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Protein

Complexin-2

Gene

CPLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: Ensembl
  • SNARE binding Source: GO_Central
  • syntaxin-1 binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processDifferentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-2
Alternative name(s):
Complexin II
Short name:
CPX II
Synaphin-1
Gene namesi
Name:CPLX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145920.14
HGNCiHGNC:2310 CPLX2
MIMi605033 gene
neXtProtiNX_Q6PUV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10814
OpenTargetsiENSG00000145920
PharmGKBiPA26827

Polymorphism and mutation databases

BioMutaiCPLX2
DMDMi51316998

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448751 – 134Complexin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PUV4
PaxDbiQ6PUV4
PeptideAtlasiQ6PUV4
PRIDEiQ6PUV4
ProteomicsDBi67260
TopDownProteomicsiQ6PUV4

PTM databases

iPTMnetiQ6PUV4
PhosphoSitePlusiQ6PUV4

Expressioni

Tissue specificityi

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.5 Publications

Gene expression databases

BgeeiENSG00000145920 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CPLX2
ExpressionAtlasiQ6PUV4 baseline and differential
GenevisibleiQ6PUV4 HS

Organism-specific databases

HPAiHPA071191

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116027, 8 interactors
CORUMiQ6PUV4
IntActiQ6PUV4, 6 interactors
STRINGi9606.ENSP00000352544

Structurei

3D structure databases

ProteinModelPortaliQ6PUV4
SMRiQ6PUV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 97Interaction with the SNARE complexBy similarityAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 84Sequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS Eukaryota
ENOG4111MX0 LUCA
GeneTreeiENSGT00490000043416
HOVERGENiHBG062792
InParanoidiQ6PUV4
KOiK15294
OMAiAMEQPCE
OrthoDBiEOG093718WG
PhylomeDBiQ6PUV4
TreeFamiTF315172

Family and domain databases

InterProiView protein in InterPro
IPR008849 Synaphin
PANTHERiPTHR16705 PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835 Synaphin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q6PUV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA
60 70 80 90 100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA
110 120 130
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
Length:134
Mass (Da):15,394
Last modified:August 16, 2004 - v2
Checksum:i7791812FD4194AC5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R960D6R960_HUMAN
Complexin-2
CPLX2
119Annotation score:
D6RGY3D6RGY3_HUMAN
Complexin-2
CPLX2
111Annotation score:
D6RBA5D6RBA5_HUMAN
Complexin-2
CPLX2
77Annotation score:
D6RI05D6RI05_HUMAN
Complexin-2
CPLX2
70Annotation score:
D6RDN3D6RDN3_HUMAN
Complexin-2
CPLX2
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35100 mRNA Translation: AAC50229.1
AK314177 mRNA Translation: BAG36859.1
BC093706 mRNA Translation: AAH93706.1
BC112287 mRNA Translation: AAI12288.1
AY576870 mRNA Translation: AAS93622.1
BN000499 mRNA Translation: CAG26663.1
BN000500 mRNA Translation: CAG26664.1
CCDSiCCDS4396.1
PIRiE57233
RefSeqiNP_001008221.1, NM_001008220.1
NP_006641.1, NM_006650.3
XP_005265855.1, XM_005265798.1
XP_005265856.1, XM_005265799.1
XP_011532721.1, XM_011534419.1
XP_016864453.1, XM_017008964.1
UniGeneiHs.193235

Genome annotation databases

EnsembliENST00000359546; ENSP00000352544; ENSG00000145920
ENST00000393745; ENSP00000377346; ENSG00000145920
ENST00000515094; ENSP00000421825; ENSG00000145920
GeneIDi10814
KEGGihsa:10814
UCSCiuc003mde.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35100 mRNA Translation: AAC50229.1
AK314177 mRNA Translation: BAG36859.1
BC093706 mRNA Translation: AAH93706.1
BC112287 mRNA Translation: AAI12288.1
AY576870 mRNA Translation: AAS93622.1
BN000499 mRNA Translation: CAG26663.1
BN000500 mRNA Translation: CAG26664.1
CCDSiCCDS4396.1
PIRiE57233
RefSeqiNP_001008221.1, NM_001008220.1
NP_006641.1, NM_006650.3
XP_005265855.1, XM_005265798.1
XP_005265856.1, XM_005265799.1
XP_011532721.1, XM_011534419.1
XP_016864453.1, XM_017008964.1
UniGeneiHs.193235

3D structure databases

ProteinModelPortaliQ6PUV4
SMRiQ6PUV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116027, 8 interactors
CORUMiQ6PUV4
IntActiQ6PUV4, 6 interactors
STRINGi9606.ENSP00000352544

PTM databases

iPTMnetiQ6PUV4
PhosphoSitePlusiQ6PUV4

Polymorphism and mutation databases

BioMutaiCPLX2
DMDMi51316998

Proteomic databases

MaxQBiQ6PUV4
PaxDbiQ6PUV4
PeptideAtlasiQ6PUV4
PRIDEiQ6PUV4
ProteomicsDBi67260
TopDownProteomicsiQ6PUV4

Protocols and materials databases

DNASUi10814
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359546; ENSP00000352544; ENSG00000145920
ENST00000393745; ENSP00000377346; ENSG00000145920
ENST00000515094; ENSP00000421825; ENSG00000145920
GeneIDi10814
KEGGihsa:10814
UCSCiuc003mde.2 human

Organism-specific databases

CTDi10814
DisGeNETi10814
EuPathDBiHostDB:ENSG00000145920.14
GeneCardsiCPLX2
HGNCiHGNC:2310 CPLX2
HPAiHPA071191
MIMi605033 gene
neXtProtiNX_Q6PUV4
OpenTargetsiENSG00000145920
PharmGKBiPA26827
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWGS Eukaryota
ENOG4111MX0 LUCA
GeneTreeiENSGT00490000043416
HOVERGENiHBG062792
InParanoidiQ6PUV4
KOiK15294
OMAiAMEQPCE
OrthoDBiEOG093718WG
PhylomeDBiQ6PUV4
TreeFamiTF315172

Miscellaneous databases

ChiTaRSiCPLX2 human
GeneWikiiCPLX2
GenomeRNAii10814
PROiPR:Q6PUV4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145920 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CPLX2
ExpressionAtlasiQ6PUV4 baseline and differential
GenevisibleiQ6PUV4 HS

Family and domain databases

InterProiView protein in InterPro
IPR008849 Synaphin
PANTHERiPTHR16705 PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835 Synaphin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPLX2_HUMAN
AccessioniPrimary (citable) accession number: Q6PUV4
Secondary accession number(s): B2RAG2
, O09056, Q13329, Q28184, Q52M15, Q64386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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