Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 64 (02 Dec 2020)
Sequence version 2 (05 Sep 2006)
Previous versions | rss
Add a publicationFeedback
Protein

RNA-directed RNA polymerase L

Gene

RdRp

Organism
European mountain ash ringspot-associated virus (isolate Sorbus aucuparia) (EMARAV)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RdRp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEuropean mountain ash ringspot-associated virus (isolate Sorbus aucuparia) (EMARAV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1980426 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesFimoviridaeEmaravirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEriophyes pyri (pearleaf blister mite) [TaxID: 483436]
Sorbus aucuparia (European mountain ash) (Rowan) [TaxID: 36599]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006676 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003956041 – 2293RNA-directed RNA polymerase LAdd BLAST2293

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6Q305

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1111 – 1297RdRp catalyticPROSITE-ProRule annotationAdd BLAST187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007099, RNA-dir_pol_NSvirus
IPR007322, RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196, Bunya_RdRp, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50525, RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6Q305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENIRKLEAQ RRKEYLRAET EIRNNNVFEK DILQKFLHIV GKKQRHYTIS
60 70 80 90 100
SKKKEVQDIF NKCSTNPGFT KDVIDLAERI LYAPPNLNQI DFAMTIVSLI
110 120 130 140 150
EMQRHDDLIH KLNELLVRSG MKVISFEFKL CDHFPFTNSI LTPDILFEDP
160 170 180 190 200
YGSRYILEVK VRNKHTDLEH YYMRYKKVVG VHAKVGVFNL SQSGYMQHGD
210 220 230 240 250
YKLSEKINLE SDDFDDILLC VELAGKIREK YIQYPQYFLY TLQSEVTNPD
260 270 280 290 300
SFLDGFKTRL SDLSMFEEIK SGFGDYWNDI TYHMDNYSLI DNHDEVTEDL
310 320 330 340 350
LNSTDDLTQY CNDLYDEFLD HSQSYSRQGK YGKTILRNSG LDNIIDKKNR
360 370 380 390 400
SKYTITSKLK PSVYIPITKT IKLDTYGGSR LKFYKDAFIN IKCTGDSYSR
410 420 430 440 450
SAYNLVDNVF NTSSIDLLMT KDDKIDPSLY YEVLDPGFIA HLHDDQVKYK
460 470 480 490 500
KIAKVTNITS DMTILANNSF SIHCHTDQRL KDNICGYDKK HYDSTQKAKE
510 520 530 540 550
CLDFSNSSLL LPSLGVHLSA IFKSEHHAGV YWNDLVTLGT DNLNHMTSDI
560 570 580 590 600
PEEAQTKFLE HLYNSHIIFK AIISLNTINS HKFRLLQSPD PGTIIILLPN
610 620 630 640 650
SDGLKGAPLR YFVVSILQKQ DNDSIEANKL LGIYHSHTES KKYKIMLSKV
660 670 680 690 700
ISLDITRLKL LSNSFVKYSL LISYYSQFKK SLKFDTHMLS WMLSQVTTIA
710 720 730 740 750
SLSITDVYKN FIMAIYSDYS NIDDLINDKL ECRPRTLGHV FVMKHLFQGI
760 770 780 790 800
TSAVEQLGKI NKNKLIADVN DEGELISTGF DPNLRLKLPI SQLSTNNPKE
810 820 830 840 850
IIHESFILFY LGNKGLHGSP QELLNLYYTP MQFESEYTKM MTDCGLYCQE
860 870 880 890 900
LGNNGNLSFS FQAMFLTSKV AYAKLLNNTD EIRRSLVKEM KMDEPIMSIK
910 920 930 940 950
QFSSTKSMVS NSVPDMSIKD CNLNKNIDVI QLERYIDTSL ISDPMKYITL
960 970 980 990 1000
MNNSIESINQ ERLLIYKDKL NKGIVLLPKL ILTTFKGKSF IGLENHYYTK
1010 1020 1030 1040 1050
LVSGDYIKQT NTKVFDEFYR LTDEIQEEKL RGFYKGYITE GDLLVRIFNK
1060 1070 1080 1090 1100
DQRTTDDREI YTGNAQVRLC LYPLEMTFKS ICKKIPEEAI TISGDQKQRK
1110 1120 1130 1140 1150
LLEQRLALIK TKRQFNKSGY KTEIYSVSSD ASKWSARDLL PKFIISIATN
1160 1170 1180 1190 1200
PYLTSDEKYF LVYLLVRYYD KKIVLTDSAF SNALRFSRED INGKYEEMTN
1210 1220 1230 1240 1250
NFTQNWFNVR SNWLQGNLNM TSSFVHHCST IMTDTLLSIS AKHNGFEAVM
1260 1270 1280 1290 1300
TSMVHSDDST YDFLIAKNSK TSSYINNEAN MGRFIISLIT YSNKKHCITL
1310 1320 1330 1340 1350
NEKKTYISTF YKEFLSTTIV SNELFFFYMA DLMPISSDTS YKSPLEDLAS
1360 1370 1380 1390 1400
YTGYINNSFS HACPIQILKC AITLLNHLTL STYNMQYTSE KNPRCNIPNS
1410 1420 1430 1440 1450
TDLPIQIYPR YKLPLSLAGC IPYYSSDAYN ILDDIIKTLE KNKVIKNSLL
1460 1470 1480 1490 1500
EDVIDDETLD EYITLVNKQK PEYAKYIQAC LLTMDYTQYE RDDEDPYNIV
1510 1520 1530 1540 1550
DYDLSQKSII NVASINKGSR IKKTYTYKKY LENETDIRLT SCVNPMWCIS
1560 1570 1580 1590 1600
KPKDEVLIKN PILANYMNPN FKDSLIFSKS ALDYGRRIIG SNKSMDTLSS
1610 1620 1630 1640 1650
HAFEKEKKQG IKTIYKKLDD KISTVEISKQ SLQRFLECIY SVIKKSLVAL
1660 1670 1680 1690 1700
QVYYSKVQVL VKTRPEFTKV IMPRSVYAEE YGKNSNTSMV ENLLVEQYCE
1710 1720 1730 1740 1750
IEQVDSKVEK FISFCKHVLQ RCGDIKIYRD PEDIDDDFRK YIEFKYTLKD
1760 1770 1780 1790 1800
ATMGLIQPHQ HLAEYAFDVY NNKLIFQGLM VRYYIDICET ISNPSYNIPS
1810 1820 1830 1840 1850
YTSPNSIIMT LDSLMKRDEI SSKIYISHIR TNRFDEYWLS RFGMYVYENY
1860 1870 1880 1890 1900
FVKYKLGYRI KIAANEKLMP TMKKVRNLRE PFKFICSLVA NDPSLFIQMT
1910 1920 1930 1940 1950
ESPDFQISGW KYSDIIAEMK STTDFSYNLF LYMMNEINFQ TLMRVMNLNR
1960 1970 1980 1990 2000
RVWNHWLMKT DSEPSDPNAS IALYMYQSTV VKVQTKTIGG GVTFSMLLLR
2010 2020 2030 2040 2050
HGMQHRQAFD EISKKIASDY APQLRIANIT PQTSFGRLQF CVNEYGRTVK
2060 2070 2080 2090 2100
PGSYRSSCIC NVNIAALTDL KPDIAYKENT INQIVTIISP TFEGEFVFKL
2110 2120 2130 2140 2150
NTYCDSEYYT CVMLENLDLN RVMILDHLCR GKYLIENPEY FTEISDQITP
2160 2170 2180 2190 2200
GACLALFSNN VNNKLWSNTI DTSKFAKLVH IGNYLKTEHE ASIVTKLCDS
2210 2220 2230 2240 2250
LVAICALNGI DHTLSLKPDN FIKSLRQYKL SYGFHEEFYN NYKKNEREPY
2260 2270 2280 2290
TELIMAIAST AGDPFQKVIL AIITIFKAYT DLFISYKTDE VEF
Length:2,293
Mass (Da):265,654
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC3F60877F5E2769
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY563040 mRNA Translation: AAS73287.2

NCBI Reference Sequences

More...
RefSeqi
YP_003104764.1, NC_013105.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8317725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:8317725

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY563040 mRNA Translation: AAS73287.2
RefSeqiYP_003104764.1, NC_013105.1

3D structure databases

SMRiQ6Q305
ModBaseiSearch...

Genome annotation databases

GeneIDi8317725
KEGGivg:8317725

Family and domain databases

InterProiView protein in InterPro
IPR007099, RNA-dir_pol_NSvirus
IPR007322, RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196, Bunya_RdRp, 1 hit
PROSITEiView protein in PROSITE
PS50525, RDRP_SSRNA_NEG_SEG, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_EMARV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Q305
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 5, 2006
Last modified: December 2, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again