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Entry version 148 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Rapamycin-insensitive companion of mTOR

Gene

RICTOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q6R327

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rapamycin-insensitive companion of mTOR
Alternative name(s):
AVO3 homolog
Short name:
hAVO3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RICTORImported
Synonyms:KIAA1999Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28611 RICTOR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609022 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6R327

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
253260

Open Targets

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OpenTargetsi
ENSG00000164327

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA165660455

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q6R327

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1795179

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RICTOR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74710068

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003081791 – 1708Rapamycin-insensitive companion of mTORAdd BLAST1708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei1103PhosphothreonineCombined sources1
Modified residuei1135Phosphothreonine; by RPS6KB1Combined sources1 Publication1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1235PhosphoserineBy similarity1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1282PhosphoserineCombined sources1
Modified residuei1284PhosphoserineCombined sources1
Modified residuei1295PhosphothreonineCombined sources1
Modified residuei1302PhosphoserineCombined sources1
Modified residuei1313PhosphoserineCombined sources1
Modified residuei1332PhosphothreonineCombined sources1
Modified residuei1346PhosphoserineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1385PhosphoserineCombined sources1
Modified residuei1388PhosphoserineCombined sources1
Modified residuei1396PhosphoserineCombined sources1
Modified residuei1411PhosphoserineCombined sources1
Modified residuei1591PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1337

Encyclopedia of Proteome Dynamics

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EPDi
Q6R327

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6R327

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6R327

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6R327

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6R327

PeptideAtlas

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PeptideAtlasi
Q6R327

PRoteomics IDEntifications database

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PRIDEi
Q6R327

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
67310 [Q6R327-1]
67311 [Q6R327-3]
67312 [Q6R327-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6R327

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6R327

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164327 Expressed in 213 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6R327 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6R327 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037802
HPA037803

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906).

Interacts with CCDC28B (PubMed:23727834).

Interacts with NBN (PubMed:23762398).

Interacts with PRR5L (PubMed:17461779, PubMed:21964062).

Interacts with SIK3 (PubMed:30232230).

8 Publications

(Microbial infection) Interacts with vaccinia virus protein F17; this interaction dysregulates mTOR.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128962, 145 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-4402 mTORC2 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6R327

Database of interacting proteins

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DIPi
DIP-39479N

Protein interaction database and analysis system

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IntActi
Q6R327, 74 interactors

Molecular INTeraction database

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MINTi
Q6R327

STRING: functional protein association networks

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STRINGi
9606.ENSP00000296782

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6R327

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 789Interaction with NBN1 PublicationAdd BLAST789

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1016 – 1058Ser-richSequence analysisAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RICTOR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3694 Eukaryota
ENOG410XQ5Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002096

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154126

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6R327

KEGG Orthology (KO)

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KOi
K08267

Identification of Orthologs from Complete Genome Data

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OMAi
TDENCLY

Database of Orthologous Groups

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OrthoDBi
128601at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6R327

TreeFam database of animal gene trees

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TreeFami
TF343656

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR028268 Pianissimo_fam
IPR028267 Pianissimo_N
IPR029453 Rictor_IV
IPR029451 RICTOR_M
IPR029259 RICTOR_phospho
IPR029452 RICTOR_V

The PANTHER Classification System

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PANTHERi
PTHR13298 PTHR13298, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14663 RasGEF_N_2, 1 hit
PF14666 RICTOR_M, 1 hit
PF14664 RICTOR_N, 1 hit
PF14665 RICTOR_phospho, 1 hit
PF14668 RICTOR_V, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01307 RICTOR_M, 1 hit
SM01308 RICTOR_N, 1 hit
SM01309 RICTOR_phospho, 1 hit
SM01310 RICTOR_V, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6R327-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG
60 70 80 90 100
VSNMRKLGHL NNFTKLLCDI GHSEEKLGFH YEDIIICLRL ALLNEAKEVR
110 120 130 140 150
AAGLRALRYL IQDSSILQKV LKLKVDYLIA RCIDIQQSNE VERTQALRLV
160 170 180 190 200
RKMITVNASL FPSSVTNSLI AVGNDGLQER DRMVRACIAI ICELALQNPE
210 220 230 240 250
VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT RQYVRADVEL
260 270 280 290 300
ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN
310 320 330 340 350
LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL
360 370 380 390 400
LSVDPGRFQD SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI
410 420 430 440 450
RNGLLEGLVE VITNSDDHIS VRATILLGEL LHMANTILPH SHSHHLHCLP
460 470 480 490 500
TLMNMAASFD IPKEKRLRAS AALNCLKRFH EMKKRGPKPY SLHLDHIIQK
510 520 530 540 550
AIATHQKRDQ YLRVQKDIFI LKDTEEALLI NLRDSQVLQH KENLEWNWNL
560 570 580 590 600
IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKAKQ
610 620 630 640 650
LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG
660 670 680 690 700
LLTTLSQHYF LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL
710 720 730 740 750
TVSSLDYSRD GLARVILSKI LTAATDACRL YATKHLRVLL RANVEFFNNW
760 770 780 790 800
GIELLVTQLH DKNKTISSEA LDILDEACED KANLHALIQM KPALSHLGDK
810 820 830 840 850
GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHREYNSKYV DLIEEQLNEA
860 870 880 890 900
LTTYRKPVDG DNYVRRSNQR LQRPHVYLPI HLYGQLVHHK TGCHLLEVQN
910 920 930 940 950
IITELCRNVR TPDLDKWEEI KKLKASLWAL GNIGSSNWGL NLLQEENVIP
960 970 980 990 1000
DILKLAKQCE VLSIRGTCVY VLGLIAKTKQ GCDILKCHNW DAVRHSRKHL
1010 1020 1030 1040 1050
WPVVPDDVEQ LCNELSSIPS TLSLNSESTS SRHNSESESV PSSMFILEDD
1060 1070 1080 1090 1100
RFGSSSTSTF FLDINEDTEP TFYDRSGPIK DKNSFPFFAS SKLVKNRILN
1110 1120 1130 1140 1150
SLTLPNKKHR SSSDPKGGKL SSESKTSNRR IRTLTEPSVD FNHSDDFTPI
1160 1170 1180 1190 1200
STVQKTLQLE TSFMGNKHIE DTGSTPSIGE NDLKFTKNFG TENHRENTSR
1210 1220 1230 1240 1250
ERLVVESSTS SHMKIRSQSF NTDTTTSGIS SMSSSPSRET VGVDATTMDT
1260 1270 1280 1290 1300
DCGSMSTVVS TKTIKTSHYL TPQSNHLSLS KSNSVSLVPP GSSHTLPRRA
1310 1320 1330 1340 1350
QSLKAPSIAT IKSLADCNFS YTSSRDAFGY ATLKRLQQQR MHPSLSHSEA
1360 1370 1380 1390 1400
LASPAKDVLF TDTITMKANS FESRLTPSRF MKALSYASLD KEDLLSPINQ
1410 1420 1430 1440 1450
NTLQRSSSVR SMVSSATYGG SDDYIGLALP VDINDIFQVK DIPYFQTKNI
1460 1470 1480 1490 1500
PPHDDRGARA FAHDAGGLPS GTGGLVKNSF HLLRQQMSLT EIMNSIHSDA
1510 1520 1530 1540 1550
SLFLESTEDT GLQEHTDDNC LYCVCIEILG FQPSNQLSAI CSHSDFQDIP
1560 1570 1580 1590 1600
YSDWCEQTIH NPLEVVPSKF SGISGCSDGV SQEGSASSTK STELLLGVKT
1610 1620 1630 1640 1650
IPDDTPMCRI LLRKEVLRLV INLSSSVSTK CHETGLLTIK EKYPQTFDDI
1660 1670 1680 1690 1700
CLYSEVSHLL SHCTFRLPCR RFIQELFQDV QFLQMHEEAE AVLATPPKQP

IVDTSAES
Length:1,708
Mass (Da):192,218
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB7B1E4A45DAE2AB
GO
Isoform 2 (identifier: Q6R327-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-257: RILAPY → NFSTLY
     258-1708: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:257
Mass (Da):28,988
Checksum:i57DCA4610207FA94
GO
Isoform 3 (identifier: Q6R327-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1379-1379: R → RIDFKKKHVGGIRSLRPTITNNLFR

Note: No experimental confirmation available.Curated
Show »
Length:1,732
Mass (Da):195,011
Checksum:i984F516A908EEC3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9S6D6R9S6_HUMAN
Rapamycin-insensitive companion of ...
RICTOR
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH18135 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545E → G in CAH18135 (PubMed:17974005).Curated1
Sequence conflicti815F → L in CAH18135 (PubMed:17974005).Curated1
Sequence conflicti1283N → S in CAH18135 (PubMed:17974005).Curated1
Sequence conflicti1699Q → R in AAH51729 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051320837S → F2 PublicationsCorresponds to variant dbSNP:rs2043112Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038362252 – 257RILAPY → NFSTLY in isoform 2. 1 Publication6
Alternative sequenceiVSP_038363258 – 1708Missing in isoform 2. 1 PublicationAdd BLAST1451
Alternative sequenceiVSP_0525811379R → RIDFKKKHVGGIRSLRPTIT NNLFR in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY515854 mRNA Translation: AAS79796.1
AL834497 mRNA Translation: CAD39155.1
CR749280 mRNA Translation: CAH18135.1 Sequence problems.
AC008964 Genomic DNA No translation available.
AC109467 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55980.1
BC051729 mRNA Translation: AAH51729.1
BC137163 mRNA Translation: AAI37164.1
BC137164 mRNA Translation: AAI37165.1
BC144509 mRNA Translation: AAI44510.1
AB082530 mRNA Translation: BAC02708.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34148.1 [Q6R327-1]
CCDS68861.1 [Q6R327-3]

NCBI Reference Sequences

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RefSeqi
NP_001272368.1, NM_001285439.1 [Q6R327-3]
NP_001272369.1, NM_001285440.1
NP_689969.2, NM_152756.4 [Q6R327-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296782; ENSP00000296782; ENSG00000164327 [Q6R327-3]
ENST00000357387; ENSP00000349959; ENSG00000164327 [Q6R327-1]
ENST00000511516; ENSP00000423019; ENSG00000164327 [Q6R327-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
253260

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:253260

UCSC genome browser

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UCSCi
uc003jlo.4 human [Q6R327-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY515854 mRNA Translation: AAS79796.1
AL834497 mRNA Translation: CAD39155.1
CR749280 mRNA Translation: CAH18135.1 Sequence problems.
AC008964 Genomic DNA No translation available.
AC109467 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55980.1
BC051729 mRNA Translation: AAH51729.1
BC137163 mRNA Translation: AAI37164.1
BC137164 mRNA Translation: AAI37165.1
BC144509 mRNA Translation: AAI44510.1
AB082530 mRNA Translation: BAC02708.1
CCDSiCCDS34148.1 [Q6R327-1]
CCDS68861.1 [Q6R327-3]
RefSeqiNP_001272368.1, NM_001285439.1 [Q6R327-3]
NP_001272369.1, NM_001285440.1
NP_689969.2, NM_152756.4 [Q6R327-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ZCSelectron microscopy4.90E/F1-1018[»]
SMRiQ6R327
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi128962, 145 interactors
ComplexPortaliCPX-4402 mTORC2 complex
CORUMiQ6R327
DIPiDIP-39479N
IntActiQ6R327, 74 interactors
MINTiQ6R327
STRINGi9606.ENSP00000296782

Chemistry databases

ChEMBLiCHEMBL1795179

PTM databases

iPTMnetiQ6R327
PhosphoSitePlusiQ6R327

Polymorphism and mutation databases

BioMutaiRICTOR
DMDMi74710068

Proteomic databases

CPTACiCPTAC-1337
EPDiQ6R327
jPOSTiQ6R327
MassIVEiQ6R327
MaxQBiQ6R327
PaxDbiQ6R327
PeptideAtlasiQ6R327
PRIDEiQ6R327
ProteomicsDBi67310 [Q6R327-1]
67311 [Q6R327-3]
67312 [Q6R327-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
253260

Genome annotation databases

EnsembliENST00000296782; ENSP00000296782; ENSG00000164327 [Q6R327-3]
ENST00000357387; ENSP00000349959; ENSG00000164327 [Q6R327-1]
ENST00000511516; ENSP00000423019; ENSG00000164327 [Q6R327-4]
GeneIDi253260
KEGGihsa:253260
UCSCiuc003jlo.4 human [Q6R327-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
253260
DisGeNETi253260

GeneCards: human genes, protein and diseases

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GeneCardsi
RICTOR
HGNCiHGNC:28611 RICTOR
HPAiHPA037802
HPA037803
MIMi609022 gene
neXtProtiNX_Q6R327
OpenTargetsiENSG00000164327
PharmGKBiPA165660455

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3694 Eukaryota
ENOG410XQ5Z LUCA
GeneTreeiENSGT00390000002096
HOGENOMiHOG000154126
InParanoidiQ6R327
KOiK08267
OMAiTDENCLY
OrthoDBi128601at2759
PhylomeDBiQ6R327
TreeFamiTF343656

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
SIGNORiQ6R327

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RICTOR human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RICTOR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
253260
PharosiQ6R327

Protein Ontology

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PROi
PR:Q6R327

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164327 Expressed in 213 organ(s), highest expression level in blood
ExpressionAtlasiQ6R327 baseline and differential
GenevisibleiQ6R327 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR028268 Pianissimo_fam
IPR028267 Pianissimo_N
IPR029453 Rictor_IV
IPR029451 RICTOR_M
IPR029259 RICTOR_phospho
IPR029452 RICTOR_V
PANTHERiPTHR13298 PTHR13298, 1 hit
PfamiView protein in Pfam
PF14663 RasGEF_N_2, 1 hit
PF14666 RICTOR_M, 1 hit
PF14664 RICTOR_N, 1 hit
PF14665 RICTOR_phospho, 1 hit
PF14668 RICTOR_V, 1 hit
SMARTiView protein in SMART
SM01307 RICTOR_M, 1 hit
SM01308 RICTOR_N, 1 hit
SM01309 RICTOR_phospho, 1 hit
SM01310 RICTOR_V, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRICTR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R327
Secondary accession number(s): B2RNX0
, B7ZMF7, Q68DT5, Q86UB7, Q8N3A0, Q8NCM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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