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Entry version 102 (22 Apr 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Spike glycoprotein

Gene

S

Organism
Human coronavirus NL63 (HCoV-NL63)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation

Caution

In contrast to beta- and gammacoronaviruses, S glycoprotein is not cleaved into S1 and S2.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Virulence, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoproteinUniRule annotation
Short name:
S glycoproteinUniRule annotation
Alternative name(s):
E2UniRule annotation
Peplomer proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUniRule annotation
ORF Names:2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman coronavirus NL63 (HCoV-NL63)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri277944 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeAlphacoronavirusSetracovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000161757 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008573 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1296Virion surfaceUniRule annotationAdd BLAST1278
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1297 – 1316HelicalUniRule annotationAdd BLAST20
Topological domaini1317 – 1356IntravirionUniRule annotationAdd BLAST40

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18UniRule annotationAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003720419 – 1356Spike glycoproteinUniRule annotationAdd BLAST1338

Keywords - PTMi

Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. During virus morphogenesis, found in a complex with M and HE proteins.

Interacts with host ANPEP.

UniRule annotation

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-49012N

Protein interaction database and analysis system

More...
IntActi
Q6Q1S2, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6Q1S2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6Q1S2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 717S1Add BLAST702
Regioni19 – 717S1UniRule annotationAdd BLAST699
Regioni598 – 728Interaction with host ANPEPUniRule annotationAdd BLAST131
Regioni718 – 1356S2UniRule annotationAdd BLAST639
Regioni934 – 954Fusion peptideUniRule annotationAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1015 – 1059UniRule annotationAdd BLAST45
Coiled coili1244 – 1286UniRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1352 – 1356KxHxxUniRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1317 – 1340Cys-richAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KxHxx motif seems to function as an ER retrieval signal.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alphacoronaviruses spike protein family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K19254

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04200 ALPHA_CORONA_SPIKE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042552 ALPHA_CORONA_SPIKE
IPR002551 Corona_S1
IPR002552 Corona_S2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01600 Corona_S1, 1 hit
PF01601 Corona_S2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Q1S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLFLILLVL PLASCFFTCN SNANLSMLQL GVPDNSSTIV TGLLPTHWFC
60 70 80 90 100
ANQSTSVYSA NGFFYIDVGN HRSAFALHTG YYDANQYYIY VTNEIGLNAS
110 120 130 140 150
VTLKICKFSR NTTFDFLSNA SSSFDCIVNL LFTEQLGAPL GITISGETVR
160 170 180 190 200
LHLYNVTRTF YVPAAYKLTK LSVKCYFNYS CVFSVVNATV TVNVTTHNGR
210 220 230 240 250
VVNYTVCDDC NGYTDNIFSV QQDGRIPNGF PFNNWFLLTN GSTLVDGVSR
260 270 280 290 300
LYQPLRLTCL WPVPGLKSST GFVYFNATGS DVNCNGYQHN SVVDVMRYNL
310 320 330 340 350
NFSANSLDNL KSGVIVFKTL QYDVLFYCSN SSSGVLDTTI PFGPSSQPYY
360 370 380 390 400
CFINSTINTT HVSTFVGILP PTVREIVVAR TGQFYINGFK YFDLGFIEAV
410 420 430 440 450
NFNVTTASAT DFWTVAFATF VDVLVNVSAT NIQNLLYCDS PFEKLQCEHL
460 470 480 490 500
QFGLQDGFYS ANFLDDNVLP ETYVALPIYY QHTDINFTAT ASFGGSCYVC
510 520 530 540 550
KPHQVNISLN GNTSVCVRTS HFSIRYIYNR VKSGSPGDSS WHIYLKSGTC
560 570 580 590 600
PFSFSKLNNF QKFKTICFST VEVPGSCNFP LEATWHYTSY TIVGALYVTW
610 620 630 640 650
SEGNSITGVP YPVSGIREFS NLVLNNCTKY NIYDYVGTGI IRSSNQSLAG
660 670 680 690 700
GITYVSNSGN LLGFKNVSTG NIFIVTPCNQ PDQVAVYQQS IIGAMTAVNE
710 720 730 740 750
SRYGLQNLLQ LPNFYYVSNG GNNCTTAVMT YSNFGICADG SLIPVRPRNS
760 770 780 790 800
SDNGISAIIT ANLSIPSNWT TSVQVEYLQI TSTPIVVDCA TYVCNGNPRC
810 820 830 840 850
KNLLKQYTSA CKTIEDALRL SAHLETNDVS SMLTFDSNAF SLANVTSFGD
860 870 880 890 900
YNLSSVLPQR NIRSSRIAGR SALEDLLFSK VVTSGLGTVD VDYKSCTKGL
910 920 930 940 950
SIADLACAQY YNGIMVLPGV ADAERMAMYT GSLIGGMVLG GLTSAAAIPF
960 970 980 990 1000
SLALQARLNY VALQTDVLQE NQKILAASFN KAINNIVASF SSVNDAITQT
1010 1020 1030 1040 1050
AEAIHTVTIA LNKIQDVVNQ QGSALNHLTS QLRHNFQAIS NSIQAIYDRL
1060 1070 1080 1090 1100
DSIQADQQVD RLITGRLAAL NAFVSQVLNK YTEVRGSRRL AQQKINECVK
1110 1120 1130 1140 1150
SQSNRYGFCG NGTHIFSIVN SAPDGLLFLH TVLLPTDYKN VKAWSGICVD
1160 1170 1180 1190 1200
GIYGYVLRQP NLVLYSDNGV FRVTSRVMFQ PRLPVLSDFV QIYNCNVTFV
1210 1220 1230 1240 1250
NISRVELHTV IPDYVDVNKT LQEFAQNLPK YVKPNFDLTP FNLTYLNLSS
1260 1270 1280 1290 1300
ELKQLEAKTA SLFQTTVELQ GLIDQINSTY VDLKLLNRFE NYIKWPWWVW
1310 1320 1330 1340 1350
LIISVVFVVL LSLLVFCCLS TGCCGCCNCL TSSMRGCCDC GSTKLPYYEF

EKVHVQ
Length:1,356
Mass (Da):149,850
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8699E079BB0D54B7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti9V → I in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti13A → V in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti17F → S in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti24 – 25NL → SI in strain: Isolate BE03-40001 and Isolate NL. 2
Natural varianti46T → V in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti49F → I in strain: Isolate BE03-1153, Isolate BE03-40001, Isolate BE03-64880 and Isolate NL. 1
Natural varianti57 – 59VYS → SYP in strain: Isolate BE03-40001 and Isolate NL. 3
Natural varianti70N → K in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti79T → S in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti84A → V in strain: Isolate BE03-1153 and Isolate BE03-64880. 1
Natural varianti91V → L in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti94 – 96EIG → KIH in strain: Isolate BE03-40001 and Isolate NL. 3
Natural varianti100S → P in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti109 – 110SR → GI in strain: Isolate BE03-1153 and Isolate BE03-64880 and Isolate NL. 2
Natural varianti109S → G in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti110Missing in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti113T → S in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti120 – 124ASSSF → VSTSH in strain: Isolate BE03-40001 and Isolate NL. 5
Natural varianti125D → H in strain: Isolate BE03-40001. 1
Natural varianti130L → S in strain: Isolate BE03-40001. 1
Natural varianti131L → S in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti138A → V in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti156V → A in strain: Isolate BE03-40001 and Isolate NL. 1
Natural varianti178 – 179NY → SE in strain: Isolate BE03-40001 and Isolate NL. 2
Natural varianti190V → I in strain: Isolate NL. 1
Natural varianti197H → L in strain: Isolate NL. 1
Natural varianti201V → I in strain: Isolate NL. 1
Natural varianti293V → A in strain: Isolate NL. 1
Natural varianti302F → L in strain: Isolate NL. 1
Natural varianti307L → V in strain: Isolate NL. 1
Natural varianti503H → R in strain: Isolate NL. 1
Natural varianti730T → I in strain: Isolate NL. 1
Natural varianti863R → H in strain: Isolate NL. 1
Natural varianti999Q → H in strain: Isolate NL. 1
Natural varianti1044Q → H in strain: Isolate NL. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY567487 Genomic RNA Translation: AAS58177.1
AY518894 Genomic RNA Translation: AAS89767.1
AY758297 Genomic RNA Translation: AAW66968.1 Different termination.
AY758298 Genomic RNA Translation: AAW66969.1 Different termination.
AY758300 Genomic RNA Translation: AAW66970.1 Different termination.
AY758301 Genomic RNA Translation: AAW66971.1 Different termination.

NCBI Reference Sequences

More...
RefSeqi
YP_003767.1, NC_005831.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2943499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:2943499

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY567487 Genomic RNA Translation: AAS58177.1
AY518894 Genomic RNA Translation: AAS89767.1
AY758297 Genomic RNA Translation: AAW66968.1 Different termination.
AY758298 Genomic RNA Translation: AAW66969.1 Different termination.
AY758300 Genomic RNA Translation: AAW66970.1 Different termination.
AY758301 Genomic RNA Translation: AAW66971.1 Different termination.
RefSeqiYP_003767.1, NC_005831.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IEQX-ray1.75A/B/C981-1037[»]
A/B/C1242-1283[»]
3KBHX-ray3.31E/F/G/H481-616[»]
5SZSelectron microscopy3.40A/B/C16-1291[»]
SMRiQ6Q1S2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-49012N
IntActiQ6Q1S2, 1 interactor

Genome annotation databases

GeneIDi2943499
KEGGivg:2943499

Phylogenomic databases

KOiK19254

Miscellaneous databases

EvolutionaryTraceiQ6Q1S2

Family and domain databases

HAMAPiMF_04200 ALPHA_CORONA_SPIKE, 1 hit
InterProiView protein in InterPro
IPR042552 ALPHA_CORONA_SPIKE
IPR002551 Corona_S1
IPR002552 Corona_S2
PfamiView protein in Pfam
PF01600 Corona_S1, 1 hit
PF01601 Corona_S2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_CVHNL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Q1S2
Secondary accession number(s): Q5DIX7
, Q5DIX8, Q5DIX9, Q5DIY0, Q6R1L7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: April 22, 2020
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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