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Entry version 106 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Transporter

Gene

SERT

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transportARBA annotation, SymportUniRule annotationARBA annotation, Transport
LigandMetal-bindingARBA annotation, SodiumARBA annotation

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.22.1.11, the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TransporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei128 – 146HelicalSequence analysisAdd BLAST19
Transmembranei158 – 179HelicalSequence analysisAdd BLAST22
Transmembranei200 – 228HelicalSequence analysisAdd BLAST29
Transmembranei291 – 308HelicalSequence analysisAdd BLAST18
Transmembranei320 – 346HelicalSequence analysisAdd BLAST27
Transmembranei366 – 390HelicalSequence analysisAdd BLAST25
Transmembranei402 – 427HelicalSequence analysisAdd BLAST26
Transmembranei447 – 472HelicalSequence analysisAdd BLAST26
Transmembranei504 – 529HelicalSequence analysisAdd BLAST26
Transmembranei535 – 558HelicalSequence analysisAdd BLAST24
Transmembranei579 – 598HelicalSequence analysisAdd BLAST20
Transmembranei610 – 635HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membraneARBA annotation, EndosomeARBA annotation, Membrane, SynapseARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PWI2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 755HT_transport_NInterPro annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
PFMIMEF

Database of Orthologous Groups

More...
OrthoDBi
250396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PWI2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175, Na/ntran_symport
IPR013086, Na/ntran_symport_serotonin_N
IPR037272, SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616, PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03491, 5HT_transport_N, 1 hit
PF00209, SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00176, NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070, SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PWI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENKATSNET QPLTSKKGIS DCNEGEDCKE NGLLIRNPKS ALRLVDDGNK
60 70 80 90 100
VHPGQGDKEE AAQISNGYSG VQSSGPCSGM GEAEDAQCTA PAATTTTTTT
110 120 130 140 150
TSTTCGAEGQ QQLMELGDRE TWSKKIDFLL SVIGYAVDLG NVWRFPYICY
160 170 180 190 200
QNGGGAFLIP YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG
210 220 230 240 250
IGFAICIIDL YVASYYNTIM AWVFYYLVSS FTTELPWTSC NNAWNTGNCT
260 270 280 290 300
TYFSKDNISW ALHSISPAEE FYTRQVLQVH RSNGLDDLGG ISWQLTLCLL
310 320 330 340 350
LIFIIVYFSI WKGVKTSGKV VWVTATFPYV ILFILLVRGA TLPGAWRGVL
360 370 380 390 400
YYLKPEWQKL LATEVWVDAA AQIFFSLGPG FGVLLAYASY NKFHNNCYQD
410 420 430 440 450
ALVTSTVNCL TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD MGPSLLFITY
460 470 480 490 500
AEAIANMPAS TFFAIIFFLM LLTLGLDSTF AGLEGVITGV LDEFPHVWSK
510 520 530 540 550
RREFFVLGLI IICFLGSLAT LTFGGAYVVK LFEEYATGPA VLTVVFLEAV
560 570 580 590 600
AVAWFYGITQ FCNDVKEMLG FAPGWYWRVC WVAISPIFLL FVTCSFLSNP
610 620 630 640 650
PELRLFDYNY PYWTTVVGYC IGTSSIICIP IYMAYRLIIT PGTLKERILK
660 670
SITPETATEI PFGDIRMNAV
Length:670
Mass (Da):74,427
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36AB5354615A657B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY573844 mRNA Translation: AAS79016.1

NCBI Reference Sequences

More...
RefSeqi
NP_998737.1, NM_213572.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
404747

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:404747

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573844 mRNA Translation: AAS79016.1
RefSeqiNP_998737.1, NM_213572.1

3D structure databases

SMRiQ6PWI2
ModBaseiSearch...

Protein family/group databases

TCDBi2.A.22.1.11, the neurotransmitter:sodium symporter (nss) family

Genome annotation databases

GeneIDi404747
KEGGigga:404747

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6532

Phylogenomic databases

OMAiPFMIMEF
OrthoDBi250396at2759
PhylomeDBiQ6PWI2

Family and domain databases

InterProiView protein in InterPro
IPR000175, Na/ntran_symport
IPR013086, Na/ntran_symport_serotonin_N
IPR037272, SNS_sf
PANTHERiPTHR11616, PTHR11616, 1 hit
PfamiView protein in Pfam
PF03491, 5HT_transport_N, 1 hit
PF00209, SNF, 1 hit
PRINTSiPR00176, NANEUSMPORT
SUPFAMiSSF161070, SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6PWI2_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PWI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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