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Entry version 137 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Gene

Gnas

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms.1 Publication

Miscellaneous

This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame.By similarity
The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi793MagnesiumBy similarity1
Metal bindingi943MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1105GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi786 – 794GTPBy similarity9
Nucleotide bindingi936 – 943GTPBy similarity8
Nucleotide bindingi962 – 966GTPBy similarity5
Nucleotide bindingi1031 – 1034GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein
Extra large alphas protein
Short name:
XLalphas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GnasImported
Synonyms:Gnas1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95777 Gnas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice cells lacking XLas isoforms which are then transfected with these isoforms and a range of receptors demonstrate that the XLas isoforms are capable of functionally coupling to the same receptors as the Gnas isoforms including Adrb2, Crfr1, Pthr1 and Tshr.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002539851 – 1133Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasAdd BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei940ADP-ribosylarginine; by cholera toxinBy similarity1
Modified residuei1091PhosphoserineBy similarity1

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6R0H7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6R0H7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6R0H7

PeptideAtlas

More...
PeptideAtlasi
Q6R0H7

PRoteomics IDEntifications database

More...
PRIDEi
Q6R0H7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6R0H7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6R0H7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027523 Expressed in 324 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6R0H7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6R0H7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Interacts through its N-terminal region with ALEX which is produced from the same locus in a different open reading frame. This interaction may inhibit its adenylyl cyclase-stimulating activity (By similarity).

Interacts with MAGED2.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
199972, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q6R0H7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000079341

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6R0H7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini778 – 1133G-alphaPROSITE-ProRule annotationAdd BLAST356

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni781 – 794G1 motifPROSITE-ProRule annotationAdd BLAST14
Regioni935 – 943G2 motifPROSITE-ProRule annotation9
Regioni958 – 967G3 motifPROSITE-ProRule annotation10
Regioni1027 – 1034G4 motifPROSITE-ProRule annotation8
Regioni1103 – 1108G5 motifPROSITE-ProRule annotation6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili737 – 761Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 303Pro-richSequence analysisAdd BLAST285
Compositional biasi450 – 619Ala-richSequence analysisAdd BLAST170

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-alpha family. G(s) subfamily.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0099 Eukaryota
ENOG410XPC4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156300

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6R0H7

Database of Orthologous Groups

More...
OrthoDBi
754573at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6R0H7

TreeFam database of animal gene trees

More...
TreeFami
TF300673

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00066 G-alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10218 PTHR10218, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00503 G-alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00318 GPROTEINA
PR00443 GPROTEINAS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00275 G_alpha, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51882 G_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform XLas-1 (identifier: Q6R0H7-1) [UniParc]FASTAAdd to basket
Also known as: XXL1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGMFNCLHGN NMSGQHDIPP EVGEQPEQEP LEAPGAAAPG AGAGPAEEMA
60 70 80 90 100
TEPDSEPSNN EPVPDETGSE ISGPPEDSKS DIQSPCQAFE EVRVGGDYSP
110 120 130 140 150
PPEEAMPFET QQPSLGDFWP TLEQPGPSGT PSGLQAFNPA ILEPGTPTGA
160 170 180 190 200
SPGLGAYTPP PEEAMPFEFN EPAQGDHSQP PLQVPDLAPG GPEALVPRAL
210 220 230 240 250
PAEPGNIRFE NAGFREDYSP PPEESVPFQV GGEEFGGDSP PPGLPRVIPQ
260 270 280 290 300
IGIGGEFPTV AVPSALCLAP AENAPPLWVR GAIDRPFREA VRSPPNFACD
310 320 330 340 350
SPPMEITRPL LEIGRASIGV DDDTAVNMDS PPIASDGPPI EVSGAPDKSE
360 370 380 390 400
CAERPPVERE AAEMEGSPTT ATAVEGKVPS PERGDGSSTQ PEAMDAKPAP
410 420 430 440 450
AAQAVSTGSD AGAPTDSAML TDSQSDAGED GTAPGTPSDL QSDPEELEEA
460 470 480 490 500
PAVRADPDGG AAPVAPATPA ESESEGSRDP AAEPASEAVP ATTAESASGA
510 520 530 540 550
APVTQVEPAA AAVSATLAEP AARAAPITPK EPTTRAVPSA RAHPAAGAVP
560 570 580 590 600
GAPAMSASAR AAAARAAYAG PLVWGARSLS ATPAARASLP ARAAAAARAA
610 620 630 640 650
SAARAVAAGR SASAAPSRAH LRPPSPEIQV ADPPTPRPPP RPTAWPDKYE
660 670 680 690 700
RGRSCCRYEA SSGICEIESS SDESEEGATG CFQWLLRRNR RPGLPRSHTV
710 720 730 740 750
GSNPVRNFFT RAFGSCFGLS ECTRSRSLSP GKAKDPMEER RKQMRKEAIE
760 770 780 790 800
MREQKRADKK RSKLIDKQLE EEKMDYMCTH RLLLLGAGES GKSTIVKQMR
810 820 830 840 850
ILHVNGFNGE GGEEDPQAAR SNSDGEKATK VQDIKNNLKE AIETIVAAMS
860 870 880 890 900
NLVPPVELAN PENQFRVDYI LSVMNVPNFD FPPEFYEHAK ALWEDEGVRA
910 920 930 940 950
CYERSNEYQL IDCAQYFLDK IDVIKQADYV PSDQDLLRCR VLTSGIFETK
960 970 980 990 1000
FQVDKVNFHM FDVGGQRDER RKWIQCFNDV TAIIFVVASS SYNMVIREDN
1010 1020 1030 1040 1050
QTNRLQEALN LFKSIWNNRW LRTISVILFL NKQDLLAEKV LAGKSKIEDY
1060 1070 1080 1090 1100
FPEFARYTTP EDATPEPGED PRVTRAKYFI RDEFLRISTA SGDGRHYCYP
1110 1120 1130
HFTCAVDTEN IRRVFNDCRD IIQRMHLRQY ELL
Length:1,133
Mass (Da):121,505
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1497D45498172F7
GO
Isoform XLas-2 (identifier: Q6R0H7-2) [UniParc]FASTAAdd to basket
Also known as: XXLb11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     787-876: AGESGKSTIV...VDYILSVMNV → RKVVPSDTEG...WCPFSVFACA
     877-1133: Missing.

Show »
Length:876
Mass (Da):91,094
Checksum:iA5C9C8616F7D5655
GO
Isoform XLas-3 (identifier: Q6R0H7-3) [UniParc]FASTAAdd to basket
Also known as: XXLb21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     787-827: AGESGKSTIV...AARSNSDGEK → RKVVPSDTEG...VLESLAKAPL
     828-1133: Missing.

Show »
Length:827
Mass (Da):85,918
Checksum:i212C34DCA37D0D07
GO
Isoform XLas-4 (identifier: Q6R0H7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-825: EGGEEDPQAARSNSDG → DS

Show »
Length:1,119
Mass (Da):120,107
Checksum:i7CE085576EBF061E
GO
Isoform Gnas-1Curated (identifier: P63094-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P63094.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:394
Mass (Da):45,664
GO
Isoform Gnas-2Curated (identifier: P63094-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P63094.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:380
Mass (Da):44,265
GO
Isoform Gnas-3Curated (identifier: P63094-3) [UniParc]FASTAAdd to basket
Also known as: NTasCurated
The sequence of this isoform can be found in the external entry P63094.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:362
Mass (Da):41,818
GO
Isoform Nesp55-1Curated (identifier: Q9Z0F1-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9Z0F1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares no sequence similarity with other isoforms (except isoform Nesp55-2) due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.
Length:257
Mass (Da):29,301
GO
Isoform Nesp55-2Curated (identifier: Q9Z0F1-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9Z0F1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares no sequence similarity with other isoforms (except isoform Nesp55-1) due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.
Length:253
Mass (Da):28,930
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6R0H6ALEX_MOUSE
Protein ALEX
Gnas Gnas1
725Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YKV1Z4YKV1_MOUSE
Guanine nucleotide-binding protein ...
Gnas
379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A610A2A610_MOUSE
Guanine nucleotide-binding protein ...
Gnas
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BE38A0A571BE38_MOUSE
Guanine nucleotide-binding protein ...
Gnas
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PW70A6PW70_MOUSE
Guanine nucleotide-binding protein ...
Gnas
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEI3A0A571BEI3_MOUSE
Guanine nucleotide-binding protein ...
Gnas mCG_126326
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BE25A0A571BE25_MOUSE
Guanine nucleotide-binding protein ...
Gnas
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEG2A0A571BEG2_MOUSE
Guanine nucleotide-binding protein ...
Gnas
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BDL4A0A571BDL4_MOUSE
Guanine nucleotide-binding protein ...
Gnas
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEM2A0A571BEM2_MOUSE
Guanine nucleotide-binding protein ...
Gnas
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD14686 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB83219 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti371A → G in CAB83219 (PubMed:10931851).Curated1
Sequence conflicti381P → S in CAB83219 (PubMed:10931851).Curated1
Sequence conflicti578 – 591SLSAT…ASLPA → YSRYSQLLPPLGHPFLPR (PubMed:10749992).CuratedAdd BLAST14
Sequence conflicti595 – 596Missing (PubMed:10749992).Curated2
Sequence conflicti599A → Q (PubMed:10749992).Curated1
Sequence conflicti613 – 617SAAPS → LPPH (PubMed:10749992).Curated5
Sequence conflicti622 – 628RPPSPEI → DPQPRD (PubMed:10749992).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052176787 – 876AGESG…SVMNV → RKVVPSDTEGRYRPEASASA SDRRLDRRGREVSPELLGWA LRGSPGSIVRDRGGLGPSGC APPPRLARLLRLRQLVVGVC WCPFSVFACA in isoform XLas-2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_052177787 – 827AGESG…SDGEK → RKVVPSDTEGRYRPEASASA SDRRLDRRGREVLESLAKAP L in isoform XLas-3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_052178810 – 825EGGEE…SNSDG → DS in isoform XLas-4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_052179828 – 1133Missing in isoform XLas-3. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_052180877 – 1133Missing in isoform XLas-2. 1 PublicationAdd BLAST257

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY518305 Genomic DNA Translation: AAR99380.1
AY518306 Genomic DNA Translation: AAR99381.1
AY518307 Genomic DNA Translation: AAR99382.1
AY518308 Genomic DNA Translation: AAR99383.1
AY519501 mRNA Translation: AAS00601.1
AY519503 mRNA Translation: AAS00603.1
AY519504 mRNA Translation: AAS00604.1
AL593857 Genomic DNA No translation available.
AJ251761 Genomic DNA Translation: CAB83219.1 Different initiation.
AF116268 mRNA Translation: AAD14686.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17151.1 [Q6R0H7-1]
CCDS38354.1 [Q6R0H7-4]
CCDS38355.1 [Q6R0H7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001070975.1, NM_001077507.2 [Q6R0H7-4]
NP_001297014.1, NM_001310085.1 [Q6R0H7-3]
NP_034439.2, NM_010309.4 [Q6R0H7-1]
NP_963911.1, NM_201617.2 [Q6R0H7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000080493; ENSMUSP00000079341; ENSMUSG00000027523 [Q6R0H7-1]
ENSMUST00000087876; ENSMUSP00000085184; ENSMUSG00000027523 [Q6R0H7-4]
ENSMUST00000087877; ENSMUSP00000085185; ENSMUSG00000027523 [Q6R0H7-2]
ENSMUST00000154658; ENSMUSP00000158758; ENSMUSG00000027523 [Q6R0H7-3]
ENSMUST00000185956; ENSMUSP00000140174; ENSMUSG00000027523 [Q6R0H7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14683

UCSC genome browser

More...
UCSCi
uc008oet.1 mouse [Q6R0H7-2]
uc033hrq.1 mouse [Q6R0H7-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518305 Genomic DNA Translation: AAR99380.1
AY518306 Genomic DNA Translation: AAR99381.1
AY518307 Genomic DNA Translation: AAR99382.1
AY518308 Genomic DNA Translation: AAR99383.1
AY519501 mRNA Translation: AAS00601.1
AY519503 mRNA Translation: AAS00603.1
AY519504 mRNA Translation: AAS00604.1
AL593857 Genomic DNA No translation available.
AJ251761 Genomic DNA Translation: CAB83219.1 Different initiation.
AF116268 mRNA Translation: AAD14686.1 Different initiation.
CCDSiCCDS17151.1 [Q6R0H7-1]
CCDS38354.1 [Q6R0H7-4]
CCDS38355.1 [Q6R0H7-2]
RefSeqiNP_001070975.1, NM_001077507.2 [Q6R0H7-4]
NP_001297014.1, NM_001310085.1 [Q6R0H7-3]
NP_034439.2, NM_010309.4 [Q6R0H7-1]
NP_963911.1, NM_201617.2 [Q6R0H7-2]

3D structure databases

SMRiQ6R0H7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi199972, 8 interactors
IntActiQ6R0H7, 1 interactor
STRINGi10090.ENSMUSP00000079341

PTM databases

iPTMnetiQ6R0H7
SwissPalmiQ6R0H7

Proteomic databases

EPDiQ6R0H7
jPOSTiQ6R0H7
PaxDbiQ6R0H7
PeptideAtlasiQ6R0H7
PRIDEiQ6R0H7

Genome annotation databases

EnsembliENSMUST00000080493; ENSMUSP00000079341; ENSMUSG00000027523 [Q6R0H7-1]
ENSMUST00000087876; ENSMUSP00000085184; ENSMUSG00000027523 [Q6R0H7-4]
ENSMUST00000087877; ENSMUSP00000085185; ENSMUSG00000027523 [Q6R0H7-2]
ENSMUST00000154658; ENSMUSP00000158758; ENSMUSG00000027523 [Q6R0H7-3]
ENSMUST00000185956; ENSMUSP00000140174; ENSMUSG00000027523 [Q6R0H7-1]
GeneIDi14683
UCSCiuc008oet.1 mouse [Q6R0H7-2]
uc033hrq.1 mouse [Q6R0H7-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2778
MGIiMGI:95777 Gnas

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00940000156300
InParanoidiQ6R0H7
OrthoDBi754573at2759
PhylomeDBiQ6R0H7
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gnas mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027523 Expressed in 324 organ(s), highest expression level in brain
ExpressionAtlasiQ6R0H7 baseline and differential
GenevisibleiQ6R0H7 MM

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51882 G_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNAS1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6R0H7
Secondary accession number(s): A2A607
, A2A608, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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