
Transmembranei735 – 753HelicalSequence analysisAdd BLAST19
Topological domaini754 – 772CytoplasmicSequence analysisAdd BLAST19
Transmembranei773 – 792HelicalSequence analysisAdd BLAST20
Topological domaini793 – 820ExtracellularSequence analysisAdd BLAST28
Transmembranei821 – 839HelicalSequence analysisAdd BLAST19
Topological domaini840 – 858CytoplasmicSequence analysisAdd BLAST19
Transmembranei859 – 875HelicalSequence analysisAdd BLAST17
Topological domaini876 – 880ExtracellularSequence analysis5
Transmembranei881 – 900HelicalSequence analysisAdd BLAST20
Topological domaini901 – 920CytoplasmicSequence analysisAdd BLAST20
Transmembranei921 – 940HelicalSequence analysisAdd BLAST20
Topological domaini941 – 945ExtracellularSequence analysis5
Transmembranei946 – 966HelicalSequence analysisAdd BLAST21
Topological domaini967 – 992CytoplasmicSequence analysisAdd BLAST26
Transmembranei993 – 1010HelicalSequence analysisAdd BLAST18
Topological domaini1011 – 1015ExtracellularSequence analysis5
Transmembranei1016 – 1033HelicalSequence analysisAdd BLAST18
Topological domaini1034 – 1112CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289211 – 1112Electrogenic sodium bicarbonate cotransporter 4Add BLAST1112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi671 ↔ 673By similarity
Disulfide bondi717 ↔ 729By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6RI88

PRoteomics IDEntifications database

More...
PRIDEi
Q6RI88

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6RI88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Observed in hepatocytes and in the apical region of bile duct intrahepatic cholangiocytes of liver. Also observed in uroepithelium cells lining the outer pelvic wall of the kidney (at protein level). Highly expressed in colon, distal colon, liver, kidney and testis. Moderate expression in duodenum and stomach and weak expression in heart. In kidney, very weakly expressed in the inner medulla, but abundantly expressed in cortex and outer medulla in the medullary thick ascending and cortical thick ascending limbs of the loop of Henle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010378, Expressed in testis and 14 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6RI88, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000014249

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6RI88

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi432 – 465Gly-richSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6RI88

Identification of Orthologs from Complete Genome Data

More...
OMAi
YVTTYKC

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6RI88

TreeFam database of animal gene trees

More...
TreeFami
TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834, ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6RI88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVEEKAGVK KLEPTSYRRR HPEQDFPSIH IGFPVPGYSQ RKSDSKGHLS
60 70 80 90 100
GLQRVQWSLQ PDKSQQDLAG PDGIKASSLG GSVDFTKRIR SPAAEQLQDI
110 120 130 140 150
LGEEDEAPNP TLFTEMDTLQ HDGDQMEWKE SARWIKFEEK VEEGGERWSK
160 170 180 190 200
PHVSTLSLHS LFELRTCLQT GTVLLDLDSG SLPQIIDDVI EKQIEGGLLR
210 220 230 240 250
PELRERVSYV LLRKHRHQTK KPIHRSLADI GKSVSTTNRS SARSPSAGPT
260 270 280 290 300
LHHSTEDLRI RQSTSYGHLC HAQSRSMNDI SHTPNTDQRK NKFMKKIPKD
310 320 330 340 350
SEASNVLVGE VDFLDQPFIA FVRLAQSSML GGVTEVPVPT RFLFILLGPS
360 370 380 390 400
GRAKSYNEIG RAIATLMVDD LFSDVAYKAR NREDLIAGVD EFLDEVIVLP
410 420 430 440 450
PGEWDPNIRI EPPKKVPSAD KRKSVFSLAE LGQMNGSVGR SGASAGGGGS
460 470 480 490 500
GGGAGGSGAG GGGSGNEAEM PAMHEIGEEL IWTGRFFGGL RLDVKRKLPW
510 520 530 540 550
FPSDFYDGFH IQSISAVLFI YLGCITNAIT FGGLLGDATD NYQGVMESFL
560 570 580 590 600
GTAMAGSLFC LFSGQPLIIL SSTGPILIFE KLLFDFSKAN GLDYMEFRLW
610 620 630 640 650
IGLHSAIQCL ILVATDASFI IKYITRFTEE GFSTLISFIF IYDAIKKMIG
660 670 680 690 700
AFKYYPINTD FKPDSITTYK CECVAPDTVN TTTVNDSALL VPNTNMSVYT
710 720 730 740 750
PLNLTALDWS LLSKKECLSY GGRLLGSSCQ FVPDLALMSF ILFFGTYSMT
760 770 780 790 800
LTLKKFKFSR YFPTKVRTLV ADFSIVFSIL LFCGIDACFG LQTPKLHVPN
810 820 830 840 850
VIKPTRPDRG WFVAPFGKNP WWVYPASILP ALLVTILIFM DQQITAVIVN
860 870 880 890 900
RKENKLRKAA GYHLDLFWVG ILMALCSFMG LPWYVAATVI SIAHIDSLKM
910 920 930 940 950
ETETSAPGEQ PQFLGVREQR VTGVMVFILT GISVFLAPIL KYIPMPVLYG
960 970 980 990 1000
VFLYMGVASL NGIQFWDRCK LFLMPAKHQP DHAFLRHVPL RRIHLFTLVQ
1010 1020 1030 1040 1050
ILCLALLWIL KSTMAAIIFP VMILGLIIVR RLLDLIFSQH DLAWIDNILP
1060 1070 1080 1090 1100
EKEKKESDRK KRRKEVHENT DKEPQFLPPS VVKIPMEGIP SDPQNGIHCV
1110
GRKRSSSWSH SL
Length:1,112
Mass (Da):123,944
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE5EF90A543DA35C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
L0N559L0N559_RAT
Anion exchange protein
Slc4a5 SLC4A5
997Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY496959 mRNA Translation: AAS98674.1

NCBI Reference Sequences

More...
RefSeqi
NP_997677.1, NM_212512.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000014249; ENSRNOP00000014249; ENSRNOG00000010378

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
297386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:297386

UCSC genome browser

More...
UCSCi
RGD:1303009, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY496959 mRNA Translation: AAS98674.1
RefSeqiNP_997677.1, NM_212512.1

3D structure databases

SMRiQ6RI88
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014249

PTM databases

CarbonylDBiQ6RI88

Proteomic databases

PaxDbiQ6RI88
PRIDEiQ6RI88

Genome annotation databases

EnsembliENSRNOT00000014249; ENSRNOP00000014249; ENSRNOG00000010378
GeneIDi297386
KEGGirno:297386
UCSCiRGD:1303009, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57835
RGDi1303009, Slc4a5

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
GeneTreeiENSGT00940000157488
InParanoidiQ6RI88
OMAiYVTTYKC
OrthoDBi265068at2759
PhylomeDBiQ6RI88
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-RNO-425381, Bicarbonate transporters

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6RI88

Gene expression databases

BgeeiENSRNOG00000010378, Expressed in testis and 14 other tissues
ExpressionAtlasiQ6RI88, baseline and differential

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RI88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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