UniProtKB - Q6R3Q6 (BSH_DANRE)
Protein
Brain-specific homeobox protein homolog
Gene
bsx
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 103 – 163 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 61 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- brain development Source: UniProtKB
- pineal gland development Source: ZFIN
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Brain-specific homeobox protein homolog |
Gene namesi | Name:bsxImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040628-4, bsx |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048842 | 1 – 227 | Brain-specific homeobox protein homologAdd BLAST | 227 |
Proteomic databases
PaxDbi | Q6R3Q6 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000068976, Expressed in head and 8 other tissues |
ExpressionAtlasi | Q6R3Q6, baseline |
Family & Domainsi
Sequence similaritiesi
Belongs to the distal-less homeobox family.Sequence analysis
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0491, Eukaryota |
GeneTreei | ENSGT00940000165707 |
HOGENOMi | CLU_104234_0_0_1 |
InParanoidi | Q6R3Q6 |
OMAi | DLPGKHC |
OrthoDBi | 1572711at2759 |
PhylomeDBi | Q6R3Q6 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6R3Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLNYTSPVP QMPTQRSTSF FIEDILLHKP KPLREVFPSP FSNSIASRMP
60 70 80 90 100
LLEYGYPLMP TPILAPHPHH PLHKPEHHPY FFTSGMQMPA LFQHHPELPG
110 120 130 140 150
KHCRRRKART VFSDSQLSGL EKRFEIQRYL STPERVELAT ALSLSETQVK
160 170 180 190 200
TWFQNRRMKH KKQLRKTQDD QKTPNDVDRS LENTSESEMH EKNTDGKNGM
210 220
SPDRYTLDDN EDDVDIEDDI CSPEHLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY515251 mRNA Translation: AAR99056.1 |
RefSeqi | NP_999892.1, NM_214727.1 |
Genome annotation databases
Ensembli | ENSDART00000099983; ENSDARP00000090755; ENSDARG00000068976 ENSDART00000185401; ENSDARP00000149609; ENSDARG00000110782 |
GeneIDi | 573364 |
KEGGi | dre:573364 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY515251 mRNA Translation: AAR99056.1 |
RefSeqi | NP_999892.1, NM_214727.1 |
3D structure databases
SMRi | Q6R3Q6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000090755 |
Proteomic databases
PaxDbi | Q6R3Q6 |
Genome annotation databases
Ensembli | ENSDART00000099983; ENSDARP00000090755; ENSDARG00000068976 ENSDART00000185401; ENSDARP00000149609; ENSDARG00000110782 |
GeneIDi | 573364 |
KEGGi | dre:573364 |
Organism-specific databases
CTDi | 390259 |
ZFINi | ZDB-GENE-040628-4, bsx |
Phylogenomic databases
eggNOGi | KOG0491, Eukaryota |
GeneTreei | ENSGT00940000165707 |
HOGENOMi | CLU_104234_0_0_1 |
InParanoidi | Q6R3Q6 |
OMAi | DLPGKHC |
OrthoDBi | 1572711at2759 |
PhylomeDBi | Q6R3Q6 |
Miscellaneous databases
PROi | PR:Q6R3Q6 |
Gene expression databases
Bgeei | ENSDARG00000068976, Expressed in head and 8 other tissues |
ExpressionAtlasi | Q6R3Q6, baseline |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BSH_DANRE | |
Accessioni | Q6R3Q6Primary (citable) accession number: Q6R3Q6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families