UniProtKB - Q6Q7P4 (EPB41_CANLF)
Protein 4.1
EPB41
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- structural molecule activity Source: InterPro
GO - Biological processi
- actomyosin structure organization Source: GO_Central
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cortical actin cytoskeleton organization Source: InterPro
- positive regulation of protein localization to cell cortex Source: UniProtKB
- regulation of calcium ion transport Source: UniProtKB
- regulation of intestinal absorption Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding |
Biological process | Cell cycle, Cell division, Mitosis, Transport |
Enzyme and pathway databases
Reactomei | R-CFA-6794361, Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: Protein 4.1Short name: P4.1 Alternative name(s): 4.1R Band 4.1 Erythrocyte membrane protein band 4.1By similarity |
Gene namesi | Name:EPB41By similarity |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- cell cortex By similarity
Cytoskeleton
- cytoskeleton Source: GO_Central
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- cell cortex region Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219389 | 1 – 810 | Protein 4.1Add BLAST | 810 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineBy similarity | 1 | |
Modified residuei | 61 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphoserineBy similarity | 1 | |
Modified residuei | 96 | PhosphoserineBy similarity | 1 | |
Modified residuei | 105 | PhosphoserineBy similarity | 1 | |
Modified residuei | 122 | PhosphoserineBy similarity | 1 | |
Modified residuei | 150 | PhosphoserineBy similarity | 1 | |
Modified residuei | 152 | PhosphoserineBy similarity | 1 | |
Modified residuei | 153 | PhosphoserineBy similarity | 1 | |
Modified residuei | 189 | PhosphoserineBy similarity | 1 | |
Modified residuei | 192 | PhosphoserineBy similarity | 1 | |
Modified residuei | 223 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 379 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 522 | PhosphoserineBy similarity | 1 | |
Modified residuei | 541 | PhosphoserineBy similarity | 1 | |
Modified residuei | 543 | PhosphoserineBy similarity | 1 | |
Modified residuei | 555 | PhosphoserineBy similarity | 1 | |
Modified residuei | 620 | PhosphoserineBy similarity | 1 | |
Modified residuei | 630 | PhosphoserineBy similarity | 1 | |
Modified residuei | 655 | PhosphoserineBy similarity | 1 | |
Modified residuei | 658 | PhosphoserineBy similarity | 1 | |
Modified residuei | 682 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 805 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q6Q7P4 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000011677, Expressed in thymus and 51 other tissues |
Interactioni
Subunit structurei
Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions.
Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes for anaphase-specific localization of NUMA1 in symmetrically dividing cells.
Interacts with ATP2B1; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000041578 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 492 | FERMPROSITE-ProRule annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 615 – 659 | Spectrin--actin-bindingAdd BLAST | 45 | |
Regioni | 660 – 810 | C-terminal (CTD)Add BLAST | 151 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 680 – 752 | Thr-richAdd BLAST | 73 |
Phylogenomic databases
eggNOGi | KOG3527, Eukaryota |
InParanoidi | Q6Q7P4 |
OrthoDBi | 262540at2759 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTTEKSLVAE AENSQHQQQK EEGEGVTNSG QQETQLEELS QEAAEGDNHC
60 70 80 90 100
EQKLKTSNGD TPTHEDLTKN KERTSENRGL SRLFSSFLKR PKSQVSEEEG
110 120 130 140 150
KDVESAKEKC EGGQKEIEFG TSLDEEIILK APIAAPEPEL KTDPSLDLHS
160 170 180 190 200
LSSAETQPAQ EEHREDPDFE TKEGGGLEEC SKIEVKEESP ESKAERELKA
210 220 230 240 250
SQKSIRRHRN MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED
260 270 280 290 300
YFGLAIWDNG ASKTWLDSAK EIKKQVRGVP WNFTFNVKFY PPDPAQLTED
310 320 330 340 350
ITRYYLCLQL RQDIVSGRLP CSFATLALLG SYTIQSELGD YDPELHGAEY
360 370 380 390 400
VSDFKLAPNQ TKELEEKVME LHKSYRSMTP AQADLEFLEN AKKLSMYGVD
410 420 430 440 450
LHKAKDLEGV DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI
460 470 480 490 500
KIRPGEQEQY ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTLPKSK
510 520 530 540 550
FLALGSKFRY SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV
560 570 580 590 600
DSDRSPRPTS APAIAQSQDA EGTVPGAPVK KTVVSKAQKE TVKDEEKKEE
610 620 630 640 650
GPPDQAEPEP TEVWKDLDKS QEEIKKHHAS ISELKKNFME SVPEPRPSEW
660 670 680 690 700
DKRLSTHSPF RTLNINGQLP TGEGPPLVKT QTVTISDTAN SVKSEIPTKD
710 720 730 740 750
VPIVHTETKT ITYEAAQTDD SNGDLDPGVL LTAQTITSET TSSTTTTQIT
760 770 780 790 800
KTVKGGISET RIEKRIVITG DADIDHDQVL VQAIKEAKEQ HPDMSVTKVV
810
VHQETEISEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY553843 mRNA Translation: AAS59144.1 |
RefSeqi | NP_001003362.1, NM_001003362.1 XP_013962011.1, XM_014106536.1 |
Genome annotation databases
GeneIDi | 442955 |
KEGGi | cfa:442955 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY553843 mRNA Translation: AAS59144.1 |
RefSeqi | NP_001003362.1, NM_001003362.1 XP_013962011.1, XM_014106536.1 |
3D structure databases
BMRBi | Q6Q7P4 |
SMRi | Q6Q7P4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000041578 |
Proteomic databases
PaxDbi | Q6Q7P4 |
Genome annotation databases
GeneIDi | 442955 |
KEGGi | cfa:442955 |
Organism-specific databases
CTDi | 2035 |
Phylogenomic databases
eggNOGi | KOG3527, Eukaryota |
InParanoidi | Q6Q7P4 |
OrthoDBi | 262540at2759 |
Enzyme and pathway databases
Reactomei | R-CFA-6794361, Neurexins and neuroligins |
Gene expression databases
Bgeei | ENSCAFG00000011677, Expressed in thymus and 51 other tissues |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPB41_CANLF | |
Accessioni | Q6Q7P4Primary (citable) accession number: Q6Q7P4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |