Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cytoskeletal 14

Gene

KRT14

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • intermediate filament bundle assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 14
Alternative name(s):
Cytokeratin-14
Short name:
CK-14
Keratin-14
Short name:
K14
Gene namesi
Name:KRT14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636561 – 467Keratin, type I cytoskeletal 14Add BLAST467

Proteomic databases

PaxDbiQ6PVZ1
PRIDEiQ6PVZ1

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006090

Structurei

3D structure databases

ProteinModelPortaliQ6PVZ1
SMRiQ6PVZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 420IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 108HeadBy similarityAdd BLAST108
Regioni109 – 144Coil 1ABy similarityAdd BLAST36
Regioni145 – 162Linker 1By similarityAdd BLAST18
Regioni163 – 254Coil 1BBy similarityAdd BLAST92
Regioni255 – 277Linker 12By similarityAdd BLAST23
Regioni278 – 416Coil 2By similarityAdd BLAST139
Regioni417 – 467TailBy similarityAdd BLAST51
Regioni419 – 467Interaction with Type I keratins and keratin filamentsBy similarityAdd BLAST49

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ6PVZ1
KOiK07604
PhylomeDBiQ6PVZ1

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 2 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PVZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVRQFSS STSLKGLGGG SSRLSCGRAA GYQAPSVHGG SSSYSVSSRI
60 70 80 90 100
VSGLGAGYGG GYCSSVGGGL GGGFGASYGA GYGAGFGGGF GAGFGGGFGG
110 120 130 140 150
GDGILPAGEK ETMQNLNDRL AAYLDKVRAL EEANTDLEVK IREWYKKQGP
160 170 180 190 200
GPERDYSPYY RTIEELRSKI LAATVENANI VLQIDNARLA ADDFRTKFET
210 220 230 240 250
EQALRLSVEA DINGLRRVLD ELTLSRADLE MQIENLKEEL AYLKKNHEEE
260 270 280 290 300
MNALRGQVGG EISVEMDAAP GIDLTKILAE MREQYESLAE KNRRDAEQWF
310 320 330 340 350
FSKTEELNRE VAVNTEQLQS GKTEITELRR TIQSLEIDLQ SQLSTKAALE
360 370 380 390 400
GTLADTEARY GTQLAQLQAL ITSVEEQLAE LRCDMERQNH EYRVLLDVKC
410 420 430 440 450
RLEQEIATYR RLLEGEDAHI SSQYSSAMSS HSGRDAITTS RQVRTIVEEV
460
QDGKVVSSRE QMALTTR
Length:467
Mass (Da):50,986
Last modified:July 5, 2004 - v1
Checksum:iAA9E3E3046E5D3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574987 mRNA Translation: AAS92202.1
RefSeqiNP_001001311.2, NM_001001311.2
UniGeneiGga.16196

Genome annotation databases

GeneIDi408039
KEGGigga:408039

Similar proteinsi

Entry informationi

Entry nameiK1C14_CHICK
AccessioniPrimary (citable) accession number: Q6PVZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health