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Entry version 69 (26 Feb 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Protein dispatched homolog 1

Gene

disp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (PubMed:15110707). Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein dispatched homolog 1
Alternative name(s):
Protein chameleon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:disp1
Synonyms:con
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030911-7 disp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Transmembranei586 – 606HelicalSequence analysisAdd BLAST21
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Transmembranei701 – 721HelicalSequence analysisAdd BLAST21
Transmembranei970 – 990HelicalSequence analysisAdd BLAST21
Transmembranei992 – 1012HelicalSequence analysisAdd BLAST21
Transmembranei1022 – 1042HelicalSequence analysisAdd BLAST21
Transmembranei1065 – 1085HelicalSequence analysisAdd BLAST21
Transmembranei1089 – 1109HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003106951 – 1464Protein dispatched homolog 1Add BLAST1464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi818N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6R5J2

PRoteomics IDEntifications database

More...
PRIDEi
Q6R5J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in the notochord, the ventral floor of the brain as well as dorsal and ventral margins of the myotome.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHH; via the cholesterol anchor of the dually lipid-modified SHH (ShhNp).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000068639

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini468 – 640SSDPROSITE-ProRule annotationAdd BLAST173

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dispatched family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3664 Eukaryota
ENOG410XT7M LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6R5J2

Database of Orthologous Groups

More...
OrthoDBi
1156918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6R5J2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460 Patched, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6R5J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSEDFTEL QTLSNGRSSS IFPTTNTPVD PEEEEEQSVS ACTQPNEHTQ
60 70 80 90 100
MMQTGQNGGL KSTRLSSSSS SSSQLTDAQR LAVLLPNALP PGFCVCCSLC
110 120 130 140 150
CNGNQQDCAL FQSAVPSAAL HMGSCCVQGV PCFCMQHHWP EHLQNQPNMA
160 170 180 190 200
TLSPPRPFRF PKNYAELIAD WPVVVLGICT VLIVVCALVG ILVPDLPDFS
210 220 230 240 250
NPLQGFEPRG TAIGQRLVTW NNMVKNTGYK ATLANYPFKY ADEQAKSHQD
260 270 280 290 300
DRWSKDHYDR KKRQAEWDFS KDSFFCDVPG DSYSRIVFAS AEGKNLWNIQ
310 320 330 340 350
AIKSMCNFDN TRVRSHPQYL DLCQRTTAAS CCPSWTLGNY IAVLTNKSSC
360 370 380 390 400
QKITERDVSH TLNILRSCAK FYHNGTLGPE CWDMTTRKKD LKCGNLPRKC
410 420 430 440 450
TKYNAVYQIF HFLVDKDFLN PKNTDYLPPN LKYSMLFAPT EKGETMMNIY
460 470 480 490 500
LDNFENRNSS DGITTITGIE FGIKHSLFQD YLLTDTMYPA IAIVIVLVVM
510 520 530 540 550
CVYTRSMFIT LMTMFAIISS LIVSYFLYRV VFNFDFFPFM NLTALIILVG
560 570 580 590 600
IGADDAFVLC DVWNYTKFDK PNSELSETVS ITLQHAALSM FVTSFTTAAA
610 620 630 640 650
FYANYVSNIT AIRCFGVYAG TAILVNYILM VTWLPAVVVL HERYLVNLLT
660 670 680 690 700
CSRTQNHQSQ GAATFWTSLC QVVNKCLFSI SEASRIFFEK VLPCVVIKLR
710 720 730 740 750
YLWLLWFLAL TVGGAYVVCV NPKMKLPSLE LSEFQVFRSS HPFERYDAEY
760 770 780 790 800
KKLFMFERVN HGEDLHMPIT IIWGVTPIDS GDPLNPKNKG KLTLDTTFNI
810 820 830 840 850
ASPASQVWIL NFCQKLRNQS FVYQSEEQDF TSCFMETFKQ WMENQDCEEA
860 870 880 890 900
SVYPCCSQST FPYRQDVFEL CIKRAIMELD RSTIYHLDSK TPGPRFDIND
910 920 930 940 950
TIRAIVLEFQ STYHFTLAYE KMHQFYREVD TWIQEELRDA PEGLSYGWFV
960 970 980 990 1000
SNLEFYDLQD SLSDGTLIAM ALSVVVAFSV MLLTTWNIII SLYAIISIAG
1010 1020 1030 1040 1050
TIFVTVGSLV LLGWELNVLE SVTISVAVGL SVDFAVHYGV AYRLAPEPDR
1060 1070 1080 1090 1100
EGKVVFSLSR MGSAIAMAAL TTFVAGAMMM PSTVLAYTQL GTFLMLIMCI
1110 1120 1130 1140 1150
SWAFATFFFQ CMCRLLGPQG TCGQIPLPKK LQCAERTSEN QSTVNNQGKA
1160 1170 1180 1190 1200
GACYTTKHEH YELEPLAANV RNEGKASDEE QEACTQLQNN ITSLHDDATL
1210 1220 1230 1240 1250
CASHEEPKHE FENGVQATEH SHLHQYAFNT RCTCENSMHQ YIRERQRTAC
1260 1270 1280 1290 1300
HPCGQSRETQ CATKQSNHLP VCLNRDMIHA PTNSGHFQHC TPSQISRPAA
1310 1320 1330 1340 1350
HRCFSGGCGM HAVHISQQQT ETESYISACV PSSSPQESQN RPAHLQFPDV
1360 1370 1380 1390 1400
QRCSSPDTTG VCTLNHDTQN AGELAINSQS PQKIPWNHLK TKANGTCVLQ
1410 1420 1430 1440 1450
DCREVVPEDS IGCRVDKEKT VSPKKFNCFK KNVNAKCNSV EFHKTRTSVP
1460
TIAINSKASS ESLC
Length:1,464
Mass (Da):164,535
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBFF4B1849702DFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QHY7F1QHY7_DANRE
Protein dispatched homolog 1
disp1
1,464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY512779 mRNA Translation: AAR99503.1

NCBI Reference Sequences

More...
RefSeqi
NP_997965.1, NM_212800.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
619201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:619201

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY512779 mRNA Translation: AAR99503.1
RefSeqiNP_997965.1, NM_212800.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068639

Proteomic databases

PaxDbiQ6R5J2
PRIDEiQ6R5J2

Genome annotation databases

GeneIDi619201
KEGGidre:619201

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84976
ZFINiZDB-GENE-030911-7 disp1

Phylogenomic databases

eggNOGiKOG3664 Eukaryota
ENOG410XT7M LUCA
InParanoidiQ6R5J2
OrthoDBi1156918at2759
PhylomeDBiQ6R5J2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6R5J2

Family and domain databases

InterProiView protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF02460 Patched, 2 hits
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDISP1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R5J2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: February 26, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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