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Protein

Alpha-conotoxin Lp1.1

Gene
N/A
Organism
Conus leopardus (Leopard cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Synthetic peptide inhibits alpha-6/alpha-3/beta-2 and alpha-3/beta-2 nicotinic acetylcholine receptors and causes uncoordinated movement when intramuscularly injected into goldfish.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin Lp1.11 Publication
OrganismiConus leopardus (Leopard cone)
Taxonomic identifieri101306 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusLithoconus

Organism-specific databases

ConoServeri119 Lp1.1 precursor
543 Lp1.1 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037064722 – 481 PublicationAdd BLAST27
PeptideiPRO_000037064849 – 65Alpha-conotoxin Lp1.11 PublicationAdd BLAST17
PropeptideiPRO_000037064966 – 681 Publication3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 561 Publication
Disulfide bondi51 ↔ 641 Publication
Modified residuei65Glycine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6PTD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PTD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMFIMF MLVVLATTVV TFTSDRALDA MNAAASNKAS RLIALAVRGC
60
CARAACAGIH QELCGGGR
Length:68
Mass (Da):7,155
Last modified:July 5, 2004 - v1
Checksum:i30B30442453B2F3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20V → D in ABC39769 (PubMed:17400270).Curated1
Sequence conflicti26R → H in ABC39769 (PubMed:17400270).Curated1
Sequence conflicti67G → R in ABC39769 (PubMed:17400270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY580321 mRNA Translation: AAS93424.1
DQ359141 mRNA Translation: ABD48792.1
DQ309776 Genomic DNA Translation: ABC39769.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY580321 mRNA Translation: AAS93424.1
DQ359141 mRNA Translation: ABD48792.1
DQ309776 Genomic DNA Translation: ABC39769.1

3D structure databases

ProteinModelPortaliQ6PTD5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri119 Lp1.1 precursor
543 Lp1.1 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA11_CONLE
AccessioniPrimary (citable) accession number: Q6PTD5
Secondary accession number(s): A0SE61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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