40S ribosomal protein S29

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• structural constituent of ribosome Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence."
    Burns C.E., Galloway J.L., Smith A.C., Keefe M.D., Cashman T.J., Paik E.J., Mayhall E.A., Amsterdam A.H., Zon L.I.
    Blood 113:5776-5782(2009) [PubMed] [Europe PMC] [Abstract]
• chordate embryonic development Source: ZFINInferred from mutant phenotypeⁱ
  • "Ribosomal protein gene knockdown causes developmental defects in zebrafish."
    Uechi T., Nakajima Y., Nakao A., Torihara H., Chakraborty A., Inoue K., Kenmochi N.
    PLoS One 1:e37-e37(2006) [PubMed] [Europe PMC] [Abstract]
• erythrocyte development Source: ZFINInferred from mutant phenotypeⁱ
  • "Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation."
    Taylor A.M., Humphries J.M., White R.M., Murphey R.D., Burns C.E., Zon L.I.
    Exp Hematol 40:228-237.e5(2012) [PubMed] [Europe PMC] [Abstract]
• erythrocyte differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families."
    Mirabello L., Macari E.R., Jessop L., Ellis S.R., Myers T., Giri N., Taylor A.M., McGrath K.E., Humphries J.M., Ballew B.J., Yeager M., Boland J.F., He J., Hicks B.D., Burdett L., Alter B.P., Zon L., Savage S.A.
    Blood 124:24-32(2014) [PubMed] [Europe PMC] [Abstract]
• hematopoietic stem cell differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence."
    Burns C.E., Galloway J.L., Smith A.C., Keefe M.D., Cashman T.J., Paik E.J., Mayhall E.A., Amsterdam A.H., Zon L.I.
    Blood 113:5776-5782(2009) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway by p53 class mediator Source: ZFINInferred from mutant phenotypeⁱ
  • "Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation."
    Taylor A.M., Humphries J.M., White R.M., Murphey R.D., Burns C.E., Zon L.I.
    Exp Hematol 40:228-237.e5(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle Source: ZFINInferred from mutant phenotypeⁱ
  • Ref.1

    "Many ribosomal protein genes are cancer genes in zebrafish."
    Amsterdam A., Sadler K.C., Lai K., Farrington S., Bronson R.T., Lees J.A., Hopkins N.
    PLoS Biol. 2:690-698(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• translation Source: InterPro
• vasculogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence."
    Burns C.E., Galloway J.L., Smith A.C., Keefe M.D., Cashman T.J., Paik E.J., Mayhall E.A., Amsterdam A.H., Zon L.I.
    Blood 113:5776-5782(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

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MGHQQLYWSH PRKYGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI 

GFVKLD                                                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ