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Entry version 53 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Brain-enriched guanylate kinase-associated protein

Gene

BEGAIN

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May sustain the structure of the postsynaptic density (PSD).

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brain-enriched guanylate kinase-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BEGAIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649071 – 653Brain-enriched guanylate kinase-associated proteinAdd BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphotyrosineBy similarity1
Modified residuei249PhosphoserineBy similarity1
Modified residuei278PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei435Asymmetric dimethylarginineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei533PhosphoserineBy similarity1
Modified residuei535PhosphoserineBy similarity1
Modified residuei558PhosphoserineBy similarity1
Modified residuei560PhosphoserineBy similarity1
Modified residuei564PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6R6L0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DLG4 and DLGAP1 and forms a ternary complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000002408

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6R6L0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
443898at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033584 BEGAIN

The PANTHER Classification System

More...
PANTHERi
PTHR28664:SF2 PTHR28664:SF2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6R6L0-1) [UniParc]FASTAAdd to basket
Also known as: BEGAIN-2B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWTGGRRPGR LRRAASAADM EKLRLRSAWV PSCLGQSRNL QGRRARSSPS
60 70 80 90 100
LWDSSLQEQK GELRKRLSYT THRLEKLENE FDSTRHFLEI ELRRAQEELE
110 120 130 140 150
KVTEKLRRIQ SNYMALQRIN QELEDKLFRM GQHYEEEKRA LSHEIVALNS
160 170 180 190 200
HLLEAKVTID KLSEDNELYR KDCSLAAQLL QCSQAYGRGR KMAELPAEFQ
210 220 230 240 250
ERMNLHAEKP GCSLPAPPRR PAYADSVPPC VLAKVLEKPD PGSLSSHLSE
260 270 280 290 300
ASAQDLGFPE GLEKPGSRPP YKGDIYCSDT ALYCPEARHQ DRRPSVEGPG
310 320 330 340 350
SDVGFLQAQN STDSTAEEEE EEEEDTEAGA AAYPASYRHE AFGGYAASLP
360 370 380 390 400
TSSSYSSFSA ASEEKEHAQA STLTASQQAI YLNSRDELFG RKPAAAYGSS
410 420 430 440 450
PRYAAAAAAV AAPLEAAMAP GFPRTVSPFP GEPFRFPLSP GPQPALMPPN
460 470 480 490 500
LWNLRAKPGS ARLVAGAGRG QWRPLSVDDI GAYPFPAAAA APAPSLASPG
510 520 530 540 550
GGFNDRYFGA RGGPGDNAEG RASPLYASYK ADSFSEGDDL SQGHLVEPRY
560 570 580 590 600
LRAAGDLSLS PGHSADPLPS YAASEGDRER LGVQLLGASG SPEPELSLRS
610 620 630 640 650
SRDSLEPSSM EASPEMHPGA RLSPQPAFPR AGSSGLSRKD SLTKAQLYGT

LLN
Length:653
Mass (Da):70,854
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99FF1A913C04EB7A
GO
Isoform 2 (identifier: Q6R6L0-2) [UniParc]FASTAAdd to basket
Also known as: BEGAIN-2A

The sequence of this isoform differs from the canonical sequence as follows:
     24-53: Missing.

Show »
Length:623
Mass (Da):67,431
Checksum:i9E4A87500288920C
GO
Isoform 3 (identifier: Q6R6L0-3) [UniParc]FASTAAdd to basket
Also known as: BEGAIN-1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MWTGGRRPGRLRRA → MGSHQSSQ

Show »
Length:647
Mass (Da):70,045
Checksum:i6B6992E43D281A21
GO
Isoform 4 (identifier: Q6R6L0-4) [UniParc]FASTAAdd to basket
Also known as: BEGAIN-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MWTGGRRPGRLRRA → MGSHQSSQ
     24-53: Missing.

Show »
Length:617
Mass (Da):66,622
Checksum:i97E5E0E4DB9502EA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125851 – 14MWTGG…RLRRA → MGSHQSSQ in isoform 3 and isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_01258624 – 53Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY509922 mRNA Translation: AAR98700.1
AY509923 mRNA Translation: AAR98701.1
AY509924 mRNA Translation: AAR98702.1
AY509925 mRNA Translation: AAR98703.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009766.1, NM_001009766.1 [Q6R6L0-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
443287

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
oas:443287

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509922 mRNA Translation: AAR98700.1
AY509923 mRNA Translation: AAR98701.1
AY509924 mRNA Translation: AAR98702.1
AY509925 mRNA Translation: AAR98703.1
RefSeqiNP_001009766.1, NM_001009766.1 [Q6R6L0-1]

3D structure databases

SMRiQ6R6L0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000002408

Proteomic databases

PRIDEiQ6R6L0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443287
KEGGioas:443287

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57596

Phylogenomic databases

OrthoDBi443898at2759

Family and domain databases

InterProiView protein in InterPro
IPR033584 BEGAIN
PANTHERiPTHR28664:SF2 PTHR28664:SF2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBEGIN_SHEEP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R6L0
Secondary accession number(s): Q6R6L1, Q6R6L2, Q6R6L3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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