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Entry version 152 (17 Jun 2020)
Sequence version 4 (11 Dec 2019)
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Protein

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Gene

PAOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Flavoenzyme which catalyzes the oxidation of N1-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N1-acetylspermidine to putrescine. Substrate specificity: N1-acetylspermine = N1-acetylspermidine > N1,N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380).1 Publication

Miscellaneous

Oxidizes N1-acetylated polyamines on the exo-side of their N4-amino groups. Plant PAO oxidizes spermine on the endo-side of the N4-nitrogen (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: spermine metabolism

This protein is involved in the pathway spermine metabolism, which is part of Amine and polyamine metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway spermine metabolism and in Amine and polyamine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei24FAD; via amide nitrogenBy similarity1
Binding sitei45FADBy similarity1
Binding sitei53FADBy similarity1
Binding sitei72SubstrateBy similarity1
Binding sitei194Substrate; via carbonyl oxygenBy similarity1
Binding sitei247FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei320SubstrateBy similarity1
Binding sitei472FAD; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi69 – 70FADBy similarity2
Nucleotide bindingi481 – 482FADBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.5.3.13 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141334 PAOs oxidise polyamines to amines
R-HSA-351200 Interconversion of polyamines
R-HSA-9033241 Peroxisomal protein import

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q6QHF9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00826

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC:1.5.3.131 Publication)
Alternative name(s):
Polyamine oxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAOX
Synonyms:PAO
ORF Names:UNQ1923/PRO4398
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148832.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20837 PAOX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615853 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6QHF9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
196743

Open Targets

More...
OpenTargetsi
ENSG00000148832

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134907695

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6QHF9 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2105

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAOX

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000998751 – 511Peroxisomal N(1)-acetyl-spermine/spermidine oxidaseAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6QHF9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6QHF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6QHF9

PeptideAtlas

More...
PeptideAtlasi
Q6QHF9

PRoteomics IDEntifications database

More...
PRIDEi
Q6QHF9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67292 [Q6QHF9-2]
67294 [Q6QHF9-4]
67295 [Q6QHF9-5]
67296 [Q6QHF9-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6QHF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6QHF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By polyamine analogs.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148832 Expressed in left testis and 158 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6QHF9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000148832 Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128224, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278060

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6QHF9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6QHF9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6QHF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi509 – 511Microbody targeting signalSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0685 Eukaryota
ENOG410XQW0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158274

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004498_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6QHF9

KEGG Orthology (KO)

More...
KOi
K00308

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELGAHWI

Database of Orthologous Groups

More...
OrthoDBi
508351at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6QHF9

TreeFam database of animal gene trees

More...
TreeFami
TF318348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01593 Amino_oxidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6QHF9-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESTGSVGEA PGGPRVLVVG GGIAGLGAAQ RLCGHSAFPH LRVLEATARA
60 70 80 90 100
GGRIRSERCF GGVVEVGAHW IHGPSRGNPV FQLAAEYGLL GEKELSQENQ
110 120 130 140 150
LVETGGHVGL PSVSYASSGA SVSLQLVAEM ATLFYGLIDQ TREFLHAAET
160 170 180 190 200
PVPSVGEYLK KEIGQHVAGW TEDEETRKLK LAVLNSFFNL ECCVSGTHSM
210 220 230 240 250
DLVALAPFGE YTVLPGLDCT FSKGYQGLTN CMMAALPEDT VVFEKPVKTI
260 270 280 290 300
HWNGSFQEAA FPGETFPVSV ECEDGDRFPA HHVIVTVPLG FLREHLDTFF
310 320 330 340 350
DPPLPAEKAE AIRKIGFGTN NKIFLEFEEP FWEPDCQLIQ LVWEDTSPLE
360 370 380 390 400
DAAPELQDAW FRKLIGFVVL PAFASVHVLC GFIAGLESEF METLSDEEVL
410 420 430 440 450
LCLTQVLRRV TGNPRLPAPK SVLRSRWHSA PYTRGSYSYV AVGSTGGDLD
460 470 480 490 500
LLAQPLPADG AGAQLQILFA GEATHRTFYS TTHGALLSGW READRLLSLW
510
APQVQQPRPR L
Length:511
Mass (Da):55,513
Last modified:December 11, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF1A6E43AA09965A
GO
Isoform 2 (identifier: Q6QHF9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-69: GVVEVGAH → AIKDSQTA
     70-511: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:69
Mass (Da):6,917
Checksum:i6479901AFA86F3BC
GO
Isoform 3 (identifier: Q6QHF9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     291-325: FLREHLDTFFDPPLPAEKAEAIRKIGFGTNNKIFL → LSTFSVGSLPDLSLSSWRLCRMKKYFCVSPKCSGE
     326-511: Missing.

Show »
Length:325
Mass (Da):34,706
Checksum:i9F461E2A9F42C661
GO
Isoform 4 (identifier: Q6QHF9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-486: GNPRLPAPKS...TFYSTTHGAL → APDPVCGGSH...SFLLTDFSLA
     487-511: Missing.

Show »
Length:486
Mass (Da):51,963
Checksum:i8F044535B0B0296E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88784 differs from that shown. Aberrant splicing.Curated
The sequence AAS64377 differs from that shown. Reason: Frameshift.Curated
The sequence AAS64379 differs from that shown. Aberrant splicing.Curated
The sequence AAS64380 differs from that shown. Probable cloning artifact.Curated
The sequence AAS64381 differs from that shown. Probable cloning artifact.Curated
The sequence AAS64382 differs from that shown. Aberrant splicing.Curated
The sequence AAS64383 differs from that shown. Aberrant splicing.Curated
The sequence AAS64384 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23I → M in AAS64378 (Ref. 2) Curated1
Sequence conflicti40H → Q in AAS64378 (Ref. 2) Curated1
Sequence conflicti76R → Q in AAN40706 (PubMed:12660232).Curated1
Sequence conflicti85A → V in AAN40706 (PubMed:12660232).Curated1
Sequence conflicti238E → G in AAS64376 (Ref. 2) Curated1
Sequence conflicti258E → K in AAS64373 (Ref. 2) Curated1
Sequence conflicti364L → F in AAS64381 (Ref. 2) Curated1
Sequence conflicti368V → G in AAN40706 (PubMed:12660232).Curated1
Isoform 4 (identifier: Q6QHF9-4)
Sequence conflicti457Q → E in AAS64376 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_06044662 – 69GVVEVGAH → AIKDSQTA in isoform 2. 8
Alternative sequenceiVSP_06044770 – 511Missing in isoform 2. Add BLAST442
Alternative sequenceiVSP_060448291 – 325FLREH…NKIFL → LSTFSVGSLPDLSLSSWRLC RMKKYFCVSPKCSGE in isoform 3. Add BLAST35
Alternative sequenceiVSP_060449326 – 511Missing in isoform 3. Add BLAST186
Alternative sequenceiVSP_060450412 – 486GNPRL…THGAL → APDPVCGGSHTSHVLLHDAR GSAVGMEGGRPPPQSVGPAG AAAQAQALAGPSLLCSTRVG GRLGPSFLLTDFSLA in isoform 4. Add BLAST75
Alternative sequenceiVSP_060451487 – 511Missing in isoform 4. Add BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF226657 mRNA Translation: AAN40706.1
AF312698 mRNA Translation: AAO63265.1
AY541513 mRNA Translation: AAS64373.1
AY541514 mRNA Translation: AAS64374.1
AY541515 mRNA Translation: AAS64375.1
AY541516 mRNA Translation: AAS64376.1
AY541517 mRNA Translation: AAS64377.1 Frameshift.
AY541518 mRNA Translation: AAS64378.1
AY541519 mRNA Translation: AAS64379.1 Sequence problems.
AY541520 mRNA Translation: AAS64380.1 Sequence problems.
AY541521 mRNA Translation: AAS64381.1 Sequence problems.
AY541522 mRNA Translation: AAS64382.1 Sequence problems.
AY541523 mRNA Translation: AAS64383.1 Sequence problems.
AY541524 mRNA Translation: AAS64384.1 Sequence problems.
AY358418 mRNA Translation: AAQ88784.1 Sequence problems.
AL360181 Genomic DNA No translation available.
CH471211 Genomic DNA Translation: EAW61340.1
CH471211 Genomic DNA Translation: EAW61341.1
CH471211 Genomic DNA Translation: EAW61344.1
BC032778 mRNA Translation: AAH32778.1
AL834535 mRNA Translation: CAD39191.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7682.1 [Q6QHF9-4]
CCDS7683.1 [Q6QHF9-2]
CCDS7684.1 [Q6QHF9-5]

NCBI Reference Sequences

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RefSeqi
NP_690875.1, NM_152911.3 [Q6QHF9-2]
NP_997010.1, NM_207127.2 [Q6QHF9-5]
NP_997011.1, NM_207128.2 [Q6QHF9-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000278060; ENSP00000278060; ENSG00000148832 [Q6QHF9-2]
ENST00000356306; ENSP00000348654; ENSG00000148832 [Q6QHF9-5]
ENST00000357296; ENSP00000349847; ENSG00000148832 [Q6QHF9-4]
ENST00000476834; ENSP00000432737; ENSG00000148832 [Q6QHF9-6]
ENST00000480071; ENSP00000435514; ENSG00000148832 [Q6QHF9-5]
ENST00000483211; ENSP00000434550; ENSG00000148832 [Q6QHF9-6]
ENST00000529585; ENSP00000432517; ENSG00000148832 [Q6QHF9-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
196743

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:196743

UCSC genome browser

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UCSCi
uc001lmv.5 human [Q6QHF9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226657 mRNA Translation: AAN40706.1
AF312698 mRNA Translation: AAO63265.1
AY541513 mRNA Translation: AAS64373.1
AY541514 mRNA Translation: AAS64374.1
AY541515 mRNA Translation: AAS64375.1
AY541516 mRNA Translation: AAS64376.1
AY541517 mRNA Translation: AAS64377.1 Frameshift.
AY541518 mRNA Translation: AAS64378.1
AY541519 mRNA Translation: AAS64379.1 Sequence problems.
AY541520 mRNA Translation: AAS64380.1 Sequence problems.
AY541521 mRNA Translation: AAS64381.1 Sequence problems.
AY541522 mRNA Translation: AAS64382.1 Sequence problems.
AY541523 mRNA Translation: AAS64383.1 Sequence problems.
AY541524 mRNA Translation: AAS64384.1 Sequence problems.
AY358418 mRNA Translation: AAQ88784.1 Sequence problems.
AL360181 Genomic DNA No translation available.
CH471211 Genomic DNA Translation: EAW61340.1
CH471211 Genomic DNA Translation: EAW61341.1
CH471211 Genomic DNA Translation: EAW61344.1
BC032778 mRNA Translation: AAH32778.1
AL834535 mRNA Translation: CAD39191.1
CCDSiCCDS7682.1 [Q6QHF9-4]
CCDS7683.1 [Q6QHF9-2]
CCDS7684.1 [Q6QHF9-5]
RefSeqiNP_690875.1, NM_152911.3 [Q6QHF9-2]
NP_997010.1, NM_207127.2 [Q6QHF9-5]
NP_997011.1, NM_207128.2 [Q6QHF9-4]

3D structure databases

SMRiQ6QHF9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128224, 2 interactors
STRINGi9606.ENSP00000278060

Chemistry databases

BindingDBiQ6QHF9
ChEMBLiCHEMBL2105

PTM databases

iPTMnetiQ6QHF9
PhosphoSitePlusiQ6QHF9

Polymorphism and mutation databases

BioMutaiPAOX
DMDMi51316248

Proteomic databases

MassIVEiQ6QHF9
MaxQBiQ6QHF9
PaxDbiQ6QHF9
PeptideAtlasiQ6QHF9
PRIDEiQ6QHF9
ProteomicsDBi67292 [Q6QHF9-2]
67294 [Q6QHF9-4]
67295 [Q6QHF9-5]
67296 [Q6QHF9-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32666 209 antibodies

The DNASU plasmid repository

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DNASUi
196743

Genome annotation databases

EnsembliENST00000278060; ENSP00000278060; ENSG00000148832 [Q6QHF9-2]
ENST00000356306; ENSP00000348654; ENSG00000148832 [Q6QHF9-5]
ENST00000357296; ENSP00000349847; ENSG00000148832 [Q6QHF9-4]
ENST00000476834; ENSP00000432737; ENSG00000148832 [Q6QHF9-6]
ENST00000480071; ENSP00000435514; ENSG00000148832 [Q6QHF9-5]
ENST00000483211; ENSP00000434550; ENSG00000148832 [Q6QHF9-6]
ENST00000529585; ENSP00000432517; ENSG00000148832 [Q6QHF9-6]
GeneIDi196743
KEGGihsa:196743
UCSCiuc001lmv.5 human [Q6QHF9-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
196743
DisGeNETi196743
EuPathDBiHostDB:ENSG00000148832.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PAOX
HGNCiHGNC:20837 PAOX
HPAiENSG00000148832 Tissue enhanced (testis)
MIMi615853 gene
neXtProtiNX_Q6QHF9
OpenTargetsiENSG00000148832
PharmGKBiPA134907695

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0685 Eukaryota
ENOG410XQW0 LUCA
GeneTreeiENSGT00940000158274
HOGENOMiCLU_004498_2_0_1
InParanoidiQ6QHF9
KOiK00308
OMAiELGAHWI
OrthoDBi508351at2759
PhylomeDBiQ6QHF9
TreeFamiTF318348

Enzyme and pathway databases

UniPathwayiUPA00826
BRENDAi1.5.3.13 2681
ReactomeiR-HSA-141334 PAOs oxidise polyamines to amines
R-HSA-351200 Interconversion of polyamines
R-HSA-9033241 Peroxisomal protein import
SABIO-RKiQ6QHF9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
196743 6 hits in 787 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PAOX

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
196743
PharosiQ6QHF9 Tchem

Protein Ontology

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PROi
PR:Q6QHF9
RNActiQ6QHF9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148832 Expressed in left testis and 158 other tissues
GenevisibleiQ6QHF9 HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAOX_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6QHF9
Secondary accession number(s): D3DXI6
, Q5VWY0, Q6QHF5, Q6QHF6, Q6QHF7, Q6QHF8, Q6QHG0, Q6QHG1, Q6QHG2, Q6QHG3, Q6QHG4, Q6QHG5, Q6QHG6, Q86WP9, Q8N555, Q8NCX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 11, 2019
Last modified: June 17, 2020
This is version 152 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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