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Entry version 139 (12 Aug 2020)
Sequence version 2 (30 Nov 2010)
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Protein

Bromodomain and WD repeat-containing protein 3

Gene

BRWD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

Caution

The translocation involving this gene was originally published as t(X;11)(q13;23), but BRWD3 is localized to Xq21 and not to Xq13.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6RI45

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6RI45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRWD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165288.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17342, BRWD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300553, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6RI45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.
Mental retardation, X-linked 93 (MRX93)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX93 is associated with macrocephaly.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0369401596K → E in MRX93; may be a rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs137853272EnsemblClinVar.1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
254065

MalaCards human disease database

More...
MalaCardsi
BRWD3
MIMi300659, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000165288

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
323, NON RARE IN EUROPE: FG syndrome phenotypic spectrum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134900775

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6RI45, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3769296

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRWD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002830891 – 1802Bromodomain and WD repeat-containing protein 3Add BLAST1802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei693PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei885PhosphoserineBy similarity1
Modified residuei886PhosphoserineBy similarity1
Modified residuei1577PhosphoserineCombined sources1
Modified residuei1579PhosphoserineCombined sources1
Modified residuei1763PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6RI45

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6RI45

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6RI45

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6RI45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6RI45

PeptideAtlas

More...
PeptideAtlasi
Q6RI45

PRoteomics IDEntifications database

More...
PRIDEi
Q6RI45

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67319 [Q6RI45-1]
67320 [Q6RI45-2]
67321 [Q6RI45-3]
67322 [Q6RI45-4]
67323 [Q6RI45-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6RI45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6RI45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165288, Expressed in epithelium of mammary gland and 188 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6RI45, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165288, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129012, 10 interactors

Protein interaction database and analysis system

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IntActi
Q6RI45, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362372

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6RI45, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati170 – 209WD 1Add BLAST40
Repeati213 – 251WD 2Add BLAST39
Repeati255 – 297WD 3Add BLAST43
Repeati307 – 347WD 4Add BLAST41
Repeati353 – 393WD 5Add BLAST41
Repeati400 – 452WD 6Add BLAST53
Repeati456 – 495WD 7Add BLAST40
Repeati502 – 542WD 8Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1158 – 1228Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1317 – 1412Bromo 2PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1659 – 1719Gly-richAdd BLAST61

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0644, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001108_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6RI45

KEGG Orthology (KO)

More...
KOi
K11798

Identification of Orthologs from Complete Genome Data

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OMAi
DAWWFGS

Database of Orthologous Groups

More...
OrthoDBi
240778at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6RI45

TreeFam database of animal gene trees

More...
TreeFami
TF324197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 2 hits
PF00400, WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 2 hits
SM00320, WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 2 hits
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 2 hits
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6RI45-1) [UniParc]FASTAAdd to basket
Also known as: BRWD3-A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG
60 70 80 90 100
KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV
110 120 130 140 150
GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR
160 170 180 190 200
QLTGCSRFGH IFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD
210 220 230 240 250
DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC
260 270 280 290 300
LRTCAPVAVL QGHSASITSI QFCPSTKGTN RYLTSTGADG TICFWQWHVK
310 320 330 340 350
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE
360 370 380 390 400
VPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS
410 420 430 440 450
IVLDMATKMT GNNLPSGEDK ITKLKVTMVA WDRYDTTVIT AVNNFLLKVW
460 470 480 490 500
NSITGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK
510 520 530 540 550
IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK
560 570 580 590 600
IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK
610 620 630 640 650
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQDESILDGI
660 670 680 690 700
IRELQREQDL RLINEGDVPH LPVNRAYSVN GALRSPNMDI SSSPNIRLRR
710 720 730 740 750
HSSQIEGVRQ MHNNAPRSQM ATERDLMAWS RRVVVNELNN GVSRVQEECR
760 770 780 790 800
TAKGDIEISL YTVEKKKKPS YTTQRNDYEP SCGRSLRRTQ RKRQHTYQTR
810 820 830 840 850
SNIEHNSQAS CQNSGVQEDS DSSSEEDETV GTSDASVEDP VVEWQSESSS
860 870 880 890 900
SDSSSEYSDW TADAGINLQP PKRQTRQTTR KICSSSDEEN LKSLEERQKK
910 920 930 940 950
PKQTRKKKGG LVSIAGEPNE EWFAPQWILD TIPRRSPFVP QMGDELIYFR
960 970 980 990 1000
QGHEAYVRAV RKSKIYSVNL QKQPWNKMDL REQEFVKIVG IKYEVGPPTL
1010 1020 1030 1040 1050
CCLKLAFLDP ISGKMTGESF SIKYHDMPDV IDFLVLHQFY NEAKERNWQI
1060 1070 1080 1090 1100
GDRFRSIIDD AWWFGTVESQ QPFQPEYPDS SFQCYSVHWD NNEREKMSPW
1110 1120 1130 1140 1150
DMEPIPEGTA FPDEVGAGVP VSQEELTALL YKPQEGEWGA HSRDEECERV
1160 1170 1180 1190 1200
IQGINHLLSL DFASPFAVPV DLSAYPLYCT VVAYPTDLNT IRRRLENRFY
1210 1220 1230 1240 1250
RRISALMWEV RYIEHNARTF NEPDSPIVKA AKIVTDVLLR FIGDQSCTDI
1260 1270 1280 1290 1300
LDTYNKIKAE ERNSTDAEED TEIVDLDSDG PGTSSGRKVK CRGRRQSLKC
1310 1320 1330 1340 1350
NPDAWKKQCK ELLSLIYERE DSEPFRQPAD LLSYPGHQEQ EGESSESVVP
1360 1370 1380 1390 1400
ERQQDSSLSE DYQDVIDTPV DFSTVKETLE AGNYGSPLEF YKDVRQIFNN
1410 1420 1430 1440 1450
SKAYTSNKKS RIYSMMLRLS ALFESHIKNI ISEYKSAIQS QKRRRPRYRK
1460 1470 1480 1490 1500
RLRSSSSSLS SSGAPSPKGK QKQMKLQPKN DQNTSVSHAR TSSPFSSPVS
1510 1520 1530 1540 1550
DAAEGLSLYL LDDEPDGPFS SSSFGGYSRS GNSHDPGKAK SFRNRVLPVK
1560 1570 1580 1590 1600
QDHSLDGPLT NGDGREPRTG IKRKLLSASE EDENMGGEDK EKKETKEKSH
1610 1620 1630 1640 1650
LSTSESGELG SSLSSESTCG SDSDSESTSR TDQDYVDGDH DYSKFIQTRP
1660 1670 1680 1690 1700
KRKLRKQHGN GKRNWKTRGT GGRGRWGRWG RWSRGGRGRG GRGRGSRGRG
1710 1720 1730 1740 1750
GGGTRGRGRG RGGRGASRGA TRAKRARIAD DEFDTMFSGR FSRLPRIKTR
1760 1770 1780 1790 1800
NQGRRTVLYN DDSDNDNFVS TEDPLNLGTS RSGRVRKMTE KARVSHLMGW

NY
Length:1,802
Mass (Da):203,598
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AA086ABFDCBA2C9
GO
Isoform 2 (identifier: Q6RI45-2) [UniParc]FASTAAdd to basket
Also known as: BRWD3-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:1,631
Mass (Da):184,485
Checksum:iF7AC8B9608C0B2A9
GO
Isoform 3 (identifier: Q6RI45-3) [UniParc]FASTAAdd to basket
Also known as: BRWD3-C, BRWD3-D, BRWD3-E, BRWD3-F, BRWD3-G, BRWD3-L, BRWD3-M, BRWD3-N, BRWD3-O

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Show »
Length:1,398
Mass (Da):158,529
Checksum:i2897D71915E102BD
GO
Isoform 4 (identifier: Q6RI45-4) [UniParc]FASTAAdd to basket
Also known as: BRWD3-H, BRWD3-I, BRWD3-K, BRWD3-P

The sequence of this isoform differs from the canonical sequence as follows:
     1-330: Missing.

Show »
Length:1,472
Mass (Da):166,977
Checksum:iFC57697514C87C5C
GO
Isoform 5 (identifier: Q6RI45-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1386: GS → DL
     1387-1802: Missing.

Show »
Length:1,386
Mass (Da):157,335
Checksum:i936B9BFE5FB91B64
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04641 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0314911288K → R2 PublicationsCorresponds to variant dbSNP:rs3122407EnsemblClinVar.1
Natural variantiVAR_0369401596K → E in MRX93; may be a rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs137853272EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0243031 – 404Missing in isoform 3. 1 PublicationAdd BLAST404
Alternative sequenceiVSP_0243041 – 330Missing in isoform 4. 1 PublicationAdd BLAST330
Alternative sequenceiVSP_0243051 – 171Missing in isoform 2. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_0243061385 – 1386GS → DL in isoform 5. 1 Publication2
Alternative sequenceiVSP_0243071387 – 1802Missing in isoform 5. 1 PublicationAdd BLAST416

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY497046 mRNA Translation: AAS45471.1
AY497047 mRNA Translation: AAS45472.1
AY497048 mRNA Translation: AAS45473.1
AY497049 mRNA Translation: AAS45474.1
AY497050 mRNA Translation: AAS45475.1
AY497051 mRNA Translation: AAS45476.1
AY497052 mRNA Translation: AAS45477.1
AY497053 mRNA Translation: AAS45478.1
AY497054 mRNA Translation: AAS45479.1
AY497055 mRNA Translation: AAS45480.1
AY497056 mRNA Translation: AAS45481.1
AY497057 mRNA Translation: AAS45482.1
AY497058 mRNA Translation: AAS45483.1
AY497059 mRNA Translation: AAS45484.1
AY497060 mRNA Translation: AAS45485.1
AL512504 Genomic DNA No translation available.
AL590031 Genomic DNA No translation available.
AL669934 Genomic DNA No translation available.
BC111490 mRNA Translation: AAI11491.1
AK095887 mRNA Translation: BAC04641.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS14447.1 [Q6RI45-1]

NCBI Reference Sequences

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RefSeqi
NP_694984.4, NM_153252.4 [Q6RI45-1]
XP_016884873.1, XM_017029384.1 [Q6RI45-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373275; ENSP00000362372; ENSG00000165288 [Q6RI45-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
254065

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:254065

UCSC genome browser

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UCSCi
uc004edt.4, human [Q6RI45-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497046 mRNA Translation: AAS45471.1
AY497047 mRNA Translation: AAS45472.1
AY497048 mRNA Translation: AAS45473.1
AY497049 mRNA Translation: AAS45474.1
AY497050 mRNA Translation: AAS45475.1
AY497051 mRNA Translation: AAS45476.1
AY497052 mRNA Translation: AAS45477.1
AY497053 mRNA Translation: AAS45478.1
AY497054 mRNA Translation: AAS45479.1
AY497055 mRNA Translation: AAS45480.1
AY497056 mRNA Translation: AAS45481.1
AY497057 mRNA Translation: AAS45482.1
AY497058 mRNA Translation: AAS45483.1
AY497059 mRNA Translation: AAS45484.1
AY497060 mRNA Translation: AAS45485.1
AL512504 Genomic DNA No translation available.
AL590031 Genomic DNA No translation available.
AL669934 Genomic DNA No translation available.
BC111490 mRNA Translation: AAI11491.1
AK095887 mRNA Translation: BAC04641.1 Different initiation.
CCDSiCCDS14447.1 [Q6RI45-1]
RefSeqiNP_694984.4, NM_153252.4 [Q6RI45-1]
XP_016884873.1, XM_017029384.1 [Q6RI45-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi129012, 10 interactors
IntActiQ6RI45, 8 interactors
STRINGi9606.ENSP00000362372

Chemistry databases

ChEMBLiCHEMBL3769296

PTM databases

iPTMnetiQ6RI45
PhosphoSitePlusiQ6RI45

Polymorphism and mutation databases

BioMutaiBRWD3
DMDMi313104082

Proteomic databases

EPDiQ6RI45
jPOSTiQ6RI45
MassIVEiQ6RI45
MaxQBiQ6RI45
PaxDbiQ6RI45
PeptideAtlasiQ6RI45
PRIDEiQ6RI45
ProteomicsDBi67319 [Q6RI45-1]
67320 [Q6RI45-2]
67321 [Q6RI45-3]
67322 [Q6RI45-4]
67323 [Q6RI45-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
537, 47 antibodies

Genome annotation databases

EnsembliENST00000373275; ENSP00000362372; ENSG00000165288 [Q6RI45-1]
GeneIDi254065
KEGGihsa:254065
UCSCiuc004edt.4, human [Q6RI45-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
254065
DisGeNETi254065
EuPathDBiHostDB:ENSG00000165288.10

GeneCards: human genes, protein and diseases

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GeneCardsi
BRWD3
HGNCiHGNC:17342, BRWD3
HPAiENSG00000165288, Low tissue specificity
MalaCardsiBRWD3
MIMi300553, gene
300659, phenotype
neXtProtiNX_Q6RI45
OpenTargetsiENSG00000165288
Orphaneti323, NON RARE IN EUROPE: FG syndrome phenotypic spectrum
PharmGKBiPA134900775

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0644, Eukaryota
GeneTreeiENSGT00950000183107
HOGENOMiCLU_001108_0_0_1
InParanoidiQ6RI45
KOiK11798
OMAiDAWWFGS
OrthoDBi240778at2759
PhylomeDBiQ6RI45
TreeFamiTF324197

Enzyme and pathway databases

PathwayCommonsiQ6RI45
SignaLinkiQ6RI45

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
254065, 5 hits in 501 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BRWD3, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BRWD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
254065
PharosiQ6RI45, Tbio

Protein Ontology

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PROi
PR:Q6RI45
RNActiQ6RI45, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165288, Expressed in epithelium of mammary gland and 188 other tissues
GenevisibleiQ6RI45, HS

Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00439, Bromodomain, 2 hits
PF00400, WD40, 5 hits
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 2 hits
SM00320, WD40, 8 hits
SUPFAMiSSF47370, SSF47370, 2 hits
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 2 hits
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRWD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RI45
Secondary accession number(s): C9IZ39
, C9J3F3, Q2T9J6, Q5JRN1, Q6RI37, Q6RI42, Q6RI44, Q8N916
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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