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Protein

Cell surface glycoprotein CD200 receptor 2

Gene

CD200R1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a receptor for the CD200/OX2 cell surface glycoprotein.By similarity

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 2
Alternative name(s):
CD200 cell surface glycoprotein receptor-like 2
Short name:
CD200 receptor-like 2
Short name:
HuCD200R2
CD200 cell surface glycoprotein receptor-like a
Short name:
CD200RLa
Cell surface glycoprotein CD200 receptor 1-like
Cell surface glycoprotein OX2 receptor 2
Gene namesi
Name:CD200R1L
Synonyms:CD200R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000206531.10
HGNCiHGNC:24665 CD200R1L
neXtProtiNX_Q6Q8B3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 239ExtracellularSequence analysisAdd BLAST216
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 271CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi344807
OpenTargetsiENSG00000206531
PharmGKBiPA164717784

Polymorphism and mutation databases

BioMutaiCD200R1L
DMDMi205829216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000034645124 – 271Cell surface glycoprotein CD200 receptor 2Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 209PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6Q8B3
PeptideAtlasiQ6Q8B3
PRIDEiQ6Q8B3
ProteomicsDBi67278
67279 [Q6Q8B3-2]

PTM databases

iPTMnetiQ6Q8B3
PhosphoSitePlusiQ6Q8B3

Expressioni

Gene expression databases

BgeeiENSG00000206531
CleanExiHS_CD200R1L
ExpressionAtlasiQ6Q8B3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381272

Structurei

3D structure databases

ProteinModelPortaliQ6Q8B3
SMRiQ6Q8B3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 132Ig-like V-typeAdd BLAST87
Domaini133 – 221Ig-like C2-typeAdd BLAST89

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUJX Eukaryota
ENOG4112DF0 LUCA
GeneTreeiENSGT00390000014496
HOGENOMiHOG000113622
HOVERGENiHBG108141
InParanoidiQ6Q8B3
KOiK21668
OMAiFFQRINH
OrthoDBiEOG091G0IYA
PhylomeDBiQ6Q8B3
TreeFamiTF335960

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q8B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPRLLISI IIMVSASSSS CMGGKQMTQN YSTIFAEGNI SQPVLMDINA
60 70 80 90 100
VLCCPPIALR NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTVERITW
110 120 130 140 150
VSRPDQNSDL QIRPVDTTHD GYYRGIVVTP DGNFHRGYHL QVLVTPEVNL
160 170 180 190 200
FQSRNITAVC KAVTGKPAAQ ISWIPEGSIL ATKQEYWGNG TVTVKSTCPW
210 220 230 240 250
EGHKSTVTCH VSHLTGNKSL SVKLNSGLRT SGSPALSLLI ILYVKLSLFV
260 270
VILVTTGFVF FQRINHVRKV L
Length:271
Mass (Da):29,920
Last modified:September 2, 2008 - v2
Checksum:i9D8E3074F7D34F90
GO
Isoform 2 (identifier: Q6Q8B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:250
Mass (Da):27,771
Checksum:i43D0AA1BE1B56BC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045897113R → L1 PublicationCorresponds to variant dbSNP:rs4682119Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0350021 – 21Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284976 mRNA Translation: AAQ19773.1
AY552790 mRNA Translation: AAT00538.1
AC074044 Genomic DNA No translation available.
AC092892 Genomic DNA No translation available.
CCDSiCCDS43131.1 [Q6Q8B3-1]
CCDS56267.1 [Q6Q8B3-2]
RefSeqiNP_001008784.2, NM_001008784.2 [Q6Q8B3-1]
NP_001186144.1, NM_001199215.1 [Q6Q8B3-2]
XP_011511065.1, XM_011512763.2 [Q6Q8B3-2]
XP_016861789.1, XM_017006300.1 [Q6Q8B3-2]
UniGeneiHs.531814

Genome annotation databases

EnsembliENST00000398214; ENSP00000381272; ENSG00000206531 [Q6Q8B3-1]
ENST00000488794; ENSP00000418413; ENSG00000206531 [Q6Q8B3-2]
GeneIDi344807
KEGGihsa:344807
UCSCiuc003dzi.1 human [Q6Q8B3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMO2R2_HUMAN
AccessioniPrimary (citable) accession number: Q6Q8B3
Secondary accession number(s): Q6WHB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 20, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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