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Entry version 132 (25 May 2022)
Sequence version 1 (05 Jul 2004)
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Protein

Sperm-associated antigen 17

Gene

SPAG17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts (By similarity).

Essential for normal spermatogenesis and male fertility (By similarity).

Required for normal manchette structure, transport of proteins along the manchette microtubules and formation of the sperm head and flagellum (By similarity).

Essential for sperm flagellum development and proper assembly of the respiratory motile cilia central pair apparatus, but not the brain ependymal cilia (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Differentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6Q759

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6Q759

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm-associated antigen 17
Alternative name(s):
Projection protein PF6 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPAG17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26620, SPAG17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616554, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6Q759

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000155761

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Flagellum, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 55 (SPGF55)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive male infertility disorder characterized by asthenozoospermia.Semen analysis shows severely reduced sperm motility.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0859651448R → Q in SPGF55; unknown pathological significance; decreased protein expression in homozygous patient sperm. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
200162

MalaCards human disease database

More...
MalaCardsi
SPAG17
MIMi619380, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000155761

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
276234, Non-syndromic male infertility due to sperm motility disorder

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670888

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6Q759, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPAG17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749284

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314451 – 2223Sperm-associated antigen 17Add BLAST2223

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6Q759

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6Q759

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6Q759

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6Q759

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6Q759

PeptideAtlas

More...
PeptideAtlasi
Q6Q759

PRoteomics IDEntifications database

More...
PRIDEi
Q6Q759

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67275

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6Q759

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6Q759

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Expressed in organs that contain cilia-bearing cells including brain, oviduct, lung, and uterus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155761, Expressed in right uterine tube and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6Q759, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6Q759, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000155761, Tissue enhanced (choroid plexus, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the C-terminus) with SPAG6; the interaction probably occurs on polymerized microtubules.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128304, 5 interactors

Protein interaction database and analysis system

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IntActi
Q6Q759, 3 interactors

Molecular INTeraction database

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MINTi
Q6Q759

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337804

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6Q759, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q6Q759

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6Q759

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 214DisorderedSequence analysisAdd BLAST71
Regioni387 – 416DisorderedSequence analysisAdd BLAST30
Regioni680 – 710DisorderedSequence analysisAdd BLAST31
Regioni731 – 762DisorderedSequence analysisAdd BLAST32
Regioni950 – 1015DisorderedSequence analysisAdd BLAST66
Regioni1179 – 1212DisorderedSequence analysisAdd BLAST34
Regioni1345 – 1378DisorderedSequence analysisAdd BLAST34
Regioni1938 – 1957DisorderedSequence analysisAdd BLAST20
Regioni1962 – 2008DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili266 – 295Sequence analysisAdd BLAST30
Coiled coili940 – 966Sequence analysisAdd BLAST27
Coiled coili1874 – 1907Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi739 – 762Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi950 – 1009Basic and acidic residuesSequence analysisAdd BLAST60
Compositional biasi1179 – 1210Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1985 – 1999Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSCB, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013693

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001433_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6Q759

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDIMVRQ

Database of Orthologous Groups

More...
OrthoDBi
32420at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6Q759

TreeFam database of animal gene trees

More...
TreeFami
TF328540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026173, SPAG17

The PANTHER Classification System

More...
PANTHERi
PTHR21963, PTHR21963, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6Q759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKKEKGGT VNTSSKIWEP SLIAAQFNQN DWQASIAFVV GNQIEDDLLI
60 70 80 90 100
QALTVAVQVP QRKLFSMVSW QDILQQINEI NTLVGSASSK KAKKPVGGNA
110 120 130 140 150
PLYYEVLTAA KAIMDSGEKL TLPLIGKLLK FQLLQIKFKD QQRRENEKKV
160 170 180 190 200
IEDKPKLEKD KGKAKSPKEK KAPSAKPAKG KGKDQPEANA PVKKTTQLKR
210 220 230 240 250
RGEDDHTNRY IDDEPDDGAQ HYIIVVGFNN PQLLAIMAEL GIPITSVIKI
260 270 280 290 300
SSENYEPLQT HLAAVNQQQE VLLQSEDLEA EKLKKENAIK ELKTFWKYLE
310 320 330 340 350
PVLNNEKPET NLFDVARLEY MVKAADFPSD WSDGEMMLKL GTDIFENIAC
360 370 380 390 400
LMYDILDWKR QHQHYLESMQ LINVPQVVNE KPVLEAMPTS EAPQPAVPAP
410 420 430 440 450
GKKKAQYEEP QAPPPVTSVI TTEVDMRYYN YLLNPIREEF ISVPLILHCM
460 470 480 490 500
LEQVVATEED LVPPSLREPS PRADGLDHRI AAHIVSLLPS LCLSEREKKN
510 520 530 540 550
LHDIFLSEEE NESKAVPKGP LLLNYHDAHA HKKYALQDQK NFDPVQIEQE
560 570 580 590 600
MQSKLPLWEF LQFPLPPPWN NTKRLATIHE LMHFCTSDVL SWNEVERAFK
610 620 630 640 650
VFTFESLKLS EVDEKGKLKP SGMMCGSDSE MFNIPWDNPA RFAKQIRQQY
660 670 680 690 700
VMKMNTQEAK QKADIKIKDR TLFVDQNLSM SVQDNESNRE PSDPSQCDAN
710 720 730 740 750
NMKHSDLNNL KLSVPDNRQL LEQESIMKAQ PQHESLEQTT NNEIKDDAVT
760 770 780 790 800
KADSHEKKPK KMMVEADLED IKKTQQRSLM DWSFTEHFKP KVLLQVLQEA
810 820 830 840 850
HKQYRCVDSY YHTQDNSLLL VFHNPMNRQR LHCEYWNIAL HSNVGFRNYL
860 870 880 890 900
ELVAKSIQDW ITKEEAIYQE SKMNEKIIRT RAELELKSSA NAKLTSASKI
910 920 930 940 950
FSIKESKSNK GISKTEISDQ EKEKEKEKIP FILEGSLKAW KEEQHRLAEE
960 970 980 990 1000
ERLREEKKAE KKGKEAGKKK GKDNAEKEDS RSLKKKSPYK EKSKEEQVKI
1010 1020 1030 1040 1050
QEVTEESPHQ PEPKITYPFH GYNMGNIPTQ ISGSNYYLYP SDGGQIEVEK
1060 1070 1080 1090 1100
TMFEKGPTFI KVRVVKDNHN FMIHLNDPKE IVKKEEKGDY YLEEEEEGDE
1110 1120 1130 1140 1150
EQSLETEVSD AKNKAFSKFG SFSATLENGI CLSISYYGSN GMAPEDKDPD
1160 1170 1180 1190 1200
LETILNIPSA LTPTVVPVIV TVPQSKAKGK IKGKEKPKES LKEEEHPKEE
1210 1220 1230 1240 1250
EKKEEEVEPE PVLQETLDVP TFQSLNVSCP SGLLLTFIGQ ESTGQYVIDE
1260 1270 1280 1290 1300
EPTWDIMVRQ SYPQRVKHYE FYKTVMPPAE QEASRVITSQ GTVVKYMLDG
1310 1320 1330 1340 1350
STQILFADGA VSRSPNSGLI CPPSEMPATP HSGDLMDSIS QQKSETIPSE
1360 1370 1380 1390 1400
ITNTKKGKSH KSQSSMAHKG EIHDPPPEAV QTVTPVEVHI GTWFTTTPEG
1410 1420 1430 1440 1450
NRIGTKGLER IADLTPLLSF QATDPVNGTV MTTREDKVVI VERKDGTRIV
1460 1470 1480 1490 1500
DHADGTRITT FYQVYEDQII LPDDQETTEG PRTVTRQVKC MRVESSRYAT
1510 1520 1530 1540 1550
VIANCEDSSC CATFGDGTTI IAKPQGTYQV LPPNTGSLYI DKDCSAVYCH
1560 1570 1580 1590 1600
ESSSNIYYPF QKREQLRAGR YIMRHTSEVI CEVLDPEGNT FQVMADGSIS
1610 1620 1630 1640 1650
TILPEKKLED DLNEKTEGYD SLSSMHLEKN HQQIYGEHVP RFFVMYADGS
1660 1670 1680 1690 1700
GMELLRDSDI EEYLSLAYKE SNTVVLQEPV QEQPGTLTIT VLRPFHEASP
1710 1720 1730 1740 1750
WQVKKEDTIV PPNLRSRSWE TFPSVEKKTP GPPFGTQIWK GLCIESKQLV
1760 1770 1780 1790 1800
SAPGAILKSP SVLQMRQFIQ HEVIKNEVKL RLQVSLKDYI NYILKKEDEL
1810 1820 1830 1840 1850
QEMMVKDSRT EEERGNAADL LKLVMSFPKM EETTKSHVTE VAAHLTDLFK
1860 1870 1880 1890 1900
QSLATPPKCP PDTFGKDFFE KTWRHTASSK RWKEKIDKTR KEIETTQNYL
1910 1920 1930 1940 1950
MDIKNRIIPP FFKSELNQLY QSQYNHLDSL SKKLPSFTKK NEDANETAVQ
1960 1970 1980 1990 2000
DTSDLNLDFK PHKVSEQKSS SVPSLPKPEI SADKKDFTAQ NQTENLTKSP
2010 2020 2030 2040 2050
EEAESYEPVK IPTQSLLQDV AGQTRKEKVK LPHYLLSSKP KSQPLAKVQD
2060 2070 2080 2090 2100
SVGGKVNTSS VASAAINNAK SSLFGFHLLP SSVKFGVLKE GHTYATVVKL
2110 2120 2130 2140 2150
KNVGVDFCRF KVKQPPPSTG LKVTYKPGPV AAGMQTELNI ELFATAVGED
2160 2170 2180 2190 2200
GAKGSAHISH NIEIMTEHEV LFLPVEATVL TSSNYDKRPK DFPQGKENPM
2210 2220
VQRTSTIYSS TLGVFMSRKV SPH
Length:2,223
Mass (Da):251,742
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07C248C5B2A5B561
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TDG6Q5TDG6_HUMAN
Sperm-associated antigen 17
SPAG17
660Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52A → S in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti211I → M in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti675D → G in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti736L → P in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti816N → H in BAC03753 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042863143R → Q. Corresponds to variant dbSNP:rs12133381Ensembl.1
Natural variantiVAR_042864158E → V. Corresponds to variant dbSNP:rs17185492Ensembl.1
Natural variantiVAR_0428651253T → P. Corresponds to variant dbSNP:rs34366834Ensembl.1
Natural variantiVAR_0428661348P → L. Corresponds to variant dbSNP:rs10923472Ensembl.1
Natural variantiVAR_0859651448R → Q in SPGF55; unknown pathological significance; decreased protein expression in homozygous patient sperm. 1 Publication1
Natural variantiVAR_0428671707D → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY555274 mRNA Translation: AAS66753.1
AL513191 Genomic DNA No translation available.
AL121993 Genomic DNA No translation available.
AL139345 Genomic DNA No translation available.
AK091816 mRNA Translation: BAC03753.1
AL137581 mRNA Translation: CAB70823.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS899.1

Protein sequence database of the Protein Information Resource

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PIRi
T46291

NCBI Reference Sequences

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RefSeqi
NP_996879.1, NM_206996.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336338.10; ENSP00000337804.5; ENSG00000155761.14

Database of genes from NCBI RefSeq genomes

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GeneIDi
200162

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:200162

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000336338.10; ENSP00000337804.5; NM_206996.4; NP_996879.1

UCSC genome browser

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UCSCi
uc001ehk.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555274 mRNA Translation: AAS66753.1
AL513191 Genomic DNA No translation available.
AL121993 Genomic DNA No translation available.
AL139345 Genomic DNA No translation available.
AK091816 mRNA Translation: BAC03753.1
AL137581 mRNA Translation: CAB70823.1
CCDSiCCDS899.1
PIRiT46291
RefSeqiNP_996879.1, NM_206996.3

3D structure databases

AlphaFoldDBiQ6Q759
SMRiQ6Q759
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128304, 5 interactors
IntActiQ6Q759, 3 interactors
MINTiQ6Q759
STRINGi9606.ENSP00000337804

PTM databases

iPTMnetiQ6Q759
PhosphoSitePlusiQ6Q759

Genetic variation databases

BioMutaiSPAG17
DMDMi74749284

Proteomic databases

EPDiQ6Q759
jPOSTiQ6Q759
MassIVEiQ6Q759
MaxQBiQ6Q759
PaxDbiQ6Q759
PeptideAtlasiQ6Q759
PRIDEiQ6Q759
ProteomicsDBi67275

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33897, 35 antibodies from 8 providers

The DNASU plasmid repository

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DNASUi
200162

Genome annotation databases

EnsembliENST00000336338.10; ENSP00000337804.5; ENSG00000155761.14
GeneIDi200162
KEGGihsa:200162
MANE-SelectiENST00000336338.10; ENSP00000337804.5; NM_206996.4; NP_996879.1
UCSCiuc001ehk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
200162
DisGeNETi200162

GeneCards: human genes, protein and diseases

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GeneCardsi
SPAG17
HGNCiHGNC:26620, SPAG17
HPAiENSG00000155761, Tissue enhanced (choroid plexus, testis)
MalaCardsiSPAG17
MIMi616554, gene
619380, phenotype
neXtProtiNX_Q6Q759
OpenTargetsiENSG00000155761
Orphaneti276234, Non-syndromic male infertility due to sperm motility disorder
PharmGKBiPA142670888
VEuPathDBiHostDB:ENSG00000155761

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSCB, Eukaryota
GeneTreeiENSGT00390000013693
HOGENOMiCLU_001433_0_0_1
InParanoidiQ6Q759
OMAiWDIMVRQ
OrthoDBi32420at2759
PhylomeDBiQ6Q759
TreeFamiTF328540

Enzyme and pathway databases

PathwayCommonsiQ6Q759
SignaLinkiQ6Q759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
200162, 9 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPAG17, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
200162
PharosiQ6Q759, Tdark

Protein Ontology

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PROi
PR:Q6Q759
RNActiQ6Q759, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155761, Expressed in right uterine tube and 133 other tissues
ExpressionAtlasiQ6Q759, baseline and differential
GenevisibleiQ6Q759, HS

Family and domain databases

InterProiView protein in InterPro
IPR026173, SPAG17
PANTHERiPTHR21963, PTHR21963, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPG17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Q759
Secondary accession number(s): Q8NAZ1, Q9NT21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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