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Entry version 85 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

DNA polymerase

Gene

ORF100

Organism
Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOstreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri654903 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesMalacoherpesviridaeOstreavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCrassostrea gigas (Pacific oyster) (Crassostrea angulata) [TaxID: 29159]
Pecten maximus (King scallop) (Pilgrim's clam) [TaxID: 6579]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007021 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003850221 – 1878DNA polymeraseAdd BLAST1878

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni691 – 727DisorderedSequence analysisAdd BLAST37
Regioni1839 – 1878DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi695 – 713Acidic residuesSequence analysisAdd BLAST19
Compositional biasi1840 – 1863Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR012337, RNaseH-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486, POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6R7C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMEIDDVDN LWTYRSVCMP DYKDAAEIIR PEFDMTKRIF NQRKHLLGMD
60 70 80 90 100
GHCSTGMTMN EFGTRPMVFT VSKGCYPDLP TDKDKFVGDP QGPKELYMHV
110 120 130 140 150
YGRFDTYYLD LQNEFQDINN VMNTTHDYNI YDLLKTGART AMVREAFAGA
160 170 180 190 200
NIHGWLGTKL VYKRPPQSSA GGCRFMVKVY IAGQKTASAY QIKNTLNATS
210 220 230 240 250
NRFRKKVYNS CVQTYTDFLV AKNAGPIGEM RIKKGVNPGV KKGAKYDYVD
260 270 280 290 300
VHYRDIEFSN YDTFVLSEID GVGEDLINLA TSILNNHRNN FDILTKTFIK
310 320 330 340 350
SRLKSLAPII GGLIGSPNDF TKFKKKMVMY IMTKEFKNCM EYYLTELRSK
360 370 380 390 400
GIQLYHALGI KSEDVKEEYV RTFCVNMLRY QYLLVMSLKE FWVEKVRGKL
410 420 430 440 450
YSAVMAKEKE MLTQKIGMQL RTMCFDIETN FVPHSDAEQQ VTLIHCVLYD
460 470 480 490 500
EGAHNCPIEQ RTFHYKAEER SMESLKTDLT YDKVVELCKK QVRDGYDLKM
510 520 530 540 550
KEWLTRTVEQ TGMFKSKKIL SLFFEKMMTE SKIKIHPDSH DYDADNSEPK
560 570 580 590 600
SVEECLAFCK KRIIEVFDIC MEPGKNYFIY NFKTEKEMLL AFLKYVRDSN
610 620 630 640 650
LTVLTHYNGD SFDLPFVINR CEKLKIDGMK EYTPATFSDG STETKRRRFQ
660 670 680 690 700
LKLTHRHDIL TIKYKKSGKV ADSTHKKNAI NSYLESKREK LFQADDDDDD
710 720 730 740 750
DDEDEDDGLL DERQQDSAED MKKKGPNVYR PMAEARNIFT LQSNFVASRD
760 770 780 790 800
VMKMVPDQAP NVDDKILKDK TLNSSAFSFL GIRKIDHEAV SYANLCKTWK
810 820 830 840 850
FGDLNIFVAY CAVDTLLTMK IDQTLKTGMN AVATASNVYL PIRELYGNQA
860 870 880 890 900
LVRTLAIMYS YQWYKNICSP DPSVFKNEDR FWNPEYVWKD DDFKDLKPRA
910 920 930 940 950
GRTISNVSGV YNSFFSVLFD FNSQYPGVMI SENVCVSTLL DKEDADKMSK
960 970 980 990 1000
DDYVEMTIPN VYPKVRHACE PGSEKCGMNL EVVKKKKDYG LKCKWTQEFV
1010 1020 1030 1040 1050
MCEHIAKFAK KSVMEGIAGE CCKNLLAKRK HYKKLMAEAA KGGNHTEVVI
1060 1070 1080 1090 1100
YNQLQLVMKV NANSIFGILL LLDSVTGGAI THEARMQNER GSEYLKKVSG
1110 1120 1130 1140 1150
PMAMADTDST APIAENLPLD WQPGDDKDDV GPLNRLCRRL FPGRKRPKIS
1160 1170 1180 1190 1200
EFVHKIDTMY ESYGSYLNDG VPEKGIPPAW IKPANLEIEK MFIGLVFIKK
1210 1220 1230 1240 1250
KNYYALKMLP GGELATHVAG LACMKSDKTK IKGATQLVLL KMLVEGDYEG
1260 1270 1280 1290 1300
YIRYATDLFS LMVVTLRAEE ASKSAVKMAV ENGQLEGLDE LEEKTKRDFG
1310 1320 1330 1340 1350
YRDLIPKVYY TSREKVNSIE NPKTVADKME QLRCKRYGID FSIAATVTDV
1360 1370 1380 1390 1400
VRGIKPQVGA PLTAINNTIL IREPTEEQKT IEREMDMRWM ARSFRQQTRE
1410 1420 1430 1440 1450
DNRLSDKKEK IKKKNAEVKP LDITDMPDRL KVDQQVHTTP FPTRIRLGVK
1460 1470 1480 1490 1500
KLNNMIDYSE KAITKERDSD FVKELFHQPE LMADEEELQR ATEQVVEMIE
1510 1520 1530 1540 1550
NFKSFSLHFP LFWYDERYCI SNILELEDLD EVWHTLPNDE SCVDLWNMYK
1560 1570 1580 1590 1600
NLEYEPRYIA VKVGKMGERL QMAFFDSVEE SWMEYKCTNC YIFKENVWSL
1610 1620 1630 1640 1650
DDKNLAGKIY YMDMQEYEKQ TRTTPLIITS PDKKKRYLVN RGSYVRNKNN
1660 1670 1680 1690 1700
AFSFKIKNET LMNAMSQTGD VGDKYLTFKP IYGKAGVCII GSKSAGMCKS
1710 1720 1730 1740 1750
TFIRDDGREM PATWPYKRLN NQGIKIPRQK LLKIMNDSLE IRNIHNNHNL
1760 1770 1780 1790 1800
EFSFDSKTKN LTIRVETAFD EKRIKFYDES KQEKLEIDIG TNGQTQLGSF
1810 1820 1830 1840 1850
YTSVRIENKV EKKPKEVLPE KKQSTLSHFV GMSSAPKFTQ DDVVKKKRAP
1860 1870
KRAAIDRKSG SGGKKSKITA GKTAGTMF
Length:1,878
Mass (Da):216,469
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D2C7A6088E1022A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY509253 Genomic DNA Translation: AAS00986.1

NCBI Reference Sequences

More...
RefSeqi
YP_024639.1, NC_005881.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2948204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:2948204

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509253 Genomic DNA Translation: AAS00986.1
RefSeqiYP_024639.1, NC_005881.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi2948204
KEGGivg:2948204

Family and domain databases

InterProiView protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR012337, RNaseH-like_sf
PfamiView protein in Pfam
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 1 hit
SMARTiView protein in SMART
SM00486, POLBc, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOL_OSHVF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R7C9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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