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Entry version 67 (12 Aug 2020)
Sequence version 3 (30 Aug 2017)
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Protein

Serine/threonine-protein kinase WNK1

Gene

WNK1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).By similarity

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity
HSN2 was originally thought to be an intronless gene lying within a WNK1 gene intron. However, it is most probably an alternative exon which has been also described in alternative splicing products of the human and mouse WNK1 genes. Isoforms bearing this exon are specifically expressed in the nervous system in these species.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

By hypertonicity (By similarity). Activation requires autophosphorylation of Ser-380, that may be regulated by calcium. Phosphorylation of Ser-376 also promotes increased activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei229ATP; via amide nitrogenBy similarity1
Binding sitei349ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei366Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi299 – 302ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase WNK1Curated (EC:2.7.11.1By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK1By similarity
Synonyms:HSN21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002239471 – 2376Serine/threonine-protein kinase WNK1Add BLAST2376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei376Phosphoserine; by autocatalysisBy similarity1
Modified residuei380Phosphoserine; by autocatalysisBy similarity1
Modified residuei1261PhosphoserineBy similarity1
Modified residuei1972PhosphoserineBy similarity1
Modified residuei1996PhosphoserineBy similarity1
Modified residuei2005PhosphoserineBy similarity1
Modified residuei2006PhosphoserineBy similarity1
Modified residuei2021PhosphoserineBy similarity1
Modified residuei2023PhosphoserineBy similarity1
Modified residuei2026PhosphoserineBy similarity1
Modified residuei2264PhosphoserineBy similarity1
Modified residuei2280PhosphoserineBy similarity1
Modified residuei2364PhosphoserineBy similarity1
Modified residuei2366PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation at Ser-380 is inhibited by intracellular calcium.By similarity
Ubiquitinated in vitro by the BCR(KLHL3) complex and in vivo by a BCR(KLHL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6R2V0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000000753, Expressed in adult mammalian kidney and 37 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYT2.

Interacts with WNK3 and WNK4.

Interacts with KLHL3.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000000801

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6R2V0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini219 – 477Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni486 – 553Autoinhibitory domainBy similarityAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0584, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6R2V0

TreeFam database of animal gene trees

More...
TreeFami
TF315363

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6R2V0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGGADQQS SPPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAGAGR
60 70 80 90 100
TEEYRRRRHT MDKDSRGAAA TTTTEHRFFR RSVICDSNAT ALELPGLPLP
110 120 130 140 150
LPQPGAAAVA QQRSPPEPHR EETLTPAVAH VAQQPPAAAT PGEPAAAVPA
160 170 180 190 200
AASAPGSASR DRQVAQPSQA GSKEEPPSAR SGSGGGSAKE PQEERSQQQD
210 220 230 240 250
DIEELETKAV GMSNDGRFLK FDIEIGRGSF KTVYKGLDTE TTVEVAWCEL
260 270 280 290 300
QDRKLTKSER QRFKEEAEML KGLQHPNIVR FYDSWESTVK GKKCIVLVTE
310 320 330 340 350
LMTSGTLKTY LKRFKVMKIK VLRSWCRQIL KGLQFLHTRT PPIIHRDLKC
360 370 380 390 400
DNIFITGPTG SVKIGDLGLA TLKRASFAKS VIGTPEFMAP EMYEEKYDES
410 420 430 440 450
VDVYAFGMCM LEMATSEYPY SECQNAAQIY RRVTSGVKPA SFDKVAIPEV
460 470 480 490 500
KEIIEGCIRQ NKDERYSIKD LLNHAFFQEE TGVRVELAEE DDGEKIAIKL
510 520 530 540 550
WLRIEDIKKL KGKYKDNEAI EFSFDLERDV PEDVAQEMVE SGYVCEGDHK
560 570 580 590 600
TMAKAIKDRV SLIKRKREQR QLVREEQEKR KQEESSLKQQ GEQQSSASQA
610 620 630 640 650
GILQPSSAST GLPAAATTSA SVSTQVEPEE PEADQHQQLQ YQQPSISVLS
660 670 680 690 700
DGTVDSGQGS SVFTESRVSS QQTVSYGSQH EQAHSTCTLP GHTASVVQAQ
710 720 730 740 750
AQPHGGYPPS SMAQGQSQGQ PSSSSLTGIP SSQPVQHSQQ QQGVQQTAPS
760 770 780 790 800
QQTVQYSLPQ TSAPSEPTTA QPASQPQPPQ VLPPVSAGKQ LPVSQPVPTI
810 820 830 840 850
QGEPQISVAT QPSVVPVHSG AHFLPVGQPL PPSLLPQYPV SQVPSAPHVS
860 870 880 890 900
AAQPGFSPLP VTAAAGVNQP LLTLASSAAA AAVPGGSTVV PSQLPTLLQP
910 920 930 940 950
VTQLPSQAHP QLLQTAVQSM GIPANLGQTA EAPLPSGDVL YQGFPPRLPP
960 970 980 990 1000
QYPGDSNIAP SSSVASVCIP STVLSPPRPT EALAAPGYFP TVVQSYAESN
1010 1020 1030 1040 1050
LLVPVGSIGG QIQVSQPAVS LAQAPTTSSQ QAALESTQGV SQVAPPEPVP
1060 1070 1080 1090 1100
AAPPQPTQPT TLVSSIDRSA HSDVASGMSD GNENVPSSSG RHEGRTIKRH
1110 1120 1130 1140 1150
YRKSVRSRSR HEKTSRPKLR ILNVSNKGDR VVECQLETHN RKMVTFKFDL
1160 1170 1180 1190 1200
DGDNPEEIAT IMVNNDFILA IEREAFVDQV REIIEKADEM LSEDVSVEPE
1210 1220 1230 1240 1250
GDQGLENLQG KDDYGFSGSQ KLEGEFKQPI PASSMPQQIA GLPTSSLTQV
1260 1270 1280 1290 1300
VHSAGRRFIV SPVPESRLRE SKVFTSEISD TVAASTSPGT GMNLSHSASS
1310 1320 1330 1340 1350
LSLQQAFSEL RRAQMTEGPS TAPPHFSHTG PTFPVVPPSM SSIAGAAATP
1360 1370 1380 1390 1400
SVSVPATSCP FSDISTSVTP SEVTASTEKG IAGVATCTGV ISSSGLTVPP
1410 1420 1430 1440 1450
ASDSPILSSV VSSITVPVAV SVSTTSLSVQ APTPGSIVSN TGTFPSISVA
1460 1470 1480 1490 1500
MTSASAVSST AAPGAKPPPV SSQQVSGSTA GITTLASVPT TAPAPSVASQ
1510 1520 1530 1540 1550
PSLSLSSSTS APTLAETIVV SAHSLDKASH SSTAGLALSL PASSSSASPA
1560 1570 1580 1590 1600
AGVSSSVSQP GVAHPLVIPS AVASIPVLSQ AGPTCAPLLP QVPGIPPLVQ
1610 1620 1630 1640 1650
PAASVPAVQQ TLVHSQPQPA LLPNQPHTHC PEMDADAQPR APGIDDIKTL
1660 1670 1680 1690 1700
EEKLRSLFSE HSSSGTQHAS VSLETSLVVE TTVTPGIPTT AVAPGKLMTS
1710 1720 1730 1740 1750
TTSTCLPPTS LPLGTTGLSI LPVVTPGQVS TPVSTIPAVK PGTAPSKPPS
1760 1770 1780 1790 1800
TKPPVLPLGT ELPAGTPPSE QLPPFPGPSL MQAQQPLEDL DAQLRRTLSP
1810 1820 1830 1840 1850
ETVVLTSTVG PVSVVAPTAA VEAGAQLQKD VSQVTEGPIP APTSGTGVFQ
1860 1870 1880 1890 1900
MGRFQVSVAM DDTQKEGKNK SEDVKSVHFE SSTSESSVLS SSSPESTLVK
1910 1920 1930 1940 1950
PEPNGTAIRG ISSDMPDSAH KTSASEAKSE AGQPTKVGRF QVTTTADKVG
1960 1970 1980 1990 2000
RFSVSRTEDA IAEAKKEGPV ASPPFMDLEH SILPAVIPKK EKPELSEPSH
2010 2020 2030 2040 2050
LNGPSSDLEA AFLSRDGDDG SGSPHSPPQL CSKSLPIQSL SQSLSNSFNS
2060 2070 2080 2090 2100
SYMSSDNESD IEDEDLKLEL RRLREKHLKE IQDLQSRQKH EIESLYTRLG
2110 2120 2130 2140 2150
KAPPAVIIPA AAPLAGRRRR PTKSKGSKSS RSSSLGNKSP GPAGNLSGQS
2160 2170 2180 2190 2200
TATVLHPQQT LPAPGNIPET GQNQLLQPLK PSPSSDNLYS AFTSDGAISV
2210 2220 2230 2240 2250
PSLSAPGQGT SSTNTVGGTV SSQAAQAQPP TMTSSRKGTF TDDLHKLVDN
2260 2270 2280 2290 2300
WARDAMNLSG RRGSKGHMSY EGPGMARKFS APGQLCISMT SNLGGSAPIS
2310 2320 2330 2340 2350
AASATSLGHF TKSMCPPQQY GFPAPPFGTQ WSGTGGPAPQ PLSQFQPVGT
2360 2370
ASLQNFNISN LQKSISNPPG SNLRTT
Length:2,376
Mass (Da):248,976
Last modified:August 30, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i508CB7AC7C4A057C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS86809 differs from that shown. Probable cloning artifact.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU463193 Genomic DNA No translation available.
CU915332 Genomic DNA No translation available.
FP340582 Genomic DNA No translation available.
AY517853 mRNA Translation: AAS86809.1 Sequence problems.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00040102601; ENSSSCP00040046393; ENSSSCG00040074009

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU463193 Genomic DNA No translation available.
CU915332 Genomic DNA No translation available.
FP340582 Genomic DNA No translation available.
AY517853 mRNA Translation: AAS86809.1 Sequence problems.

3D structure databases

SMRiQ6R2V0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000801

Proteomic databases

PRIDEiQ6R2V0

Genome annotation databases

EnsembliENSSSCT00040102601; ENSSSCP00040046393; ENSSSCG00040074009

Phylogenomic databases

eggNOGiKOG0584, Eukaryota
InParanoidiQ6R2V0
TreeFamiTF315363

Gene expression databases

BgeeiENSSSCG00000000753, Expressed in adult mammalian kidney and 37 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNK1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R2V0
Secondary accession number(s): F1SHS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 30, 2017
Last modified: August 12, 2020
This is version 67 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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