DNA polymerase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• a 2'-deoxyribonucleoside 5'-triphosphate

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + DNA_(n)

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  • Search chemical reactions in Rhea for this molecule.

  = diphosphate

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + DNA_(n+1)

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  UniRule annotation

  <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000256">More...</a></p> Automatic assertion according to rulesⁱ

  • RuleBase:RU000442
  EC:2.7.7.7
  • Search proteins in UniProtKB for this EC number.
  • See the description of this EC number in ENZYME.
  UniRule annotation

  Automatic assertion according to rulesⁱ

  • RuleBase:RU000442
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  . Show »« Hide
  a 2'-deoxyribonucleoside 5'-triphosphate

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  DNA_(n)

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  zoom

  =

  diphosphate

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  DNA_(n+1)

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  zoom

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-KW
• DNA-directed DNA polymerase activity Source: UniProtKB-KW
• nucleotide binding Source: InterPro

GO - Biological processⁱ

• DNA replication Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAIRTGFCNP FLTQASGIKY NPRTGRGSNR EFLHSYKTTM SSFQFLAPKC 
        60         70         80         90        100
LDEDVPMEER KGVHVGTLSR PPKVYCNGKE VPILDFRCSS PWPRRVNIWG 
       110        120        130        140        150
EIDFRGDKFD PRFNTFHVYD IVETTEAASN GDVSRFATAT RPLGTVITLL 
       160        170        180        190        200
GMSRCGKRVA VHVYGICQYF YINKAEVDTA CGIRSGSELS VLLAECLRSS 
       210        220        230        240        250
MITQNDATLN GDKNAFHGTS FKSASPESFR VEVIERTDVY YYDTQPCAFY 
       260        270        280        290        300
RVYSPSSKFT NYLCDNFHPE LKKYEGRVDA TTRFLMDNPG FVSFGWYQLK 
       310        320        330        340        350
PGVDGERVRV RPASRQLTLS DVEIDCMSDN LQAIPNDDSW PDYKLLCFDI 
       360        370        380        390        400
ECKSGGSNEL AFPDATHLED LVIQISCLLY SIPRQSLEHI LLFSLGSCDL 
       410        420        430        440        450
PQRYVQEMKD AGLPEPTVLE FDSEFELLIA FMTLVKQYAP EFATGYNIVN 
       460        470        480        490        500
FDWAFIMEKL NSIYSLKLDG YGSINRGGLF KIWDVGKSGF QRRSKVKING 
       510        520        530        540        550
LISLDMYAIA TEKLKLSSYK LDSVAREALN ESKRDLPYKD IPGYYASGPN 
       560        570        580        590        600
TRGIIGEYCI QDSALVGKLF FKYLPHLELS AVARLARITL TKAIYDGQQV 
       610        620        630        640        650
RIYTCLLGLA SSRGFILPDG GYPATFEYKD VIPDVGDVEE EMDEDESVSP 
       660        670        680        690        700
TGTSSGRNVG YKGARVFDPD TGFYIDPVVV LDFASLYPSI IQAHNLCFTT 
       710        720        730        740        750
LTLNFETVKR LNPSDYATFT VGGKRLFFVR SNVRESLLGV LLKDWLAMRK 
       760        770        780        790        800
AIRARIPGSS SDEAVLLDKQ QAAIKVVCNS VYGFTGVAQG FLPCLYVAAT 
       810        820        830        840        850
VTTIGRQMLL STRDYIHNNW AAFERFITAF PDIESSVLSQ KAYEVKVIYG 
       860        870        880        890        900
DTDSVFIRFK GVSVEGIAKI GEKMAHIIST ALFCPPIKLE CEKTFIKLLL 
       910        920        930        940        950
ITKKKYIGVI YGGKVLMKGV DLVRKNNCQF INDYARKLVE LLLYDDTVSR 
       960        970        980        990       1000
AAAEASCVSI AEWNRRAMPS GMAGFGRIIA DAHRQITSPK LDINKFVMTA 
      1010       1020       1030       1040       1050
ELSRPPSAYI NRRLAHLTVY YKLVMRQGQI PNVRERIPYV IVAPTDEVEA 
      1060       1070       1080       1090       1100
DAKSVALLRG DPLQNTAGKR CGEAKRKLII SDLAEDPIHV TSHGLSLNID 
      1110       1120       1130       1140       1150
YYFSHLIGTA SVTFKALFGN DTKLTERLLK RFIPETRVVN VKMLNRLQAA 
      1160       1170       1180       1190 
GFVCIHAPCW DNKMNTEAEI TEEEQSHQIM RRVFCIPKAI LHQS       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ