UniProtKB - Q6QCM7 (Q6QCM7_HHV3)
DNA polymerase
ORF28
Functioni
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.
ARBA annotationCatalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)UniRule annotationARBA annotationEC:2.7.7.7UniRule annotationARBA annotation
- Endonucleolytic cleavage to 5'-phosphomonoester.ARBA annotation EC:3.1.26.4
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- nucleotide binding Source: InterPro
- RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- viral DNA genome replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, EndonucleaseARBA annotation, Hydrolase, Multifunctional enzymeARBA annotation, Nuclease, Nucleotidyltransferase, Transferase |
Biological process | DNA replication, Viral DNA replicationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ORF28Imported ORF Names:HHV3_E_SVETAgp30Imported, HHV3gp30Imported |
Organismi | Human herpesvirus 3 (HHV-3) (Varicella-zoster virus)Imported |
Taxonomic identifieri | 10335 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- Host nucleus ARBA annotation
Other locations
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host nucleusARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 524 | DNA_pol_B_exo1InterPro annotationAdd BLAST | 372 | |
Domaini | 588 – 1116 | DNA_pol_BInterPro annotationAdd BLAST | 529 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_thumb IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAIRTGFCNP FLTQASGIKY NPRTGRGSNR EFLHSYKTTM SSFQFLAPKC
60 70 80 90 100
LDEDVPMEER KGVHVGTLSR PPKVYCNGKE VPILDFRCSS PWPRRVNIWG
110 120 130 140 150
EIDFRGDKFD PRFNTFHVYD IVETTEAASN GDVSRFATAT RPLGTVITLL
160 170 180 190 200
GMSRCGKRVA VHVYGICQYF YINKAEVDTA CGIRSGSELS VLLAECLRSS
210 220 230 240 250
MITQNDATLN GDKNAFHGTS FKSASPESFR VEVIERTDVY YYDTQPCAFY
260 270 280 290 300
RVYSPSSKFT NYLCDNFHPE LKKYEGRVDA TTRFLMDNPG FVSFGWYQLK
310 320 330 340 350
PGVDGERVRV RPASRQLTLS DVEIDCMSDN LQAIPNDDSW PDYKLLCFDI
360 370 380 390 400
ECKSGGSNEL AFPDATHLED LVIQISCLLY SIPRQSLEHI LLFSLGSCDL
410 420 430 440 450
PQRYVQEMKD AGLPEPTVLE FDSEFELLIA FMTLVKQYAP EFATGYNIVN
460 470 480 490 500
FDWAFIMEKL NSIYSLKLDG YGSINRGGLF KIWDVGKSGF QRRSKVKING
510 520 530 540 550
LISLDMYAIA TEKLKLSSYK LDSVAREALN ESKRDLPYKD IPGYYASGPN
560 570 580 590 600
TRGIIGEYCI QDSALVGKLF FKYLPHLELS AVARLARITL TKAIYDGQQV
610 620 630 640 650
RIYTCLLGLA SSRGFILPDG GYPATFEYKD VIPDVGDVEE EMDEDESVSP
660 670 680 690 700
TGTSSGRNVG YKGARVFDPD TGFYIDPVVV LDFASLYPSI IQAHNLCFTT
710 720 730 740 750
LTLNFETVKR LNPSDYATFT VGGKRLFFVR SNVRESLLGV LLKDWLAMRK
760 770 780 790 800
AIRARIPGSS SDEAVLLDKQ QAAIKVVCNS VYGFTGVAQG FLPCLYVAAT
810 820 830 840 850
VTTIGRQMLL STRDYIHNNW AAFERFITAF PDIESSVLSQ KAYEVKVIYG
860 870 880 890 900
DTDSVFIRFK GVSVEGIAKI GEKMAHIIST ALFCPPIKLE CEKTFIKLLL
910 920 930 940 950
ITKKKYIGVI YGGKVLMKGV DLVRKNNCQF INDYARKLVE LLLYDDTVSR
960 970 980 990 1000
AAAEASCVSI AEWNRRAMPS GMAGFGRIIA DAHRQITSPK LDINKFVMTA
1010 1020 1030 1040 1050
ELSRPPSAYI NRRLAHLTVY YKLVMRQGQI PNVRERIPYV IVAPTDEVEA
1060 1070 1080 1090 1100
DAKSVALLRG DPLQNTAGKR CGEAKRKLII SDLAEDPIHV TSHGLSLNID
1110 1120 1130 1140 1150
YYFSHLIGTA SVTFKALFGN DTKLTERLLK RFIPETRVVN VKMLNRLQAA
1160 1170 1180 1190
GFVCIHAPCW DNKMNTEAEI TEEEQSHQIM RRVFCIPKAI LHQS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY548171 Genomic DNA Translation: AAT07710.1 AY548170 Genomic DNA Translation: AAT07786.1 DQ479953 Genomic DNA Translation: ABF21528.1 DQ479954 Genomic DNA Translation: ABF21601.1 DQ479955 Genomic DNA Translation: ABF21674.1 DQ479956 Genomic DNA Translation: ABF21747.1 DQ479961 Genomic DNA Translation: ABF22112.1 DQ479962 Genomic DNA Translation: ABF22185.1 DQ479963 Genomic DNA Translation: ABF22258.1 DQ674250 Genomic DNA Translation: ABH08463.1 EU154348 Genomic DNA Translation: ABW06913.1 JN704690 Genomic DNA Translation: AEW88005.1 JN704691 Genomic DNA Translation: AEW88077.1 JN704692 Genomic DNA Translation: AEW88149.1 JN704693 Genomic DNA Translation: AEW88221.1 JN704694 Genomic DNA Translation: AEW88293.1 JN704695 Genomic DNA Translation: AEW88365.1 JN704696 Genomic DNA Translation: AEW88437.1 JN704699 Genomic DNA Translation: AEW88653.1 JN704701 Genomic DNA Translation: AEW88797.1 JN704702 Genomic DNA Translation: AEW88869.1 JN704704 Genomic DNA Translation: AEW89013.1 JQ911599 Genomic DNA Translation: AFJ68529.1 JQ972913 Genomic DNA Translation: AFO85532.1 KP771889 Genomic DNA Translation: AKG56097.1 KP771891 Genomic DNA Translation: AKG56243.1 KP771892 Genomic DNA Translation: AKG56316.1 KP771893 Genomic DNA Translation: AKG56389.1 KP771894 Genomic DNA Translation: AKG56462.1 KP771895 Genomic DNA Translation: AKG56535.1 KP771896 Genomic DNA Translation: AKG56608.1 KP771897 Genomic DNA Translation: AKG56681.1 KP771899 Genomic DNA Translation: AKG56827.1 KP771900 Genomic DNA Translation: AKG56900.1 KP771901 Genomic DNA Translation: AKG56973.1 KP771902 Genomic DNA Translation: AKG57046.1 KP771903 Genomic DNA Translation: AKG57119.1 KP771907 Genomic DNA Translation: AKG57411.1 KP771908 Genomic DNA Translation: AKG57484.1 KP771909 Genomic DNA Translation: AKG57557.1 KP771910 Genomic DNA Translation: AKG57630.1 KP771912 Genomic DNA Translation: AKG57774.1 KP771913 Genomic DNA Translation: AKG57847.1 KP771915 Genomic DNA Translation: AKG57991.1 KP771916 Genomic DNA Translation: AKG58066.1 KP771918 Genomic DNA Translation: AKG58212.1 KP771920 Genomic DNA Translation: AKG58358.1 KP771921 Genomic DNA Translation: AKG58431.1 KP771923 Genomic DNA Translation: AKG58577.1 KU529484 Genomic DNA Translation: AMS24320.1 KU529485 Genomic DNA Translation: AMS24321.1 KU529488 Genomic DNA Translation: AMS24324.1 KU529490 Genomic DNA Translation: AMS24326.1 KU529492 Genomic DNA Translation: AMS24328.1 KU529495 Genomic DNA Translation: AMS24331.1 KU529497 Genomic DNA Translation: AMS24333.1 KU529498 Genomic DNA Translation: AMS24334.1 KU529500 Genomic DNA Translation: AMS24336.1 KU529501 Genomic DNA Translation: AMS24337.1 KU529502 Genomic DNA Translation: AMS24338.1 KU529503 Genomic DNA Translation: AMS24339.1 KU529509 Genomic DNA Translation: AMS24345.1 KU529513 Genomic DNA Translation: AMS24349.1 KU529514 Genomic DNA Translation: AMS24350.1 KU529517 Genomic DNA Translation: AMS24353.1 KU529518 Genomic DNA Translation: AMS24354.1 KU529519 Genomic DNA Translation: AMS24355.1 KU529520 Genomic DNA Translation: AMS24356.1 KU529521 Genomic DNA Translation: AMS24357.1 KU529523 Genomic DNA Translation: AMS24359.1 KU529525 Genomic DNA Translation: AMS24361.1 KU529526 Genomic DNA Translation: AMS24362.1 KU529527 Genomic DNA Translation: AMS24363.1 KU529529 Genomic DNA Translation: AMS24365.1 KU529530 Genomic DNA Translation: AMS24366.1 KU529531 Genomic DNA Translation: AMS24367.1 KU529532 Genomic DNA Translation: AMS24368.1 KU529533 Genomic DNA Translation: AMS24369.1 KU529534 Genomic DNA Translation: AMS24370.1 KU529535 Genomic DNA Translation: AMS24371.1 KU529536 Genomic DNA Translation: AMS24372.1 KU529538 Genomic DNA Translation: AMS24374.1 KU529541 Genomic DNA Translation: AMS24377.1 KU529543 Genomic DNA Translation: AMS24379.1 KU529544 Genomic DNA Translation: AMS24380.1 KU529545 Genomic DNA Translation: AMS24381.1 KU529546 Genomic DNA Translation: AMS24382.1 KU529547 Genomic DNA Translation: AMS24383.1 KU529550 Genomic DNA Translation: AMS24386.1 KU529552 Genomic DNA Translation: AMS24388.1 KU529554 Genomic DNA Translation: AMS24390.1 KU529555 Genomic DNA Translation: AMS24391.1 KU529556 Genomic DNA Translation: AMS24392.1 KU529558 Genomic DNA Translation: AMS24394.1 KU529559 Genomic DNA Translation: AMS24395.1 KU529560 Genomic DNA Translation: AMS24396.1 KU529561 Genomic DNA Translation: AMS24397.1 KU529563 Genomic DNA Translation: AMS24399.1 KU529564 Genomic DNA Translation: AMS24400.1 KU529566 Genomic DNA Translation: AMS24402.1 KU926311 Genomic DNA Translation: ANS12900.1 KX262864 Genomic DNA Translation: AON76494.1 KX262865 Genomic DNA Translation: AON76567.1 KX262866 Genomic DNA Translation: AON76640.1 MG764305 Genomic DNA Translation: AYN61597.1 MG764313 Genomic DNA Translation: AYN62181.1 AJ871403 Genomic DNA Translation: CAI44871.1 MH709354 Genomic DNA Translation: QCA46012.1 MH709361 Genomic DNA Translation: QCA46523.1 MH709367 Genomic DNA Translation: QCA46961.1 MH709368 Genomic DNA Translation: QCA47034.1 MH709369 Genomic DNA Translation: QCA47107.1 |
RefSeqi | NP_040151.1, NC_001348.1 |
Genome annotation databases
GeneIDi | 1487712 |
KEGGi | vg:1487712 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY548171 Genomic DNA Translation: AAT07710.1 AY548170 Genomic DNA Translation: AAT07786.1 DQ479953 Genomic DNA Translation: ABF21528.1 DQ479954 Genomic DNA Translation: ABF21601.1 DQ479955 Genomic DNA Translation: ABF21674.1 DQ479956 Genomic DNA Translation: ABF21747.1 DQ479961 Genomic DNA Translation: ABF22112.1 DQ479962 Genomic DNA Translation: ABF22185.1 DQ479963 Genomic DNA Translation: ABF22258.1 DQ674250 Genomic DNA Translation: ABH08463.1 EU154348 Genomic DNA Translation: ABW06913.1 JN704690 Genomic DNA Translation: AEW88005.1 JN704691 Genomic DNA Translation: AEW88077.1 JN704692 Genomic DNA Translation: AEW88149.1 JN704693 Genomic DNA Translation: AEW88221.1 JN704694 Genomic DNA Translation: AEW88293.1 JN704695 Genomic DNA Translation: AEW88365.1 JN704696 Genomic DNA Translation: AEW88437.1 JN704699 Genomic DNA Translation: AEW88653.1 JN704701 Genomic DNA Translation: AEW88797.1 JN704702 Genomic DNA Translation: AEW88869.1 JN704704 Genomic DNA Translation: AEW89013.1 JQ911599 Genomic DNA Translation: AFJ68529.1 JQ972913 Genomic DNA Translation: AFO85532.1 KP771889 Genomic DNA Translation: AKG56097.1 KP771891 Genomic DNA Translation: AKG56243.1 KP771892 Genomic DNA Translation: AKG56316.1 KP771893 Genomic DNA Translation: AKG56389.1 KP771894 Genomic DNA Translation: AKG56462.1 KP771895 Genomic DNA Translation: AKG56535.1 KP771896 Genomic DNA Translation: AKG56608.1 KP771897 Genomic DNA Translation: AKG56681.1 KP771899 Genomic DNA Translation: AKG56827.1 KP771900 Genomic DNA Translation: AKG56900.1 KP771901 Genomic DNA Translation: AKG56973.1 KP771902 Genomic DNA Translation: AKG57046.1 KP771903 Genomic DNA Translation: AKG57119.1 KP771907 Genomic DNA Translation: AKG57411.1 KP771908 Genomic DNA Translation: AKG57484.1 KP771909 Genomic DNA Translation: AKG57557.1 KP771910 Genomic DNA Translation: AKG57630.1 KP771912 Genomic DNA Translation: AKG57774.1 KP771913 Genomic DNA Translation: AKG57847.1 KP771915 Genomic DNA Translation: AKG57991.1 KP771916 Genomic DNA Translation: AKG58066.1 KP771918 Genomic DNA Translation: AKG58212.1 KP771920 Genomic DNA Translation: AKG58358.1 KP771921 Genomic DNA Translation: AKG58431.1 KP771923 Genomic DNA Translation: AKG58577.1 KU529484 Genomic DNA Translation: AMS24320.1 KU529485 Genomic DNA Translation: AMS24321.1 KU529488 Genomic DNA Translation: AMS24324.1 KU529490 Genomic DNA Translation: AMS24326.1 KU529492 Genomic DNA Translation: AMS24328.1 KU529495 Genomic DNA Translation: AMS24331.1 KU529497 Genomic DNA Translation: AMS24333.1 KU529498 Genomic DNA Translation: AMS24334.1 KU529500 Genomic DNA Translation: AMS24336.1 KU529501 Genomic DNA Translation: AMS24337.1 KU529502 Genomic DNA Translation: AMS24338.1 KU529503 Genomic DNA Translation: AMS24339.1 KU529509 Genomic DNA Translation: AMS24345.1 KU529513 Genomic DNA Translation: AMS24349.1 KU529514 Genomic DNA Translation: AMS24350.1 KU529517 Genomic DNA Translation: AMS24353.1 KU529518 Genomic DNA Translation: AMS24354.1 KU529519 Genomic DNA Translation: AMS24355.1 KU529520 Genomic DNA Translation: AMS24356.1 KU529521 Genomic DNA Translation: AMS24357.1 KU529523 Genomic DNA Translation: AMS24359.1 KU529525 Genomic DNA Translation: AMS24361.1 KU529526 Genomic DNA Translation: AMS24362.1 KU529527 Genomic DNA Translation: AMS24363.1 KU529529 Genomic DNA Translation: AMS24365.1 KU529530 Genomic DNA Translation: AMS24366.1 KU529531 Genomic DNA Translation: AMS24367.1 KU529532 Genomic DNA Translation: AMS24368.1 KU529533 Genomic DNA Translation: AMS24369.1 KU529534 Genomic DNA Translation: AMS24370.1 KU529535 Genomic DNA Translation: AMS24371.1 KU529536 Genomic DNA Translation: AMS24372.1 KU529538 Genomic DNA Translation: AMS24374.1 KU529541 Genomic DNA Translation: AMS24377.1 KU529543 Genomic DNA Translation: AMS24379.1 KU529544 Genomic DNA Translation: AMS24380.1 KU529545 Genomic DNA Translation: AMS24381.1 KU529546 Genomic DNA Translation: AMS24382.1 KU529547 Genomic DNA Translation: AMS24383.1 KU529550 Genomic DNA Translation: AMS24386.1 KU529552 Genomic DNA Translation: AMS24388.1 KU529554 Genomic DNA Translation: AMS24390.1 KU529555 Genomic DNA Translation: AMS24391.1 KU529556 Genomic DNA Translation: AMS24392.1 KU529558 Genomic DNA Translation: AMS24394.1 KU529559 Genomic DNA Translation: AMS24395.1 KU529560 Genomic DNA Translation: AMS24396.1 KU529561 Genomic DNA Translation: AMS24397.1 KU529563 Genomic DNA Translation: AMS24399.1 KU529564 Genomic DNA Translation: AMS24400.1 KU529566 Genomic DNA Translation: AMS24402.1 KU926311 Genomic DNA Translation: ANS12900.1 KX262864 Genomic DNA Translation: AON76494.1 KX262865 Genomic DNA Translation: AON76567.1 KX262866 Genomic DNA Translation: AON76640.1 MG764305 Genomic DNA Translation: AYN61597.1 MG764313 Genomic DNA Translation: AYN62181.1 AJ871403 Genomic DNA Translation: CAI44871.1 MH709354 Genomic DNA Translation: QCA46012.1 MH709361 Genomic DNA Translation: QCA46523.1 MH709367 Genomic DNA Translation: QCA46961.1 MH709368 Genomic DNA Translation: QCA47034.1 MH709369 Genomic DNA Translation: QCA47107.1 |
RefSeqi | NP_040151.1, NC_001348.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 1487712 |
KEGGi | vg:1487712 |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_thumb IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6QCM7_HHV3 | |
Accessioni | Q6QCM7Primary (citable) accession number: Q6QCM7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | January 19, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |