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UniProtKB - Q6Q1Q8 (Q6Q1Q8_CHICK)

Entry version 130 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Mannan-binding lectin associated serine protease 3

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, ProteaseImported
LigandLectinImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-GGA-2132263, Creation of classical C3 convertase
R-GGA-2132270, Lectin-mediated initiation of complement cascade

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.132

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mannan-binding lectin associated serine protease 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500427839920 – 730Sequence analysisAdd BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi183 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, HydroxylationARBA annotation, ZymogenARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 136CUBInterPro annotationAdd BLAST127
Domaini183 – 295CUBInterPro annotationAdd BLAST113
Domaini297 – 362SushiInterPro annotationAdd BLAST66
Domaini363 – 432SushiInterPro annotationAdd BLAST70
Domaini448 – 716Peptidase S1InterPro annotationAdd BLAST269

Keywords - Domaini

EGF-like domainARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, SushiPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		156878at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6Q1Q8

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 2 hits
cd00041, CUB, 2 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001254, Trypsin_dom
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 2 hits
PF00084, Sushi, 2 hits
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 2 hits
SM00042, CUB, 2 hits
SM00181, EGF, 1 hit
SM00179, EGF_CA, 1 hit
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 2 hits
PS01186, EGF_2, 1 hit
PS01187, EGF_CA, 1 hit
PS50923, SUSHI, 2 hits
PS50240, TRYPSIN_DOM, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6Q1Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRYPLAWSMC AWLLGVVGAV ELTDMFGEIR SPNFPDSYPS DSEVTWNISV 
        60         70         80         90        100
PEGFKIKLYY MHFDLESSYL CEYDYVKIEA EDQELATFCG RETTDTEQAP 
       110        120        130        140        150
GQQVILSPGP YMGLTFRSDF SNEERFTGFD AHYTAVDVDE CLEKSDEELA 
       160        170        180        190        200
CDHYCHNYIG GYYCSCRFGY ILHSDNRTCK VECSDNLYTQ RSGVVTSADF 
       210        220        230        240        250
PSPYPKSSDC LYRIELEDGF FITLSFEDSF DVEDHPEVTC PYDYIKIKAG 
       260        270        280        290        300
QREFGPFCGE KSPGRIETQT NSVQILFHSD NSGENRGWKL SYTAIGNPCP 
       310        320        330        340        350
LVQPPINGKI EPSQAKYTFK DQVVISCNTG YKVLKDNLES DSFQIECLKD 
       360        370        380        390        400
GTWSNKIPIC KIADCQAPPE LEHGFVTFLS RNNLTTYRAR IQYHCQHPYY 
       410        420        430        440        450
HMAPNSTATY TCDASGVWRS EELGTVLPSC RPVCGRPVRA LPGIIKRIIG 
       460        470        480        490        500
GRNAEPGFFP WQALIVVEDM SRVPNDKWFG SGALLSDSWV LTAAHVLRSQ 
       510        520        530        540        550
RRDKTVIPVS KEHVTVYLAL HDVRNKLEAV NRTVERIILH EDFDIQNYNH 
       560        570        580        590        600
DIALVKLKEK VTMGNYVMPI CLPQFEHELE GPHPNTLGLV AGWGISNPNI 
       610        620        630        640        650
TVDEIISSGM RTLSDILQYV KLPVVLHAEC KTSYESRSGN YSVTENMFCA 
       660        670        680        690        700
GYYEGGKDTC LGDSGGAFVI QDPGTRRWVA QGLVSWGGPE ECGSKQVYGV 
       710        720        730
YTKVSNYVDW VEKNTGSSER WTFLDPELER
Length:730
Mass (Da):82,403
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BBAD04A22843CF0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY567829 mRNA Translation: AAS73180.1

NCBI Reference Sequences

More...RefSeqi		NP_998751.1, NM_213586.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		407088

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		gga:407088

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY567829 mRNA Translation: AAS73180.1
RefSeqiNP_998751.1, NM_213586.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiS01.132

Genome annotation databases

GeneIDi407088
KEGGigga:407088

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5648

Phylogenomic databases

OrthoDBi156878at2759
PhylomeDBiQ6Q1Q8

Enzyme and pathway databases

ReactomeiR-GGA-2132263, Creation of classical C3 convertase
R-GGA-2132270, Lectin-mediated initiation of complement cascade

Family and domain databases

CDDicd00033, CCP, 2 hits
cd00041, CUB, 2 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001254, Trypsin_dom
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF00084, Sushi, 2 hits
PF00089, Trypsin, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032, CCP, 2 hits
SM00042, CUB, 2 hits
SM00181, EGF, 1 hit
SM00179, EGF_CA, 1 hit
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01186, EGF_2, 1 hit
PS01187, EGF_CA, 1 hit
PS50923, SUSHI, 2 hits
PS50240, TRYPSIN_DOM, 1 hit
PS00135, TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6Q1Q8_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Q1Q8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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