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UniProtKB - Q6PUV4 (CPLX2_HUMAN)
Protein
Complexin-2
Gene
CPLX2
Organism
Homo sapiens (Human)
Status
Functioni
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).
By similarityGO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
- SNARE binding Source: GO_Central
- syntaxin-1 binding Source: Ensembl
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- mast cell degranulation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
- positive regulation of synaptic plasticity Source: UniProtKB
- regulation of exocytosis Source: ParkinsonsUK-UCL
- regulation of neurotransmitter secretion Source: GO_Central
- regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
- synaptic vesicle exocytosis Source: GO_Central
- vesicle docking involved in exocytosis Source: ProtInc
Keywordsi
Biological process | Differentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q6PUV4 |
SignaLinki | Q6PUV4 |
Names & Taxonomyi
Protein namesi | Recommended name: Complexin-2Alternative name(s): Complexin II Short name: CPX II Synaphin-1 |
Gene namesi | Name:CPLX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2310, CPLX2 |
MIMi | 605033, gene |
neXtProti | NX_Q6PUV4 |
VEuPathDBi | HostDB:ENSG00000145920 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Nucleus
- Nucleus By similarity
Other locations
- presynapse By similarity
- Perikaryon By similarity
Note: Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- calyx of Held Source: Ensembl
- dendrite Source: Ensembl
- glutamatergic synapse Source: Ensembl
- perikaryon Source: UniProtKB-SubCell
- postsynapse Source: Ensembl
- SNARE complex Source: GO_Central
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex Source: ParkinsonsUK-UCL
- terminal bouton Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Nucleus, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 10814 |
OpenTargetsi | ENSG00000145920 |
PharmGKBi | PA26827 |
Miscellaneous databases
Pharosi | Q6PUV4, Tbio |
Genetic variation databases
BioMutai | CPLX2 |
DMDMi | 51316998 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144875 | 1 – 134 | Complexin-2Add BLAST | 134 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 93 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q6PUV4 |
MassIVEi | Q6PUV4 |
MaxQBi | Q6PUV4 |
PaxDbi | Q6PUV4 |
PeptideAtlasi | Q6PUV4 |
PRIDEi | Q6PUV4 |
ProteomicsDBi | 67260 |
TopDownProteomicsi | Q6PUV4 |
PTM databases
iPTMneti | Q6PUV4 |
PhosphoSitePlusi | Q6PUV4 |
Expressioni
Tissue specificityi
Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.5 Publications
Gene expression databases
Bgeei | ENSG00000145920, Expressed in right hemisphere of cerebellum and 136 other tissues |
ExpressionAtlasi | Q6PUV4, baseline and differential |
Genevisiblei | Q6PUV4, HS |
Organism-specific databases
HPAi | ENSG00000145920, Tissue enhanced (brain, epididymis, pituitary gland) |
Interactioni
Subunit structurei
Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
By similarityBinary interactionsi
Q6PUV4
With | #Exp. | IntAct |
---|---|---|
MYG1 [Q9HB07] | 3 | EBI-2689453,EBI-709754 |
NDRG4 - isoform 2 [Q9ULP0-2] | 3 | EBI-2689453,EBI-11978907 |
PBX3 [Q96AL5] | 3 | EBI-2689453,EBI-741171 |
TSFM [P43897] | 3 | EBI-2689453,EBI-1049298 |
GO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
- SNARE binding Source: GO_Central
- syntaxin-1 binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116027, 19 interactors |
CORUMi | Q6PUV4 |
IntActi | Q6PUV4, 14 interactors |
MINTi | Q6PUV4 |
STRINGi | 9606.ENSP00000352544 |
Miscellaneous databases
RNActi | Q6PUV4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 114 | DisorderedSequence analysisAdd BLAST | 114 | |
Regioni | 41 – 97 | Interaction with the SNARE complexBy similarityAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 28 – 84 | Sequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 86 | Basic and acidic residuesSequence analysisAdd BLAST | 69 |
Sequence similaritiesi
Belongs to the complexin/synaphin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RXXI, Eukaryota |
GeneTreei | ENSGT00950000182938 |
HOGENOMi | CLU_132159_1_0_1 |
InParanoidi | Q6PUV4 |
OMAi | HARMESD |
PhylomeDBi | Q6PUV4 |
TreeFami | TF315172 |
Family and domain databases
InterProi | View protein in InterPro IPR008849, Synaphin |
PANTHERi | PTHR16705, PTHR16705, 1 hit |
Pfami | View protein in Pfam PF05835, Synaphin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q6PUV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA
60 70 80 90 100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA
110 120 130
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6R960 | D6R960_HUMAN | Complexin-2 | CPLX2 | 119 | Annotation score: | ||
D6RGY3 | D6RGY3_HUMAN | Complexin-2 | CPLX2 | 111 | Annotation score: | ||
D6RBA5 | D6RBA5_HUMAN | Complexin-2 | CPLX2 | 77 | Annotation score: | ||
D6RDN3 | D6RDN3_HUMAN | Complexin-2 | CPLX2 | 37 | Annotation score: | ||
D6RI05 | D6RI05_HUMAN | Complexin-2 | CPLX2 | 70 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35100 mRNA Translation: AAC50229.1 AK314177 mRNA Translation: BAG36859.1 BC093706 mRNA Translation: AAH93706.1 BC112287 mRNA Translation: AAI12288.1 AY576870 mRNA Translation: AAS93622.1 BN000499 mRNA Translation: CAG26663.1 BN000500 mRNA Translation: CAG26664.1 |
CCDSi | CCDS4396.1 |
PIRi | E57233 |
RefSeqi | NP_001008221.1, NM_001008220.1 NP_006641.1, NM_006650.3 XP_005265855.1, XM_005265798.1 XP_005265856.1, XM_005265799.1 XP_011532721.1, XM_011534419.1 XP_016864453.1, XM_017008964.1 |
Genome annotation databases
Ensembli | ENST00000359546; ENSP00000352544; ENSG00000145920 ENST00000393745; ENSP00000377346; ENSG00000145920 ENST00000515094; ENSP00000421825; ENSG00000145920 |
GeneIDi | 10814 |
KEGGi | hsa:10814 |
MANE-Selecti | ENST00000393745.8; ENSP00000377346.3; NM_001008220.2; NP_001008221.1 |
UCSCi | uc003mde.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35100 mRNA Translation: AAC50229.1 AK314177 mRNA Translation: BAG36859.1 BC093706 mRNA Translation: AAH93706.1 BC112287 mRNA Translation: AAI12288.1 AY576870 mRNA Translation: AAS93622.1 BN000499 mRNA Translation: CAG26663.1 BN000500 mRNA Translation: CAG26664.1 |
CCDSi | CCDS4396.1 |
PIRi | E57233 |
RefSeqi | NP_001008221.1, NM_001008220.1 NP_006641.1, NM_006650.3 XP_005265855.1, XM_005265798.1 XP_005265856.1, XM_005265799.1 XP_011532721.1, XM_011534419.1 XP_016864453.1, XM_017008964.1 |
3D structure databases
SMRi | Q6PUV4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116027, 19 interactors |
CORUMi | Q6PUV4 |
IntActi | Q6PUV4, 14 interactors |
MINTi | Q6PUV4 |
STRINGi | 9606.ENSP00000352544 |
PTM databases
iPTMneti | Q6PUV4 |
PhosphoSitePlusi | Q6PUV4 |
Genetic variation databases
BioMutai | CPLX2 |
DMDMi | 51316998 |
Proteomic databases
jPOSTi | Q6PUV4 |
MassIVEi | Q6PUV4 |
MaxQBi | Q6PUV4 |
PaxDbi | Q6PUV4 |
PeptideAtlasi | Q6PUV4 |
PRIDEi | Q6PUV4 |
ProteomicsDBi | 67260 |
TopDownProteomicsi | Q6PUV4 |
Protocols and materials databases
Antibodypediai | 45968, 179 antibodies from 26 providers |
DNASUi | 10814 |
Genome annotation databases
Ensembli | ENST00000359546; ENSP00000352544; ENSG00000145920 ENST00000393745; ENSP00000377346; ENSG00000145920 ENST00000515094; ENSP00000421825; ENSG00000145920 |
GeneIDi | 10814 |
KEGGi | hsa:10814 |
MANE-Selecti | ENST00000393745.8; ENSP00000377346.3; NM_001008220.2; NP_001008221.1 |
UCSCi | uc003mde.2, human |
Organism-specific databases
CTDi | 10814 |
DisGeNETi | 10814 |
GeneCardsi | CPLX2 |
HGNCi | HGNC:2310, CPLX2 |
HPAi | ENSG00000145920, Tissue enhanced (brain, epididymis, pituitary gland) |
MIMi | 605033, gene |
neXtProti | NX_Q6PUV4 |
OpenTargetsi | ENSG00000145920 |
PharmGKBi | PA26827 |
VEuPathDBi | HostDB:ENSG00000145920 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RXXI, Eukaryota |
GeneTreei | ENSGT00950000182938 |
HOGENOMi | CLU_132159_1_0_1 |
InParanoidi | Q6PUV4 |
OMAi | HARMESD |
PhylomeDBi | Q6PUV4 |
TreeFami | TF315172 |
Enzyme and pathway databases
PathwayCommonsi | Q6PUV4 |
SignaLinki | Q6PUV4 |
Miscellaneous databases
BioGRID-ORCSi | 10814, 11 hits in 1034 CRISPR screens |
ChiTaRSi | CPLX2, human |
GeneWikii | CPLX2 |
GenomeRNAii | 10814 |
Pharosi | Q6PUV4, Tbio |
PROi | PR:Q6PUV4 |
RNActi | Q6PUV4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145920, Expressed in right hemisphere of cerebellum and 136 other tissues |
ExpressionAtlasi | Q6PUV4, baseline and differential |
Genevisiblei | Q6PUV4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008849, Synaphin |
PANTHERi | PTHR16705, PTHR16705, 1 hit |
Pfami | View protein in Pfam PF05835, Synaphin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CPLX2_HUMAN | |
Accessioni | Q6PUV4Primary (citable) accession number: Q6PUV4 Secondary accession number(s): B2RAG2 Q64386 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families