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Protein

Sodium channel protein type 10 subunit alpha

Gene

Scn10a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.1 Publication

Miscellaneous

Mus musculus is sensitive to the pain-inducing components of the bark scorpion (Centruroides sculpturatus) venom while Onychomys torridus is not. Gln-861 may account for the difference between both rodents and its replacement by a glutamate, the corresponding amino acid found in the Onychomys torridus ortholog, allows inhibition of Snc10a by the venom, which in turn, inhibits sodium currents, blocks action potential propagation and may induce analgesia (PubMed:24159039).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5576892 Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel protein type 10 subunit alpha
Alternative name(s):
Peripheral nerve sodium channel 3
Short name:
PN3
Sensory neuron sodium channel
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn10a
Synonyms:Sns
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108029 Scn10a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 125CytoplasmicCuratedAdd BLAST125
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei126 – 149Helical; Name=S1 of repeat ISequence analysisAdd BLAST24
Topological domaini150 – 154ExtracellularCurated5
Transmembranei155 – 174Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini175 – 187CytoplasmicCuratedAdd BLAST13
Transmembranei188 – 206Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini207 – 212ExtracellularCurated6
Transmembranei213 – 232Helical; Voltage-sensor; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini233 – 248CytoplasmicCuratedAdd BLAST16
Transmembranei249 – 272Helical; Name=S5 of repeat ISequence analysisAdd BLAST24
Topological domaini273 – 340ExtracellularCuratedAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei341 – 365Pore-formingBy similarityAdd BLAST25
Topological domaini366 – 372ExtracellularCurated7
Transmembranei373 – 398Helical; Name=S6 of repeat ISequence analysisAdd BLAST26
Topological domaini399 – 658CytoplasmicCuratedAdd BLAST260
Transmembranei659 – 683Helical; Name=S1 of repeat IISequence analysisAdd BLAST25
Topological domaini684 – 694ExtracellularCuratedAdd BLAST11
Transmembranei695 – 718Helical; Name=S2 of repeat IISequence analysisAdd BLAST24
Topological domaini719 – 726CytoplasmicCurated8
Transmembranei727 – 746Helical; Name=S3 of repeat IISequence analysisAdd BLAST20
Topological domaini747 – 752ExtracellularCurated6
Transmembranei753 – 772Helical; Voltage-sensor; Name=S4 of repeat IISequence analysisAdd BLAST20
Topological domaini773 – 788CytoplasmicCuratedAdd BLAST16
Transmembranei789 – 809Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini810 – 833ExtracellularCuratedAdd BLAST24
Intramembranei834 – 854Pore-formingBy similarityAdd BLAST21
Topological domaini855 – 863ExtracellularCurated9
Transmembranei864 – 889Helical; Name=S6 of repeat IISequence analysisAdd BLAST26
Topological domaini890 – 1148CytoplasmicCuratedAdd BLAST259
Transmembranei1149 – 1172Helical; Name=S1 of repeat IIISequence analysisAdd BLAST24
Topological domaini1173 – 1185ExtracellularCuratedAdd BLAST13
Transmembranei1186 – 1211Helical; Name=S2 of repeat IIISequence analysisAdd BLAST26
Topological domaini1212 – 1217CytoplasmicCurated6
Transmembranei1218 – 1239Helical; Name=S3 of repeat IIISequence analysisAdd BLAST22
Topological domaini1240 – 1243ExtracellularCurated4
Transmembranei1244 – 1265Helical; Voltage-sensor; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1266 – 1284CytoplasmicCuratedAdd BLAST19
Transmembranei1285 – 1312Helical; Name=S5 of repeat IIISequence analysisAdd BLAST28
Topological domaini1313 – 1354ExtracellularCuratedAdd BLAST42
Intramembranei1355 – 1376Pore-formingBy similarityAdd BLAST22
Topological domaini1377 – 1392ExtracellularCuratedAdd BLAST16
Transmembranei1393 – 1419Helical; Name=S6 of repeat IIISequence analysisAdd BLAST27
Topological domaini1420 – 1472CytoplasmicCuratedAdd BLAST53
Transmembranei1473 – 1496Helical; Name=S1 of repeat IVSequence analysisAdd BLAST24
Topological domaini1497 – 1507ExtracellularCuratedAdd BLAST11
Transmembranei1508 – 1531Helical; Name=S2 of repeat IVSequence analysisAdd BLAST24
Topological domaini1532 – 1537CytoplasmicCurated6
Transmembranei1538 – 1561Helical; Name=S3 of repeat IVSequence analysisAdd BLAST24
Topological domaini1562 – 1573ExtracellularCuratedAdd BLAST12
Transmembranei1574 – 1595Helical; Voltage-sensor; Name=S4 of repeat IVSequence analysisAdd BLAST22
Topological domaini1596 – 1610CytoplasmicCuratedAdd BLAST15
Transmembranei1611 – 1633Helical; Name=S5 of repeat IVSequence analysisAdd BLAST23
Topological domaini1634 – 1647ExtracellularCuratedAdd BLAST14
Intramembranei1648 – 1670Pore-formingBy similarityAdd BLAST23
Topological domaini1671 – 1698ExtracellularCuratedAdd BLAST28
Transmembranei1699 – 1723Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1724 – 1958CytoplasmicCuratedAdd BLAST235

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi861Q → E: Sensitive to inhibition by some components of the venom of Centruroides sculpturatus. 1 Publication1
Mutagenesisi1922Y → A: No regulation by NEDD4L. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5158

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485081 – 1958Sodium channel protein type 10 subunit alphaAdd BLAST1958

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi276 ↔ 318By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei440PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Disulfide bondi856 ↔ 865By similarity
Glycosylationi1323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1337N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1452Phosphoserine; by PKCBy similarity1
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1687N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by NEDD4L; which promotes its endocytosis.Curated
Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity
Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6QIY3

PRoteomics IDEntifications database

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PRIDEi
Q6QIY3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6QIY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6QIY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in dorsal root ganglion and trigeminal ganglion.

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_SCN10A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6QIY3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
203097, 3 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000081845

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6QIY3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6QIY3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati116 – 404ICuratedAdd BLAST289
Repeati646 – 910IICuratedAdd BLAST265
Repeati1141 – 1450IIICuratedAdd BLAST310
Repeati1459 – 1758IVCuratedAdd BLAST300
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1852 – 1881IQAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231755

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053100

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6QIY3

KEGG Orthology (KO)

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KOi
K04842

Identification of Orthologs from Complete Genome Data

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OMAi
DCIIVTV

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6QIY3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10037:SF208 PTHR10037:SF208, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6QIY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFPFGSVGT TNFRRFTPES LAEIEKQIAA HRAAKKGRPK QRGQKDKSEK
60 70 80 90 100
PRPQLDLKAC NQLPRFYGEL PAELVGEPLE DLDPFYSTHR TFIVLDKSRT
110 120 130 140 150
ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITVTI LVNCVCMTRT
160 170 180 190 200
DLPEKLEYAF TVVYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA
210 220 230 240 250
YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT
260 270 280 290 300
ILTVFCLSVF ALVGLQLFKG NLKNKCIKNG TDPHKADNLS SEMAGDIFIK
310 320 330 340 350
PGTTDPLLCG NGSDAGHCPN DYVCRKTSDN PDFNYTSFDS FAWAFLSLFR
360 370 380 390 400
LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE
410 420 430 440 450
EQSQATIAEI EAKEKKFKEA LEVLQKEQEV LAALGIDTTS LYSHNGSPLA
460 470 480 490 500
PKNANERRPR VKSRMSEGST DDNRSLQSDP YNQRRMSFLG LSSGRRRASH
510 520 530 540 550
SSVFHFRAPS QDVSFPDGIL DDGVFHGDQE SRRSSILLGR GAGQAGPLPR
560 570 580 590 600
SPLPQSPNPG PRRGEEGQRG VPTGELATGA PEGPALDAAG QKNFLSADYL
610 620 630 640 650
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISLAQK YLIWECCPKW
660 670 680 690 700
KKFKMVLFEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN
710 720 730 740 750
IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSTSKKGS
760 770 780 790 800
LSVLRTFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT FILAIIVFIF
810 820 830 840 850
ALVGKQLLSE NYGCRRDGIS VWNGERLRWH MCDFFHSFLV VFRILCGEWI
860 870 880 890 900
ENMWVCMEVS QDYICLTLFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP
910 920 930 940 950
EDDGEVNNLQ VALARIQVFG HRASRAITSY IRSHCRLRWP KVETQLGMKP
960 970 980 990 1000
PLTSCKAENH IATDAVNAAV GNLAKPALGG PKENHGDFIT DPNVWVSVPI
1010 1020 1030 1040 1050
AEGESDLDEL EEDVEHASQS SWQEESPKGQ QELLQQVQKC EDHQAARSPP
1060 1070 1080 1090 1100
SGMSSEDLAP YLGERWQREE SPRVPAEGVD DTSSSEGSTV DCPDPEEILR
1110 1120 1130 1140 1150
KIPELAEELD EPDDCFPEGC TRRCPCCKVN TSKFPWATGW QVRKTCYRIV
1160 1170 1180 1190 1200
EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF
1210 1220 1230 1240 1250
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL
1260 1270 1280 1290 1300
RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG
1310 1320 1330 1340 1350
VNLFAGKFSR CVDTRSNPFS VVNSTFVTNK SDCYNQNNTG HFFWVNVKVN
1360 1370 1380 1390 1400
FDNVAMGYLA LLQVATFKGW MDIMYAAVDS RDINSQPNWE ESLYMYLYFV
1410 1420 1430 1440 1450
VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMALICLN MITMMVETDN
1510 1520 1530 1540 1550
QSEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL
1560 1570 1580 1590 1600
SISSLLFSAI LSSLESYFSP TLLRVIRLAR IGRILRLIRA AKGIRTLLFA
1610 1620 1630 1640 1650
LMMSLPALFN IGLLLFLVMF IYSIFGMASF ANVIDEAGID DMFNFKTFGN
1660 1670 1680 1690 1700
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNRPNSNGSK GNCGSPAVGI
1710 1720 1730 1740 1750
LFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE
1760 1770 1780 1790 1800
KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH
1810 1820 1830 1840 1850
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRCK
1860 1870 1880 1890 1900
QEDISATIIQ KAYRNYMLQR SLMLSNPLHV PRAEEDGVSL PREGYVTFMA
1910 1920 1930 1940 1950
NDNGGLPDKS ETASATSFPP SYDSVTRGLS DRANISTSSS MQNEDEVTAK

EGKSPGPQ
Length:1,958
Mass (Da):220,552
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24830634E86490FF
GO
Isoform 2 (identifier: Q6QIY3-2) [UniParc]FASTAAdd to basket
Also known as: Nav1.8c

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1030: Missing.

Show »
Length:1,957
Mass (Da):220,424
Checksum:i23426D535A65601D
GO
Isoform 3 (identifier: Q6QIY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1435: Missing.

Show »
Length:523
Mass (Da):58,512
Checksum:iD9DB3D0D96A3C622
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4P8K3W4P8_MOUSE
Sodium channel protein
Scn10a mCG_126202
1,958Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122561 – 1435Missing in isoform 3. CuratedAdd BLAST1435
Alternative sequenceiVSP_0122571030Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ622906 Genomic DNA Translation: CAF22039.1
AJ623269 mRNA Translation: CAF25039.1
AJ623270 mRNA Translation: CAF25040.1
L42342 mRNA Translation: AAA68000.1
AY538273 mRNA Translation: AAS45602.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57716.1 [Q6QIY3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_033160.2, NM_009134.3 [Q6QIY3-2]
XP_017168712.1, XM_017313223.1 [Q6QIY3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.247042
Mm.455125
Mm.489505

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000213392; ENSMUSP00000148987; ENSMUSG00000034533 [Q6QIY3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20264

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20264

UCSC genome browser

More...
UCSCi
uc009sbf.2 mouse [Q6QIY3-3]
uc009sbg.3 mouse [Q6QIY3-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ622906 Genomic DNA Translation: CAF22039.1
AJ623269 mRNA Translation: CAF25039.1
AJ623270 mRNA Translation: CAF25040.1
L42342 mRNA Translation: AAA68000.1
AY538273 mRNA Translation: AAS45602.1
CCDSiCCDS57716.1 [Q6QIY3-1]
RefSeqiNP_033160.2, NM_009134.3 [Q6QIY3-2]
XP_017168712.1, XM_017313223.1 [Q6QIY3-1]
UniGeneiMm.247042
Mm.455125
Mm.489505

3D structure databases

ProteinModelPortaliQ6QIY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203097, 3 interactors
STRINGi10090.ENSMUSP00000081845

Chemistry databases

BindingDBiQ6QIY3
ChEMBLiCHEMBL5158

PTM databases

iPTMnetiQ6QIY3
PhosphoSitePlusiQ6QIY3

Proteomic databases

PaxDbiQ6QIY3
PRIDEiQ6QIY3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000213392; ENSMUSP00000148987; ENSMUSG00000034533 [Q6QIY3-2]
GeneIDi20264
KEGGimmu:20264
UCSCiuc009sbf.2 mouse [Q6QIY3-3]
uc009sbg.3 mouse [Q6QIY3-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6336
MGIiMGI:108029 Scn10a

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00940000154992
HOGENOMiHOG000231755
HOVERGENiHBG053100
InParanoidiQ6QIY3
KOiK04842
OMAiDCIIVTV
PhylomeDBiQ6QIY3

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6QIY3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_SCN10A
ExpressionAtlasiQ6QIY3 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF208 PTHR10037:SF208, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCNAA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6QIY3
Secondary accession number(s): Q62243
, Q6EWG7, Q6KCH7, Q703F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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