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Entry version 130 (25 May 2022)
Sequence version 1 (05 Jul 2004)
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Protein

Toll-like receptor 12

Gene

Tlr12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system.

1 Publication

Caution

There is some confusion regarding the nomenclature of this gene. In the literature, Tlr12 is frequently referred to as Tlr11 and vice-versa.1 Publication
In some plant proteins and in human SARM1, the TIR domain has NAD+ hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.By similarityCurated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 121 Publication
Alternative name(s):
Toll-like receptor 111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tlr121 PublicationImported
Synonyms:Gm1365Imported, Tlr111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045221, Tlr12

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000062545

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 709ExtracellularSequence analysisAdd BLAST688
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 906CytoplasmicSequence analysisAdd BLAST176

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Has increased susceptibility to the uropathogenic E.coli strain 8NU. Following infection, kidneys show a significantly increased bacterial load and increased inflammatory response, whereas bladder shows a similar response to wild type.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi804P → H: Fails to activate NF-kappa-B. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004279422 – 906Toll-like receptor 12Add BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6QNU9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6QNU9

PRoteomics IDEntifications database

More...
PRIDEi
Q6QNU9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
258892

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6QNU9, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6QNU9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6QNU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Macrophages, liver, kidney and bladder epithelial cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000062545, Expressed in proximal tubule and 76 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6QNU9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6QNU9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds MYD88 via their respective TIR domains.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000074381

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6QNU9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q6QNU9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6QNU9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati91 – 114LRR 1Add BLAST24
Repeati115 – 140LRR 2Add BLAST26
Repeati142 – 170LRR 3Add BLAST29
Repeati198 – 222LRR 4Add BLAST25
Repeati224 – 247LRR 5Add BLAST24
Repeati267 – 290LRR 6Add BLAST24
Repeati291 – 314LRR 7Add BLAST24
Repeati316 – 338LRR 8Add BLAST23
Repeati341 – 364LRR 9Add BLAST24
Repeati366 – 388LRR 10Add BLAST23
Repeati389 – 412LRR 11Add BLAST24
Repeati414 – 436LRR 12Add BLAST23
Repeati462 – 484LRR 13Add BLAST23
Repeati485 – 508LRR 14Add BLAST24
Repeati510 – 533LRR 15Add BLAST24
Repeati562 – 586LRR 16Add BLAST25
Repeati591 – 614LRR 17Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini759 – 905TIRPROSITE-ProRule annotationAdd BLAST147

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165464

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_318753_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6QNU9

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEMILAM

Database of Orthologous Groups

More...
OrthoDBi
282372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6QNU9

TreeFam database of animal gene trees

More...
TreeFami
TF351113

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR017241, Toll-like_receptor
IPR035897, Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24365, PTHR24365, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 2 hits
PF13676, TIR_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 7 hits
SM00255, TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 7 hits
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6QNU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRYWLLPGL LLSLPLVTGW STSNCLVTEG SRLPLVSRYF TFCRHSKLSF
60 70 80 90 100
LAACLSVSNL TQTLEVVPRT VEGLCLGGTV STLLPDAFSA FPGLKVLALS
110 120 130 140 150
LHLTQLLPGA LRGLGQLQSL SFFDSPLRRS LFLPPDAFSD LISLQRLHIS
160 170 180 190 200
GPCLDKKAGI RLPPGLQWLG VTLSCIQDVG ELAGMFPDLV QGSSSRVSWT
210 220 230 240 250
LQKLDLSSNW KLKMASPGSL QGLQVEILDL TRTPLDAVWL KGLGLQKLDV
260 270 280 290 300
LYAQTATAEL AAEAVAHFEL QGLIVKESKI GSISQEALAS CHSLKTLGLS
310 320 330 340 350
STGLTKLPPG FLTAMPRLQR LELSGNQLQS AVLCMNETGD VSGLTTLDLS
360 370 380 390 400
GNRLRILPPA AFSCLPHLRE LLLRYNQLLS LEGYLFQELQ QLETLKLDGN
410 420 430 440 450
PLLHLGKNWL AALPALTTLS LLDTQIRMSP EPGFWGAKNL HTLSLKLPAL
460 470 480 490 500
PAPAVLFLPM YLTSLELHIA SGTTEHWTLS PAIFPSLETL TISGGGLKLK
510 520 530 540 550
LGSQNASGVF PALQKLSLLK NSLDAFCSQG TSNLFLWQLP KLQSLRVWGA
560 570 580 590 600
GNSSRPCLIT GLPSLRELKL ASLQSITQPR SVQLEELVGD LPQLQALVLS
610 620 630 640 650
STGLKSLSAA AFQRLHSLQV LVLEYEKDLM LQDSLREYSP QMPHYIYILE
660 670 680 690 700
SNLACHCANA WMEPWVKRST KTYIYIRDNR LCPGQDRLSA RGSLPSFLWD
710 720 730 740 750
HCPQTLELKL FLASSALVFM LIALPLLQEA RNSWIPYLQA LFRVWLQGLR
760 770 780 790 800
GKGDKGKRFL FDVFVSHCRQ DQGWVIEELL PALEGFLPAG LGLRLCLPER
810 820 830 840 850
DFEPGKDVVD NVVDSMLSSR TTLCVLSGQA LCNPRCRLEL RLATSLLLAA
860 870 880 890 900
PSPPVLLLVF LEPISRHQLP GYHRLARLLR RGDYCLWPEE EERKSGFWTW

LRSRLG
Length:906
Mass (Da):99,945
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D6372CCB42DFA14
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY531552 mRNA Translation: AAS83531.1
AY510705 mRNA Translation: AAS37673.1
AK137624 mRNA Translation: BAE23434.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18673.1

NCBI Reference Sequences

More...
RefSeqi
NP_991392.1, NM_205823.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
384059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:384059

UCSC genome browser

More...
UCSCi
uc008uvf.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531552 mRNA Translation: AAS83531.1
AY510705 mRNA Translation: AAS37673.1
AK137624 mRNA Translation: BAE23434.1
CCDSiCCDS18673.1
RefSeqiNP_991392.1, NM_205823.2

3D structure databases

AlphaFoldDBiQ6QNU9
SMRiQ6QNU9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074381

PTM databases

GlyGeniQ6QNU9, 4 sites
iPTMnetiQ6QNU9
PhosphoSitePlusiQ6QNU9

Proteomic databases

MaxQBiQ6QNU9
PaxDbiQ6QNU9
PRIDEiQ6QNU9
ProteomicsDBi258892

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
384059

Genome annotation databases

EnsembliENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545
GeneIDi384059
KEGGimmu:384059
UCSCiuc008uvf.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
384059
MGIiMGI:3045221, Tlr12
VEuPathDBiHostDB:ENSMUSG00000062545

Phylogenomic databases

eggNOGiKOG4641, Eukaryota
GeneTreeiENSGT00940000165464
HOGENOMiCLU_318753_0_0_1
InParanoidiQ6QNU9
OMAiNEMILAM
OrthoDBi282372at2759
PhylomeDBiQ6QNU9
TreeFamiTF351113

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
384059, 1 hit in 72 CRISPR screens

Protein Ontology

More...
PROi
PR:Q6QNU9
RNActiQ6QNU9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000062545, Expressed in proximal tubule and 76 other tissues
ExpressionAtlasiQ6QNU9, baseline and differential
GenevisibleiQ6QNU9, MM

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR017241, Toll-like_receptor
IPR035897, Toll_tir_struct_dom_sf
PANTHERiPTHR24365, PTHR24365, 1 hit
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF13676, TIR_2, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 7 hits
SM00255, TIR, 1 hit
SUPFAMiSSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 7 hits
PS50104, TIR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR12_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6QNU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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