UniProtKB - Q6PTD3 (Q6PTD3_CONLE)
Protein
Alpha-conotoxin-like
Gene
N/A
Organism
Conus leopardus (Leopard cone)
Status
Functioni
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.UniRule annotation
GO - Molecular functioni
- acetylcholine receptor inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxinUniRule annotation, Ion channel impairing toxinARBA annotation, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-conotoxin-likeUniRule annotation |
Organismi | Conus leopardus (Leopard cone)Imported |
Taxonomic identifieri | 101306 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Lithoconus |
Organism-specific databases
ConoServeri | 121, Lp1.3 precursor |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- host cell postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5004279180 | 22 – 67 | Alpha-conotoxin-likeSequence analysisAdd BLAST | 46 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisFamily and domain databases
InterProi | View protein in InterPro IPR009958, Conotoxin_a-typ IPR018072, Conotoxin_a-typ_CS |
Pfami | View protein in Pfam PF07365, Toxin_8, 1 hit |
PROSITEi | View protein in PROSITE PS60014, ALPHA_CONOTOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PTD3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGMRMMFIMF MLVVLATTVV SFTSDRASDG RNAEAKALDL IAATARPRCC
60
SNPACGAGHP EICAGRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY580323 mRNA Translation: AAS93426.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY580323 mRNA Translation: AAS93426.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Organism-specific databases
ConoServeri | 121, Lp1.3 precursor |
Family and domain databases
InterProi | View protein in InterPro IPR009958, Conotoxin_a-typ IPR018072, Conotoxin_a-typ_CS |
Pfami | View protein in Pfam PF07365, Toxin_8, 1 hit |
PROSITEi | View protein in PROSITE PS60014, ALPHA_CONOTOXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6PTD3_CONLE | |
Accessioni | Q6PTD3Primary (citable) accession number: Q6PTD3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 7, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |