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Entry version 85 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Phosphate transporter PHO1 homolog 8

Gene

PHO1-H8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May transport inorganic phosphate (Pi).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPhosphate transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphate transporter PHO1 homolog 8
Alternative name(s):
Protein PHO1 homolog 8
Short name:
AtPHO1;H8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHO1-H8
Ordered Locus Names:At1g35350
ORF Names:T9I1.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G35350

The Arabidopsis Information Resource

More...
TAIRi
locus:2206742 AT1G35350

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 351CytoplasmicSequence analysisAdd BLAST351
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 392ExtracellularSequence analysisAdd BLAST20
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 434CytoplasmicSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Topological domaini456 – 473ExtracellularSequence analysisAdd BLAST18
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 623CytoplasmicSequence analysisAdd BLAST129
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Topological domaini645 – 667ExtracellularSequence analysisAdd BLAST23
Transmembranei668 – 688HelicalSequence analysisAdd BLAST21
Topological domaini689 – 751CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003981621 – 751Phosphate transporter PHO1 homolog 8Add BLAST751

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6R8G2

PRoteomics IDEntifications database

More...
PRIDEi
Q6R8G2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
236157

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6R8G2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in root epidermis, leaf hydathodes, trichomes and petioles, stem vascular cylinder, receptacle, stigma apex and pollen grains.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not induced by Pi deficiency.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6R8G2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6R8G2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
25656, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G35350.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 299SPXPROSITE-ProRule annotationAdd BLAST299
Domaini558 – 751EXSPROSITE-ProRule annotationAdd BLAST194

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1162 Eukaryota
COG5409 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006116_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6R8G2

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMVSEMI

Database of Orthologous Groups

More...
OrthoDBi
536327at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6R8G2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14476 SPX_PHO1_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004342 EXS_C
IPR034092 PHO1_SPX
IPR004331 SPX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03124 EXS, 1 hit
PF03105 SPX, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51380 EXS, 1 hit
PS51382 SPX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6R8G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFGKEYVAQ MIPEWQQAYM DYTCLKTILR EIKTSQKRSE SQGVLKRKLS
60 70 80 90 100
GRRNFSGLTK RYSRTFSSRD LENHDIMVHA TTGDDGFEKY ETTILKVSEV
110 120 130 140 150
GRESELVFFK TLDLEFDKVN RFYRSNVEEL VKEAVVLNRQ MDALIAYRIK
160 170 180 190 200
LDQPSTSWSC SETVSVDINA LDSKEQKGKT LAEEMGIKVE ENVSNGGDST
210 220 230 240 250
KETAPEALSV LDRIRLNKNQ ENPLSTIRNV LKLSNKEDIK FTKENLKKIE
260 270 280 290 300
ERLKNVFIEF YRKLRHLKNY SFLNTLAISK IMKKYDKIAL RNAAKLYMEM
310 320 330 340 350
VDKSYLTSSD EINKLMLRVE SIFVEHFAGS NRSKGMNLLR PKVTKEKHRI
360 370 380 390 400
TFSTGFFVGC TVSLVIALGL FIHARNIMGA VGHKLYMETM FPLYSLFAFV
410 420 430 440 450
VLHMIMYASN IYFWKRYRVN YPFIFGFKEG TELGYGHVLL LSFGLGTLAL
460 470 480 490 500
CAVLVNMDME MDPNTNDYKT ITELVPLFVV ALVIAISVCP FNIFYRSSRF
510 520 530 540 550
FFLMVLFRCI AAPLYKVNLP DFFLADQLTS QVQALRSLEF YICYYGWGDF
560 570 580 590 600
KQRQSTCKSS DVYSTFYFIV AVIPYWSRFL QCVRRLIEEK DVSQGFNALK
610 620 630 640 650
YLLTIVAVCL RTAFSINRGN DWKIAAWVFS GLATFYGTYW DIVYDWGLLH
660 670 680 690 700
RPSKSWLREK LLVPHKSVYY VAMVVNVVLR LAWLQTVLDF NISFLHRETM
710 720 730 740 750
VALIAILEII RRGIWNFFRL ENEHLNNVGK FRAFKSVPLP FNYDEEEDRD

S
Length:751
Mass (Da):87,396
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF48A179E66B5951E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8APE1A0A1P8APE1_ARATH
EXS (ERD1/XPR1/SYG1) family protein
At1g35350, T9I1.12, T9I1_12
567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG51461 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY507960 mRNA Translation: AAR99490.1
AC069160 Genomic DNA Translation: AAG51461.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE31785.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F86474

NCBI Reference Sequences

More...
RefSeqi
NP_174768.2, NM_103232.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G35350.1; AT1G35350.1; AT1G35350

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
840424

Gramene; a comparative resource for plants

More...
Gramenei
AT1G35350.1; AT1G35350.1; AT1G35350

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G35350

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY507960 mRNA Translation: AAR99490.1
AC069160 Genomic DNA Translation: AAG51461.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE31785.1
PIRiF86474
RefSeqiNP_174768.2, NM_103232.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi25656, 1 interactor
STRINGi3702.AT1G35350.1

PTM databases

iPTMnetiQ6R8G2

Proteomic databases

PaxDbiQ6R8G2
PRIDEiQ6R8G2
ProteomicsDBi236157

Genome annotation databases

EnsemblPlantsiAT1G35350.1; AT1G35350.1; AT1G35350
GeneIDi840424
GrameneiAT1G35350.1; AT1G35350.1; AT1G35350
KEGGiath:AT1G35350

Organism-specific databases

AraportiAT1G35350
TAIRilocus:2206742 AT1G35350

Phylogenomic databases

eggNOGiKOG1162 Eukaryota
COG5409 LUCA
HOGENOMiCLU_006116_2_0_1
InParanoidiQ6R8G2
OMAiIMVSEMI
OrthoDBi536327at2759
PhylomeDBiQ6R8G2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6R8G2

Gene expression databases

ExpressionAtlasiQ6R8G2 baseline and differential
GenevisibleiQ6R8G2 AT

Family and domain databases

CDDicd14476 SPX_PHO1_like, 1 hit
InterProiView protein in InterPro
IPR004342 EXS_C
IPR034092 PHO1_SPX
IPR004331 SPX_dom
PfamiView protein in Pfam
PF03124 EXS, 1 hit
PF03105 SPX, 1 hit
PROSITEiView protein in PROSITE
PS51380 EXS, 1 hit
PS51382 SPX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHO18_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R8G2
Secondary accession number(s): Q9C7H9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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