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Protein

C-type lectin domain family 7 member A

Gene

Clec7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.8 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi156Divalent metal cation1
Metal bindingi158Divalent metal cation1
Metal bindingi162Divalent metal cation1
Metal bindingi241Divalent metal cation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity
LigandLectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5607764 CLEC7A (Dectin-1) signaling

Protein family/group databases

UniLectiniQ6QLQ4

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 7 member A
Alternative name(s):
Beta-glucan receptor
C-type lectin superfamily member 12
Dendritic cell-associated C-type lectin 1
Short name:
DC-associated C-type lectin 1
Short name:
Dectin-1
CD_antigen: CD369
Gene namesi
Name:Clec7a
Synonyms:Bgr, Clecsf12, Dectin1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1861431 Clec7a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini71 – 244ExtracellularSequence analysisAdd BLAST174

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi221W → A: Loss of glucan binding. Abolishes activation of NF-kappa-B. 1 Publication1
Mutagenesisi223H → A: Loss of glucan binding. Abolishes activation of NF-kappa-B. 1 Publication1
Mutagenesisi232C → A: Abolishes cell surface expression. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2034809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002694931 – 244C-type lectin domain family 7 member AAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 130PROSITE-ProRule annotation1 Publication
Disulfide bondi147 ↔ 240PROSITE-ProRule annotation1 Publication
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi219 ↔ 232PROSITE-ProRule annotation1 Publication
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated on tyrosine residues in response to glucan binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6QLQ4
PRIDEiQ6QLQ4

PTM databases

iPTMnetiQ6QLQ4
PhosphoSitePlusiQ6QLQ4

Expressioni

Tissue specificityi

Detected in spleen (at protein level). Highly expressed in dendritic cells, spleen and thymus. Detected in epidermal Langerhans cells. Detected in macrophages, liver and lung.3 Publications

Gene expression databases

BgeeiENSMUSG00000079293 Expressed in 142 organ(s), highest expression level in bone marrow
CleanExiMM_CLEC7A
ExpressionAtlasiQ6QLQ4 baseline and differential
GenevisibleiQ6QLQ4 MM

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens.Curated2 Publications

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6QLQ4
SMRiQ6QLQ4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6QLQ4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 241C-type lectinPROSITE-ProRule annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi15 – 18ITAM-like4

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000104266
HOGENOMiHOG000220926
HOVERGENiHBG105854
InParanoidiQ6QLQ4
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6QLQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYHSHIENL DEDGYTQLDF STQDIHKRPR GSEKGSQAPS SPWRPIAVGL
60 70 80 90 100
GILCFVVVVV AAVLGALGEY GHNSGRNPEE KDNFLSRNKE NHKPTESSLD
110 120 130 140 150
EKVAPSKASQ TTGGFSQPCL PNWIMHGKSC YLFSFSGNSW YGSKRHCSQL
160 170 180 190 200
GAHLLKIDNS KEFEFIESQT SSHRINAFWI GLSRNQSEGP WFWEDGSAFF
210 220 230 240
PNSFQVRNTA PQESLLHNCV WIHGSEVYNQ ICNTSSYSIC EKEL
Length:244
Mass (Da):27,420
Last modified:October 3, 2012 - v3
Checksum:iC9435DD135D2F122
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXI5V9GXI5_MOUSE
C-type lectin domain family 7 membe...
Clec7a
199Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → R in AAF72710 (PubMed:10779524).Curated1
Sequence conflicti37Q → R in AAS37670 (PubMed:11544516).Curated1
Sequence conflicti37Q → R in AAH27742 (PubMed:15489334).Curated1
Sequence conflicti68 – 71GEYG → AFWR in AAF72710 (PubMed:10779524).Curated4
Sequence conflicti68 – 71GEYG → AFWR in AAS37670 (PubMed:11544516).Curated4
Sequence conflicti68 – 71GEYG → AFWR in AAH27742 (PubMed:15489334).Curated4
Sequence conflicti83N → S in AAS37670 (PubMed:11544516).Curated1
Sequence conflicti85L → P in AAH27742 (PubMed:15489334).Curated1
Sequence conflicti118P → S in AAF72710 (PubMed:10779524).Curated1
Sequence conflicti118P → S in AAS37670 (PubMed:11544516).Curated1
Sequence conflicti124I → T in AAH27742 (PubMed:15489334).Curated1
Sequence conflicti174 – 176RIN → HIT in AAH27742 (PubMed:15489334).Curated3
Sequence conflicti209 – 210TA → AV in AAS37670 (PubMed:11544516).Curated2
Sequence conflicti210A → V in AAF72710 (PubMed:10779524).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262985 mRNA Translation: AAF72710.1
AY534909 mRNA Translation: AAS37670.1
AC138620 Genomic DNA No translation available.
BC027742 mRNA Translation: AAH27742.1
UniGeneiMm.239516

Genome annotation databases

EnsembliENSMUST00000112076; ENSMUSP00000107707; ENSMUSG00000079293

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mouse recombinant soluble Dectin-1 CTLD from insect cells origin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262985 mRNA Translation: AAF72710.1
AY534909 mRNA Translation: AAS37670.1
AC138620 Genomic DNA No translation available.
BC027742 mRNA Translation: AAH27742.1
UniGeneiMm.239516

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BPDX-ray1.50A/B113-244[»]
2BPEX-ray2.25A/B113-244[»]
2BPHX-ray2.20A/B113-244[»]
2CL8X-ray2.80A/B113-244[»]
ProteinModelPortaliQ6QLQ4
SMRiQ6QLQ4
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2034809

Protein family/group databases

UniLectiniQ6QLQ4

PTM databases

iPTMnetiQ6QLQ4
PhosphoSitePlusiQ6QLQ4

Proteomic databases

MaxQBiQ6QLQ4
PRIDEiQ6QLQ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112076; ENSMUSP00000107707; ENSMUSG00000079293

Organism-specific databases

MGIiMGI:1861431 Clec7a

Phylogenomic databases

GeneTreeiENSGT00700000104266
HOGENOMiHOG000220926
HOVERGENiHBG105854
InParanoidiQ6QLQ4
TreeFamiTF336674

Enzyme and pathway databases

ReactomeiR-MMU-5607764 CLEC7A (Dectin-1) signaling

Miscellaneous databases

EvolutionaryTraceiQ6QLQ4
PROiPR:Q6QLQ4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079293 Expressed in 142 organ(s), highest expression level in bone marrow
CleanExiMM_CLEC7A
ExpressionAtlasiQ6QLQ4 baseline and differential
GenevisibleiQ6QLQ4 MM

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC7A_MOUSE
AccessioniPrimary (citable) accession number: Q6QLQ4
Secondary accession number(s): E9QPW2, Q8K1L4, Q9JI50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 3, 2012
Last modified: October 10, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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