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Protein

Solute carrier family 2, facilitated glucose transporter member 7

Gene

SLC2A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei331MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.1.1.37 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 7
Alternative name(s):
Glucose transporter type 7
Short name:
GLUT-7
Gene namesi
Name:SLC2A7
Synonyms:GLUT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197241.3
HGNCiHGNC:13445 SLC2A7
MIMi610371 gene
neXtProtiNX_Q6PXP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 78ExtracellularSequence analysisAdd BLAST36
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 138ExtracellularSequence analysis10
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 172CytoplasmicSequence analysisAdd BLAST13
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 198ExtracellularSequence analysis5
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 281CytoplasmicSequence analysisAdd BLAST62
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 321ExtracellularSequence analysisAdd BLAST19
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 350CytoplasmicSequence analysis8
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 379ExtracellularSequence analysis8
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 415CytoplasmicSequence analysisAdd BLAST15
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 445ExtracellularSequence analysis9
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 512CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37770

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaiSLC2A7
DMDMi167008866

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172741 – 512Solute carrier family 2, facilitated glucose transporter member 7Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PXP3
PeptideAtlasiQ6PXP3
PRIDEiQ6PXP3
ProteomicsDBi67261

Expressioni

Tissue specificityi

Expressed in small intestine and colon. Weakly expressed in testis and prostate.1 Publication

Gene expression databases

BgeeiENSG00000197241 Expressed in 5 organ(s), highest expression level in heart left ventricle
CleanExiHS_SLC2A7

Organism-specific databases

HPAiHPA039931

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383698

Structurei

3D structure databases

ProteinModelPortaliQ6PXP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni294 – 300Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiQ6PXP3
KOiK12201
OMAiVDSCGRK
OrthoDBiEOG091G0A9K
PhylomeDBiQ6PXP3
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PXP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK
60 70 80 90 100
VFKSFYNETY FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD
110 120 130 140 150
SCGRKGTLLI NNIFAIIPAI LMGVSKVAKA FELIVFSRVV LGVCAGISYS
160 170 180 190 200
ALPMYLGELA PKNLRGMVGT MTEVFVIVGV FLAQIFSLQA ILGNPAGWPV
210 220 230 240 250
LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL RRLRGHTDME
260 270 280 290 300
AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN
310 320 330 340 350
AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL
360 370 380 390 400
LLAGYGICGS ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV
410 420 430 440 450
PSVVRTEIFL QSSRRAAFMV DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII
460 470 480 490 500
FAGICLLTAI YIYVVIPETK GKTFVEINRI FAKRNRVKLP EEKEETIDAG
510
PPTASPAKET SF
Length:512
Mass (Da):55,728
Last modified:May 1, 2007 - v2
Checksum:iDCA09E35AB720382
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052504135V → I. Corresponds to variant dbSNP:rs34545462Ensembl.1
Natural variantiVAR_061879261R → Q. Corresponds to variant dbSNP:rs12402973Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571960 mRNA Translation: AAS78590.2
AL158048 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71607.1
CCDSiCCDS98.2
RefSeqiNP_997303.2, NM_207420.2
UniGeneiHs.531239

Genome annotation databases

EnsembliENST00000400906; ENSP00000383698; ENSG00000197241
GeneIDi155184
KEGGihsa:155184
UCSCiuc009vmo.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571960 mRNA Translation: AAS78590.2
AL158048 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71607.1
CCDSiCCDS98.2
RefSeqiNP_997303.2, NM_207420.2
UniGeneiHs.531239

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YG7model-A1-512[»]
ProteinModelPortaliQ6PXP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383698

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.37 the major facilitator superfamily (mfs)

Polymorphism and mutation databases

BioMutaiSLC2A7
DMDMi167008866

Proteomic databases

PaxDbiQ6PXP3
PeptideAtlasiQ6PXP3
PRIDEiQ6PXP3
ProteomicsDBi67261

Protocols and materials databases

DNASUi155184
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400906; ENSP00000383698; ENSG00000197241
GeneIDi155184
KEGGihsa:155184
UCSCiuc009vmo.1 human

Organism-specific databases

CTDi155184
EuPathDBiHostDB:ENSG00000197241.3
GeneCardsiSLC2A7
HGNCiHGNC:13445 SLC2A7
HPAiHPA039931
MIMi610371 gene
neXtProtiNX_Q6PXP3
PharmGKBiPA37770
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiQ6PXP3
KOiK12201
OMAiVDSCGRK
OrthoDBiEOG091G0A9K
PhylomeDBiQ6PXP3
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

GeneWikiiSLC2A7
GenomeRNAii155184
PROiPR:Q6PXP3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197241 Expressed in 5 organ(s), highest expression level in heart left ventricle
CleanExiHS_SLC2A7

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR7_HUMAN
AccessioniPrimary (citable) accession number: Q6PXP3
Secondary accession number(s): A2A333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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