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Protein

Aminopeptidase Q

Gene

LVRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by bestatin.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=78.2 µM for Leu-4-methylcoumaryl-7-amide1 Publication

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei240SubstrateBy similarity1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi415Zinc; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei416Proton acceptorPROSITE-ProRule annotation1
    Metal bindingi419Zinc; catalyticPROSITE-ProRule annotation1
    Metal bindingi438Zinc; catalyticPROSITE-ProRule annotation1
    Active sitei503Proton donorPROSITE-ProRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei503Transition state stabilizerBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • metalloaminopeptidase activity Source: GO_Central
    • peptide binding Source: GO_Central
    • zinc ion binding Source: GO_Central

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q6Q4G3

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M01.026

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aminopeptidase QCurated (EC:3.4.11.-1 Publication)
    Short name:
    AP-QCurated
    Short name:
    APQ1 Publication
    Alternative name(s):
    CHL2 antigen1 Publication
    Laeverin1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:LVRNImported
    Synonyms:AQPEPImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000172901.19

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:26904 LVRN

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610046 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6Q4G3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 13Cytoplasmic1 PublicationAdd BLAST12
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini35 – 990Lumenal1 PublicationAdd BLAST956

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    206338

    Open Targets

    More...
    OpenTargetsi
    ENSG00000172901

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3831223

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    AQPEP

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296439457

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470682 – 990Aminopeptidase QAdd BLAST989

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi653N-linked (GlcNAc...) asparagineSequence analysis1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6Q4G3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6Q4G3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6Q4G3

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    67267
    67268 [Q6Q4G3-2]
    67269 [Q6Q4G3-3]
    67270 [Q6Q4G3-4]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6Q4G3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6Q4G3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000172901 Expressed in 98 organ(s), highest expression level in placenta

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6Q4G3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6Q4G3 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA053254

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    128502, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000350541

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q6Q4G3

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6Q4G3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni379 – 383Substrate bindingBy similarity5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1046 Eukaryota
    COG0308 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160535

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6Q4G3

    KEGG Orthology (KO)

    More...
    KOi
    K13724

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    RNVFPCF

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G01GH

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6Q4G3

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd09601 M1_APN_2, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR024571 ERAP1-like_C_dom
    IPR034016 M1_APN-typ
    IPR001930 Peptidase_M1
    IPR014782 Peptidase_M1_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11533 PTHR11533, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF11838 ERAP1_C, 1 hit
    PF01433 Peptidase_M1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00756 ALADIPTASE

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6Q4G3-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG
    60 70 80 90 100
    LRDLEAESSP PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP
    110 120 130 140 150
    WLVPLHYDLE LWPQLRPDEL PAGSLPFTGR VNITVRCTVA TSRLLLHSLF
    160 170 180 190 200
    QDCERAEVRG PLSPGTGNAT VGRVPVDDVW FALDTEYMVL ELSEPLKPGS
    210 220 230 240 250
    SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE PTFARYVFPC
    260 270 280 290 300
    FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT
    310 320 330 340 350
    PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP
    360 370 380 390 400
    IFSFLEDLFN ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD
    410 420 430 440 450
    QLTEKKTLIS YVVSHEIGHQ WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN
    460 470 480 490 500
    YFNPKLPRNE IFFSNILHNI LREDHALVTR AVAMKVENFK TSEIQELFDI
    510 520 530 540 550
    FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ DDLWRHFQMA
    560 570 580 590 600
    IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN
    610 620 630 640 650
    RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL
    660 670 680 690 700
    NLNMTGYYRV NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN
    710 720 730 740 750
    YIEIETALEL TKYLAEEDEI IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR
    760 770 780 790 800
    YLLKRLNLIW NIYSTIIREN VLALQDDYLA LISLEKLFVT ACWLGLEDCL
    810 820 830 840 850
    QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD ILLNTYTNTT
    860 870 880 890 900
    NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV
    910 920 930 940 950
    GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS
    960 970 980 990
    NMLEEHQRIR VHANLQTIKN ENLKNKKLSA RIAAWLRRNT
    Length:990
    Mass (Da):113,283
    Last modified:May 18, 2010 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i570A7072E66D0DCA
    GO
    Isoform 2 (identifier: Q6Q4G3-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         698-701: KNNY → KGTY
         702-990: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:701
    Mass (Da):79,566
    Checksum:iD63CE25BF86F3C71
    GO
    Isoform 3 (identifier: Q6Q4G3-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-483: Missing.
         698-709: KNNYIEIETALE → NLQDFGHLKVPN
         710-990: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:226
    Mass (Da):26,244
    Checksum:i500DAA17E0E09FD1
    GO
    Isoform 4 (identifier: Q6Q4G3-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-483: Missing.
         680-681: AI → MR
         682-990: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:198
    Mass (Da):23,178
    Checksum:i97F6C600E390BD5B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0A0MS63A0A0A0MS63_HUMAN
    Aminopeptidase
    LVRN
    978Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAC11422 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13R → H in AAS66719 (PubMed:14706636).Curated1
    Sequence conflicti54L → S in AAS66719 (PubMed:14706636).Curated1
    Sequence conflicti54L → S in BAF84344 (PubMed:14702039).Curated1
    Sequence conflicti54L → S in EAW48946 (Ref. 4) Curated1
    Sequence conflicti54L → S in AAH68560 (PubMed:15489334).Curated1
    Sequence conflicti54L → S in AAI09023 (PubMed:15489334).Curated1
    Sequence conflicti54L → S in AAI09024 (PubMed:15489334).Curated1
    Sequence conflicti374P → S in AAS66719 (PubMed:14706636).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027059640V → F. Corresponds to variant dbSNP:rs17138632Ensembl.1
    Natural variantiVAR_027060689L → F3 PublicationsCorresponds to variant dbSNP:rs10078759Ensembl.1
    Natural variantiVAR_027061936V → I. Corresponds to variant dbSNP:rs17138681Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0199151 – 483Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST483
    Alternative sequenceiVSP_019916680 – 681AI → MR in isoform 4. 1 Publication2
    Alternative sequenceiVSP_019917682 – 990Missing in isoform 4. 1 PublicationAdd BLAST309
    Alternative sequenceiVSP_019918698 – 709KNNYI…ETALE → NLQDFGHLKVPN in isoform 3. 1 PublicationAdd BLAST12
    Alternative sequenceiVSP_019919698 – 701KNNY → KGTY in isoform 2. 1 Publication4
    Alternative sequenceiVSP_019920702 – 990Missing in isoform 2. 1 PublicationAdd BLAST289
    Alternative sequenceiVSP_019921710 – 990Missing in isoform 3. 1 PublicationAdd BLAST281

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY560010 mRNA Translation: AAS66719.1
    AK075131 mRNA Translation: BAC11422.1 Different initiation.
    AK291655 mRNA Translation: BAF84344.1
    AC010282 Genomic DNA No translation available.
    AC034236 Genomic DNA No translation available.
    CH471086 Genomic DNA Translation: EAW48946.1
    BC036440 mRNA No translation available.
    BC045809 mRNA No translation available.
    BC068560 mRNA Translation: AAH68560.1
    BC070028 mRNA No translation available.
    BC094716 mRNA No translation available.
    BC109022 mRNA Translation: AAI09023.1
    BC109023 mRNA Translation: AAI09024.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4124.1 [Q6Q4G3-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_776161.3, NM_173800.4 [Q6Q4G3-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.556880
    Hs.98288

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000357872; ENSP00000350541; ENSG00000172901 [Q6Q4G3-1]
    ENST00000503329; ENSP00000427418; ENSG00000172901 [Q6Q4G3-4]
    ENST00000504467; ENSP00000423604; ENSG00000172901 [Q6Q4G3-2]
    ENST00000512314; ENSP00000427500; ENSG00000172901 [Q6Q4G3-4]
    ENST00000514509; ENSP00000427574; ENSG00000172901 [Q6Q4G3-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    206338

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:206338

    UCSC genome browser

    More...
    UCSCi
    uc003kro.4 human [Q6Q4G3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY560010 mRNA Translation: AAS66719.1
    AK075131 mRNA Translation: BAC11422.1 Different initiation.
    AK291655 mRNA Translation: BAF84344.1
    AC010282 Genomic DNA No translation available.
    AC034236 Genomic DNA No translation available.
    CH471086 Genomic DNA Translation: EAW48946.1
    BC036440 mRNA No translation available.
    BC045809 mRNA No translation available.
    BC068560 mRNA Translation: AAH68560.1
    BC070028 mRNA No translation available.
    BC094716 mRNA No translation available.
    BC109022 mRNA Translation: AAI09023.1
    BC109023 mRNA Translation: AAI09024.1
    CCDSiCCDS4124.1 [Q6Q4G3-1]
    RefSeqiNP_776161.3, NM_173800.4 [Q6Q4G3-1]
    UniGeneiHs.556880
    Hs.98288

    3D structure databases

    ProteinModelPortaliQ6Q4G3
    SMRiQ6Q4G3
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi128502, 2 interactors
    STRINGi9606.ENSP00000350541

    Chemistry databases

    ChEMBLiCHEMBL3831223

    Protein family/group databases

    MEROPSiM01.026

    PTM databases

    iPTMnetiQ6Q4G3
    PhosphoSitePlusiQ6Q4G3

    Polymorphism and mutation databases

    BioMutaiAQPEP
    DMDMi296439457

    Proteomic databases

    PaxDbiQ6Q4G3
    PeptideAtlasiQ6Q4G3
    PRIDEiQ6Q4G3
    ProteomicsDBi67267
    67268 [Q6Q4G3-2]
    67269 [Q6Q4G3-3]
    67270 [Q6Q4G3-4]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000357872; ENSP00000350541; ENSG00000172901 [Q6Q4G3-1]
    ENST00000503329; ENSP00000427418; ENSG00000172901 [Q6Q4G3-4]
    ENST00000504467; ENSP00000423604; ENSG00000172901 [Q6Q4G3-2]
    ENST00000512314; ENSP00000427500; ENSG00000172901 [Q6Q4G3-4]
    ENST00000514509; ENSP00000427574; ENSG00000172901 [Q6Q4G3-3]
    GeneIDi206338
    KEGGihsa:206338
    UCSCiuc003kro.4 human [Q6Q4G3-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    206338
    DisGeNETi206338
    EuPathDBiHostDB:ENSG00000172901.19

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    LVRN

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0005107
    HIX0164328
    HGNCiHGNC:26904 LVRN
    HPAiHPA053254
    MIMi610046 gene
    neXtProtiNX_Q6Q4G3
    OpenTargetsiENSG00000172901

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1046 Eukaryota
    COG0308 LUCA
    GeneTreeiENSGT00940000160535
    InParanoidiQ6Q4G3
    KOiK13724
    OMAiRNVFPCF
    OrthoDBiEOG091G01GH
    PhylomeDBiQ6Q4G3

    Enzyme and pathway databases

    SABIO-RKiQ6Q4G3

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    LVRN human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    206338

    Protein Ontology

    More...
    PROi
    PR:Q6Q4G3

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000172901 Expressed in 98 organ(s), highest expression level in placenta
    ExpressionAtlasiQ6Q4G3 baseline and differential
    GenevisibleiQ6Q4G3 HS

    Family and domain databases

    CDDicd09601 M1_APN_2, 1 hit
    InterProiView protein in InterPro
    IPR024571 ERAP1-like_C_dom
    IPR034016 M1_APN-typ
    IPR001930 Peptidase_M1
    IPR014782 Peptidase_M1_N
    PANTHERiPTHR11533 PTHR11533, 1 hit
    PfamiView protein in Pfam
    PF11838 ERAP1_C, 1 hit
    PF01433 Peptidase_M1, 1 hit
    PRINTSiPR00756 ALADIPTASE
    PROSITEiView protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPQ_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Q4G3
    Secondary accession number(s): A8K6J0
    , C9JGD2, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: May 18, 2010
    Last modified: December 5, 2018
    This is version 120 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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