UniProtKB - Q6Q3E8 (Q6Q3E8_RAT)
Protein
Submitted name:
Endoglin
Gene
Eng
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- coreceptor activity Source: RGD
- galactose binding Source: RGD
- glycosaminoglycan binding Source: RGD
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
- transforming growth factor beta-activated receptor activity Source: GO_Central
- transforming growth factor beta binding Source: RGD
- type II transforming growth factor beta receptor binding Source: RGD
- type I transforming growth factor beta receptor binding Source: RGD
GO - Biological processi
- angiogenesis Source: RGD
- artery morphogenesis Source: RGD
- atrial cardiac muscle tissue morphogenesis Source: RGD
- atrioventricular canal morphogenesis Source: RGD
- bone development Source: RGD
- branching involved in blood vessel morphogenesis Source: RGD
- cardiac atrium morphogenesis Source: RGD
- cardiac ventricle morphogenesis Source: RGD
- cell chemotaxis Source: RGD
- cell migration Source: RGD
- cell migration involved in endocardial cushion formation Source: RGD
- cell motility Source: RGD
- cellular response to mechanical stimulus Source: RGD
- central nervous system vasculogenesis Source: RGD
- chronological cell aging Source: RGD
- detection of hypoxia Source: RGD
- dorsal aorta morphogenesis Source: RGD
- endocardial cushion morphogenesis Source: RGD
- epithelial to mesenchymal transition Source: GO_Central
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
- extracellular matrix constituent secretion Source: RGD
- extracellular matrix disassembly Source: RGD
- heart development Source: RGD
- heart looping Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of endothelial cell proliferation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of nitric-oxide synthase activity Source: RGD
- negative regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
- negative regulation of protein autophosphorylation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- outflow tract septum morphogenesis Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of BMP signaling pathway Source: RGD
- positive regulation of collagen biosynthetic process Source: RGD
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
- positive regulation of protein kinase B signaling Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of systemic arterial blood pressure Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of vascular associated smooth muscle cell differentiation Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transforming growth factor beta receptor signaling pathway Source: RGD
- response to corticosteroid Source: RGD
- response to drug Source: RGD
- response to hypoxia Source: RGD
- response to transforming growth factor beta Source: RGD
- smooth muscle tissue development Source: RGD
- transforming growth factor beta receptor signaling pathway Source: RGD
- vascular associated smooth muscle cell development Source: RGD
- vasculogenesis Source: RGD
- venous blood vessel morphogenesis Source: RGD
- ventricular trabecula myocardium morphogenesis Source: RGD
- wound healing Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: EndoglinImported |
Gene namesi | Name:EngImported ORF Names:rCG_45763Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Organism-specific databases
RGDi | 1593188, Eng |
Subcellular locationi
Extracellular region or secreted
- endothelial microparticle Source: RGD
- extracellular space Source: RGD
Plasma Membrane
- external side of plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- integral component of membrane Source: RGD
- receptor complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 579 – 606 | HelicalSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5013533443 | 26 – 650 | Sequence analysisAdd BLAST | 625 |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
- transforming growth factor beta binding Source: RGD
- type II transforming growth factor beta receptor binding Source: RGD
- type I transforming growth factor beta receptor binding Source: RGD
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 360 – 505 | ZPInterPro annotationAdd BLAST | 146 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 622 – 650 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 624 – 650 | PolarSequence analysisAdd BLAST | 27 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 1263397at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6Q3E8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS
60 70 80 90 100
EGCVAQVANA AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI
110 120 130 140 150
SNENVLVKLQ APEIPLHLVY NSSLEVFKGP KVNSTPLPSF TSKTQILDWA
160 170 180 190 200
ATKGTITSIA ALDDPKSIVL RLGQDPKAPP FCFPEAQKDM GVTLEWQPRT
210 220 230 240 250
QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL SCTSGDAVLI
260 270 280 290 300
LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE
310 320 330 340 350
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE
360 370 380 390 400
LLMSLIQPKC GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL
410 420 430 440 450
VLSSTYSSCG MKVTDHVISN EVIINLPSGL PPLRKKVQCI DMDSLSFQLG
460 470 480 490 500
LYLSPHFLQA SNTIELGQQG FVQVSMSPLT SEVTVQLDSC HLDLGPEGDM
510 520 530 540 550
VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA AGTLSCNLAL
560 570 580 590 600
HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA
610 620 630 640 650
ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY562420 mRNA Translation: AAS67893.1 CH474001 Genomic DNA Translation: EDL93221.1 |
RefSeqi | NP_001010968.1, NM_001010968.2 |
Genome annotation databases
GeneIDi | 497010 |
KEGGi | rno:497010 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY562420 mRNA Translation: AAS67893.1 CH474001 Genomic DNA Translation: EDL93221.1 |
RefSeqi | NP_001010968.1, NM_001010968.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 497010 |
KEGGi | rno:497010 |
Organism-specific databases
CTDi | 2022 |
RGDi | 1593188, Eng |
Phylogenomic databases
OrthoDBi | 1263397at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6Q3E8_RAT | |
Accessioni | Q6Q3E8Primary (citable) accession number: Q6Q3E8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |