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Entry version 51 (02 Dec 2020)
Sequence version 2 (10 May 2005)
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Protein

Vitellogenin

Gene
N/A
Organism
Penaeus merguiensis (Banana prawn) (Fenneropenaeus merguiensis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • oogenesis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionStorage protein
Biological processLipid transport, Transport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitellogenin
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPenaeus merguiensis (Banana prawn) (Fenneropenaeus merguiensis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri71412 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaePenaeus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025941319 – 2586Vitellogenin1 PublicationAdd BLAST2568
ChainiPRO_000025941419 – ?Vitellin1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi170 ↔ 194PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication
May be modified covalently by lipidation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the ovary and hepatopancrease of vitellogenic females. Not expressed in the muscle, heart and intestine of female or in the hepatopancrease of the male. Detected in the ovary and hemolymph of female (at protein level). Not detected in the female hepatopancreas or in the male hemolymph and testis (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Vitellogenin is detected in stage 1 of the ovarian cycle and protein levels increase to reach a maximum in stage 3. Thereafter vitellogen levels in the ovary decrease gradually. Vitellin is detected at low levels in stage 1 of the ovarian cycle and protein levels increase steadily in stages 2 through to 4.1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 653VitellogeninPROSITE-ProRule annotationAdd BLAST612
Domaini2354 – 2546VWFDPROSITE-ProRule annotationAdd BLAST193

Keywords - Domaini

Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.20, 1 hit
2.20.50.20, 1 hit
2.30.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015819, Lipid_transp_b-sht_shell
IPR001747, Lipid_transpt_N
IPR009454, Lipid_transpt_open_b-sht
IPR011030, Lipovitellin_superhlx_dom
IPR015816, Vitellinogen_b-sht_N
IPR015255, Vitellinogen_open_b-sht
IPR015817, Vitellinogen_open_b-sht_sub1
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06448, DUF1081, 1 hit
PF09172, DUF1943, 1 hit
PF01347, Vitellogenin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01169, DUF1943, 1 hit
SM00638, LPD_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48431, SSF48431, 1 hit
SSF56968, SSF56968, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51211, VITELLOGENIN, 1 hit
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RG02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSTLLFVL AFVAGGLAAP WGADVPRCST ECPVTGSPKL AYQPDKTYAY
60 70 80 90 100
AYSGKSTVQL KGVDNGDTET EWTAGVDLTW ISPCDMAISF RNTKMDGARG
110 120 130 140 150
PTAARTLERY PLVVAVVDGR VQHVCAHPED EAWAINLKKG VASAFQNSIP
160 170 180 190 200
SLSAVSSGIT VTETDVVGKC PTKYEIETEG EKVIVVKEKN HRHCQERYPT
210 220 230 240 250
PAALPAPWLK APLPIEESKS QCRQEIANGI YTAITCQDKN IVRPAIGIYK
260 270 280 290 300
YVEASQYSTL RFISESSDTS AISGIPSGEL NIESLLYNHE TMKDPQLAPE
310 320 330 340 350
LDELMKEICD KTKDTVEAEA GALVAKALHV LRRIPDTVVV ETAQKVRQGH
360 370 380 390 400
YCSDSARLES IFLDAVAFIH ESGAVKVMVN EIENGRATGG RLALYTAALY
410 420 430 440 450
LIPRPNIEAV KALTPLFESP RPMPSLLLAA ATMVNHYCRH TPACYEKAPV
460 470 480 490 500
ARIAEILANR VQTHCSPSAG VEDNEVALAI FKTIGNMGVA TPAVTRAAVH
510 520 530 540 550
CIEVEGLETS VRVAAAEAFR QANCFRPAVE KLVDIAVRPA FETEVRIASY
560 570 580 590 600
LAAVRCAEQE HLETIIEKIS KEENTQVRGF VLGHLINIQE STCPAKENLR
610 620 630 640 650
YLLANVIPTD FERDFRKFSR NIDVAYHAPA FGMGAGLESN IIYAPGSFVP
660 670 680 690 700
RAVNLKMKAD VDETHMDIAE IGARFVGIES IIEEPLGPQG YLRTATFGKI
710 720 730 740 750
MEDITGFAGE KGYKVMEQLK HTLRTRRSID SSVIADFFGK LYGKSRSHTH
760 770 780 790 800
AELFARFMGH EITYADVAGS LKGVTADTLI ETFFSFFENS LEHMKDLNLN
810 820 830 840 850
TARTAQLSMD YSLPTIQGTP LRLRLAGTAV AGLKMEGNVN IAQILSDLGN
860 870 880 890 900
SQTGVKFFPG LSVHATGFVG FDWLLARVGI EMQNTISSAT GAAIKIRTTE
910 920 930 940 950
NKKIEMELEV PEKMELLNIK AETYLVKAVG KKMTEISPSS MRDVRIQRNS
960 970 980 990 1000
CIGALEPVFG LKVCYDMNIP DVFRANALPL GEPAIAKLYV EKADPSMRGY
1010 1020 1030 1040 1050
LVTAAIKNKR GNKVIKMNVE AAGASTPRRA EMTLSYTKEE GSHIVSAKLD
1060 1070 1080 1090 1100
SSSIAAGVWT TLTNEQGHKA METYVNFNYG QIAISRGIKL EAIAREASVG
1110 1120 1130 1140 1150
EEFQVNVFSS GTRSFPSESH IVEARFIKKT SGPEFNVDVI CRTKNALAEL
1160 1170 1180 1190 1200
FDLNIEVGAD FMKFSPKNLY PARYIPKTRI VLPVNLRKME INAATAAWKL
1210 1220 1230 1240 1250
ISYIRAGSQS GGSREFISAL KLAKGRKDFI SVQATHTIEG TFPQNIIIKN
1260 1270 1280 1290 1300
VATAEVGRSS YKAMYDLFYH SEKMGASLEV LQAAGNEKVA HLEAIYELSG
1310 1320 1330 1340 1350
SKYCTKFLAE IPGYIQPVKV EAGIEQGAEG RYTLESAITY GQRTVLEASG
1360 1370 1380 1390 1400
PIMARFSSKI AKLQANIKVR AMASEPYIIG ANVAFGSKKQ MIAMEIKGRS
1410 1420 1430 1440 1450
EAVIGLEWKM VRESSEKTTV GIVFVLPALI ENKIDAEITD GLIHVSFNNL
1460 1470 1480 1490 1500
VLPKTSSRRR VKGFADVHIA EKKANVEFSW DADNAPEKKL VLDASLISSS
1510 1520 1530 1540 1550
ANPGHAEIHG NIVIAGEPFH AKLVLTAANL VEHMEGENGF KLILTTPSQK
1560 1570 1580 1590 1600
TIVLGASCDV QVAGATTKVI STVEYKNMKD RKYKYASVIA YEKLGGPFDY
1610 1620 1630 1640 1650
AVEAKVTYKQ PGTAEIKLGT AVKHHWTPEE HVVAVRVEAD APILKTPATI
1660 1670 1680 1690 1700
EFSIHNAPNA FVGFCKIERN APATVFEWNV QITPEGGIEA VEAGVDMKAI
1710 1720 1730 1740 1750
IEVLKIVHAA ATLQEESYET YGPHTSQYQY RFTRPSPTSY TMQMRTPTRT
1760 1770 1780 1790 1800
MEGRAKLSPR ESGIKFYPNK GKTESKYEIG YKANHEGRWG GHASKLEVRM
1810 1820 1830 1840 1850
NHPVLPKPIM AAVQYTVAEE TTKGTIELDI FPEEANKITG SLETQRISEN
1860 1870 1880 1890 1900
AIRAEAFLTS RMLKVNPKAI ITAAYAPETV AFDVVFHKTP SAAPIFAIAA
1910 1920 1930 1940 1950
KYDKTAAHNA AATFTVKMEE RPVFEITAVT EPEEAATCNG IRMRAVAYAA
1960 1970 1980 1990 2000
TFGKYNVISK MCRPAFIEVT AMRPGGAKEY IAKLGLRYPD AAEAGVYVAS
2010 2020 2030 2040 2050
GRAGETHGVA VAAVKLASPT MLKVEMAYEP QEAEAIINEM TEEFEKIAAS
2060 2070 2080 2090 2100
FTSVEMEVVE FLKQEAAAKG IQFPSSQLVN LLGVAKEEIA EIYRDIVSEA
2110 2120 2130 2140 2150
IIFDTEILGD ILGSPVVSFI SRVYFGVWSE IIHLQHHLSV SLIQTIERFQ
2160 2170 2180 2190 2200
QELGSISEIL MEVVMTAARM AETGEVPGVV FDALEEIKAT KVFRIVRREV
2210 2220 2230 2240 2250
DAILEEYPEE YEAVKHIVHN VVAILKRDVG IVRERLMEIP AVLKIIDYTM
2260 2270 2280 2290 2300
YHFHSERAFA AEAEKLVSLM LNELLFVSME REGNGVAVRI PLHRPLYSLT
2310 2320 2330 2340 2350
QVAQEAVPNP VTMLENLIFA YVDYIPIPVS DAIWAFYNLV PRYITDVLPP
2360 2370 2380 2390 2400
YPRTATVVGG SEILTFSGLV VRAPRSPCKV VLAAHGSHRL MMSHPQASAP
2410 2420 2430 2440 2450
AQFELKTPAA TVMIKPDFEV VVNGQPLAGS QQTIGNVRIV NTAEHIEVGC
2460 2470 2480 2490 2500
PLMKVVVAKA GEAVAVEASG WVFGRVAGLL GPNNGEIAHD RLMPSGAAAS
2510 2520 2530 2540 2550
NPRDLVAAWQ EDRQCSTPEV PRAETTVARL IQCEALLGIR SRCNPVVHPQ
2560 2570 2580
PFIKMCHAAH KACDAAQAYR TVCSLRGVGE VFPLGC
Length:2,586
Mass (Da):283,029
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE68C3991C9783F06
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY499620 mRNA Translation: AAR88442.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY499620 mRNA Translation: AAR88442.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.20.50.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819, Lipid_transp_b-sht_shell
IPR001747, Lipid_transpt_N
IPR009454, Lipid_transpt_open_b-sht
IPR011030, Lipovitellin_superhlx_dom
IPR015816, Vitellinogen_b-sht_N
IPR015255, Vitellinogen_open_b-sht
IPR015817, Vitellinogen_open_b-sht_sub1
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF06448, DUF1081, 1 hit
PF09172, DUF1943, 1 hit
PF01347, Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM01169, DUF1943, 1 hit
SM00638, LPD_N, 1 hit
SUPFAMiSSF48431, SSF48431, 1 hit
SSF56968, SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211, VITELLOGENIN, 1 hit
PS51233, VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIT_PENME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6RG02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 10, 2005
Last modified: December 2, 2020
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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