Endoglin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• coreceptor activity Source: RGD
• galactose binding Source: RGD
• glycosaminoglycan binding Source: RGD
• identical protein binding Source: RGD
• protein homodimerization activity Source: RGD
• transforming growth factor beta-activated receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: RGD
• type II transforming growth factor beta receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling."
    Meurer S.K., Tihaa L., Borkham-Kamphorst E., Weiskirchen R.
    Cell Signal 23:683-699(2011) [PubMed] [Europe PMC] [Abstract]
• type I transforming growth factor beta receptor binding Source: RGD

GO - Biological processⁱ

• angiogenesis Source: RGD
• artery morphogenesis Source: RGD
• atrial cardiac muscle tissue morphogenesis Source: RGD
• atrioventricular canal morphogenesis Source: RGD
• bone development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus."
    Ozbey O., Sahin Z., Acar N., Ustunel I.
    Histol Histopathol 25:1437-1445(2010) [PubMed] [Europe PMC] [Abstract]
• branching involved in blood vessel morphogenesis Source: RGD
• cardiac atrium morphogenesis Source: RGD
• cardiac ventricle morphogenesis Source: RGD
• cell chemotaxis Source: RGD
• cell migration Source: RGD
• cell migration involved in endocardial cushion formation Source: RGD
• cell motility Source: RGD
• cellular response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Mechanical stretch via transforming growth factor-beta1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts."
    Shyu K.G., Wang B.W., Wu G.J., Lin C.M., Chang H.
    Eur J Heart Fail 15:36-45(2013) [PubMed] [Europe PMC] [Abstract]
• central nervous system vasculogenesis Source: RGD
• chronological cell aging Source: RGD
• detection of hypoxia Source: RGD
• dorsal aorta morphogenesis Source: RGD
• endocardial cushion morphogenesis Source: RGD
• epithelial to mesenchymal transition Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
• extracellular matrix constituent secretion Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II."
    Chen K., Mehta J.L., Li D., Joseph L., Joseph J.
    Circ Res 95:1167-1173(2004) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix disassembly Source: RGD
• heart development Source: RGD
• heart looping Source: RGD
• negative regulation of cell migration Source: RGD
• negative regulation of endothelial cell proliferation Source: RGD
• negative regulation of gene expression Source: RGD
• negative regulation of nitric-oxide synthase activity Source: RGD
• negative regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
• negative regulation of protein autophosphorylation Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• outflow tract septum morphogenesis Source: RGD
• positive regulation of angiogenesis Source: RGD
• positive regulation of BMP signaling pathway Source: RGD
• positive regulation of collagen biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • "Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts."
    Shyu K.G., Wang B.W., Chen W.J., Kuan P., Hung C.R.
    Eur J Heart Fail 12:219-226(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling."
    Meurer S.K., Tihaa L., Borkham-Kamphorst E., Weiskirchen R.
    Cell Signal 23:683-699(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
• positive regulation of protein kinase B signaling Source: RGD
• positive regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling."
    Meurer S.K., Tihaa L., Borkham-Kamphorst E., Weiskirchen R.
    Cell Signal 23:683-699(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of systemic arterial blood pressure Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of vascular associated smooth muscle cell differentiation Source: RGD
• regulation of transcription, DNA-templated Source: RGD
• regulation of transforming growth factor beta receptor signaling pathway Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling."
    Scherner O., Meurer S.K., Tihaa L., Gressner A.M., Weiskirchen R.
    J Biol Chem 282:13934-13943(2007) [PubMed] [Europe PMC] [Abstract]
• response to corticosteroid Source: RGDInferred from expression patternⁱ
  • "The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage."
    Ozbey O., Sahin Z., Ozenci A.M., Acar N., Ustunel I.
    Acta Histochem 112:424-431(2010) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts."
    Shyu K.G., Wang B.W., Chen W.J., Kuan P., Hung C.R.
    Eur J Heart Fail 12:219-226(2010) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGD
• response to transforming growth factor beta Source: RGDInferred from expression patternⁱ
  • "Mechanical stretch via transforming growth factor-beta1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts."
    Shyu K.G., Wang B.W., Wu G.J., Lin C.M., Chang H.
    Eur J Heart Fail 15:36-45(2013) [PubMed] [Europe PMC] [Abstract]
• smooth muscle tissue development Source: RGD
• transforming growth factor beta receptor signaling pathway Source: RGD
• vascular associated smooth muscle cell development Source: RGD
• vasculogenesis Source: RGD
• venous blood vessel morphogenesis Source: RGD
• ventricular trabecula myocardium morphogenesis Source: RGD
• wound healing Source: RGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGD
• protein homodimerization activity Source: RGD
• transforming growth factor beta binding Source: RGD
• type II transforming growth factor beta receptor binding Source: RGDInferred from physical interactionⁱ
  • "Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling."
    Meurer S.K., Tihaa L., Borkham-Kamphorst E., Weiskirchen R.
    Cell Signal 23:683-699(2011) [PubMed] [Europe PMC] [Abstract]
• type I transforming growth factor beta receptor binding Source: RGD

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS 
        60         70         80         90        100
EGCVAQVANA AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI 
       110        120        130        140        150
SNENVLVKLQ APEIPLHLVY NSSLEVFKGP KVNSTPLPSF TSKTQILDWA 
       160        170        180        190        200
ATKGTITSIA ALDDPKSIVL RLGQDPKAPP FCFPEAQKDM GVTLEWQPRT 
       210        220        230        240        250
QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL SCTSGDAVLI 
       260        270        280        290        300
LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE 
       310        320        330        340        350
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE 
       360        370        380        390        400
LLMSLIQPKC GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL 
       410        420        430        440        450
VLSSTYSSCG MKVTDHVISN EVIINLPSGL PPLRKKVQCI DMDSLSFQLG 
       460        470        480        490        500
LYLSPHFLQA SNTIELGQQG FVQVSMSPLT SEVTVQLDSC HLDLGPEGDM 
       510        520        530        540        550
VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA AGTLSCNLAL 
       560        570        580        590        600
HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA 
       610        620        630        640        650
ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ