UniProtKB - Q6PZD9 (CEBPE_MOUSE)
Protein
CCAAT/enhancer-binding protein epsilon
Gene
Cebpe
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.By similarity
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- identical protein binding Source: MGI
- protein-containing complex binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cellular response to lipopolysaccharide Source: Ensembl
- cytokine biosynthetic process Source: MGI
- defense response to bacterium Source: MGI
- granulocyte differentiation Source: MGI
- macrophage differentiation Source: MGI
- phagocytosis Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein epsilonShort name: C/EBP epsilon |
Gene namesi | Name:Cebpe Synonyms:Gm294 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103572, Cebpe |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076625 | 1 – 281 | CCAAT/enhancer-binding protein epsilonAdd BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 181 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q6PZD9 |
PaxDbi | Q6PZD9 |
PRIDEi | Q6PZD9 |
PTM databases
iPTMneti | Q6PZD9 |
PhosphoSitePlusi | Q6PZD9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052435, Expressed in granulocyte and 34 other tissues |
Interactioni
Subunit structurei
Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPD (By similarity).
Interacts with GATA1 AND SPI1 (By similarity).
Interacts with SMARCD2 (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000068927 |
Miscellaneous databases
RNActi | Q6PZD9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 204 – 267 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 208 – 245 | Basic motifPROSITE-ProRule annotationAdd BLAST | 38 | |
Regioni | 246 – 267 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000161681 |
HOGENOMi | CLU_043327_0_0_1 |
InParanoidi | Q6PZD9 |
OMAi | YPSHTFG |
OrthoDBi | 1284308at2759 |
PhylomeDBi | Q6PZD9 |
TreeFami | TF105008 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PZD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAM KPTPEARSLK GPGAPSFPHY LPADPRPFAY PSHTFGPDRK
110 120 130 140 150
ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTSRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRNRV
260 270 280
DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY570294 mRNA Translation: AAS78198.1 BC108953 mRNA Translation: AAI08954.1 |
CCDSi | CCDS27100.1 |
RefSeqi | NP_997014.1, NM_207131.1 |
Genome annotation databases
Ensembli | ENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435 |
GeneIDi | 110794 |
KEGGi | mmu:110794 |
UCSCi | uc007twz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY570294 mRNA Translation: AAS78198.1 BC108953 mRNA Translation: AAI08954.1 |
CCDSi | CCDS27100.1 |
RefSeqi | NP_997014.1, NM_207131.1 |
3D structure databases
SMRi | Q6PZD9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000068927 |
PTM databases
iPTMneti | Q6PZD9 |
PhosphoSitePlusi | Q6PZD9 |
Proteomic databases
MaxQBi | Q6PZD9 |
PaxDbi | Q6PZD9 |
PRIDEi | Q6PZD9 |
Protocols and materials databases
Antibodypediai | 150, 365 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435 |
GeneIDi | 110794 |
KEGGi | mmu:110794 |
UCSCi | uc007twz.1, mouse |
Organism-specific databases
CTDi | 1053 |
MGIi | MGI:103572, Cebpe |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000161681 |
HOGENOMi | CLU_043327_0_0_1 |
InParanoidi | Q6PZD9 |
OMAi | YPSHTFG |
OrthoDBi | 1284308at2759 |
PhylomeDBi | Q6PZD9 |
TreeFami | TF105008 |
Miscellaneous databases
BioGRID-ORCSi | 110794, 0 hits in 17 CRISPR screens |
PROi | PR:Q6PZD9 |
RNActi | Q6PZD9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052435, Expressed in granulocyte and 34 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPE_MOUSE | |
Accessioni | Q6PZD9Primary (citable) accession number: Q6PZD9 Secondary accession number(s): Q32MW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families