BLOC1S2

Functionⁱ

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421).By similarity4 Publications

GO - Molecular functionⁱ

gamma-tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15381421
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18329849

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterograde axonal transport Source: UniProtKB
anterograde synaptic vesicle transport Source: UniProtKB
endosomal transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
extrinsic apoptotic signaling pathway via death domain receptors
Source: UniProtKB
Inferred from direct assayⁱ
- 18188704
lysosome localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25898167
melanosome organization
Source: UniProtKB
Non-traceable author statementⁱ
- 15102850
- 22203680
microtubule nucleation
Source: UniProtKB
Non-traceable author statementⁱ
- 15381421
mitochondrial outer membrane permeabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 18188704
neuron projection development Source: UniProtKB
platelet dense granule organization
Source: UniProtKB
Non-traceable author statementⁱ
- 15102850
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 15381421
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18329849

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Biogenesis of lysosome-related organelles complex 1 subunit 2 Short name: BLOC-1 subunit 2 Alternative name(s): Centrosome-associated protein
Gene namesⁱ	Name:BLOC1S2 Synonyms:BLOS2, CEAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196072.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20984 BLOC1S2
MIMⁱ	609768 gene
neXtProtⁱ	NX_Q6QNY1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	282991
Open Targets More...OpenTargetsⁱ	ENSG00000196072
PharmGKBⁱ	PA134936108

Polymorphism and mutation databases

BioMutaⁱ	BLOC1S2
DMDMⁱ	74749300

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000234543	2 – 142	Biogenesis of lysosome-related organelles complex 1 subunit 2Add BLAST		141

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q6QNY1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6QNY1
PaxDbⁱ	Q6QNY1
PeptideAtlas More...PeptideAtlasⁱ	Q6QNY1
PRIDEⁱ	Q6QNY1
ProteomicsDBⁱ	67307 67308 [Q6QNY1-2]
TopDownProteomicsⁱ	Q6QNY1-1 [Q6QNY1-1] Q6QNY1-2 [Q6QNY1-2]

PTM databases

iPTMnetⁱ	Q6QNY1
PhosphoSitePlusⁱ	Q6QNY1

Expressionⁱ

Tissue specificityⁱ

Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000196072 Expressed in 202 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_BLOC1S2
ExpressionAtlasⁱ	Q6QNY1 baseline and differential
Genevisibleⁱ	Q6QNY1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048088 HPA055010

HPAⁱ

HPA048088
HPA055010

Interactionⁱ

Subunit structureⁱ

Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN (PubMed:15102850, PubMed:22203680). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (By similarity). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Interacts with gamma-tubulin (PubMed:15381421). Interacts with IFT57 (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BLOC1S1	P78537	3	EBI-465872,EBI-348630
BLOC1S3	Q6QNY0	3	EBI-465872,EBI-465930
BLOC1S5	Q8TDH9	2	EBI-465872,EBI-465861
BLOC1S6	Q9UL45	3	EBI-465872,EBI-465781
DTNBP1	Q96EV8	6	EBI-465872,EBI-465804
FAM9B	Q8IZU0	3	EBI-465872,EBI-10175124
IFT57	Q9NWB7	3	EBI-465872,EBI-725672
SNAPIN	O95295	9	EBI-465872,EBI-296723

GO - Molecular functionⁱ

gamma-tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15381421
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18329849

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	129431, 38 interactors
ComplexPortalⁱ	CPX-1910 BLOC-1 complex CPX-1912 BLOC1S2-SNAPN-DTBP1
CORUMⁱ	Q6QNY1
IntActⁱ	Q6QNY1, 36 interactors
Molecular INTeraction database More...MINTⁱ	Q6QNY1
STRINGⁱ	9606.ENSP00000359398

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6QNY1
SMRⁱ	Q6QNY1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	79 – 127	Sequence analysisAdd BLAST		49

Sequence similaritiesⁱ

Belongs to the BLOC1S2 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4559 Eukaryota ENOG4111XFP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005889
HOGENOMⁱ	HOG000111279
HOVERGENⁱ	HBG079627
InParanoidⁱ	Q6QNY1
KEGG Orthology (KO) More...KOⁱ	K16750
OMAⁱ	KYKDMRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0V5M
PhylomeDBⁱ	Q6QNY1
TreeFamⁱ	TF313861

Family and domain databases

InterProⁱ	View protein in InterPro IPR019269 BLOC1_su2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10046 BLOC1_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6QNY1-1) [UniParc]FASTA Add to basket

Also known as: Ceap-16

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAEGVLA TRSDEPARDD AAVETAEEAK EPAEADITEL CRDMFSKMAT 
        60         70         80         90        100
YLTGELTATS EDYKLLENMN KLTSLKYLEM KDIAINISRN LKDLNQKYAG 
       110        120        130        140 
LQPYLDQINV IEEQVAALEQ AAYKLDAYSK KLEAKYKKLE KR

Length:142

Mass (Da):15,961

Last modified:July 5, 2004 - v1

Checksum:ⁱ023DDBAC66E1912B

GO

Isoform 2 (identifier: Q6QNY1-2) [UniParc]FASTA Add to basket

Also known as: Ceap-11

The sequence of this isoform differs from the canonical sequence as follows:
1-43: Missing.

« Hide

        10         20         30         40         50
MFSKMATYLT GELTATSEDY KLLENMNKLT SLKYLEMKDI AINISRNLKD 
        60         70         80         90 
LNQKYAGLQP YLDQINVIEE QVAALEQAAY KLDAYSKKLE AKYKKLEKR

Show »

Length:99

Mass (Da):11,489

Checksum:ⁱ9F88B6AF46B7FCDA

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X1N6	A0A087X1N6_HUMAN	Biogenesis of lysosome-related orga... Biogenesis of lysosome-related organelles complex 1 subunit 2 (Biogenesis of lysosome-related organelles complex-1, subunit 2, isoform CRA_c)	BLOC1S2 hCG_19416	95	Annotation score:
J3QRU7	J3QRU7_HUMAN	Biogenesis of lysosome-related orga... Biogenesis of lysosome-related organelles complex 1 subunit 2	BLOC1S2	117	Annotation score:

Sequence cautionⁱ

The sequence AAH20494 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_054068	13	S → R. Corresponds to variant dbSNP:rs33965491Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018350	1 – 43	Missing in isoform 2. 1 PublicationAdd BLAST		43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY531265 mRNA Translation: AAT00461.1 AY278457 mRNA Translation: AAQ19606.1 AK298969 mRNA Translation: BAG61064.1 AL138921 Genomic DNA No translation available. AL139819 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49836.1 BC020494 mRNA Translation: AAH20494.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7490.1 [Q6QNY1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001001342.1, NM_001001342.2 [Q6QNY1-2] NP_001269366.1, NM_001282437.1 [Q6QNY1-2] NP_001269367.1, NM_001282438.1 [Q6QNY1-2] NP_776170.2, NM_173809.4 [Q6QNY1-1]
UniGeneⁱ	Hs.34906 Hs.715064

Genome annotation databases

Ensemblⁱ	ENST00000370372; ENSP00000359398; ENSG00000196072 [Q6QNY1-1] ENST00000441611; ENSP00000410865; ENSG00000196072 [Q6QNY1-2] ENST00000614731; ENSP00000481847; ENSG00000196072 [Q6QNY1-2]
GeneIDⁱ	282991
KEGGⁱ	hsa:282991
UCSC genome browser More...UCSCⁱ	uc001kqv.4 human [Q6QNY1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6QNY1	Biogenesis of lysosome-related organelles complex 1 subunit 2		HUMAN		142	UniRef100_Q6QNY1
Q6QNY1-2	BLOC1S2 isoform 3		PANTR		99	UniRef100_A0A2J8PDE3
BLOC1S2 isoform 1		PONAB		99
Biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1		MACMU		99
Uncharacterized protein		CERAT		99
Uncharacterized protein		PANPA		99
+4

Protein	Similar proteins		Species	Score	Length	Source
Q6QNY1	Biogenesis of lysosome-related organelles complex 1 subunit 2		MACFA		142	UniRef90_Q6QNY1
Biogenesis of lysosome-related organelles complex-1 subunit 2		RAT		142
Biogenesis of lysosome-related organelles complex 1 subunit 2		HUMAN		142
Biogenesis of lysosomal organelles complex 1 subunit 2		MACMU		142
Uncharacterized protein		MACNE		142
+40
Q6QNY1-2	Biogenesis of lysosome-related organelles complex-1 subunit 2		PTEAL		144	UniRef90_L5JNA3
Biogenesis of lysosome-related organelles complex 1 subunit 2		MYODS		160
Biogenesis of lysosomal organelles complex 1 subunit 2		CALJA		140
BLOC1S2 isoform 3		PANTR		99
BLOC1S2 isoform 1		PONAB		99
+13

Protein	Similar proteins		Species	Score	Length	Source
Q6QNY1	Biogenesis of lysosome-related organelles complex-1 subunit 2		RAT		142	UniRef50_Q6QNY1
Biogenesis of lysosome-related organelles complex 1 subunit 2		MACFA		142
Biogenesis of lysosome-related organelles complex 1 subunit 2		MOUSE		143
Biogenesis of lysosome-related organelles complex 1 subunit 2		HUMAN		142
biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X1		ERIEU		142
+178
Q6QNY1-2	Biogenesis of lysosomal organelles complex 1 subunit 2		TAEGU		124	UniRef50_H0ZBN4
Biogenesis of lysosomal organelles complex 1 subunit 2		HORSE		155
biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X1		ODORO		155
biogenesis of lysosome-related organelles complex-1 subunit 2 isoform X1		LEPWE		149
Uncharacterized protein		MACFA		130
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY531265 mRNA Translation: AAT00461.1 AY278457 mRNA Translation: AAQ19606.1 AK298969 mRNA Translation: BAG61064.1 AL138921 Genomic DNA No translation available. AL139819 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49836.1 BC020494 mRNA Translation: AAH20494.1 Different initiation.
CCDSⁱ	CCDS7490.1 [Q6QNY1-1]
RefSeqⁱ	NP_001001342.1, NM_001001342.2 [Q6QNY1-2] NP_001269366.1, NM_001282437.1 [Q6QNY1-2] NP_001269367.1, NM_001282438.1 [Q6QNY1-2] NP_776170.2, NM_173809.4 [Q6QNY1-1]
UniGeneⁱ	Hs.34906 Hs.715064

3D structure databases

ProteinModelPortalⁱ	Q6QNY1
SMRⁱ	Q6QNY1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129431, 38 interactors
ComplexPortalⁱ	CPX-1910 BLOC-1 complex CPX-1912 BLOC1S2-SNAPN-DTBP1
CORUMⁱ	Q6QNY1
IntActⁱ	Q6QNY1, 36 interactors
MINTⁱ	Q6QNY1
STRINGⁱ	9606.ENSP00000359398

PTM databases

iPTMnetⁱ	Q6QNY1
PhosphoSitePlusⁱ	Q6QNY1

Polymorphism and mutation databases

BioMutaⁱ	BLOC1S2
DMDMⁱ	74749300

Proteomic databases

EPDⁱ	Q6QNY1
MaxQBⁱ	Q6QNY1
PaxDbⁱ	Q6QNY1
PeptideAtlasⁱ	Q6QNY1
PRIDEⁱ	Q6QNY1
ProteomicsDBⁱ	67307 67308 [Q6QNY1-2]
TopDownProteomicsⁱ	Q6QNY1-1 [Q6QNY1-1] Q6QNY1-2 [Q6QNY1-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370372; ENSP00000359398; ENSG00000196072 [Q6QNY1-1] ENST00000441611; ENSP00000410865; ENSG00000196072 [Q6QNY1-2] ENST00000614731; ENSP00000481847; ENSG00000196072 [Q6QNY1-2]
GeneIDⁱ	282991
KEGGⁱ	hsa:282991
UCSCⁱ	uc001kqv.4 human [Q6QNY1-1]

Organism-specific databases

CTDⁱ	282991
DisGeNETⁱ	282991
EuPathDBⁱ	HostDB:ENSG00000196072.11
GeneCardsⁱ	BLOC1S2
HGNCⁱ	HGNC:20984 BLOC1S2
HPAⁱ	HPA048088 HPA055010
MIMⁱ	609768 gene
neXtProtⁱ	NX_Q6QNY1
OpenTargetsⁱ	ENSG00000196072
PharmGKBⁱ	PA134936108
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4559 Eukaryota ENOG4111XFP LUCA
GeneTreeⁱ	ENSGT00390000005889
HOGENOMⁱ	HOG000111279
HOVERGENⁱ	HBG079627
InParanoidⁱ	Q6QNY1
KOⁱ	K16750
OMAⁱ	KYKDMRQ
OrthoDBⁱ	EOG091G0V5M
PhylomeDBⁱ	Q6QNY1
TreeFamⁱ	TF313861

Miscellaneous databases

ChiTaRSⁱ	BLOC1S2 human
GeneWikiⁱ	BLOC1S2
GenomeRNAiⁱ	282991
Protein Ontology More...PROⁱ	PR:Q6QNY1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196072 Expressed in 202 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_BLOC1S2
ExpressionAtlasⁱ	Q6QNY1 baseline and differential
Genevisibleⁱ	Q6QNY1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019269 BLOC1_su2
Pfamⁱ	View protein in Pfam PF10046 BLOC1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BL1S2_HUMAN
Accessionⁱ	Q6QNY1Primary (citable) accession number: Q6QNY1 Secondary accession number(s): B4DQV2, Q5W040, Q8WUI8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q6QNY1 (BL1S2_HUMAN)

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Biogenesis of lysosome-related organelles complex 1 subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Lysosome

Cytoskeleton

Cytosol

Lysosome

Mitochondrion

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ