CPLX2

Functionⁱ

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).By similarity

GO - Molecular functionⁱ

calcium-dependent protein binding Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin-1 binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
mast cell degranulation Source: UniProtKB-KW
nervous system development Source: UniProtKB-KW
positive regulation of synaptic plasticity Source: UniProtKB
regulation of exocytosis
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 15217342
regulation of neurotransmitter secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
synaptic vesicle exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle docking involved in exocytosis
Source: ProtInc
Traceable author statementⁱ
- 7553862

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport

Biological process

Differentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complexin-2 Alternative name(s): Complexin II Short name: CPX II Synaphin-1
Gene namesⁱ	Name:CPLX2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145920.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2310 CPLX2
MIMⁱ	605033 gene
neXtProtⁱ	NX_Q6PUV4

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10814
Open Targets More...OpenTargetsⁱ	ENSG00000145920
PharmGKBⁱ	PA26827

Polymorphism and mutation databases

BioMutaⁱ	CPLX2
DMDMⁱ	51316998

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144875	1 – 134	Complexin-2Add BLAST		134

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	93	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PUV4
PaxDbⁱ	Q6PUV4
PeptideAtlas More...PeptideAtlasⁱ	Q6PUV4
PRIDEⁱ	Q6PUV4
ProteomicsDBⁱ	67260
TopDownProteomicsⁱ	Q6PUV4

PTM databases

iPTMnetⁱ	Q6PUV4
PhosphoSitePlusⁱ	Q6PUV4

Expressionⁱ

Tissue specificityⁱ

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.5 Publications

Gene expression databases

Bgeeⁱ	ENSG00000145920 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CPLX2
ExpressionAtlasⁱ	Q6PUV4 baseline and differential
Genevisibleⁱ	Q6PUV4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071191

HPAⁱ

HPA071191

Interactionⁱ

Subunit structureⁱ

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

GO - Molecular functionⁱ

calcium-dependent protein binding Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin-1 binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116027, 8 interactors
CORUMⁱ	Q6PUV4
IntActⁱ	Q6PUV4, 6 interactors
STRINGⁱ	9606.ENSP00000352544

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PUV4
SMRⁱ	Q6PUV4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	41 – 97	Interaction with the SNARE complexBy similarityAdd BLAST		57

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	28 – 84	Sequence analysisAdd BLAST		57

Sequence similaritiesⁱ

Belongs to the complexin/synaphin family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IWGS Eukaryota ENOG4111MX0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043416
HOVERGENⁱ	HBG062792
InParanoidⁱ	Q6PUV4
KEGG Orthology (KO) More...KOⁱ	K15294
OMAⁱ	AMEQPCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG093718WG
PhylomeDBⁱ	Q6PUV4
TreeFamⁱ	TF315172

Family and domain databases

InterProⁱ	View protein in InterPro IPR008849 Synaphin
PANTHERⁱ	PTHR16705 PTHR16705, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05835 Synaphin, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q6PUV4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA 
        60         70         80         90        100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA 
       110        120        130 
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK

Length:134

Mass (Da):15,394

Last modified:August 16, 2004 - v2

Checksum:ⁱ7791812FD4194AC5

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6R960	D6R960_HUMAN	Complexin-2 Complexin-2	CPLX2	119	Annotation score:
D6RGY3	D6RGY3_HUMAN	Complexin-2 Complexin-2	CPLX2	111	Annotation score:
D6RBA5	D6RBA5_HUMAN	Complexin-2 Complexin-2	CPLX2	77	Annotation score:
D6RI05	D6RI05_HUMAN	Complexin-2 Complexin-2	CPLX2	70	Annotation score:
D6RDN3	D6RDN3_HUMAN	Complexin-2 Complexin-2	CPLX2	37	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35100 mRNA Translation: AAC50229.1 AK314177 mRNA Translation: BAG36859.1 BC093706 mRNA Translation: AAH93706.1 BC112287 mRNA Translation: AAI12288.1 AY576870 mRNA Translation: AAS93622.1 BN000499 mRNA Translation: CAG26663.1 BN000500 mRNA Translation: CAG26664.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4396.1
PIRⁱ	E57233
NCBI Reference Sequences More...RefSeqⁱ	NP_001008221.1, NM_001008220.1 NP_006641.1, NM_006650.3 XP_005265855.1, XM_005265798.1 XP_005265856.1, XM_005265799.1 XP_011532721.1, XM_011534419.1 XP_016864453.1, XM_017008964.1
UniGeneⁱ	Hs.193235

Genome annotation databases

Ensemblⁱ	ENST00000359546; ENSP00000352544; ENSG00000145920 ENST00000393745; ENSP00000377346; ENSG00000145920 ENST00000515094; ENSP00000421825; ENSG00000145920
GeneIDⁱ	10814
KEGGⁱ	hsa:10814
UCSC genome browser More...UCSCⁱ	uc003mde.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PUV4	Complexin-2		BOVIN		134	UniRef100_Q6PUV4
Complexin-2		MOUSE		134
Complexin-2		RAT		134
Synaphin containing protein		CRIGR		119
CPLX2 isoform 1		PANTR		134
+81

Protein	Similar proteins		Species	Score	Length	Source
Q6PUV4	Complexin-2		BOVIN		134	UniRef90_Q6PUV4
Complexin-2		MOUSE		134
Complexin-2		RAT		134
Synaphin containing protein		CRIGR		119
CPLX2 isoform 1		PANTR		134
+81

Protein	Similar proteins		Species	Score	Length	Source
Q6PUV4	Complexin-2		BOVIN		134	UniRef50_Q6PUV4
Complexin-2		MOUSE		134
Complexin-2		RAT		134
Synaphin containing protein		CRIGR		119
CPLX2 isoform 1		PANTR		134
+83

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35100 mRNA Translation: AAC50229.1 AK314177 mRNA Translation: BAG36859.1 BC093706 mRNA Translation: AAH93706.1 BC112287 mRNA Translation: AAI12288.1 AY576870 mRNA Translation: AAS93622.1 BN000499 mRNA Translation: CAG26663.1 BN000500 mRNA Translation: CAG26664.1
CCDSⁱ	CCDS4396.1
PIRⁱ	E57233
RefSeqⁱ	NP_001008221.1, NM_001008220.1 NP_006641.1, NM_006650.3 XP_005265855.1, XM_005265798.1 XP_005265856.1, XM_005265799.1 XP_011532721.1, XM_011534419.1 XP_016864453.1, XM_017008964.1
UniGeneⁱ	Hs.193235

3D structure databases

ProteinModelPortalⁱ	Q6PUV4
SMRⁱ	Q6PUV4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116027, 8 interactors
CORUMⁱ	Q6PUV4
IntActⁱ	Q6PUV4, 6 interactors
STRINGⁱ	9606.ENSP00000352544

PTM databases

iPTMnetⁱ	Q6PUV4
PhosphoSitePlusⁱ	Q6PUV4

Polymorphism and mutation databases

BioMutaⁱ	CPLX2
DMDMⁱ	51316998

Proteomic databases

MaxQBⁱ	Q6PUV4
PaxDbⁱ	Q6PUV4
PeptideAtlasⁱ	Q6PUV4
PRIDEⁱ	Q6PUV4
ProteomicsDBⁱ	67260
TopDownProteomicsⁱ	Q6PUV4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10814
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359546; ENSP00000352544; ENSG00000145920 ENST00000393745; ENSP00000377346; ENSG00000145920 ENST00000515094; ENSP00000421825; ENSG00000145920
GeneIDⁱ	10814
KEGGⁱ	hsa:10814
UCSCⁱ	uc003mde.2 human

Organism-specific databases

CTDⁱ	10814
DisGeNETⁱ	10814
EuPathDBⁱ	HostDB:ENSG00000145920.14
GeneCardsⁱ	CPLX2
HGNCⁱ	HGNC:2310 CPLX2
HPAⁱ	HPA071191
MIMⁱ	605033 gene
neXtProtⁱ	NX_Q6PUV4
OpenTargetsⁱ	ENSG00000145920
PharmGKBⁱ	PA26827
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWGS Eukaryota ENOG4111MX0 LUCA
GeneTreeⁱ	ENSGT00490000043416
HOVERGENⁱ	HBG062792
InParanoidⁱ	Q6PUV4
KOⁱ	K15294
OMAⁱ	AMEQPCE
OrthoDBⁱ	EOG093718WG
PhylomeDBⁱ	Q6PUV4
TreeFamⁱ	TF315172

Miscellaneous databases

ChiTaRSⁱ	CPLX2 human
GeneWikiⁱ	CPLX2
GenomeRNAiⁱ	10814
Protein Ontology More...PROⁱ	PR:Q6PUV4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145920 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CPLX2
ExpressionAtlasⁱ	Q6PUV4 baseline and differential
Genevisibleⁱ	Q6PUV4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008849 Synaphin
PANTHERⁱ	PTHR16705 PTHR16705, 1 hit
Pfamⁱ	View protein in Pfam PF05835 Synaphin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CPLX2_HUMAN
Accessionⁱ	Q6PUV4Primary (citable) accession number: Q6PUV4 Secondary accession number(s): B2RAG2 , O09056, Q13329, Q28184, Q52M15, Q64386
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	August 16, 2004
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6PUV4 (CPLX2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Complexin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Cytosol

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ