Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 25 member 47

Gene

SLC25A47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.8.10 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 47
Alternative name(s):
Hepatocellular carcinoma down-regulated mitochondrial carrier protein
Gene namesi
Name:SLC25A47
Synonyms:C14orf68, HDMCP
ORF Names:HMFN1655
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140107.10
HGNCiHGNC:20115 SLC25A47
MIMi609911 gene
neXtProtiNX_Q6Q0C1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei98 – 116Helical; Name=3Sequence analysisAdd BLAST19
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei273 – 293Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283600
OpenTargetsiENSG00000140107
PharmGKBiPA165479287

Polymorphism and mutation databases

BioMutaiSLC25A47
DMDMi74749277

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917791 – 308Solute carrier family 25 member 47Add BLAST308

Proteomic databases

PaxDbiQ6Q0C1
PeptideAtlasiQ6Q0C1
PRIDEiQ6Q0C1
ProteomicsDBi67265
67266 [Q6Q0C1-2]

PTM databases

iPTMnetiQ6Q0C1
PhosphoSitePlusiQ6Q0C1

Expressioni

Tissue specificityi

Specifically expressed in liver.1 Publication

Inductioni

Down-regulated in hepatocarcinoma.1 Publication

Gene expression databases

BgeeiENSG00000140107
CleanExiHS_C14orf68
ExpressionAtlasiQ6Q0C1 baseline and differential
GenevisibleiQ6Q0C1 HS

Interactioni

Protein-protein interaction databases

BioGridi129619, 5 interactors
IntActiQ6Q0C1, 2 interactors
STRINGi9606.ENSP00000354886

Structurei

3D structure databases

ProteinModelPortaliQ6Q0C1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 80Solcar 1Add BLAST80
Repeati93 – 206Solcar 2Add BLAST114
Repeati215 – 302Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0762 Eukaryota
ENOG410Z9ZS LUCA
GeneTreeiENSGT00700000104295
HOGENOMiHOG000168307
HOVERGENiHBG003500
InParanoidiQ6Q0C1
KOiK15123
OMAiHCLAHIC
OrthoDBiEOG091G0HVE
PhylomeDBiQ6Q0C1
TreeFamiTF351739

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q0C1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFVAGAIGG VCGVAVGYPL DTVKVRIQTE PKYTGIWHCV RDTYHRERVW
60 70 80 90 100
GFYRGLSLPV CTVSLVSSVS FGTYRHCLAH ICRLRYGNPD AKPTKADITL
110 120 130 140 150
SGCASGLVRV FLTSPTEVAK VRLQTQTQAQ KQQRRLSASG PLAVPPMCPV
160 170 180 190 200
PPACPEPKYR GPLHCLATVA REEGLCGLYK GSSALVLRDG HSFATYFLSY
210 220 230 240 250
AVLCEWLSPA GHSRPDVPGV LVAGGCAGVL AWAVATPMDV IKSRLQADGQ
260 270 280 290 300
GQRRYRGLLH CMVTSVREEG PRVLFKGLVL NCCRAFPVNM VVFVAYEAVL

RLARGLLT
Length:308
Mass (Da):33,435
Last modified:July 5, 2004 - v1
Checksum:i995BC7342F99AFCC
GO
Isoform 2 (identifier: Q6Q0C1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-30: VRIQTE → GLLALP
     31-308: Missing.

Show »
Length:30
Mass (Da):2,904
Checksum:i6FE4DF1638A68F9A
GO

Sequence cautioni

The sequence BAD38636 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAD62588 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02623325 – 30VRIQTE → GLLALP in isoform 2. 2 Publications6
Alternative sequenceiVSP_02623431 – 308Missing in isoform 2. 2 PublicationsAdd BLAST278

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569438 mRNA Translation: AAS80155.1
AY570298 mRNA Translation: AAS77211.1
AB073385 mRNA Translation: BAD38636.1 Sequence problems.
AK092001 mRNA Translation: BAG52460.1
BX248260 mRNA Translation: CAD62588.1 Different initiation.
CH471061 Genomic DNA Translation: EAW81697.1
BC137253 mRNA Translation: AAI37254.1
BC137254 mRNA Translation: AAI37255.1
CCDSiCCDS9959.1 [Q6Q0C1-1]
RefSeqiNP_997000.2, NM_207117.2 [Q6Q0C1-1]
UniGeneiHs.108268

Genome annotation databases

EnsembliENST00000361529; ENSP00000354886; ENSG00000140107 [Q6Q0C1-1]
GeneIDi283600
KEGGihsa:283600
UCSCiuc001yhc.4 human [Q6Q0C1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2547_HUMAN
AccessioniPrimary (citable) accession number: Q6Q0C1
Secondary accession number(s): B2RP39
, Q68CL2, Q6PZD8, Q86U14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health