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UniProtKB - Q6Q8A5 (HXK2_TOBAC)
Protein
Hexokinase-2, chloroplastic
Gene
HXK2
Organism
Nicotiana tabacum (Common tobacco)
Status
Functioni
Fructose and glucose phosphorylating enzyme.
1 PublicationCatalytic activityi
- EC:2.7.1.11 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:2.7.1.11 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:2.7.1.11 PublicationThis reaction proceeds in the forward1 Publication direction.
: hexose metabolism Pathwayi
This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.
Pathwayi: glycolysis
This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.1 Publication This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- fructokinase activity Source: GO_Central
- glucokinase activity Source: GO_Central
- glucose binding Source: InterPro
- mannokinase activity Source: GO_Central
GO - Biological processi
- cellular glucose homeostasis Source: GO_Central
- glucose 6-phosphate metabolic process Source: GO_Central
- glycolytic process Source: GO_Central
- hexose metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.1, 3645 |
SABIO-RKi | Q6Q8A5 |
UniPathwayi | UPA00109;UER00180 UPA00242 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HXK2 |
Organismi | Nicotiana tabacum (Common tobacco) |
Taxonomic identifieri | 4097 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Proteomesi |
|
Subcellular locationi
Chloroplast
- chloroplast stroma 1 Publication
Chloroplast
- chloroplast stroma Source: UniProtKB-SubCell
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 30 | ChloroplastSequence analysisAdd BLAST | 30 | |
ChainiPRO_0000247574 | 31 – 499 | Hexokinase-2, chloroplasticAdd BLAST | 469 |
Proteomic databases
PRIDEi | Q6Q8A5 |
Expressioni
Tissue specificityi
Expressed in vascular starch sheath, xylem parenchyma, guard cells and root tips.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 490 | HexokinasePROSITE-ProRule annotationAdd BLAST | 452 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 232 | Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST | 139 | |
Regioni | 233 – 479 | Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST | 247 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
OMAi | VCSIDLH |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR001312, Hexokinase IPR022673, Hexokinase_C IPR022672, Hexokinase_N |
PANTHERi | PTHR19443, PTHR19443, 1 hit |
Pfami | View protein in Pfam PF00349, Hexokinase_1, 1 hit PF03727, Hexokinase_2, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS51748, HEXOKINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6Q8A5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVTVSSPAG RSFHISRSPY KKISKPRVII AAVRSGVSLA VAPILTKLQK
60 70 80 90 100
DCATPLPVLR HVADAMAVDM RAGLAVDGGS DLKMILSYID TLPTGNEKGL
110 120 130 140 150
FYALDLGGTN FRVLRVQLGG KEERVIATEF EQVSIPQELM FATSEELFDF
160 170 180 190 200
IASELGKFSQ SEGGKFEMQQ GRTREIGFTF SFPVKQTSVK SGILIKWTKG
210 220 230 240 250
FAVSGTAGKD VVACLNEAME RQGLGMQVSA LVNDTVATLA GARYWDNDVM
260 270 280 290 300
VAVILGTGTN ACYVERVDAI PKLPQRMSNS PETIVNTEWG AFSNGLPLTE
310 320 330 340 350
FDREMDAESI NPGEQIFEKT ISGMYLGEIV RRVLVKMAKV GGLFGGGYVP
360 370 380 390 400
EKLVTPFVLR TPDICAMQQD TSRDLEAVES VLYDIAGVKS DLSARKTVVD
410 420 430 440 450
ICDTIANRGG RLAGAGIVGI LQKMEEDSKG VIFGKRTVVA MDGGLYEHYP
460 470 480 490
QYREYLQEAV TELLGSEISK NVVIEHSKDG SGIGAALLAA ANSKYEHDY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY553215 mRNA Translation: AAS60193.1 |
RefSeqi | NP_001312431.1, NM_001325502.1 |
Genome annotation databases
GeneIDi | 107790581 |
KEGGi | nta:107790581 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY553215 mRNA Translation: AAS60193.1 |
RefSeqi | NP_001312431.1, NM_001325502.1 |
3D structure databases
SMRi | Q6Q8A5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4097.Q6Q8A5 |
Proteomic databases
PRIDEi | Q6Q8A5 |
Genome annotation databases
GeneIDi | 107790581 |
KEGGi | nta:107790581 |
Phylogenomic databases
OMAi | VCSIDLH |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00180 UPA00242 |
BRENDAi | 2.7.1.1, 3645 |
SABIO-RKi | Q6Q8A5 |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR001312, Hexokinase IPR022673, Hexokinase_C IPR022672, Hexokinase_N |
PANTHERi | PTHR19443, PTHR19443, 1 hit |
Pfami | View protein in Pfam PF00349, Hexokinase_1, 1 hit PF03727, Hexokinase_2, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS51748, HEXOKINASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXK2_TOBAC | |
Accessioni | Q6Q8A5Primary (citable) accession number: Q6Q8A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families