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Entry version 147 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Gene

Magi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi103 – 110ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • signal transduction Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alternative name(s):
BAI1-associated protein 1
Short name:
BAP-1
Membrane-associated guanylate kinase inverted 1
Short name:
MAGI-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Magi1
Synonyms:Baiap1, Bap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1203522 Magi1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945901 – 1471Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1Add BLAST1471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei357PhosphoserineBy similarity1
Modified residuei722PhosphoserineBy similarity1
Modified residuei733PhosphoserineBy similarity1
Modified residuei792PhosphoserineCombined sources1
Modified residuei1051PhosphoserineBy similarity1
Modified residuei1341PhosphoserineBy similarity1
Modified residuei1392PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6RHR9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6RHR9

PRoteomics IDEntifications database

More...
PRIDEi
Q6RHR9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6RHR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6RHR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including kidney glomeruli.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045095 Expressed in 248 organ(s), highest expression level in ear vesicle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6RHR9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6RHR9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of ADGRB1. Interacts via its WW domains with DRPLA (By similarity). Interacts with ESAM, LRP2 and CXADR (PubMed:15383320, PubMed:11274227, PubMed:15304526). Isoform 2 interacts with CTNNB1 (PubMed:10772923). Interacts through its PDZ 1 domain with NET1 (PubMed:11350080). Interacts with ASIC3 and AMOT (By similarity) (PubMed:15317815). Interacts with FCHSD2 (By similarity). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts with DDN. May interact (via PDZ domain) with RAPGEF2 (By similarity). Interacts with DLL1 (PubMed:15509766). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells (By similarity).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Net1Q9Z2066EBI-7440897,EBI-7840997

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200129, 4 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6RHR9

Protein interaction database and analysis system

More...
IntActi
Q6RHR9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q6RHR9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000086730

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6RHR9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6RHR9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 105PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini96 – 287Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST192
Domaini300 – 333WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini359 – 392WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini464 – 546PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini635 – 713PDZ 3PROSITE-ProRule annotationAdd BLAST79
Domaini833 – 915PDZ 4PROSITE-ProRule annotationAdd BLAST83
Domaini990 – 1074PDZ 5PROSITE-ProRule annotationAdd BLAST85
Domaini1132 – 1214PDZ 6PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni990 – 1074Interaction with FCHSD2By similarityAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 242Poly-Glu6
Compositional biasi402 – 410Poly-Gln9
Compositional biasi970 – 980Poly-GlyAdd BLAST11
Compositional biasi1378 – 1381Poly-Arg4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3209 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113463

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6RHR9

KEGG Orthology (KO)

More...
KOi
K05631

Database of Orthologous Groups

More...
OrthoDBi
284488at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6RHR9

TreeFam database of animal gene trees

More...
TreeFami
TF316816

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201 WW, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR030033 MAGI1
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10316:SF12 PTHR10316:SF12, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 5 hits
PF00397 WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 6 hits
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 6 hits
SSF51045 SSF51045, 2 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 6 hits
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6RHR9-1) [UniParc]FASTAAdd to basket
Also known as: MAGI1c alpha beta2 gamma, MAGI-1c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKVIQKKNH WTGRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAA
60 70 80 90 100
EAAGLPGGGE GPKLAEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK
110 120 130 140 150
AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR
160 170 180 190 200
EGEVPGVDYS FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK
210 220 230 240 250
VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHPENEE EEDVPEMNSS
260 270 280 290 300
FTADSGDQDE HTLQEATLPP VNSSILAAPI TDPSQKFPQY LPLSAEDNLG
310 320 330 340 350
PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV
360 370 380 390 400
HTEELDSELE LPAGWEKIED PVYGVYYVDH INRKTQYENP VLEAKRKKQL
410 420 430 440 450
EQQQQQQQPQ PPQPEEWTED HASVVPPVAP SHPPSNPEPA RETPLQGKPF
460 470 480 490 500
FTRNPSELKG KFIHTKLRKS SRGFGFTVVG GDEPDEFLQI KSLVLDGPAA
510 520 530 540 550
LDGKMETGDV IVSVNDTCVL GHTHAQVVKI FQSIPIGASV DLELCRGYPL
560 570 580 590 600
PFDPDDPNTS LVTSVAILDK EPIIVNGQET YDSPASHSSK TGKVSSMKDA
610 620 630 640 650
RPSSPADVAS NSSHGYPNDT VSLASSIATQ PELITVHIVK GPMGFGFTIA
660 670 680 690 700
DSPGGGGQRV KQIVDSPRCR GLKEGDLIVE VNKKNVQALT HNQVVDMLIE
710 720 730 740 750
CPKGSEVTLL VQRGGLPVPK KSPKSQPLER KDSQNSSQHS VSSHRSLHTA
760 770 780 790 800
SPSHGIQVLP EYLPADAPAP DQTDSSGQKK PDPFKIWAQS RSMYENRPMS
810 820 830 840 850
PSPASGLSKG ERDREINSTN FGECQIPDYQ EQDIFLWRKE TGFGFRILGG
860 870 880 890 900
NEPGEPIYIG HIVPLGAADT DGRLRSGDEL ICVDGTPVIG KSHQLVVQLM
910 920 930 940 950
QQAAKQGHVN LTVRRKVVFA VPKAENEVPS PASSHHSSNQ PASLTEEKRT
960 970 980 990 1000
PQGSQNSLNT VSSGSGSTSG IGSGGGGGSG VVSAVLQPYD VEIRRGENEG
1010 1020 1030 1040 1050
FGFVIVSSVS RPEAGTTFGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK
1060 1070 1080 1090 1100
SHSDIVNLIK EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHAPSQQ
1110 1120 1130 1140 1150
GTQETRTTTK PKQDSQFEFK GPQAAQEQDF YTVELERGAK GFGFSLRGGR
1160 1170 1180 1190 1200
EYNMDLYVLR LAEDGPAERC GKMRIGDEIL EINGETTKNM KHSRAIELIK
1210 1220 1230 1240 1250
NGGRRVRLFL RRGDGSVPEY DPSSDRNGPS TGAQGVPEVR PGPPDHRPHP
1260 1270 1280 1290 1300
ALESSYPPEL HKSSQHAEKR AHAKDPKGNR EHSKQPNEHH TWNGTSRKQD
1310 1320 1330 1340 1350
SGACRPKDRP PDAWREAQPE RTATNGSKRR SPEKRREGTR SADNTLERRE
1360 1370 1380 1390 1400
KHEKRREISP ERKRERSPTR RKDSSPSRRR RSLERLLDQR RSPERRRGGS
1410 1420 1430 1440 1450
PERRAKSTDR RRARSPERRR ERSLDKRNRD DKVGHREREE AGLKLEAGRS
1460 1470
PRNPPEQRRR PYKECSTDLS I
Length:1,471
Mass (Da):161,974
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C780C71CAC37CB1
GO
Isoform 2 (identifier: Q6RHR9-2) [UniParc]FASTAAdd to basket
Also known as: MAGI-1b

The sequence of this isoform differs from the canonical sequence as follows:
     348-359: Missing.
     798-826: PMSPSPASGLSKGERDREINSTNFGECQI → L
     1019-1074: Missing.
     1221-1268: DPSSDRNGPS...ELHKSSQHAE → AMIPPKIAAC...PPPVHKVFRK
     1269-1471: Missing.

Show »
Length:1,172
Mass (Da):127,651
Checksum:i1255479BA421DAA0
GO
Isoform 3 (identifier: Q6RHR9-3) [UniParc]FASTAAdd to basket
Also known as: MAGI-1a

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1236: DPSSDRNGPSTGAQGV → GGSNYENIPSFPGMTP
     1238-1268: Missing.
     1269-1471: Missing.

Show »
Length:1,237
Mass (Da):134,404
Checksum:i4B2D712E64126A55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ12E9PZ12_MOUSE
Membrane-associated guanylate kinas...
Magi1
1,255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SWH0A0A0N4SWH0_MOUSE
Membrane-associated guanylate kinas...
Magi1
1,020Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUZ0A0A0N4SUZ0_MOUSE
Membrane-associated guanylate kinas...
Magi1
1,280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J0S6A0A0R4J0S6_MOUSE
Membrane-associated guanylate kinas...
Magi1
1,171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUP9A0A0N4SUP9_MOUSE
Membrane-associated guanylate kinas...
Magi1
496Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4VBG2Q4VBG2_MOUSE
Magi1 protein
Magi1
1,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SWA1A0A0N4SWA1_MOUSE
Membrane-associated guanylate kinas...
Magi1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVU9A0A0N4SVU9_MOUSE
Membrane-associated guanylate kinas...
Magi1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti726Missing in AAB91995 (PubMed:9395497).Curated1
Sequence conflicti1342A → D in AAB91997 (PubMed:9395497).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011673348 – 359Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_011674798 – 826PMSPS…GECQI → L in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0116751019 – 1074Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0116761221 – 1268DPSSD…SQHAE → AMIPPKIAACMRNEKLGEAC FYLMGHNQTTTPAATGTAPP PVHKVFRK in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0116781221 – 1236DPSSD…GAQGV → GGSNYENIPSFPGMTP in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0116791238 – 1268Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0116771269 – 1471Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY497557 mRNA Translation: AAS77818.1
AF027503 mRNA Translation: AAB91995.1
AF027504 mRNA Translation: AAB91996.1
AF027505 mRNA Translation: AAB91997.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS20377.1 [Q6RHR9-1]

Protein sequence database of the Protein Information Resource

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PIRi
T42372

NCBI Reference Sequences

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RefSeqi
NP_001025021.1, NM_001029850.4 [Q6RHR9-1]
NP_034497.1, NM_010367.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000089317; ENSMUSP00000086730; ENSMUSG00000045095 [Q6RHR9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
14924

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:14924

UCSC genome browser

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UCSCi
uc009czj.2 mouse [Q6RHR9-1]
uc009czk.2 mouse [Q6RHR9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497557 mRNA Translation: AAS77818.1
AF027503 mRNA Translation: AAB91995.1
AF027504 mRNA Translation: AAB91996.1
AF027505 mRNA Translation: AAB91997.1
CCDSiCCDS20377.1 [Q6RHR9-1]
PIRiT42372
RefSeqiNP_001025021.1, NM_001029850.4 [Q6RHR9-1]
NP_034497.1, NM_010367.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I04X-ray2.15A/B463-546[»]
5ZYSX-ray1.78A826-918[»]
SMRiQ6RHR9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200129, 4 interactors
ELMiQ6RHR9
IntActiQ6RHR9, 2 interactors
MINTiQ6RHR9
STRINGi10090.ENSMUSP00000086730

PTM databases

iPTMnetiQ6RHR9
PhosphoSitePlusiQ6RHR9

Proteomic databases

jPOSTiQ6RHR9
PaxDbiQ6RHR9
PRIDEiQ6RHR9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089317; ENSMUSP00000086730; ENSMUSG00000045095 [Q6RHR9-1]
GeneIDi14924
KEGGimmu:14924
UCSCiuc009czj.2 mouse [Q6RHR9-1]
uc009czk.2 mouse [Q6RHR9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9223
MGIiMGI:1203522 Magi1

Phylogenomic databases

eggNOGiKOG3209 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000155820
HOGENOMiHOG000113463
InParanoidiQ6RHR9
KOiK05631
OrthoDBi284488at2759
PhylomeDBiQ6RHR9
TreeFamiTF316816

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Magi1 mouse
EvolutionaryTraceiQ6RHR9

Protein Ontology

More...
PROi
PR:Q6RHR9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045095 Expressed in 248 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ6RHR9 baseline and differential
GenevisibleiQ6RHR9 MM

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR030033 MAGI1
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR10316:SF12 PTHR10316:SF12, 2 hits
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 5 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 6 hits
SM00456 WW, 2 hits
SUPFAMiSSF50156 SSF50156, 6 hits
SSF51045 SSF51045, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 6 hits
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGI1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RHR9
Secondary accession number(s): O54893, O54894, O54895
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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