EPB41

Functionⁱ

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.By similarity

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
calmodulin binding Source: UniProtKB-KW
structural constituent of cytoskeleton Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actomyosin structure organization Source: GO_Central
cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cortical actin cytoskeleton organization Source: InterPro
positive regulation of protein localization to cell cortex Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding
Biological process	Cell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

Reactomeⁱ	R-CFA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-CFA-6794361 Neurexins and neuroligins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein 4.1 Short name: P4.1 Alternative name(s): 4.1R Band 4.1
Gene namesⁱ	Name:EPB41
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus
Proteomesⁱ	UP000002254 Componentⁱ: Chromosome 2

Organism-specific databases

VGNCⁱ	VGNC:40392 EPB41

VGNCⁱ

VGNC:40392 EPB41

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219389	1 – 810	Protein 4.1Add BLAST		810

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineBy similarity	1
Modified residueⁱ	61	PhosphothreonineBy similarity	1
Modified residueⁱ	85	PhosphoserineBy similarity	1
Modified residueⁱ	86	PhosphoserineBy similarity	1
Modified residueⁱ	96	PhosphoserineBy similarity	1
Modified residueⁱ	105	PhosphoserineBy similarity	1
Modified residueⁱ	122	PhosphoserineBy similarity	1
Modified residueⁱ	150	PhosphoserineBy similarity	1
Modified residueⁱ	152	PhosphoserineBy similarity	1
Modified residueⁱ	153	PhosphoserineBy similarity	1
Modified residueⁱ	189	PhosphoserineBy similarity	1
Modified residueⁱ	192	PhosphoserineBy similarity	1
Modified residueⁱ	223	PhosphotyrosineBy similarity	1
Modified residueⁱ	379	PhosphothreonineBy similarity	1
Modified residueⁱ	522	PhosphoserineBy similarity	1
Modified residueⁱ	541	PhosphoserineBy similarity	1
Modified residueⁱ	543	PhosphoserineBy similarity	1
Modified residueⁱ	555	PhosphoserineBy similarity	1
Modified residueⁱ	620	PhosphoserineBy similarity	1
Modified residueⁱ	630	PhosphoserineBy similarity	1
Modified residueⁱ	655	PhosphoserineBy similarity	1
Modified residueⁱ	658	PhosphoserineBy similarity	1
Modified residueⁱ	682	PhosphothreonineBy similarity	1
Modified residueⁱ	805	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.By similarity

Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6Q7P4

PaxDbⁱ

Q6Q7P4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSCAFG00000011677

Bgeeⁱ

ENSCAFG00000011677

Interactionⁱ

Subunit structureⁱ

Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions. Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes for anaphase-specific localization of NUMA1 in symmetrically dividing cells.By similarity

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9615.ENSCAFP00000041578

STRINGⁱ

9615.ENSCAFP00000041578

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6Q7P4
SMRⁱ	Q6Q7P4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	211 – 492	FERMPROSITE-ProRule annotationAdd BLAST		282

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	615 – 659	Spectrin--actin-bindingAdd BLAST		45
Regionⁱ	660 – 810	C-terminal (CTD)Add BLAST		151

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	680 – 752	Thr-richAdd BLAST		73

Phylogenomic databases

eggNOGⁱ	ENOG410IU7N Eukaryota ENOG410XS0M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118823
HOVERGENⁱ	HBG007777
InParanoidⁱ	Q6Q7P4
KEGG Orthology (KO) More...KOⁱ	K06107

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473 FERM_B-lobe, 1 hit
Gene3Dⁱ	1.20.80.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit
PRINTSⁱ	PR00935 BAND41 PR00661 ERMFAMILY
SMARTⁱ	View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit
SUPFAMⁱ	SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6Q7P4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTEKSLVAE AENSQHQQQK EEGEGVTNSG QQETQLEELS QEAAEGDNHC 
        60         70         80         90        100
EQKLKTSNGD TPTHEDLTKN KERTSENRGL SRLFSSFLKR PKSQVSEEEG 
       110        120        130        140        150
KDVESAKEKC EGGQKEIEFG TSLDEEIILK APIAAPEPEL KTDPSLDLHS 
       160        170        180        190        200
LSSAETQPAQ EEHREDPDFE TKEGGGLEEC SKIEVKEESP ESKAERELKA 
       210        220        230        240        250
SQKSIRRHRN MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED 
       260        270        280        290        300
YFGLAIWDNG ASKTWLDSAK EIKKQVRGVP WNFTFNVKFY PPDPAQLTED 
       310        320        330        340        350
ITRYYLCLQL RQDIVSGRLP CSFATLALLG SYTIQSELGD YDPELHGAEY 
       360        370        380        390        400
VSDFKLAPNQ TKELEEKVME LHKSYRSMTP AQADLEFLEN AKKLSMYGVD 
       410        420        430        440        450
LHKAKDLEGV DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI 
       460        470        480        490        500
KIRPGEQEQY ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTLPKSK 
       510        520        530        540        550
FLALGSKFRY SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV 
       560        570        580        590        600
DSDRSPRPTS APAIAQSQDA EGTVPGAPVK KTVVSKAQKE TVKDEEKKEE 
       610        620        630        640        650
GPPDQAEPEP TEVWKDLDKS QEEIKKHHAS ISELKKNFME SVPEPRPSEW 
       660        670        680        690        700
DKRLSTHSPF RTLNINGQLP TGEGPPLVKT QTVTISDTAN SVKSEIPTKD 
       710        720        730        740        750
VPIVHTETKT ITYEAAQTDD SNGDLDPGVL LTAQTITSET TSSTTTTQIT 
       760        770        780        790        800
KTVKGGISET RIEKRIVITG DADIDHDQVL VQAIKEAKEQ HPDMSVTKVV 
       810
VHQETEISEE

Length:810

Mass (Da):90,688

Last modified:July 5, 2004 - v1

Checksum:ⁱ8F033CCA3C157602

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY553843 mRNA Translation: AAS59144.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001003362.1, NM_001003362.1 XP_013962011.1, XM_014106536.1
UniGeneⁱ	Cfa.3914

Genome annotation databases

Ensemblⁱ	ENSCAFT00000013377; ENSCAFP00000012379; ENSCAFG00000011677
GeneIDⁱ	442955
KEGGⁱ	cfa:442955

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6Q7P4	UPI0004DFFA55		URSMA		827
Erythrocyte protein band 4.1		MOUSE		823
UPI000A3067C8		MUSPA		823
UPI000737D84C		VICPA		822
UPI00057AAD04		CAMBA		822
+102

Protein	Similar proteins		Species	Score	Length
Q6Q7P4	UPI0004DFFA55		URSMA		827
Erythrocyte protein band 4.1		MOUSE		823
UPI000A3067C8		MUSPA		823
UPI000737D84C		VICPA		822
UPI00057AAD04		CAMBA		822
+661

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY553843 mRNA Translation: AAS59144.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001003362.1, NM_001003362.1 XP_013962011.1, XM_014106536.1
UniGeneⁱ	Cfa.3914

3D structure databases

ProteinModelPortalⁱ	Q6Q7P4
SMRⁱ	Q6Q7P4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9615.ENSCAFP00000041578

STRINGⁱ

9615.ENSCAFP00000041578

Proteomic databases

PaxDbⁱ	Q6Q7P4

PaxDbⁱ

Q6Q7P4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSCAFT00000013377; ENSCAFP00000012379; ENSCAFG00000011677
GeneIDⁱ	442955
KEGGⁱ	cfa:442955

Organism-specific databases

CTDⁱ	2035
VGNCⁱ	VGNC:40392 EPB41

Phylogenomic databases

eggNOGⁱ	ENOG410IU7N Eukaryota ENOG410XS0M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118823
HOVERGENⁱ	HBG007777
InParanoidⁱ	Q6Q7P4
KEGG Orthology (KO) More...KOⁱ	K06107

Enzyme and pathway databases

Reactomeⁱ	R-CFA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-CFA-6794361 Neurexins and neuroligins

Gene expression databases

Bgeeⁱ	ENSCAFG00000011677

Bgeeⁱ

ENSCAFG00000011677

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473 FERM_B-lobe, 1 hit
Gene3Dⁱ	1.20.80.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit
PRINTSⁱ	PR00935 BAND41 PR00661 ERMFAMILY
SMARTⁱ	View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit
SUPFAMⁱ	SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	41_CANLF
Accessionⁱ	Q6Q7P4Primary (citable) accession number: Q6Q7P4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	July 5, 2004
	Last modified:	March 28, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6Q7P4 (41_CANLF)

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Protein 4.1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ