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UniProtKB - Q6Q783 (KMT5C_MOUSE)

Entry version 126 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Histone-lysine N-methyltransferase KMT5C

Gene

Kmt5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:28114273).

In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity).

H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825).

Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825).

KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004).

Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).

May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196).By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=510 µM for histone H4K20me1 peptide1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32S-adenosyl-L-methionineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi92Zinc 1; via pros nitrogenCombined sources1
Metal bindingi95Zinc 1Combined sources1 Publication1
Binding sitei121S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
Metal bindingi141Zinc 1Combined sources1 Publication1
Binding sitei160S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei169S-adenosyl-L-methionineBy similarity1
Metal bindingi185ZincBy similarity1
Metal bindingi185Zinc 2Combined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei217Histone H4 binding; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi229ZincBy similarity1
Metal bindingi229Zinc 2Combined sources1 Publication1
Binding sitei230S-adenosyl-L-methionine; via amide nitrogenCombined sources1 Publication1
Metal bindingi231ZincBy similarity1
Metal bindingi231Zinc 2Combined sources1 Publication1
Metal bindingi234ZincBy similarity1
Metal bindingi234Zinc 2Combined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3214841, PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase KMT5CCurated
Alternative name(s):
Lysine-specific methyltransferase 5CBy similarity
Suppressor of variegation 4-20 homolog 2
Short name:
Su(var)4-20 homolog 2
Short name:
Suv4-20h2
[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5BCurated (EC:2.1.1.3623 Publications)
[histone H4]-lysine20 N-methyltransferase KMT5BCurated (EC:2.1.1.361By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kmt5cBy similarity
Synonyms:Suv420h2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2385262, Kmt5c

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000059851

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi116M → S: Does not affect affinity for S-adenosyl-L-methionine. 1 Publication1
Mutagenesisi161S → A: Does not methylates either an unmodified or monomethylated H4K20 substrate. Methylates a di-methylated H4K20 peptide. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002817941 – 468Histone-lysine N-methyltransferase KMT5CAdd BLAST468

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6Q783

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6Q783

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6Q783

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6Q783

PeptideAtlas

More...PeptideAtlasi		Q6Q783

PRoteomics IDEntifications database

More...PRIDEi		Q6Q783

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		264788

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6Q783

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6Q783

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000059851, Expressed in retinal neural layer and 293 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6Q783, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:24049080).

Interacts with HP1 proteins CBX1, CBX3 and CBX5.

Interacts with RB1 family proteins RB1, RBL1 and RBL2.

4 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		231299, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000104223

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6Q783, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6Q783

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 218SETPROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni114 – 117S-adenosyl-L-methionine bindingBy similarity4
Regioni150 – 166Histone H4 bindingCombined sources1 PublicationAdd BLAST17
Regioni182 – 183S-adenosyl-L-methionine bindingCombined sources1 Publication2
Regioni348 – 441Required for heterochromatin localizationAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2589, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040002_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6Q783

Identification of Orthologs from Complete Genome Data

More...OMAi		GGWTAHY

Database of Orthologous Groups

More...OrthoDBi		236983at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6Q783

TreeFam database of animal gene trees

More...TreeFami		TF106433

Family and domain databases

Conserved Domains Database

More...CDDi		cd19185, SET_KMT5C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1700, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041938, Hist-Lys_N-MTase_N
IPR044425, KMT5C_SET
IPR001214, SET_dom
IPR039977, Suv4-20/Set9
IPR025790, Suv4-20_animal

The PANTHER Classification System

More...PANTHERi		PTHR12977, PTHR12977, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00317, SET, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51570, SAM_MT43_SUVAR420_2, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6Q783-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP TLRRQHHLRS 
        60         70         80         90        100
ALEAFLRQRD LEAAFRALTL GGWMAHYFQS RAPRQEAALK THIFCYLRAF 
       110        120        130        140        150
LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREEDE 
       160        170        180        190        200
DLLRAGENDF SIMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPSDGNTAC 
       210        220        230        240        250
VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CYTCERKGEG AFRLQPREPE 
       260        270        280        290        300
LRPKPLDKYE LRETKRRLQQ GLVSSQQSLM SRWACSHLSP LRPDPFCAAC 
       310        320        330        340        350
QPSCLLPASP HMDYLPLWLQ RAPQPQPIVP PRKRHRRRRP RIRQASLPPV 
       360        370        380        390        400
LRTACVPLHR WGGCGPHCQL RAEAMVTLHL RPQTRWTPQQ DWYWARRYGL 
       410        420        430        440        450
PSVGRVELTR LAPALPAAPA PAGNPGPVPT PDFIPKQALA FAPFCPPKRL 
       460 
RLVVSHGSID LDINSGEP
Length:468
Mass (Da):53,159
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD43D7A25DBDF3BB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2F5D3Z2F5_MOUSE
Histone-lysine N-methyltransferase ...
Kmt5c
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXW4E0CXW4_MOUSE
Histone-lysine N-methyltransferase ...
Kmt5c
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XZN9F6XZN9_MOUSE
Histone-lysine N-methyltransferase ...
Kmt5c
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24816 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH85473 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY555193 mRNA Translation: AAT00540.1
AK154848 mRNA Translation: BAE32874.1
BC024816 mRNA Translation: AAH24816.1 Different initiation.
BC085473 mRNA Translation: AAH85473.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20743.2

NCBI Reference Sequences

More...RefSeqi		NP_001108490.1, NM_001115018.1
NP_666289.2, NM_146177.2
XP_006539837.1, XM_006539774.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000098853; ENSMUSP00000096452; ENSMUSG00000059851
ENSMUST00000108582; ENSMUSP00000104223; ENSMUSG00000059851
ENSMUST00000108583; ENSMUSP00000104224; ENSMUSG00000059851

Database of genes from NCBI RefSeq genomes

More...GeneIDi		232811

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:232811

UCSC genome browser

More...UCSCi		uc009eyi.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555193 mRNA Translation: AAT00540.1
AK154848 mRNA Translation: BAE32874.1
BC024816 mRNA Translation: AAH24816.1 Different initiation.
BC085473 mRNA Translation: AAH85473.2 Different initiation.
CCDSiCCDS20743.2
RefSeqiNP_001108490.1, NM_001115018.1
NP_666289.2, NM_146177.2
XP_006539837.1, XM_006539774.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AU7X-ray2.07A/B1-246[»]
SMRiQ6Q783
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi231299, 3 interactors
STRINGi10090.ENSMUSP00000104223

PTM databases

iPTMnetiQ6Q783
PhosphoSitePlusiQ6Q783

Proteomic databases

EPDiQ6Q783
jPOSTiQ6Q783
MaxQBiQ6Q783
PaxDbiQ6Q783
PeptideAtlasiQ6Q783
PRIDEiQ6Q783
ProteomicsDBi264788

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46420, 75 antibodies

The DNASU plasmid repository

More...DNASUi		232811

Genome annotation databases

EnsembliENSMUST00000098853; ENSMUSP00000096452; ENSMUSG00000059851
ENSMUST00000108582; ENSMUSP00000104223; ENSMUSG00000059851
ENSMUST00000108583; ENSMUSP00000104224; ENSMUSG00000059851
GeneIDi232811
KEGGimmu:232811
UCSCiuc009eyi.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84787
MGIiMGI:2385262, Kmt5c
VEuPathDBiHostDB:ENSMUSG00000059851

Phylogenomic databases

eggNOGiKOG2589, Eukaryota
GeneTreeiENSGT00940000161700
HOGENOMiCLU_040002_0_0_1
InParanoidiQ6Q783
OMAiGGWTAHY
OrthoDBi236983at2759
PhylomeDBiQ6Q783
TreeFamiTF106433

Enzyme and pathway databases

ReactomeiR-MMU-3214841, PKMTs methylate histone lysines

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		232811, 2 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Suv420h2, mouse

Protein Ontology

More...PROi		PR:Q6Q783
RNActiQ6Q783, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000059851, Expressed in retinal neural layer and 293 other tissues
GenevisibleiQ6Q783, MM

Family and domain databases

CDDicd19185, SET_KMT5C, 1 hit
Gene3Di1.10.10.1700, 1 hit
InterProiView protein in InterPro
IPR041938, Hist-Lys_N-MTase_N
IPR044425, KMT5C_SET
IPR001214, SET_dom
IPR039977, Suv4-20/Set9
IPR025790, Suv4-20_animal
PANTHERiPTHR12977, PTHR12977, 1 hit
PfamiView protein in Pfam
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00317, SET, 1 hit
PROSITEiView protein in PROSITE
PS51570, SAM_MT43_SUVAR420_2, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKMT5C_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Q783
Secondary accession number(s): Q5RKP6, Q8R1C5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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